SK13002003A3 - Uhličitan vápenatý kompatibilný s fluoridom - Google Patents

Uhličitan vápenatý kompatibilný s fluoridom Download PDF

Info

Publication number: SK13002003A3
Authority: SK; Slovakia
Prior art keywords: calcium carbonate; composition; carbonate particles; fluoride; particles
Prior art date: 2001-04-24

Application number

SK1300-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Patrick Clinton Wernett

Ali Reza Bashey

Original Assignee

Specialty Minerals (Michigan) Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-24

Filing date

2001-04-24

Publication date

2004-09-08

2001-04-24 Application filed by Specialty Minerals (Michigan) Inc. filed Critical Specialty Minerals (Michigan) Inc.

2004-09-08 Publication of SK13002003A3 publication Critical patent/SK13002003A3/sk

Links

VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims abstract description 188
229910000019 calcium carbonate Inorganic materials 0.000 title claims abstract description 93
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title claims abstract description 31
239000002245 particle Substances 0.000 claims abstract description 41
239000000606 toothpaste Substances 0.000 claims abstract description 31
235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 29
239000000194 fatty acid Substances 0.000 claims abstract description 29
229930195729 fatty acid Natural products 0.000 claims abstract description 29
239000000203 mixture Substances 0.000 claims abstract description 28
150000004665 fatty acids Chemical class 0.000 claims abstract description 27
-1 gums Chemical class 0.000 claims abstract description 23
229940034610 toothpaste Drugs 0.000 claims abstract description 17
238000000034 method Methods 0.000 claims abstract description 16
229920001282 polysaccharide Polymers 0.000 claims abstract description 16
239000005017 polysaccharide Substances 0.000 claims abstract description 16
150000004676 glycans Chemical class 0.000 claims abstract description 15
229940091249 fluoride supplement Drugs 0.000 claims description 37
239000003795 chemical substances by application Substances 0.000 claims description 13
229910052731 fluorine Inorganic materials 0.000 claims description 11
239000011737 fluorine Substances 0.000 claims description 10
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 9
229920002907 Guar gum Polymers 0.000 claims description 9
235000010417 guar gum Nutrition 0.000 claims description 9
239000000665 guar gum Substances 0.000 claims description 9
229960002154 guar gum Drugs 0.000 claims description 9
229920001285 xanthan gum Polymers 0.000 claims description 8
238000006243 chemical reaction Methods 0.000 claims description 7
150000001875 compounds Chemical class 0.000 claims description 7
150000002222 fluorine compounds Chemical class 0.000 claims description 6
239000000463 material Substances 0.000 claims description 6
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
210000000214 mouth Anatomy 0.000 claims description 5
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
235000010493 xanthan gum Nutrition 0.000 claims description 5
239000000230 xanthan gum Substances 0.000 claims description 5
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239000011248 coating agent Substances 0.000 claims description 4
238000000576 coating method Methods 0.000 claims description 4
210000003298 dental enamel Anatomy 0.000 claims description 4
235000020778 linoleic acid Nutrition 0.000 claims description 4
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 3
OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 3
235000010418 carrageenan Nutrition 0.000 claims description 3
239000000679 carrageenan Substances 0.000 claims description 3
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UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims description 3
235000010492 gellan gum Nutrition 0.000 claims description 3
239000000216 gellan gum Substances 0.000 claims description 3
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 3
OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 3
229960004711 sodium monofluorophosphate Drugs 0.000 claims description 3
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
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POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
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QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
150000002888 oleic acid derivatives Chemical class 0.000 claims 1
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229920000715 Mucilage Polymers 0.000 abstract description 9
239000000853 adhesive Substances 0.000 abstract description 9
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238000004381 surface treatment Methods 0.000 description 15
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238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 8
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
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239000000843 powder Substances 0.000 description 6
239000000126 substance Substances 0.000 description 6
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
235000021355 Stearic acid Nutrition 0.000 description 5
238000005299 abrasion Methods 0.000 description 5
239000011575 calcium Substances 0.000 description 5
229910052791 calcium Inorganic materials 0.000 description 5
230000000694 effects Effects 0.000 description 5
239000004615 ingredient Substances 0.000 description 5
238000002156 mixing Methods 0.000 description 5
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239000002344 surface layer Substances 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 4
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 4
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
239000003082 abrasive agent Substances 0.000 description 4
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235000010413 sodium alginate Nutrition 0.000 description 4
239000000661 sodium alginate Substances 0.000 description 4
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
239000000600 sorbitol Substances 0.000 description 4
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WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
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239000010410 layer Substances 0.000 description 3
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150000003839 salts Chemical class 0.000 description 3
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241000416162 Astragalus gummifer Species 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
244000140786 Brassica hirta Species 0.000 description 2
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
239000004141 Sodium laurylsulphate Substances 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
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239000011230 binding agent Substances 0.000 description 2
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JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
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235000021313 oleic acid Nutrition 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
235000011837 pasties Nutrition 0.000 description 1
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
235000019477 peppermint oil Nutrition 0.000 description 1
239000012071 phase Substances 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
229940099402 potassium metaphosphate Drugs 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000008213 purified water Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000035807 sensation Effects 0.000 description 1
235000019615 sensations Nutrition 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229910001415 sodium ion Inorganic materials 0.000 description 1
ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
238000005211 surface analysis Methods 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
229960003080 taurine Drugs 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
229910052726 zirconium Inorganic materials 0.000 description 1
229910001928 zirconium oxide Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Birds (AREA)
Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Emergency Medicine (AREA)
Cosmetics (AREA)

