SK14262002A3 - Hydroxyfenylpiperazinylmetylbenzamidové deriváty na liečbu bolesti - Google Patents

Hydroxyfenylpiperazinylmetylbenzamidové deriváty na liečbu bolesti Download PDF

Info

Publication number: SK14262002A3
Authority: SK; Slovakia
Prior art keywords: compound; formula; methyl; protecting group; pain
Prior art date: 2000-04-04

Application number

SK1426-2002A

Other languages

English (en)

Slovak (sk)

Inventor

William Brown

Niklas Plobeck

Christopher Walpole

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-04

Filing date

2001-03-30

Publication date

2003-05-02

2001-03-30 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-05-02 Publication of SK14262002A3 publication Critical patent/SK14262002A3/sk

Links

208000002193 Pain Diseases 0.000 title claims abstract description 12
230000036407 pain Effects 0.000 title claims abstract description 10
UDDPQOROCUUQOB-UHFFFAOYSA-N 5-hydroxy-2-methyl-4-phenyl-3-piperazin-1-ylbenzamide Chemical class C1CNCCN1C=1C(C)=C(C(N)=O)C=C(O)C=1C1=CC=CC=C1 UDDPQOROCUUQOB-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 73
150000003839 salts Chemical class 0.000 claims abstract description 14
125000001072 heteroaryl group Chemical group 0.000 claims abstract description 9
238000002560 therapeutic procedure Methods 0.000 claims abstract description 8
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 5
125000002541 furyl group Chemical group 0.000 claims abstract description 5
125000001424 substituent group Chemical group 0.000 claims abstract description 5
125000001246 bromo group Chemical group Br* 0.000 claims abstract description 4
125000001309 chloro group Chemical group Cl* 0.000 claims abstract description 4
125000001153 fluoro group Chemical group F* 0.000 claims abstract description 4
125000004076 pyridyl group Chemical group 0.000 claims abstract description 4
125000001544 thienyl group Chemical group 0.000 claims abstract description 4
125000002883 imidazolyl group Chemical group 0.000 claims abstract description 3
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238000002360 preparation method Methods 0.000 claims description 18
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238000000034 method Methods 0.000 claims description 12
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239000004480 active ingredient Substances 0.000 claims description 9
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
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Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
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Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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SK1426-2002A 2000-04-04 2001-03-30 Hydroxyfenylpiperazinylmetylbenzamidové deriváty na liečbu bolesti SK14262002A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0001209A SE0001209D0 (sv)	2000-04-04	2000-04-04	Novel compounds
PCT/SE2001/000709 WO2001074805A1 (en)	2000-04-04	2001-03-30	Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain

Publications (1)

Publication Number	Publication Date
SK14262002A3 true SK14262002A3 (sk)	2003-05-02

Family

ID=20279148

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1426-2002A SK14262002A3 (sk)	2000-04-04	2001-03-30	Hydroxyfenylpiperazinylmetylbenzamidové deriváty na liečbu bolesti

Country Status (24)

Country	Link
US (1)	US6696447B2 (de)
EP (1)	EP1278740B1 (de)
JP (1)	JP2003529597A (de)
KR (1)	KR20020084284A (de)
CN (1)	CN1422266A (de)
AR (1)	AR033811A1 (de)
AT (1)	ATE297914T1 (de)
AU (1)	AU2001244983A1 (de)
BR (1)	BR0109818A (de)
CA (1)	CA2402705A1 (de)
CZ (1)	CZ20023287A3 (de)
DE (1)	DE60111520T2 (de)
EE (1)	EE200200511A (de)
HU (1)	HUP0300562A3 (de)
IL (1)	IL151765A0 (de)
IS (1)	IS6563A (de)
MX (1)	MXPA02009758A (de)
NO (1)	NO20024776L (de)
NZ (1)	NZ521388A (de)
PL (1)	PL357812A1 (de)
SE (1)	SE0001209D0 (de)
SK (1)	SK14262002A3 (de)
WO (1)	WO2001074805A1 (de)
ZA (1)	ZA200207381B (de)

