SK12002000A3 - 2-(purín-9-yl)-tetrahydrofurán-3,4-diolové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty - Google Patents

2-(purín-9-yl)-tetrahydrofurán-3,4-diolové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty Download PDF

Info

Publication number: SK12002000A3
Authority: SK; Slovakia
Prior art keywords: purin; tetrahydrofuran; diol; ethyl; oxadiazol
Prior art date: 1998-02-14

Application number

SK1200-2000A

Other languages

English (en)

Slovak (sk)

Inventor

David Edmund Bays

Chuen Chan

Caroline Mary Cook

Richard Peter Charles Cousins

Brian Cox

Hazel Joan Dyke

Frank Ellis

Joanna Victoria Geden

Stephen Swanson

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-14

Filing date

1999-02-12

Publication date

2001-07-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26313119&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK12002000(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-02-14 Priority claimed from GBGB9803169.3A external-priority patent/GB9803169D0/en

1998-06-23 Priority claimed from GBGB9813533.8A external-priority patent/GB9813533D0/en

1999-02-12 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2001-07-10 Publication of SK12002000A3 publication Critical patent/SK12002000A3/sk

Links

YQUJSBYIKMQCIT-UHFFFAOYSA-N 2-purin-9-yloxolane-3,4-diol Chemical class OC1C(O)COC1N1C2=NC=NC=C2N=C1 YQUJSBYIKMQCIT-UHFFFAOYSA-N 0.000 title claims description 29
150000001875 compounds Chemical class 0.000 claims abstract description 215
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238000000034 method Methods 0.000 claims abstract description 30
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-1 -CH = CH 2 Chemical group 0.000 claims description 246
125000000217 alkyl group Chemical group 0.000 claims description 45
125000004899 1-ethylpropylamino group Chemical group C(C)C(CC)N* 0.000 claims description 34
150000003839 salts Chemical class 0.000 claims description 27
238000002360 preparation method Methods 0.000 claims description 24
125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 22
125000003118 aryl group Chemical group 0.000 claims description 20
229910052757 nitrogen Inorganic materials 0.000 claims description 20
229910052717 sulfur Inorganic materials 0.000 claims description 18
229910052739 hydrogen Inorganic materials 0.000 claims description 17
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
239000001257 hydrogen Substances 0.000 claims description 15
239000012453 solvate Substances 0.000 claims description 15
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 13
SSYDTHANSGMJTP-UHFFFAOYSA-N oxolane-3,4-diol Chemical compound OC1COCC1O SSYDTHANSGMJTP-UHFFFAOYSA-N 0.000 claims description 13
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims description 11
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239000008194 pharmaceutical composition Substances 0.000 claims description 8
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239000003795 chemical substances by application Substances 0.000 claims description 7
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229910052760 oxygen Inorganic materials 0.000 claims description 7
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125000004545 purin-9-yl group Chemical group N1=CN=C2N(C=NC2=C1)* 0.000 claims description 7
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229910005965 SO 2 Inorganic materials 0.000 claims description 6
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238000006243 chemical reaction Methods 0.000 claims description 6
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MRAHZKUIBFCWHI-OVDFTCDZSA-N (2r,3r,4s,5s)-2-[6-(2,2-diphenylethylamino)-2-[2-(1-methylimidazol-4-yl)ethylamino]purin-9-yl]-5-(3-methyl-1,2,4-oxadiazol-5-yl)oxolane-3,4-diol Chemical compound CC1=NOC([C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC(NCCC=4N=CN(C)C=4)=NC(NCC(C=4C=CC=CC=4)C=4C=CC=CC=4)=C3N=C2)O)=N1 MRAHZKUIBFCWHI-OVDFTCDZSA-N 0.000 claims 1
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GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 8
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235000021317 phosphate Nutrition 0.000 description 1
RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 description 1
125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
230000003169 placental effect Effects 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
239000003379 purinergic P1 receptor agonist Substances 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
229940044601 receptor agonist Drugs 0.000 description 1
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230000009467 reduction Effects 0.000 description 1
230000010410 reperfusion Effects 0.000 description 1
208000023504 respiratory system disease Diseases 0.000 description 1
230000004044 response Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
238000007363 ring formation reaction Methods 0.000 description 1
229960002052 salbutamol Drugs 0.000 description 1
230000007017 scission Effects 0.000 description 1
230000028327 secretion Effects 0.000 description 1
230000036303 septic shock Effects 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
239000012265 solid product Substances 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
229960002920 sorbitol Drugs 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
208000018556 stomach disease Diseases 0.000 description 1
150000003890 succinate salts Chemical class 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
150000003892 tartrate salts Chemical class 0.000 description 1
229960000195 terbutaline Drugs 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
238000001890 transfection Methods 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000002023 wood Substances 0.000 description 1
230000029663 wound healing Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SK1200-2000A 1998-02-14 1999-02-12 2-(purín-9-yl)-tetrahydrofurán-3,4-diolové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty SK12002000A3 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9803169.3A GB9803169D0 (en)	1998-02-14	1998-02-14	Chemical compounds
GBGB9813533.8A GB9813533D0 (en)	1998-06-23	1998-06-23	Chemical compounds
PCT/EP1999/000915 WO1999041267A1 (en)	1998-02-14	1999-02-12	2-(purin-9-yl) -tetrahydrofuran-3, 4-diol derivatives

