SK144593A3 - Concave endoprosthesis with filling supportive for the growth of the bones - Google Patents
Concave endoprosthesis with filling supportive for the growth of the bones Download PDFInfo
- Publication number
- SK144593A3 SK144593A3 SK1445-93A SK144593A SK144593A3 SK 144593 A3 SK144593 A3 SK 144593A3 SK 144593 A SK144593 A SK 144593A SK 144593 A3 SK144593 A3 SK 144593A3
- Authority
- SK
- Slovakia
- Prior art keywords
- endoprosthesis according
- bone
- porous matrix
- prosthesis
- endoprosthesis
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 49
- 238000011049 filling Methods 0.000 title abstract description 20
- 230000012010 growth Effects 0.000 title description 7
- 230000003319 supportive effect Effects 0.000 title 1
- 239000000463 material Substances 0.000 claims abstract description 51
- 239000003102 growth factor Substances 0.000 claims abstract description 49
- 239000011159 matrix material Substances 0.000 claims abstract description 33
- 230000008468 bone growth Effects 0.000 claims abstract description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 16
- 239000000126 substance Substances 0.000 claims description 23
- 239000000919 ceramic Substances 0.000 claims description 22
- 210000002950 fibroblast Anatomy 0.000 claims description 22
- 239000000945 filler Substances 0.000 claims description 19
- 238000002513 implantation Methods 0.000 claims description 13
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 12
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 12
- 239000007943 implant Substances 0.000 claims description 12
- 230000001737 promoting effect Effects 0.000 claims description 12
- 239000001506 calcium phosphate Substances 0.000 claims description 10
- 235000011010 calcium phosphates Nutrition 0.000 claims description 10
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 10
- 239000008187 granular material Substances 0.000 claims description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 9
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 8
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 7
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 229920001184 polypeptide Polymers 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 230000006798 recombination Effects 0.000 claims description 5
- 238000005215 recombination Methods 0.000 claims description 5
- 229940043430 calcium compound Drugs 0.000 claims description 4
- 150000001674 calcium compounds Chemical class 0.000 claims description 4
- 229910000394 calcium triphosphate Inorganic materials 0.000 claims description 4
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 claims description 4
- 210000000689 upper leg Anatomy 0.000 claims description 4
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims description 3
- 239000004068 calcium phosphate ceramic Substances 0.000 claims description 3
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims description 2
- 210000000629 knee joint Anatomy 0.000 claims description 2
- YSJNWPJHMDWGAA-UHFFFAOYSA-H tricalcium;[oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O YSJNWPJHMDWGAA-UHFFFAOYSA-H 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000031018 biological processes and functions Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000011368 organic material Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 description 13
- 239000000243 solution Substances 0.000 description 9
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 8
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 8
