SK1292003A3 - Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient - Google Patents

Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient Download PDF

Info

Publication number: SK1292003A3
Authority: SK; Slovakia
Prior art keywords: group; alkyl; dementia; amino; prevention
Prior art date: 2000-07-31

Application number

SK129-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Kiyoshi Furukawa

Satoshi Kurumiya

Takashi Hashimoto

Original Assignee

Dainippon Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-31

Filing date

2001-07-24

Publication date

2003-08-05

2001-07-24 Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co

2003-08-05 Publication of SK1292003A3 publication Critical patent/SK1292003A3/sk

Links

206010012289 Dementia Diseases 0.000 title claims abstract description 53
239000004480 active ingredient Substances 0.000 title description 3
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 33
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150000003839 salts Chemical class 0.000 claims abstract description 30
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239000007951 isotonicity adjuster Substances 0.000 description 1
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210000003715 limbic system Anatomy 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
125000003564 m-cyanobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(C#N)=C1[H])C([H])([H])* 0.000 description 1
125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
229910000403 monosodium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
230000001537 neural effect Effects 0.000 description 1
230000004770 neurodegeneration Effects 0.000 description 1
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230000006764 neuronal dysfunction Effects 0.000 description 1
230000007135 neurotoxicity Effects 0.000 description 1
231100000228 neurotoxicity Toxicity 0.000 description 1
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125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
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125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
230000008447 perception Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229950008882 polysorbate Drugs 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229940068984 polyvinyl alcohol Drugs 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
ORNBQBCIOKFOEO-QGVNFLHTSA-N pregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 ORNBQBCIOKFOEO-QGVNFLHTSA-N 0.000 description 1
229960000249 pregnenolone Drugs 0.000 description 1
DIJBBUIOWGGQOP-QGVNFLHTSA-N pregnenolone sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 DIJBBUIOWGGQOP-QGVNFLHTSA-N 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
125000004944 pyrazin-3-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 description 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
230000009467 reduction Effects 0.000 description 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
201000000980 schizophrenia Diseases 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
XIIOFHFUYBLOLW-UHFFFAOYSA-N selpercatinib Chemical compound OC(COC=1C=C(C=2N(C=1)N=CC=2C#N)C=1C=NC(=CC=1)N1CC2N(C(C1)C2)CC=1C=NC(=CC=1)OC)(C)C XIIOFHFUYBLOLW-UHFFFAOYSA-N 0.000 description 1
150000003385 sodium Chemical class 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
230000007596 spatial working memory Effects 0.000 description 1
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238000012353 t test Methods 0.000 description 1
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229940095064 tartrate Drugs 0.000 description 1
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239000001993 wax Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SK129-2003A 2000-07-31 2001-07-24 Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient SK1292003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2000230209		2000-07-31
PCT/JP2001/006363 WO2002010167A1 (en)	2000-07-31	2001-07-24	Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient

Publications (1)

Publication Number	Publication Date
SK1292003A3 true SK1292003A3 (en)	2003-08-05

Family

ID=18723200

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK129-2003A SK1292003A3 (en)	2000-07-31	2001-07-24	Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient

Country Status (19)

Country	Link
US (1)	US6962921B2 (pl)
EP (1)	EP1306378A4 (pl)
KR (1)	KR100829297B1 (pl)
CN (1)	CN1247578C (pl)
AU (1)	AU7278701A (pl)
BR (1)	BR0112881A (pl)
CA (1)	CA2416706C (pl)
CZ (1)	CZ2003234A3 (pl)
HK (1)	HK1054231A1 (pl)
HU (1)	HUP0303714A3 (pl)
IL (1)	IL154049A0 (pl)
MX (1)	MXPA03000861A (pl)
NO (1)	NO20030474L (pl)
NZ (1)	NZ523812A (pl)
PL (1)	PL363870A1 (pl)
RU (1)	RU2277096C2 (pl)
SK (1)	SK1292003A3 (pl)
WO (1)	WO2002010167A1 (pl)
ZA (1)	ZA200300549B (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7760101B2 (en) *	2008-06-20	2010-07-20	Kimberly-Clark Worldwide, Inc.	Method of reducing sensor corrosion in absorbent articles
US8735406B2 (en) *	2009-09-09	2014-05-27	Dainippon Sumitomo Pharma Co., Ltd.	8-oxodihydropurine derivative
WO2012168697A1 (en)	2011-06-06	2012-12-13	Imperial Innovations Limited	Methods to predict binding affinity of tspo imaging agents to tspo