Publications (1)

Publication Number	Publication Date
SK12002000A3 true SK12002000A3 (sk)	2001-07-10

Family

ID=26313119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1200-2000A SK12002000A3 (sk)	1998-02-14	1999-02-12	2-(purín-9-yl)-tetrahydrofurán-3,4-diolové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty

Country Status (31)

Country	Link
US (1)	US6610665B1 (is)
EP (1)	EP1056759B1 (is)
JP (1)	JP2002503669A (is)
KR (1)	KR20010082512A (is)
AP (1)	AP2000001881A0 (is)
AR (1)	AR017457A1 (is)
AT (1)	ATE223429T1 (is)
AU (1)	AU757156B2 (is)
BR (1)	BR9907886A (is)
CA (1)	CA2319009A1 (is)
CO (1)	CO4990969A1 (is)
DE (1)	DE69902758T2 (is)
DK (1)	DK1056759T3 (is)
EA (1)	EA200000759A1 (is)
EE (1)	EE200000358A (is)
ES (1)	ES2183516T3 (is)
HR (1)	HRP20000538A2 (is)
HU (1)	HUP0100702A3 (is)
IL (1)	IL137402A0 (is)
IS (1)	IS5576A (is)
MA (1)	MA27121A1 (is)
NO (1)	NO20004045L (is)
NZ (1)	NZ505812A (is)
PE (1)	PE20000270A1 (is)
PL (1)	PL342396A1 (is)
PT (1)	PT1056759E (is)
SK (1)	SK12002000A3 (is)
SV (1)	SV1999000016A (is)
TR (1)	TR200002355T2 (is)
WO (1)	WO1999041267A1 (is)
YU (1)	YU50800A (is)

