SK18932001A3 - Farmaceutický komplex - Google Patents

Farmaceutický komplex Download PDF

Info

Publication number: SK18932001A3
Authority: SK; Slovakia
Prior art keywords: composition; eletriptan; composition according; cyclodextrin; pharmaceutically acceptable
Prior art date: 1999-06-29

Application number

SK1893-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Anne Billotte

Original Assignee

Pfizer, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-29

Filing date

2000-06-02

Publication date

2002-09-10

2000-06-02 Application filed by Pfizer, Inc. filed Critical Pfizer, Inc.

2002-09-10 Publication of SK18932001A3 publication Critical patent/SK18932001A3/sk

Links

229960002472 eletriptan Drugs 0.000 claims abstract description 42
150000003839 salts Chemical class 0.000 claims abstract description 38
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
229920000858 Cyclodextrin Polymers 0.000 claims abstract description 15
238000000034 method Methods 0.000 claims abstract description 6
229960004853 betadex Drugs 0.000 claims abstract description 3
OTLDLQZJRFYOJR-LJQANCHMSA-N eletriptan Chemical compound CN1CCC[C@@H]1CC1=CN=C2[C]1C=C(CCS(=O)(=O)C=1C=CC=CC=1)C=C2 OTLDLQZJRFYOJR-LJQANCHMSA-N 0.000 claims abstract 8
239000001116 FEMA 4028 Substances 0.000 claims abstract 2
239000000203 mixture Substances 0.000 claims description 73
PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 38
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 28
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 20
239000000243 solution Substances 0.000 claims description 16
229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims description 15
235000010323 ascorbic acid Nutrition 0.000 claims description 14
239000011668 ascorbic acid Substances 0.000 claims description 14
229960005070 ascorbic acid Drugs 0.000 claims description 14
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 12
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235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 12
239000007864 aqueous solution Substances 0.000 claims description 11
IYVZCNNIKYUHHM-WXMGBDCWSA-N OS(O)(=O)=O.CN1CCC[C@@H]1CC(C1=C2)=CNC1=CC=C2CCS(=O)(=O)C1=CC=CC=C1.CN1CCC[C@@H]1CC(C1=C2)=CNC1=CC=C2CCS(=O)(=O)C1=CC=CC=C1 Chemical compound OS(O)(=O)=O.CN1CCC[C@@H]1CC(C1=C2)=CNC1=CC=C2CCS(=O)(=O)C1=CC=CC=C1.CN1CCC[C@@H]1CC(C1=C2)=CNC1=CC=C2CCS(=O)(=O)C1=CC=CC=C1 IYVZCNNIKYUHHM-WXMGBDCWSA-N 0.000 claims description 9
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NZAQRZWBQUIBSF-UHFFFAOYSA-N 4-(4-sulfobutoxy)butane-1-sulfonic acid Chemical group OS(=O)(=O)CCCCOCCCCS(O)(=O)=O NZAQRZWBQUIBSF-UHFFFAOYSA-N 0.000 claims description 6
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PWVXXGRKLHYWKM-LJQANCHMSA-N eletriptan Chemical compound CN1CCC[C@@H]1CC(C1=C2)=CNC1=CC=C2CCS(=O)(=O)C1=CC=CC=C1 PWVXXGRKLHYWKM-LJQANCHMSA-N 0.000 description 34
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LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 2
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SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 2
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238000001704 evaporation Methods 0.000 description 1
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239000008103 glucose Substances 0.000 description 1
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231100000869 headache Toxicity 0.000 description 1
150000005828 hydrofluoroalkanes Chemical class 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
206010020718 hyperplasia Diseases 0.000 description 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
238000001802 infusion Methods 0.000 description 1
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239000007788 liquid Substances 0.000 description 1
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239000011777 magnesium Substances 0.000 description 1
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235000019359 magnesium stearate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
230000015689 metaplastic ossification Effects 0.000 description 1
TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 1
229960004503 metoclopramide Drugs 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
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235000019813 microcrystalline cellulose Nutrition 0.000 description 1
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GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
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OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
SJWFXCIHNDVPSH-UHFFFAOYSA-N octan-2-ol Chemical compound CCCCCCC(C)O SJWFXCIHNDVPSH-UHFFFAOYSA-N 0.000 description 1
238000002638 palliative care Methods 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
208000007777 paroxysmal Hemicrania Diseases 0.000 description 1
239000002245 particle Substances 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
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229940113124 polysorbate 60 Drugs 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000002325 prokinetic agent Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
238000012552 review Methods 0.000 description 1
229940076279 serotonin Drugs 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
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239000011734 sodium Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
235000019337 sorbitan trioleate Nutrition 0.000 description 1
229960000391 sorbitan trioleate Drugs 0.000 description 1
238000013223 sprague-dawley female rat Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
208000011117 substance-related disease Diseases 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
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210000001519 tissue Anatomy 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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208000019553 vascular disease Diseases 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Nanotechnology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Crystallography & Structural Chemistry (AREA)
Molecular Biology (AREA)
Medical Informatics (AREA)
General Engineering & Computer Science (AREA)
Otolaryngology (AREA)
Diabetes (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Addiction (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