SK1300-2003A 2001-04-24 2001-04-24 Uhličitan vápenatý kompatibilný s fluoridom SK13002003A3 (sk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2001/013056 WO2002085319A1 (en)	2001-04-24	2001-04-24	Fluoride compatible calcium carbonate

Publications (1)

Publication Number	Publication Date
SK13002003A3 true SK13002003A3 (sk)	2004-09-08

Family

ID=21742526

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1300-2003A SK13002003A3 (sk)	2001-04-24	2001-04-24	Uhličitan vápenatý kompatibilný s fluoridom

Country Status (11)

Country	Link
EP (1)	EP1383476A1 (pl)
JP (1)	JP2004527539A (pl)
KR (1)	KR20030090781A (pl)
CN (1)	CN1505501A (pl)
BR (1)	BR0116983A (pl)
CA (1)	CA2443747A1 (pl)
NO (1)	NO20034712D0 (pl)
PL (1)	PL363310A1 (pl)
SK (1)	SK13002003A3 (pl)
TW (1)	TW200514574A (pl)
WO (1)	WO2002085319A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040219183A1 (en) *	2003-05-02	2004-11-04	J.M. Huber	Novel gum delivery systems
US8119162B2 (en) *	2005-11-10	2012-02-21	Colgate-Palmolive Company	Particles that disrupt or impede bacterial adhesion, related compositions and methods
US7468101B2 (en)	2006-08-17	2008-12-23	Specialty Minerals (Michigan) Inc.	UV varnish gloss performance using novel pigment and process for making same
RU2475231C2 (ru) *	2008-02-08	2013-02-20	Колгейт-Палмолив Компани	Продукт для ухода за полостью рта и способы его применения и производства
US11612553B2 (en) *	2008-02-08	2023-03-28	Colgate-Palmolive Company	Oral care product and methods of use and manufacture thereof
AU2012396804B2 (en) *	2012-12-14	2015-08-20	Colgate-Palmolive Company	Abrasive coatings for peroxide-containing compositions
CN105792660B (zh) *	2013-12-13	2019-12-27	雀巢产品有限公司	采用可食用无机盐颗粒进行稳定的乳剂
PT2883573T (pt)	2013-12-13	2018-01-04	Omya Int Ag	Composição de limpeza abrasiva
WO2015172344A1 (en) *	2014-05-15	2015-11-19	The Procter & Gamble Company	Dentifrice compositions with improved fluoride stability
EP2949311B1 (en)	2014-05-30	2019-10-16	Shofu Inc.	Dental composition containing ion sustained-release glass
JP6540366B2 (ja) *	2015-08-21	2019-07-10	ライオン株式会社	歯磨組成物
CN117338605A (zh) *	2015-11-13	2024-01-05	宝洁公司	具有双氟化物源与改善的氟化物摄取的洁齿剂组合物
JP2018104301A (ja) *	2016-12-22	2018-07-05	花王株式会社	バイオフィルム形成抑制剤用顆粒の製造方法
JP6807729B2 (ja) *	2016-12-22	2021-01-06	花王株式会社	歯磨剤用顆粒及びこれを含有する歯磨剤組成物
WO2023141708A1 (en) *	2022-01-26	2023-08-03	Visionaturolab Inc.	Oral care composition comprising treated aragonite calcium carbonate
KR102870678B1 (ko) *	2023-01-18	2025-10-13	국립한국해양대학교산학협력단	탄산칼슘 비드를 포함하는 구강용 조성물 및 이의 제조방법
WO2025225707A1 (ja) *	2024-04-26	2025-10-30	株式会社メディボ	口腔ケア組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4117109A (en) *	1976-01-22	1978-09-26	Indiana University Foundation	Dentifrice preparation
AU530013B2 (en) *	1978-11-29	1983-06-30	Beecham Group Limited	Alumina free oral composition
US4357318A (en) *	1981-07-31	1982-11-02	Richardson-Vicks Inc.	Dentifrices with improved soluble fluoride availability
DE3314895A1 (de) *	1983-04-25	1984-10-25	Blendax-Werke R. Schneider Gmbh & Co, 6500 Mainz	Zahn- und mundpflegemittel
US5958380A (en) *	1997-07-07	1999-09-28	Enamelon, Inc.	Chewing gum products and the use thereof for remineralizing subsurface dental lesions and for mineralizing exposed dentinal tubules