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NZ556354A (en)	2001-10-01	2008-10-31	Univ Virginia	2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
AR044519A1 (es)	2003-05-02	2005-09-14	Novartis Ag	Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
US6930093B2 (en) *	2003-07-10	2005-08-16	Valeant Research & Development	Use of ribofuranose derivatives against inflammatory bowel diseases
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GB0411056D0 (en)	2004-05-18	2004-06-23	Novartis Ag	Organic compounds
PE20060272A1 (es)	2004-05-24	2006-05-22	Glaxo Group Ltd	(2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
WO2006023272A1 (en)	2004-08-02	2006-03-02	University Of Virginia Patent Foundation	2-polycyclic propynyl adenosine analogs having a2a agonist activity
AU2005267706B2 (en)	2004-08-02	2011-12-08	University Of Virginia Patent Foundation	2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
US7576069B2 (en)	2004-08-02	2009-08-18	University Of Virginia Patent Foundation	2-polycyclic propynyl adenosine analogs having A2A agonist activity
GB0424284D0 (en)	2004-11-02	2004-12-01	Novartis Ag	Organic compounds
GB0426164D0 (en)	2004-11-29	2004-12-29	Novartis Ag	Organic compounds
GB0510390D0 (en)	2005-05-20	2005-06-29	Novartis Ag	Organic compounds
GB0514809D0 (en)	2005-07-19	2005-08-24	Glaxo Group Ltd	Compounds
WO2007045477A2 (en)	2005-10-21	2007-04-26	Novartis Ag	Human antibodies against il-13 and therapeutic uses
GB0601951D0 (en)	2006-01-31	2006-03-15	Novartis Ag	Organic compounds
WO2008037477A1 (en)	2006-09-29	2008-04-03	Novartis Ag	Pyrazolopyrimidines as p13k lipid kinase inhibitors
JP2010508315A (ja)	2006-10-30	2010-03-18	ノバルティスアーゲー	抗炎症剤としてのヘテロ環式化合物
AU2009203693B2 (en)	2008-01-11	2012-06-07	Novartis Ag	Pyrimidines as kinase inhibitors
PL2391366T3 (pl)	2009-01-29	2013-04-30	Novartis Ag	Podstawione benzimidazole do leczenia gwiaździaków
US8389526B2 (en)	2009-08-07	2013-03-05	Novartis Ag	3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EA201200260A1 (ru)	2009-08-12	2012-09-28	Новартис Аг	Гетероциклические гидразоны и их применение для лечения рака и воспаления
NZ598220A (en)	2009-08-17	2014-02-28	Intellikine Llc	Heterocyclic compounds and uses thereof
CA2771432A1 (en)	2009-08-20	2011-02-24	Novartis Ag	Heterocyclic oxime compounds
UY33597A (es)	2010-09-09	2012-04-30	Irm Llc	Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en)	2010-09-09	2012-03-15	Irm Llc	Compounds and compositions as trk inhibitors
EP2673277A1 (en)	2011-02-10	2013-12-18	Novartis AG	[1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
WO2012116237A2 (en)	2011-02-23	2012-08-30	Intellikine, Llc	Heterocyclic compounds and uses thereof
MA34969B1 (fr)	2011-02-25	2014-03-01	Irm Llc	Composes et compositions en tant qu inibiteurs de trk
CA2848809A1 (en)	2011-09-15	2013-03-21	Novartis Ag	6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
JP6130391B2 (ja)	2011-11-23	2017-05-17	インテリカイン，エルエルシー	Ｍｔｏｒ阻害剤を使用する強化された治療レジメン
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JP3933870B2 (ja) *	1998-06-23	2007-06-20	グラクソグループリミテッド	２−（プリン−９−イル）−テトラヒドロフラン−３，４−ジオール誘導体

1999
- 1999-02-11 AR ARP990100570A patent/AR017457A1/es active IP Right Grant
- 1999-02-11 CO CO99008188A patent/CO4990969A1/es unknown
- 1999-02-11 PE PE1999000123A patent/PE20000270A1/es not_active Application Discontinuation
- 1999-02-12 TR TR2000/02355T patent/TR200002355T2/xx unknown
- 1999-02-12 JP JP2000531459A patent/JP2002503669A/ja active Pending
- 1999-02-12 IL IL13740299A patent/IL137402A0/xx unknown
- 1999-02-12 EE EEP200000358A patent/EE200000358A/xx unknown
- 1999-02-12 BR BR9907886-4A patent/BR9907886A/pt not_active IP Right Cessation
- 1999-02-12 CA CA002319009A patent/CA2319009A1/en not_active Abandoned
- 1999-02-12 AU AU26235/99A patent/AU757156B2/en not_active Ceased
- 1999-02-12 WO PCT/EP1999/000915 patent/WO1999041267A1/en not_active Ceased
- 1999-02-12 NZ NZ505812A patent/NZ505812A/en unknown
- 1999-02-12 MA MA25462A patent/MA27121A1/fr unknown
- 1999-02-12 HU HU0100702A patent/HUP0100702A3/hu unknown
- 1999-02-12 US US09/622,313 patent/US6610665B1/en not_active Expired - Fee Related
- 1999-02-12 SV SV1999000016A patent/SV1999000016A/es not_active Application Discontinuation
- 1999-02-12 SK SK1200-2000A patent/SK12002000A3/sk unknown
- 1999-02-12 PL PL99342396A patent/PL342396A1/xx unknown
- 1999-02-12 PT PT99906229T patent/PT1056759E/pt unknown
- 1999-02-12 KR KR1020007008866A patent/KR20010082512A/ko not_active Withdrawn
- 1999-02-12 YU YU50800A patent/YU50800A/sh unknown
- 1999-02-12 DK DK99906229T patent/DK1056759T3/da active
- 1999-02-12 EA EA200000759A patent/EA200000759A1/ru unknown
- 1999-02-12 AP APAP/P/2000/001881A patent/AP2000001881A0/en unknown
- 1999-02-12 ES ES99906229T patent/ES2183516T3/es not_active Expired - Lifetime
- 1999-02-12 DE DE69902758T patent/DE69902758T2/de not_active Expired - Fee Related
- 1999-02-12 EP EP99906229A patent/EP1056759B1/en not_active Expired - Lifetime
- 1999-02-12 AT AT99906229T patent/ATE223429T1/de not_active IP Right Cessation
- 1999-02-12 HR HR20000538A patent/HRP20000538A2/hr not_active Application Discontinuation
2000
- 2000-07-25 IS IS5576A patent/IS5576A/is unknown
- 2000-08-11 NO NO20004045A patent/NO20004045L/no unknown