SK1893-2001A 1999-06-29 2000-06-02 Farmaceutický komplex SK18932001A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9915231.6A GB9915231D0 (en)	1999-06-29	1999-06-29	Pharmaceutical complex
PCT/IB2000/000746 WO2001000243A1 (en)	1999-06-29	2000-06-02	Pharmaceutical complex

Publications (1)

Publication Number	Publication Date
SK18932001A3 true SK18932001A3 (sk)	2002-09-10

Family

ID=10856302

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1893-2001A SK18932001A3 (sk)	1999-06-29	2000-06-02	Farmaceutický komplex

Country Status (44)

Country	Link
US (2)	US6713461B1 (de)
EP (1)	EP1189640B1 (de)
JP (2)	JP4454900B2 (de)
KR (1)	KR20020015067A (de)
CN (1)	CN1198654C (de)
AP (1)	AP2001002369A0 (de)
AR (1)	AR033337A1 (de)
AT (1)	ATE290884T1 (de)
AU (1)	AU770169B2 (de)
BG (1)	BG106151A (de)
BR (1)	BR0011845A (de)
CA (1)	CA2376847C (de)
CO (1)	CO5170494A1 (de)
CZ (1)	CZ20014572A3 (de)
DE (1)	DE60018744T2 (de)
DZ (1)	DZ3320A1 (de)
EA (1)	EA003908B1 (de)
EC (1)	ECSP003551A (de)
EE (1)	EE200100697A (de)
ES (1)	ES2235879T3 (de)
GB (1)	GB9915231D0 (de)
GE (1)	GEP20043377B (de)
GT (1)	GT200000102A (de)
HR (1)	HRP20010951A2 (de)
HU (1)	HUP0201629A3 (de)
IL (1)	IL146341A0 (de)
IS (1)	IS6163A (de)
MA (1)	MA26801A1 (de)
MX (1)	MXPA01013274A (de)
NO (1)	NO20016430L (de)
NZ (1)	NZ515235A (de)
OA (1)	OA11964A (de)
PA (1)	PA8496801A1 (de)
PE (1)	PE20010346A1 (de)
PL (1)	PL352902A1 (de)
SK (1)	SK18932001A3 (de)
SV (1)	SV2002000112A (de)
TN (1)	TNSN00142A1 (de)
TR (1)	TR200103827T2 (de)
UA (1)	UA66932C2 (de)
UY (1)	UY26224A1 (de)
WO (1)	WO2001000243A1 (de)
YU (1)	YU87501A (de)
ZA (1)	ZA200110454B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9915231D0 (en) *	1999-06-29	1999-09-01	Pfizer Ltd	Pharmaceutical complex
NZ537995A (en) *	2002-08-20	2007-11-30	Bristol Myers Squibb Co	Inclusion complex of aripiprazole in a substituted b-cyclodextrin
GB0329918D0 (en) *	2003-12-24	2004-01-28	West Pharm Serv Drug Res Ltd	Intranasal compositions
CN1296391C (zh) *	2004-03-04	2007-01-24	中国人民解放军第二军医大学	氟代羧烷基环糊精醚类化合物及其制备方法和应用
GB0613925D0 (en)	2006-07-13	2006-08-23	Unilever Plc	Improvements relating to nanodispersions
CN101957330B (zh) *	2010-06-12	2013-10-09	南京巨环医药科技开发有限公司	磺丁基倍他环糊精含量的测定方法
WO2017122161A1 (en) *	2016-01-15	2017-07-20	Cadila Healthcare Limited	An intranasal composition comprising 5ht1b/1d receptor agonists
WO2019143925A1 (en) *	2018-01-22	2019-07-25	Insys Development Company, Inc.	Liquid rizatriptan compositions

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0166088B1 (ko) *	1990-01-23	1999-01-15	.	수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) *	1990-01-23	1994-12-27	University Of Kansas	Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
HU211648A9 (en)	1990-03-28	1995-12-28	Chinoin Gyogyszer Es Vegyeszet	Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same
HU210921B (en)	1990-03-28	1995-09-28	Chinoin Gyogyszer Es Vegyeszet	Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
HU225055B1 (en)	1990-10-15	2006-05-29	Pfizer	Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
RU2143896C1 (ru)	1993-03-05	2000-01-10	Хексаль Аг	Кристаллический комплекс циклодекстрина с гидрохлоридом ранитидина, способ его получения и содержащие его фармацевтические составы
MX9504664A (es)	1994-03-07	1997-05-31	Dow Chemical Co	Conjugados de dendrimeros bioactivos y/o dirigidos.
GB9417310D0 (en)	1994-08-27	1994-10-19	Pfizer Ltd	Therapeutic agents
US6255502B1 (en)	1996-07-11	2001-07-03	Farmarc Nederland B.V.	Pharmaceutical composition containing acid addition salt of basic drug
US5998462A (en)	1996-12-16	1999-12-07	Allelix Biopharmaceuticals Inc.	5-alkyl indole compounds
GB9704498D0 (en)	1997-03-05	1997-04-23	Glaxo Wellcome Spa	Chemical compound
EP0999841B1 (de)	1997-07-03	2001-10-17	Pfizer Limited	Eletriptanhemisulfat und kaffein enthaltende pharmazeutische zusammenstellungen
GB9816556D0 (en) *	1998-07-30	1998-09-30	Pfizer Ltd	Therapy
GB9915231D0 (en) *	1999-06-29	1999-09-01	Pfizer Ltd	Pharmaceutical complex