2001
- 2001-04-24 BR BR0116983-1A patent/BR0116983A/pt not_active IP Right Cessation
- 2001-04-24 JP JP2002582894A patent/JP2004527539A/ja active Pending
- 2001-04-24 SK SK1300-2003A patent/SK13002003A3/sk unknown
- 2001-04-24 KR KR10-2003-7013800A patent/KR20030090781A/ko not_active Ceased
- 2001-04-24 CA CA002443747A patent/CA2443747A1/en not_active Abandoned
- 2001-04-24 WO PCT/US2001/013056 patent/WO2002085319A1/en not_active Ceased
- 2001-04-24 CN CNA018231802A patent/CN1505501A/zh active Pending
- 2001-04-24 PL PL01363310A patent/PL363310A1/pl not_active Application Discontinuation
- 2001-04-24 EP EP01930657A patent/EP1383476A1/en not_active Withdrawn
2003
- 2003-10-20 TW TW092129009A patent/TW200514574A/zh unknown
- 2003-10-21 NO NO20034712A patent/NO20034712D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2002085319A1 (en)	2002-10-31
NO20034712L (no)	2003-10-21
NO20034712D0 (no)	2003-10-21
KR20030090781A (ko)	2003-11-28
BR0116983A (pt)	2004-06-29
TW200514574A (en)	2005-05-01
CA2443747A1 (en)	2002-10-31
CN1505501A (zh)	2004-06-16
PL363310A1 (pl)	2004-11-15
EP1383476A1 (en)	2004-01-28
JP2004527539A (ja)	2004-09-09

Legal Events

Date	Code	Title	Description
2010-12-07	FB9A	Suspension of patent application procedure

Publication	Publication Date	Title
SK13002003A3 (sk)	2004-09-08	Uhličitan vápenatý kompatibilný s fluoridom
EP2089038B1 (en)	2011-02-09	Oral care product
CN1298310C (zh)	2007-02-07	含有精细研磨的天然白垩的口腔组合物
CN1204506A (zh)	1999-01-13	口腔组合物
CA2424316A1 (en)	2002-04-18	Anhydrous dentifrice formulations for the delivery of incompatible ingredients
CA2863674A1 (en)	2013-08-15	Multicomponent oral care composition
EP3065833B1 (en)	2019-01-30	Compositions and methods for treating tooth hypersensitivity
US20040120902A1 (en)	2004-06-24	Fluoride compatible calcium carbonate
EP1128799A2 (fr)	2001-09-05	Composition dentrifice fluoree comprenant des particules abrasives de materiau calcique compatibles avec le fluor
EP3648731B1 (en)	2021-02-17	Oral care composition
EP3547989B1 (en)	2022-10-05	Oral care composition
RU2264208C2 (ru)	2005-11-20	Композиция для обработки зубов (варианты), композиция для обеспечения источника кальция, композиция зубной пасты и способ обработки зубов фтором
WO2022089927A1 (en)	2022-05-05	Oral care composition
AU2019208198B2 (en)	2020-07-30	Oral care compositions and methods of using the compositions
EP3554459A1 (en)	2019-10-23	Oral care composition
EP3500232B1 (en)	2020-06-10	Oral care composition
EP3668478B1 (en)	2022-04-13	Oral care composition
WO2020099068A1 (en)	2020-05-22	Oral care composition
JPH02311413A (ja)	1990-12-27	歯磨用組成物
EP4301320B1 (en)	2025-05-07	Oral care composition
CN114681341B (zh)	2023-06-27	稳定的可除渍美白、减轻牙龈炎症的牙膏及其制备方法
WO2022184875A1 (en)	2022-09-09	Oral care composition
ZA200308414B (en)	2004-07-28	Fluoride compatible calcium carbonate.
EA042242B1 (ru)	2023-01-26	Композиция для ухода за полостью рта
EA042995B1 (ru)	2023-04-14	Композиция для ухода за полостью рта