- 208000012868 Overgrowth Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000011707 mineral Substances 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000002805 bone matrix Anatomy 0.000 description 4
- 239000000316 bone substitute Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000011575 calcium Substances 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 238000011540 hip replacement Methods 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000007979 citrate buffer Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 238000011477 surgical intervention Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 241000242757 Anthozoa Species 0.000 description 1
- 241000309551 Arthraxon hispidus Species 0.000 description 1
- 208000031872 Body Remains Diseases 0.000 description 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 1
- 208000018084 Bone neoplasm Diseases 0.000 description 1
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 235000014653 Carica parviflora Nutrition 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 1
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101001052035 Homo sapiens Fibroblast growth factor 2 Proteins 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 244000273618 Sphenoclea zeylanica Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- COWYTPMAAISPHT-SWSWVKNJSA-A chembl411368 Chemical compound [K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].O1C(COS([O-])(=O)=O)[C@@H]2C(O)C(OS([O-])(=O)=O)[C@@H]1O[C@H](C(COS([O-])(=O)=O)O1)C(O)C(OS([O-])(=O)=O)[C@H]1O[C@H](C(COS([O-])(=O)=O)O1)C(O)C(OS([O-])(=O)=O)[C@H]1O[C@H](C(COS([O-])(=O)=O)O1)C(O)C(OS([O-])(=O)=O)[C@H]1O[C@H](C(COS([O-])(=O)=O)O1)C(O)C(OS([O-])(=O)=O)[C@H]1O[C@H](C(COS([O-])(=O)=O)O1)C(O)C(OS([O-])(=O)=O)[C@H]1O[C@H](C(COS([O-])(=O)=O)O1)C(O)C(OS([O-])(=O)=O)[C@H]1O2 COWYTPMAAISPHT-SWSWVKNJSA-A 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- 238000011278 co-treatment Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000009193 crawling Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229960000633 dextran sulfate Drugs 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical compound [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004821 effect on bone Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 239000002634 heparin fragment Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 230000002138 osteoinductive effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/3804—Joints for elbows or knees for elbows
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30968—Sintering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
- A61F2/3662—Femoral shafts
- A61F2002/3678—Geometrical features
- A61F2002/368—Geometrical features with lateral apertures, bores, holes or openings, e.g. for reducing the mass, for receiving fixation screws or for communicating with the inside of a hollow shaft
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Cereal-Derived Products (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4242889A DE4242889A1 (de) | 1992-12-18 | 1992-12-18 | Hohlendoprothesen mit Knochenwachstumsfördernder Füllung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK144593A3 true SK144593A3 (en) | 1994-07-06 |
Family
ID=6475710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1445-93A SK144593A3 (en) | 1992-12-18 | 1993-12-17 | Concave endoprosthesis with filling supportive for the growth of the bones |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0605799B1 (cs) |
| JP (1) | JPH06225894A (cs) |
| KR (1) | KR940013468A (cs) |
| CN (1) | CN1090746A (cs) |
| AT (1) | ATE178773T1 (cs) |
| AU (1) | AU5239793A (cs) |
| CA (1) | CA2111598A1 (cs) |
| CZ (1) | CZ283725B6 (cs) |
| DE (2) | DE4242889A1 (cs) |