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US7229994B2 (en) *	2001-05-18	2007-06-12	Astrazeneca Ab	4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
EP1469850B1 (de)	2002-01-02	2013-01-02	Versi Group, LLC	Verfahren zur behandlung von sexuellen funktionsstörungen mit delta opioid-rezeptor-agonist-verbindungen
US8476280B2 (en) *	2002-05-09	2013-07-02	Versi Group, Llc	Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203300D0 (sv)	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0203303D0 (sv) *	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0203302D0 (sv) *	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0400027D0 (sv) *	2004-01-09	2004-01-09	Astrazeneca Ab	Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
SE0401968D0 (sv) *	2004-08-02	2004-08-02	Astrazeneca Ab	Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
DK1781631T3 (da)	2004-08-02	2012-05-14	Astrazeneca Ab	Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
WO2006091160A1 (en) *	2005-02-28	2006-08-31	Astrazeneca Ab	Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
EP2296657A4 (de) *	2008-05-20	2011-12-14	Astrazeneca Ab	Verfahren zur behandlung von schwerer depression mit angstzuständen
CN117777070B (zh) *	2023-12-26	2026-04-28	济南悟通生物科技有限公司	一种2-呋喃丙酸乙酯的合成方法

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2000
- 2000-04-04 SE SE0001209A patent/SE0001209D0/xx unknown
2001
- 2001-03-28 AR ARP010101479A patent/AR033811A1/es not_active Application Discontinuation
- 2001-03-30 CN CN01807719A patent/CN1422266A/zh active Pending
- 2001-03-30 NZ NZ521388A patent/NZ521388A/en not_active Application Discontinuation
- 2001-03-30 HU HU0300562A patent/HUP0300562A3/hu unknown
- 2001-03-30 AU AU2001244983A patent/AU2001244983A1/en not_active Abandoned
- 2001-03-30 BR BR0109818-7A patent/BR0109818A/pt not_active IP Right Cessation
- 2001-03-30 MX MXPA02009758A patent/MXPA02009758A/es unknown
- 2001-03-30 US US10/240,037 patent/US6696447B2/en not_active Expired - Fee Related
- 2001-03-30 EE EEP200200511A patent/EE200200511A/xx unknown
- 2001-03-30 JP JP2001572495A patent/JP2003529597A/ja active Pending
- 2001-03-30 AT AT01918115T patent/ATE297914T1/de not_active IP Right Cessation
- 2001-03-30 DE DE60111520T patent/DE60111520T2/de not_active Expired - Fee Related
- 2001-03-30 KR KR1020027013206A patent/KR20020084284A/ko not_active Withdrawn
- 2001-03-30 WO PCT/SE2001/000709 patent/WO2001074805A1/en not_active Ceased
- 2001-03-30 EP EP01918115A patent/EP1278740B1/de not_active Expired - Lifetime
- 2001-03-30 CA CA002402705A patent/CA2402705A1/en not_active Abandoned
- 2001-03-30 PL PL01357812A patent/PL357812A1/xx not_active Application Discontinuation
- 2001-03-30 IL IL15176501A patent/IL151765A0/xx unknown
- 2001-03-30 CZ CZ20023287A patent/CZ20023287A3/cs unknown
- 2001-03-30 SK SK1426-2002A patent/SK14262002A3/sk not_active Application Discontinuation
2002
- 2002-09-13 ZA ZA200207381A patent/ZA200207381B/en unknown
- 2002-09-24 IS IS6563A patent/IS6563A/is unknown
- 2002-10-03 NO NO20024776A patent/NO20024776L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1278740B1 (de)	2005-06-15
HUP0300562A2 (hu)	2003-08-28
SE0001209D0 (sv)	2000-04-04
NO20024776L (no)	2002-12-03
CA2402705A1 (en)	2001-10-11
PL357812A1 (en)	2004-07-26
AU2001244983A1 (en)	2001-10-15
EP1278740A1 (de)	2003-01-29
HUP0300562A3 (en)	2006-02-28
EE200200511A (et)	2004-02-16
WO2001074805A1 (en)	2001-10-11
NZ521388A (en)	2004-06-25
JP2003529597A (ja)	2003-10-07
DE60111520T2 (de)	2006-05-11
NO20024776D0 (no)	2002-10-03
BR0109818A (pt)	2003-01-21
MXPA02009758A (es)	2003-03-27
US20030139421A1 (en)	2003-07-24
CZ20023287A3 (cs)	2003-03-12
ZA200207381B (en)	2003-12-15
KR20020084284A (ko)	2002-11-04
AR033811A1 (es)	2004-01-07
DE60111520D1 (de)	2005-07-21
US6696447B2 (en)	2004-02-24
ATE297914T1 (de)	2005-07-15
CN1422266A (zh)	2003-06-04
IS6563A (is)	2002-09-24
IL151765A0 (en)	2003-04-10

