SK14052003A3 - Použitie derivátov adenozínu na prípravu liečiva na liečenie syndrómu inzulínovej rezistencie a diabetu - Google Patents

Použitie derivátov adenozínu na prípravu liečiva na liečenie syndrómu inzulínovej rezistencie a diabetu Download PDF

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Publication number
SK14052003A3
SK14052003A3 SK1405-2003A SK14052003A SK14052003A3 SK 14052003 A3 SK14052003 A3 SK 14052003A3 SK 14052003 A SK14052003 A SK 14052003A SK 14052003 A3 SK14052003 A3 SK 14052003A3
Authority
SK
Slovakia
Prior art keywords
ylamino
purin
diol
pyrrolidin
hydroxymethyl
Prior art date
Application number
SK1405-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Andreas Herling
Gerhard J�Hne
Martin P. Maguire
Alfred P. Spada
Michael R. Myers
Yong Mi Choi-Sledeski
Heinz W. Pauls
William R. Ewing
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of SK14052003A3 publication Critical patent/SK14052003A3/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SK1405-2003A 2001-05-14 2002-05-14 Použitie derivátov adenozínu na prípravu liečiva na liečenie syndrómu inzulínovej rezistencie a diabetu SK14052003A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01111651A EP1258247A1 (en) 2001-05-14 2001-05-14 Adenosine analogues for the treatment of insulin resistance syndrome and diabetes
PCT/EP2002/005301 WO2002092093A1 (en) 2001-05-14 2002-05-14 Adenosine analogues for the treatment of the insulin resistance syndrome and diabetes

Publications (1)

Publication Number Publication Date
SK14052003A3 true SK14052003A3 (sk) 2004-07-07

Family

ID=8177414

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1405-2003A SK14052003A3 (sk) 2001-05-14 2002-05-14 Použitie derivátov adenozínu na prípravu liečiva na liečenie syndrómu inzulínovej rezistencie a diabetu

Country Status (23)

Country Link
US (1) US20030176390A1 (cs)
EP (2) EP1258247A1 (cs)
JP (1) JP2004533448A (cs)
KR (1) KR20040002962A (cs)
CN (1) CN1518450A (cs)
BG (1) BG108356A (cs)
BR (1) BR0209650A (cs)
CA (1) CA2447408A1 (cs)
CO (1) CO5540288A2 (cs)
CZ (1) CZ20033079A3 (cs)
EA (1) EA007253B1 (cs)
EE (1) EE200300551A (cs)
HR (1) HRP20030928A2 (cs)
HU (1) HUP0400464A3 (cs)
IL (1) IL158794A0 (cs)
MX (1) MXPA03010336A (cs)
NO (1) NO20035056D0 (cs)
NZ (1) NZ529390A (cs)
PL (1) PL364573A1 (cs)
SK (1) SK14052003A3 (cs)
WO (1) WO2002092093A1 (cs)
YU (1) YU90203A (cs)
ZA (1) ZA200308777B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP2322525B1 (en) * 2006-04-21 2013-09-18 Novartis AG Purine derivatives for use as adenosin A2A receptor agonists
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
CA2669108A1 (en) * 2006-11-10 2008-05-15 Novartis Ag Cyclopentene diol monoacetate derivatives
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2009131196A1 (ja) * 2008-04-24 2009-10-29 武田薬品工業株式会社 置換ピロリジン誘導体およびその用途
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN119798352B (zh) * 2024-01-15 2025-11-11 中国医学科学院药物研究所 化合物yzg-331的晶型及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8729994D0 (en) * 1987-12-23 1988-02-03 Glaxo Group Ltd Chemical compounds
US5055569A (en) * 1989-10-19 1991-10-08 G. D. Searle & Co. N-(6)-substituted adenosine compounds
HUT61567A (en) * 1990-12-07 1993-01-28 Sandoz Ag Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
UA51716C2 (uk) * 1996-07-08 2002-12-16 Авентіс Фармасьютікалз Продактс Інк. Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
GB9723590D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
US6258793B1 (en) * 1999-12-03 2001-07-10 Cv Therapeutics, Inc. N6 heterocyclic 5′ modified adenosine derivatives

Also Published As

Publication number Publication date
BG108356A (bg) 2004-12-30
BR0209650A (pt) 2004-07-13
EE200300551A (et) 2004-02-16
WO2002092093A1 (en) 2002-11-21
ZA200308777B (en) 2006-04-26
JP2004533448A (ja) 2004-11-04
KR20040002962A (ko) 2004-01-07
US20030176390A1 (en) 2003-09-18
HRP20030928A2 (en) 2005-10-31
MXPA03010336A (es) 2004-03-16
CZ20033079A3 (cs) 2004-08-18
EA200301231A1 (ru) 2004-04-29
CN1518450A (zh) 2004-08-04
EP1258247A1 (en) 2002-11-20
PL364573A1 (en) 2004-12-13
NZ529390A (en) 2006-06-30
IL158794A0 (en) 2004-05-12
NO20035056D0 (no) 2003-11-13
EA007253B1 (ru) 2006-08-25
HUP0400464A3 (en) 2007-03-28
EP1404338A1 (en) 2004-04-07
YU90203A (sh) 2006-08-17
CA2447408A1 (en) 2002-11-21
HUP0400464A2 (hu) 2004-07-28
CO5540288A2 (es) 2005-07-29

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