| ES (1) | ES2132164T3 (cs) |
| HU (1) | HUT67146A (cs) |
| MX (1) | MX9308004A (cs) |
| NO (2) | NO934678D0 (cs) |
| PL (1) | PL174183B1 (cs) |
| SK (1) | SK144593A3 (cs) |
| TW (1) | TW318792B (cs) |
| ZA (1) | ZA939473B (cs) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19917696A1 (de) * | 1999-04-20 | 2000-10-26 | Karlheinz Schmidt | Mittel für die Herstellung biologischer Teile mit einem Wirkstoffkomplex und für diesen geeigneten Trägermaterialien |
| US6986788B2 (en) | 1998-01-30 | 2006-01-17 | Synthes (U.S.A.) | Intervertebral allograft spacer |
| USRE38614E1 (en) | 1998-01-30 | 2004-10-05 | Synthes (U.S.A.) | Intervertebral allograft spacer |
| US7087082B2 (en) | 1998-08-03 | 2006-08-08 | Synthes (Usa) | Bone implants with central chambers |
| US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
| PT1100417E (pt) | 1998-08-03 | 2004-08-31 | Synthes Ag | Implante alogenico dilatador intervertebral |
| DE29913200U1 (de) | 1999-07-28 | 1999-09-23 | Tutogen Medical GmbH, 91077 Neunkirchen | Implantat aus Knochenmaterial |
| DE19944681A1 (de) * | 1999-08-20 | 2001-03-01 | Metz Stavenhagen Peter | Knochenersatzstoff zur Implantation im menschlichen oder tierischen Körper |
| DE19952939A1 (de) * | 1999-11-03 | 2001-05-10 | Tutogen Medical Gmbh | Implantat aus Knochenmaterial |
| US7635390B1 (en) | 2000-01-14 | 2009-12-22 | Marctec, Llc | Joint replacement component having a modular articulating surface |
| KR100358193B1 (ko) * | 2000-02-16 | 2002-10-25 | 한국과학기술원 | 시멘트 비사용 인공관절 스템용 플라스틱 자켓 및 이것을 구비한 인공관절 |
| AR027685A1 (es) | 2000-03-22 | 2003-04-09 | Synthes Ag | Forma de tejido y metodo para realizarlo |
| ITVI20000025U1 (it) * | 2000-04-07 | 2001-10-07 | Tecres Spa | Dispositivo distanziatore temporaneo per il trattamento chirurgico del ginocchio |
| KR100392140B1 (ko) * | 2000-08-16 | 2003-07-22 | 성열보 | 항생제 혼합시멘트 충전물 제작방법 |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| DE10119096A1 (de) * | 2001-04-19 | 2002-10-24 | Keramed Medizintechnik Gmbh | Biologisch funktionalisierte, metabolisch induktive Implantatoberflächen |
| US7708741B1 (en) | 2001-08-28 | 2010-05-04 | Marctec, Llc | Method of preparing bones for knee replacement surgery |
| AR038680A1 (es) | 2002-02-19 | 2005-01-26 | Synthes Ag | Implante intervertebral |
| US7166133B2 (en) | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
| DE10241572B4 (de) * | 2002-09-07 | 2007-02-08 | Werner Scholz | Stütz- oder Halteteil zum Einbringen in ein Knochenteil |
| ATE496593T1 (de) | 2003-02-06 | 2011-02-15 | Synthes Gmbh | Zwischenwirbelimplantat |
| US7819903B2 (en) | 2003-03-31 | 2010-10-26 | Depuy Spine, Inc. | Spinal fixation plate |
| US7226482B2 (en) | 2003-09-02 | 2007-06-05 | Synthes (U.S.A.) | Multipiece allograft implant |
| KR101013999B1 (ko) * | 2004-03-19 | 2011-02-14 | 재단법인서울대학교산학협력재단 | 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트 |
| DE102004016883A1 (de) * | 2004-04-06 | 2005-10-27 | Coripharm Medizinprodukte Gmbh & Co. Kg. | Verfahren zur Herstellung eines Knochen-Implantat-materials mit verbesserter mechanischer Beanspruchbarkeit auf der Basis von Formkörpern aus porösem Implantatmaterial sowie nach dem Verfahren hergestelltes Implantatmaterial |
| DE102004027657A1 (de) * | 2004-06-07 | 2006-02-02 | Zow Ag | Gekammerter Werkstoff als Implantat, Knochenersatz und allgemein als Werkstoff |
| NL1030364C2 (nl) * | 2005-11-07 | 2007-05-08 | Ft Innovations Fti B V | Implantaat en werkwijze voor het vervaardigen van een dergelijk implantaat. |
| EP1988855A2 (en) | 2006-02-27 | 2008-11-12 | Synthes GmbH | Intervertebral implant with fixation geometry |
| US8043377B2 (en) | 2006-09-02 | 2011-10-25 | Osprey Biomedical, Inc. | Implantable intervertebral fusion device |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| JP2011502708A (ja) | 2007-11-16 | 2011-01-27 | ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 低輪郭の椎間インプラント |
| EP3788973B1 (en) | 2008-11-07 | 2023-10-18 | Synthes GmbH | Vertebral interbody spacer and coupled plate assembly |
| WO2012068062A1 (en) | 2010-11-15 | 2012-05-24 | Synthes Usa, Llc | Graft collection and containment system for bone defects |
| AU2011329054B2 (en) | 2010-11-15 | 2015-05-28 | Zimmer Orthobiologics, Inc. | Bone void fillers |
| US9220604B2 (en) | 2010-12-21 | 2015-12-29 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
| US9241809B2 (en) | 2010-12-21 | 2016-01-26 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
| US8485820B1 (en) * | 2011-12-22 | 2013-07-16 | Mohamed Ikbal Ali | Devices and methods for enhancing bone growth |
| US9867718B2 (en) | 2014-10-22 | 2018-01-16 | DePuy Synthes Products, Inc. | Intervertebral implants, systems, and methods of use |
| WO2021001506A1 (de) * | 2019-07-04 | 2021-01-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Implantat und verfahren zu dessen herstellung |
| US12070392B2 (en) | 2021-05-07 | 2024-08-27 | University Of Maryland, Baltimore | Prosthetic stem for a prosthetic implant |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0183744A1 (de) * | 1984-05-08 | 1986-06-11 | Fried. Krupp Gesellschaft mit beschränkter Haftung | Künstliches gelenksystem und verfahren zur implantation dieses gelenksystems |
| CH664686A5 (en) * | 1984-12-11 | 1988-03-31 | Protek Ag | Elbow joint prosthesis - has head parts of prosthesis anchored in bone cavities by perforated tubes |
| EP0271668B1 (de) * | 1986-10-22 | 1991-12-18 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Wachstumstimulierendes Material, Herstellungsverfahren und therapeutische Zusammensetzung |
| NL8700113A (nl) * | 1987-01-19 | 1988-08-16 | Groningen Science Park | Entstuk, geschikt voor behandeling door reconstructieve chirurgie, met weefsel specifieke porositeit, alsmede werkwijze ter vervaardiging van het entstuk. |
| DE3704089A1 (de) * | 1987-02-10 | 1988-08-25 | Claus Fahrer | Heterologes implantat |
| NZ226170A (en) * | 1987-09-18 | 1990-07-26 | Ethicon Inc | Stable freeze-dried pharmaceutical composition containing epidermal growth factor |
| DE8712607U1 (de) * | 1987-09-18 | 1989-01-19 | Howmedica GmbH, 2314 Schönkirchen | Oberschenkelteil einer Hüftgelenkendoprothese |
| WO1989004646A1 (en) * | 1987-11-13 | 1989-06-01 | Jefferies Steven R | Bone repair material and delayed drug delivery |
| AU614137B2 (en) * | 1988-06-06 | 1991-08-22 | Takeda Chemical Industries Ltd. | Stabilized fgf composition and production thereof |
| CA2020654A1 (en) * | 1989-07-07 | 1991-01-08 | Yohko Akiyama | Stabilized fgf composition and production thereof |
| US4936848A (en) * | 1989-09-22 | 1990-06-26 | Bagby George W | Implant for vertebrae |
| US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
| AT393953B (de) * | 1990-09-07 | 1992-01-10 | David Thomas | Endoprothese |
| ES2088690T3 (es) * | 1990-12-19 | 1996-08-16 | Harle Anton | Procedimiento para la fabricacion de un implante medico e implante fabricado de acuerdo con dicho procedimiento. |
| DE4121043A1 (de) * | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | Knochenersatzmaterial mit fgf |
-
1992
- 1992-12-18 DE DE4242889A patent/DE4242889A1/de not_active Withdrawn
-
1993
- 1993-12-06 DE DE59309514T patent/DE59309514D1/de not_active Expired - Fee Related
- 1993-12-06 AT AT93119625T patent/ATE178773T1/de not_active IP Right Cessation
- 1993-12-06 ES ES93119625T patent/ES2132164T3/es not_active Expired - Lifetime
- 1993-12-06 EP EP93119625A patent/EP0605799B1/de not_active Expired - Lifetime
- 1993-12-14 AU AU52397/93A patent/AU5239793A/en not_active Abandoned
- 1993-12-15 TW TW082110654A patent/TW318792B/zh active
- 1993-12-15 MX MX9308004A patent/MX9308004A/es unknown
- 1993-12-16 CA CA002111598A patent/CA2111598A1/en not_active Abandoned
- 1993-12-16 CZ CZ932778A patent/CZ283725B6/cs not_active IP Right Cessation
- 1993-12-16 KR KR1019930027936A patent/KR940013468A/ko not_active Ceased
- 1993-12-16 CN CN93120129A patent/CN1090746A/zh active Pending
- 1993-12-16 PL PL93301514A patent/PL174183B1/pl unknown
- 1993-12-17 NO NO934678D patent/NO934678D0/no unknown
- 1993-12-17 NO NO934678A patent/NO934678L/no unknown
- 1993-12-17 SK SK1445-93A patent/SK144593A3/sk unknown
- 1993-12-17 ZA ZA939473A patent/ZA939473B/xx unknown
- 1993-12-17 JP JP5318424A patent/JPH06225894A/ja active Pending
- 1993-12-17 HU HU9303639A patent/HUT67146A/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL301514A1 (en) | 1994-06-27 |
| MX9308004A (es) | 1994-08-31 |
| DE59309514D1 (de) | 1999-05-20 |
| NO934678D0 (no) | 1993-12-17 |
| CZ283725B6 (cs) | 1998-06-17 |
| CA2111598A1 (en) | 1994-06-19 |
| HU9303639D0 (en) | 1994-04-28 |
| TW318792B (cs) | 1997-11-01 |
| PL174183B1 (pl) | 1998-06-30 |
| KR940013468A (ko) | 1994-07-15 |
| ATE178773T1 (de) | 1999-04-15 |
| ZA939473B (en) | 1994-08-10 |
| AU5239793A (en) | 1994-06-30 |
| HUT67146A (en) | 1995-02-28 |
| CN1090746A (zh) | 1994-08-17 |
| EP0605799B1 (de) | 1999-04-14 |
| EP0605799A1 (de) | 1994-07-13 |
| NO934678L (no) | 1994-06-20 |
| JPH06225894A (ja) | 1994-08-16 |
| DE4242889A1 (de) | 1994-06-23 |
| ES2132164T3 (es) | 1999-08-16 |
| CZ277893A3 (en) | 1994-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CZ277893A3 (en) | Hollow endoprostheses with a bone growth supporting charge | |
| Damien et al. | Bone graft and bone graft substitutes: a review of current technology and applications | |
| US5947893A (en) | Method of making a porous prothesis with biodegradable coatings | |
| Hulbert et al. | History of bioceramics | |
| US8690874B2 (en) | Composition and process for bone growth and repair | |
| US6118043A (en) | Bone replacement material with FGF | |
| Campana et al. | Bone substitutes in orthopaedic surgery: from basic science to clinical practice | |
| Marcacci et al. | Reconstruction of extensive long-bone defects in sheep using porous hydroxyapatite sponges | |
| Oryan et al. | Bone regenerative medicine: classic options, novel strategies, and future directions | |
| US10426621B2 (en) | Implantable composite containing carbonated hydroxyapatite | |
| KR20140038348A (ko) | 척추 유합 절차를 위한 조성물 및 방법 | |
| Cutter et al. | Bone grafts and substitutes | |
| Blom et al. | Cortical bone ingrowth in growth hormone-loaded grooved implants with calcium phosphate coatings in goat femurs | |
| McPherson et al. | Bone grafting with coralline hydroxyapatite | |
| EP0470305A1 (en) | Osteoprosthetic implant | |
| EP3877013B1 (en) | Bone sialoprotein functionalized materials for directed bone regeneration | |
| Olivera et al. | Bone substitutes in orthopedic and trauma surgery | |
| Glogauer | Bone Grafting | |
| McKay et al. | Local Delivery of Bone Growth Factors | |
| Tölli | Reindeer-derived bone protein extract in the healing of bone defects: evaluation of various carrier materials and delivery systems | |
| Daculsi et al. | Calcium Phosphate Bioceramics: An Alternative to Autograft and Allograft? | |
| Passuti et al. | Bone substitutes | |
| Maw | Bone Cements |