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5453428A (en) *	1991-02-14	1995-09-26	The Mount Sinai School Of Medicine Of The City Of New York	Method and composition for the treatment of apathy-amotivation syndrome
JPH06508836A (ja) *	1991-06-26	1994-10-06	セプラコア，インコーポレーテッド	光学的に純粋なｒ（＋）オンダンセトロンを使用する嘔吐、吐き気および他の障害の治療のための方法および組成物
GB9208492D0 (en) *	1992-04-16	1992-06-03	Glaxo Spa	Heterocyclic compounds
US5212195A (en) *	1992-05-13	1993-05-18	Syntex (U.S.A.) Inc.	Substituted indole antagonists derivatives which are angiotensin II
ES2232871T3 (es) *	1996-07-03	2005-06-01	Sumitomo Pharmaceuticals Company, Limited	Nuevos derivados de purina.
ZA9810490B (en) *	1997-12-03	1999-05-20	Dainippon Pharmaceutical Co	2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
ATE300947T1 (de) *	1998-12-18	2005-08-15	Scios Inc	Behandlung von erkrankungen mit zystenbildung
DE69932449T2 (de) *	1998-12-18	2007-03-15	Scios Inc., Fremont	Agonisten und antagonisten von benzodiazepinrezeptoren des peripheren typs
JP3814125B2 (ja) *	1999-06-02	2006-08-23	大日本住友製薬株式会社	２−アリール−８−オキソジヒドロプリン誘導体からなる医薬

2001
- 2001-07-24 RU RU2003105827/04A patent/RU2277096C2/ru not_active IP Right Cessation
- 2001-07-24 IL IL15404901A patent/IL154049A0/xx unknown
- 2001-07-24 SK SK129-2003A patent/SK1292003A3/sk unknown
- 2001-07-24 EP EP01951985A patent/EP1306378A4/en active Pending
- 2001-07-24 PL PL01363870A patent/PL363870A1/pl not_active Application Discontinuation
- 2001-07-24 MX MXPA03000861A patent/MXPA03000861A/es active IP Right Grant
- 2001-07-24 US US10/343,453 patent/US6962921B2/en not_active Expired - Fee Related
- 2001-07-24 CA CA002416706A patent/CA2416706C/en not_active Expired - Fee Related
- 2001-07-24 WO PCT/JP2001/006363 patent/WO2002010167A1/ja not_active Ceased
- 2001-07-24 NZ NZ523812A patent/NZ523812A/en unknown
- 2001-07-24 BR BR0112881-7A patent/BR0112881A/pt not_active IP Right Cessation
- 2001-07-24 CN CNB018163742A patent/CN1247578C/zh not_active Expired - Fee Related
- 2001-07-24 KR KR1020037001365A patent/KR100829297B1/ko not_active Expired - Fee Related
- 2001-07-24 CZ CZ2003234A patent/CZ2003234A3/cs unknown
- 2001-07-24 AU AU7278701A patent/AU7278701A/xx not_active Withdrawn
- 2001-07-24 HU HU0303714A patent/HUP0303714A3/hu unknown
- 2001-07-24 HK HK03106435.7A patent/HK1054231A1/en unknown
2003
- 2003-01-21 ZA ZA200300549A patent/ZA200300549B/en unknown
- 2003-01-30 NO NO20030474A patent/NO20030474L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU7278701A (en)	2002-02-13
BR0112881A (pt)	2003-07-01
US6962921B2 (en)	2005-11-08
EP1306378A1 (en)	2003-05-02
CN1466587A (zh)	2004-01-07
US20030166667A1 (en)	2003-09-04
NO20030474L (no)	2003-03-27
WO2002010167A1 (en)	2002-02-07
PL363870A1 (pl)	2004-11-29
CZ2003234A3 (cs)	2003-05-14
CA2416706A1 (en)	2002-02-07
MXPA03000861A (es)	2004-04-05
KR100829297B1 (ko)	2008-05-13
HUP0303714A2 (hu)	2004-03-01
RU2277096C2 (ru)	2006-05-27
NZ523812A (en)	2004-07-30
ZA200300549B (en)	2003-08-19
EP1306378A4 (en)	2005-02-09
IL154049A0 (en)	2003-07-31
CN1247578C (zh)	2006-03-29
HUP0303714A3 (en)	2007-03-28
NO20030474D0 (no)	2003-01-30
CA2416706C (en)	2009-04-07
KR20030019634A (ko)	2003-03-06
HK1054231A1 (en)	2003-11-21

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Date	Code	Title	Description
2010-05-07	FB9A	Suspension of patent application procedure

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