Legal Events

Date	Code	Title	Description
2010-04-07	FC9A	Refused patent application

Publication	Publication Date	Title
SK13982003A3 (sk)	2004-04-06	4-(Fenylpiperazinylmetyl)benzamidové deriváty a ich použitie na liečbu bolesti, anxiety alebo gastrointestinálnych porúch
SK14232002A3 (sk)	2003-06-03	Hydroxyfenylpiperidin-4-ylidénmetylbenzamidové deriváty na liečbu bolesti
KR20040039469A (ko)	2004-05-10	4[피페리딘-4-일리덴-(3-카르바모일페닐)메틸]벤즈아미드유도체 및 통증, 척추 손상 또는 위장 장애 치료에있어서의 이들의 용도
SK13952003A3 (sk)	2004-04-06	4-(Fenylpiperidín-4-ylidénmetyl)benzamidové deriváty a ich použitie na liečbu bolesti, anxiety alebo gastrointestinálnych porúch
SK8832002A3 (en)	2003-03-04	N-diarylmethylpiperazine derivatives, the use thereof and pharmaceutical compositions comprising same
CZ20023287A3 (cs)	2003-03-12	Deriváty hydroxyfenylpiperazinylmethylbenzamidu pro léčbu bolesti
RU2260006C2 (ru)	2005-09-10	4-(пиперазинил(8-хинолинил)метил)бензамиды, фармацевтическая композиция и способ лечения боли
SK14242002A3 (sk)	2003-06-03	Chinolinylpiperidin-4-ylidénmetylbenzamidové deriváty na liečbu bolesti
SK13962003A3 (en)	2004-10-05	4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
SK13942003A3 (sk)	2004-04-06	4-(Fenylpiperidin-4-ylidénmetyl)benzamidové deriváty a ich použitie na liečbu bolesti, anxiety alebo gastrointestinálnych porúch
SK13922003A3 (sk)	2004-04-06	4-(Fenyl-(piperidín-4-yl)-amino)benzamidové deriváty a ich požitie na liečbu bolesti, anxiety alebo gastrointestinálnych porúch
SK13932003A3 (sk)	2004-05-04	4-(Fenylpiperidin-4-ylidénmetyl)-benzamidové deriváty a ich použitie na liečbu bolesti, anxiety alebo gastrointestinálnych porúch
BG108330A (bg)	2004-12-30	4-(фенил-(пиперидин-4-ил)-амино)-бензамидни производни и тяхното използване за лечение на болка, потиснатост или стомашно-чревни разстройства
CZ20033091A3 (cs)	2004-07-14	4-[Fenyl (piperidin-4-yl)amino] benzamidové deriváty a jejich použití pro ošetřování bolesti, úzkosti nebo gastrointestinálních poruch
SK13992003A3 (sk)	2004-04-06	4-(Fenyl(piperidin-4-yl)amino)benzamidové deriváty a ich požitie na liečbu bolesti, anxiety alebo gastrointestinálnych porúch