Also Published As

Publication number	Publication date
TR200002355T2 (tr)	2000-11-21
PL342396A1 (en)	2001-06-04
WO1999041267A1 (en)	1999-08-19
MA27121A1 (fr)	2005-01-03
EA200000759A1 (ru)	2001-04-23
IL137402A0 (en)	2001-07-24
HRP20000538A2 (en)	2000-12-31
NO20004045D0 (no)	2000-08-11
PE20000270A1 (es)	2000-05-20
SV1999000016A (es)	1999-10-27
HUP0100702A2 (hu)	2002-01-28
EP1056759B1 (en)	2002-09-04
ES2183516T3 (es)	2003-03-16
CO4990969A1 (es)	2000-12-26
IS5576A (is)	2000-07-25
AU757156B2 (en)	2003-02-06
KR20010082512A (ko)	2001-08-30
JP2002503669A (ja)	2002-02-05
BR9907886A (pt)	2000-10-17
EE200000358A (et)	2001-10-15
PT1056759E (pt)	2003-01-31
AR017457A1 (es)	2001-09-05
YU50800A (sh)	2003-04-30
EP1056759A1 (en)	2000-12-06
DK1056759T3 (da)	2003-01-06
HUP0100702A3 (en)	2003-01-28
AU2623599A (en)	1999-08-30
US6610665B1 (en)	2003-08-26
CA2319009A1 (en)	1999-08-19
NZ505812A (en)	2002-03-01
HK1032062A1 (en)	2001-07-06
ATE223429T1 (de)	2002-09-15
AP2000001881A0 (en)	2000-09-30
DE69902758T2 (de)	2003-05-15
DE69902758D1 (de)	2002-10-10
NO20004045L (no)	2000-08-11

Publication	Publication Date	Title
SK12002000A3 (sk)	2001-07-10	2-(purín-9-yl)-tetrahydrofurán-3,4-diolové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty
US6495528B1 (en)	2002-12-17	2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives
US6534486B1 (en)	2003-03-18	2-(purin-9-yl)-Tetrahydrofuran-3,4-diol derivatives
SK19532000A3 (sk)	2001-11-06	2-(purin-9-yl)-tetrahydrofurán-3,4-diolové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty
AU733684B2 (en)	2001-05-24	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
SK11192000A3 (sk)	2001-06-11	2-(purin-9-yl)-tetrahydrofurán-3,4-diolové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty
JP2002518510A (ja)	2002-06-25	２−（プリン−９−イル）−テトラヒドロフラン−３，４−ジオール誘導体
CZ20002974A3 (cs)	2001-05-16	2-(purin-9-yl)-tetrahydrofuran-3,4-diolové deriváty
MXPA00007793A (en)	2001-11-21	2-(purin-9-yl) -tetrahydrofuran-3, 4-diol derivatives
CZ20004870A3 (cs)	2001-06-13	2 (Purin 9 yl) tetrahydrofuran 3,4 diolové deriváty
MXPA00012926A (en)	2002-05-09	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
MXPA00012895A (en)	2001-09-07	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
HK1032062B (en)	2003-06-20	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
MXPA99005888A (en)	2000-01-01	2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives