SK1502002A3 - A polynucleotide, a vector, a host cell, method for producing molecular variant mdr-1 protein, mdr-1 protein, an antibody, a nucleic acid molecule and a transgenic animal containing the same and the use thereof - Google Patents

A polynucleotide, a vector, a host cell, method for producing molecular variant mdr-1 protein, mdr-1 protein, an antibody, a nucleic acid molecule and a transgenic animal containing the same and the use thereof Download PDF

Info

Publication number: SK1502002A3
Authority: SK; Slovakia
Prior art keywords: mdr; artificial sequence; gene; dna; synthetic
Prior art date: 1999-07-30

Application number

SK150-2002A

Other languages

English (en)

Slovak (sk)

Inventor

Ulrich Brinkmann

Sven Hoffmeyer

Michel Eichelbaum

Ivar Roots

Original Assignee

Epidauros Biotechnologie Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-30

Filing date

2000-07-28

Publication date

2002-07-02

2000-07-28 Application filed by Epidauros Biotechnologie Ag filed Critical Epidauros Biotechnologie Ag

2002-07-02 Publication of SK1502002A3 publication Critical patent/SK1502002A3/sk

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SK150-2002A 1999-07-30 2000-07-28 A polynucleotide, a vector, a host cell, method for producing molecular variant mdr-1 protein, mdr-1 protein, an antibody, a nucleic acid molecule and a transgenic animal containing the same and the use thereof SK1502002A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP99114938		1999-07-30
EP00103361		2000-02-22
PCT/EP2000/007314 WO2001009183A2 (en)	1999-07-30	2000-07-28	Polymorphisms in the human mdr-1 gene and applications thereof

Publications (1)

Publication Number	Publication Date
SK1502002A3 true SK1502002A3 (en)	2002-07-02

Family

ID=26070560

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK150-2002A SK1502002A3 (en)	1999-07-30	2000-07-28	A polynucleotide, a vector, a host cell, method for producing molecular variant mdr-1 protein, mdr-1 protein, an antibody, a nucleic acid molecule and a transgenic animal containing the same and the use thereof

Country Status (20)

Country	Link
US (1)	US20050227249A1 (de)
EP (1)	EP1232260B1 (de)
JP (2)	JP2003510021A (de)
KR (1)	KR100814188B1 (de)
AT (1)	ATE373710T1 (de)
AU (1)	AU1131901A (de)
BG (1)	BG65988B1 (de)
CA (2)	CA2697207A1 (de)
CZ (1)	CZ2002329A3 (de)
DE (1)	DE60036487T2 (de)
DK (1)	DK1232260T3 (de)
EE (1)	EE200200049A (de)
ES (1)	ES2292481T3 (de)
HR (1)	HRP20020093B1 (de)
HU (1)	HUP0201997A3 (de)
MX (1)	MXPA02001094A (de)
NO (2)	NO330680B1 (de)
PL (1)	PL354034A1 (de)
SK (1)	SK1502002A3 (de)
WO (1)	WO2001009183A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001231550A1 (en) *	2000-11-29	2002-06-11	Epidauros Biotechnologie Ag	Use of mdr-1 inducers for treating or preventing diseases
EP1337661A1 (de) *	2000-11-29	2003-08-27	Epidauros Biotechnologie AG	Verfahren zur diagnose von personen mit erhöhtem risiko, eine defizienz zu entwicklen aud der basis von mdr1 genpolymorphismus
DE60234440D1 (de)	2001-01-12	2009-12-31	Univ Washington	Mdr1-varianten und verfahren zu ihrer verwendung
WO2003025174A2 (en) *	2001-09-06	2003-03-27	Bayer Healthcare Ag	Regulation of human mrp1-like protein
EP1340818A1 (de) *	2002-02-27	2003-09-03	Epigenomics AG	Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
AU2003280867A1 (en) *	2002-11-04	2004-06-07	Charite-Universitatsme Dizin Berlin	Specific haplotypes of the mdr1 gene and their use in diagnosis and therapy
US8030033B2 (en)	2004-05-12	2011-10-04	Max-Planck-Gesellschaft Zur Forderung Der Wissenshaften E.V.	Polymorphisms in ABCB1 associated with a lack of clinical response to medicaments
CA2611005A1 (en) *	2005-06-13	2006-12-21	F. Hoffmann-La Roche Ag	Impdh2 snp associated with acute rejection
WO2006133841A1 (en) *	2005-06-13	2006-12-21	F. Hoffmann-La Roche Ag	MDRl SNP IN ACUTE RETECTION
JP2008545444A (ja) *	2005-06-13	2008-12-18	エフ．ホフマン−ラロシュアーゲー	急性拒絶反応に関連するｉｌ１０ｓｎｐ
US20090325156A1 (en) *	2005-11-10	2009-12-31	Government of the United States of America, as Represented by Secretary, Dept. of Human Services	Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment
EP2520670B1 (de)	2007-06-12	2014-02-26	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Neue Polymorphismen bei ABCB1, die mit einem Mangel an klinischen Reaktionen auf Medikamente susammenhören
KR101033840B1 (ko) *	2011-03-08	2011-05-16	(주)제일엔지니어링건축사사무소	공동주택용 입상관 연결구조
AU2018289410B2 (en) *	2017-06-19	2024-06-13	Invitae Corporation	Interpretation of genetic and genomic variants via an integrated computational and experimental deep mutational learning framework

