SK12042002A3 - Azapolycyklické zlúčeniny s anelovanou arylskupinou - Google Patents

Info

Publication number

SK12042002A3

SK12042002A3 SK1204-2002A SK12042002A SK12042002A3 SK 12042002 A3 SK12042002 A3 SK 12042002A3 SK 12042002 A SK12042002 A SK 12042002A SK 12042002 A3 SK12042002 A3 SK 12042002A3

Authority

SK

Slovakia

Prior art keywords

dodeca

triene

diazatetracyclo

tricyclo

tetraene

Prior art date

2000-02-25

Links

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• 125000003118 aryl group Chemical group 0.000 title claims description 19
• 238000000034 method Methods 0.000 claims abstract description 114
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• 239000000203 mixture Substances 0.000 claims description 182
• 125000004432 carbon atom Chemical group C* 0.000 claims description 86
• 125000000217 alkyl group Chemical group 0.000 claims description 77
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 68
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 68
• 229920006395 saturated elastomer Polymers 0.000 claims description 68
• 229910052739 hydrogen Inorganic materials 0.000 claims description 66
• 239000001257 hydrogen Substances 0.000 claims description 64
• -1 aryl compound Chemical class 0.000 claims description 49
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 38
• 229910052757 nitrogen Inorganic materials 0.000 claims description 36
• 150000002431 hydrogen Chemical class 0.000 claims description 29
• 239000000460 chlorine Substances 0.000 claims description 28
• 125000001153 fluoro group Chemical group F* 0.000 claims description 21
• 125000003545 alkoxy group Chemical group 0.000 claims description 19
• 229910052736 halogen Inorganic materials 0.000 claims description 19
• 125000001424 substituent group Chemical group 0.000 claims description 19
• 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 19
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 18
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 18
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• 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 claims description 7
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 7
• 229910052794 bromium Inorganic materials 0.000 claims description 7
• 229910052801 chlorine Inorganic materials 0.000 claims description 7
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• 230000001148 spastic effect Effects 0.000 claims description 7
• 239000000126 substance Substances 0.000 claims description 7
• 239000011593 sulfur Chemical group 0.000 claims description 7
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 6
• 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 6
• VEUMBMHMMCOFAG-UHFFFAOYSA-N 2,3-dihydrooxadiazole Chemical compound N1NC=CO1 VEUMBMHMMCOFAG-UHFFFAOYSA-N 0.000 claims description 6
• 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 6
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 6
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 6
• 206010047139 Vasoconstriction Diseases 0.000 claims description 6
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 6
• 230000001149 cognitive effect Effects 0.000 claims description 6
• 238000005562 fading Methods 0.000 claims description 6
• 229910052740 iodine Inorganic materials 0.000 claims description 6
• 229940127240 opiate Drugs 0.000 claims description 6
• 229940124530 sulfonamide Drugs 0.000 claims description 6
• 230000025033 vasoconstriction Effects 0.000 claims description 6
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 5
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• 206010039966 Senile dementia Diseases 0.000 claims description 5
• 125000004122 cyclic group Chemical group 0.000 claims description 5
• 239000003937 drug carrier Substances 0.000 claims description 5
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 5
• 125000005842 heteroatom Chemical group 0.000 claims description 5
• 239000011630 iodine Substances 0.000 claims description 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
• 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 claims description 4
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 4
• XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 4
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 4
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• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
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