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4683202A (en) *	1985-03-28	1987-07-28	Cetus Corporation	Process for amplifying nucleic acid sequences
CA1284931C (en) *	1986-03-13	1991-06-18	Henry A. Erlich	Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5206352A (en) *	1986-03-28	1993-04-27	Board Of Trustees Of The University Of Illinois	Compositions for clones containing DNA sequences associated with multidrug resistance in human cells
US5851819A (en) *	1987-06-16	1998-12-22	National Institutes Of Health	Vectors carrying MDR1 cDNA which confer multidrug resistance on transduced cells
US5928637A (en) *	1987-06-16	1999-07-27	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Methods of inducing multidrug resistance using human MDR1 cDNA
JPH02100680A (ja) *	1988-10-05	1990-04-12	Suntory Ltd	ヒト正常細胞由来ｍｄｒ関連遺伝子
US5399483A (en) *	1989-03-30	1995-03-21	Suntory Limited	Expression of MDR-related gene in yeast cell
US5856104A (en) *	1996-10-28	1999-01-05	Affymetrix, Inc.	Polymorphisms in the glucose-6 phosphate dehydrogenase locus
US5830697A (en) *	1997-01-21	1998-11-03	The Board Of Trustees Of The Leland Stanford Junior University	P-glycoprotein mutant resistant to cyclosporin modulation

2000
- 2000-07-28 ES ES00972654T patent/ES2292481T3/es not_active Expired - Lifetime
- 2000-07-28 HU HU0201997A patent/HUP0201997A3/hu unknown
- 2000-07-28 HR HR20020093A patent/HRP20020093B1/xx not_active IP Right Cessation
- 2000-07-28 KR KR1020027001248A patent/KR100814188B1/ko not_active Expired - Fee Related
- 2000-07-28 EP EP00972654A patent/EP1232260B1/de not_active Expired - Lifetime
- 2000-07-28 WO PCT/EP2000/007314 patent/WO2001009183A2/en not_active Ceased
- 2000-07-28 DK DK00972654T patent/DK1232260T3/da active
- 2000-07-28 CA CA2697207A patent/CA2697207A1/en not_active Abandoned
- 2000-07-28 CA CA2376666A patent/CA2376666C/en not_active Expired - Lifetime
- 2000-07-28 JP JP2001513989A patent/JP2003510021A/ja active Pending
- 2000-07-28 MX MXPA02001094A patent/MXPA02001094A/es active IP Right Grant
- 2000-07-28 AU AU11319/01A patent/AU1131901A/en not_active Abandoned
- 2000-07-28 PL PL00354034A patent/PL354034A1/xx unknown
- 2000-07-28 CZ CZ2002329A patent/CZ2002329A3/cs unknown
- 2000-07-28 SK SK150-2002A patent/SK1502002A3/sk unknown
- 2000-07-28 AT AT00972654T patent/ATE373710T1/de active
- 2000-07-28 EE EEP200200049A patent/EE200200049A/xx unknown
- 2000-07-28 DE DE60036487T patent/DE60036487T2/de not_active Expired - Lifetime
2002
- 2002-01-29 BG BG106362A patent/BG65988B1/bg unknown
- 2002-01-29 NO NO20020470A patent/NO330680B1/no not_active IP Right Cessation
2004
- 2004-10-14 US US10/965,348 patent/US20050227249A1/en not_active Abandoned
2010
- 2010-06-02 NO NO20100798A patent/NO20100798L/no unknown
2011
- 2011-01-24 JP JP2011011834A patent/JP2011142909A/ja active Pending

Also Published As

Publication number	Publication date
JP2003510021A (ja)	2003-03-18
EE200200049A (et)	2003-04-15
BG65988B1 (bg)	2010-08-31
MXPA02001094A (es)	2003-07-21
CA2697207A1 (en)	2001-02-08
NO20020470L (no)	2002-03-26
WO2001009183A3 (en)	2002-03-28
DE60036487D1 (de)	2007-10-31
HUP0201997A2 (en)	2002-09-28
ATE373710T1 (de)	2007-10-15
AU1131901A (en)	2001-02-19
CA2376666A1 (en)	2001-02-08
KR20020059347A (ko)	2002-07-12
CZ2002329A3 (cs)	2002-07-17
NO20020470D0 (no)	2002-01-29
JP2011142909A (ja)	2011-07-28
NO330680B1 (no)	2011-06-06
BG106362A (bg)	2002-09-30
HRP20020093A2 (en)	2004-06-30
PL354034A1 (en)	2003-12-15
DK1232260T3 (da)	2008-02-04
EP1232260B1 (de)	2007-09-19
ES2292481T3 (es)	2008-03-16
KR100814188B1 (ko)	2008-03-17
DE60036487T2 (de)	2008-06-19
HRP20020093B1 (en)	2011-02-28
HUP0201997A3 (en)	2005-01-28
US20050227249A1 (en)	2005-10-13
EP1232260A2 (de)	2002-08-21
NO20100798L (no)	2002-03-26
CA2376666C (en)	2010-05-25
WO2001009183A2 (en)	2001-02-08

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Publication	Publication Date	Title
JP2011142909A (ja)	2011-07-28	ヒトｍｄｒ−１遺伝子における多型および、診断的および治療的適用におけるその使用
US20110131671A1 (en)	2011-06-02	Polymorphisms in the human gene for cytochrome p450 polypeptide 2c8 and their use in diagnostic and therapeutic applications
EP1088900A1 (de)	2001-04-04	Polymorphismen des menschlichen CYP3A4, CYP3A7 und hPXR Gene, und ihre Anwendung in Diagnose und Therapie
US7407756B2 (en)	2008-08-05	Methods for detecting mutations associated with familial dysautonomia
US20090018030A1 (en)	2009-01-15	Polymorphisms in the human genes for OCT1 and their use in diagnostic and therapeutic applications
WO2003097873A2 (en)	2003-11-27	Polymorphisms in the human gene for htr3b and their use in diagnostic and therapeutic applications
US20060078879A1 (en)	2006-04-13	Polymorphisms in the human gene for tpmt and their use in diagnostic and therapeutic applications
WO2003014387A2 (en)	2003-02-20	Polymorphisms in the human gene for cyp1a2 and their use in diagnostic and therapeutic applications
US6395488B1 (en)	2002-05-28	Cholecystokinin (CCK) gene as a risk factor for smoking in women