1999
- 1999-06-29 GB GBGB9915231.6A patent/GB9915231D0/en not_active Ceased
2000
- 2000-05-26 CO CO00039185A patent/CO5170494A1/es not_active Application Discontinuation
- 2000-06-02 NZ NZ515235A patent/NZ515235A/en unknown
- 2000-06-02 WO PCT/IB2000/000746 patent/WO2001000243A1/en not_active Ceased
- 2000-06-02 BR BR0011845-1A patent/BR0011845A/pt not_active Application Discontinuation
- 2000-06-02 CZ CZ20014572A patent/CZ20014572A3/cs unknown
- 2000-06-02 EE EEP200100697A patent/EE200100697A/xx unknown
- 2000-06-02 DE DE60018744T patent/DE60018744T2/de not_active Expired - Lifetime
- 2000-06-02 AP APAP/P/2001/002369A patent/AP2001002369A0/en unknown
- 2000-06-02 ES ES00929741T patent/ES2235879T3/es not_active Expired - Lifetime
- 2000-06-02 IL IL14634100A patent/IL146341A0/xx unknown
- 2000-06-02 MX MXPA01013274A patent/MXPA01013274A/es active IP Right Grant
- 2000-06-02 YU YU87501A patent/YU87501A/sh unknown
- 2000-06-02 TR TR2001/03827T patent/TR200103827T2/xx unknown
- 2000-06-02 SK SK1893-2001A patent/SK18932001A3/sk unknown
- 2000-06-02 UA UA2001129200A patent/UA66932C2/xx unknown
- 2000-06-02 CN CNB008097127A patent/CN1198654C/zh not_active Expired - Fee Related
- 2000-06-02 EA EA200101106A patent/EA003908B1/ru not_active IP Right Cessation
- 2000-06-02 PL PL00352902A patent/PL352902A1/xx not_active Application Discontinuation
- 2000-06-02 EP EP00929741A patent/EP1189640B1/de not_active Expired - Lifetime
- 2000-06-02 JP JP2001505950A patent/JP4454900B2/ja not_active Expired - Fee Related
- 2000-06-02 KR KR1020017016844A patent/KR20020015067A/ko not_active Ceased
- 2000-06-02 HR HR20010951A patent/HRP20010951A2/xx not_active Application Discontinuation
- 2000-06-02 DZ DZ013320A patent/DZ3320A1/fr active
- 2000-06-02 HU HU0201629A patent/HUP0201629A3/hu unknown
- 2000-06-02 CA CA002376847A patent/CA2376847C/en not_active Expired - Fee Related
- 2000-06-02 OA OA1200100328A patent/OA11964A/en unknown
- 2000-06-02 AT AT00929741T patent/ATE290884T1/de not_active IP Right Cessation
- 2000-06-02 GE GE4655A patent/GEP20043377B/en unknown
- 2000-06-02 AU AU47741/00A patent/AU770169B2/en not_active Ceased
- 2000-06-06 PA PA20008496801A patent/PA8496801A1/es unknown
- 2000-06-22 GT GT200000102A patent/GT200000102A/es unknown
- 2000-06-27 AR ARP000103223A patent/AR033337A1/es unknown
- 2000-06-27 UY UY26224A patent/UY26224A1/es not_active Application Discontinuation
- 2000-06-27 PE PE2000000648A patent/PE20010346A1/es not_active Application Discontinuation
- 2000-06-28 SV SV2000000112A patent/SV2002000112A/es unknown
- 2000-06-28 TN TNTNSN00142A patent/TNSN00142A1/fr unknown
- 2000-06-29 US US09/606,508 patent/US6713461B1/en not_active Expired - Fee Related
- 2000-06-29 EC EC2000003551A patent/ECSP003551A/es unknown
2001
- 2001-11-16 IS IS6163A patent/IS6163A/is unknown
- 2001-11-26 BG BG106151A patent/BG106151A/xx unknown
- 2001-12-20 ZA ZA200110454A patent/ZA200110454B/xx unknown
- 2001-12-24 MA MA26450A patent/MA26801A1/fr unknown
- 2001-12-28 NO NO20016430A patent/NO20016430L/no not_active Application Discontinuation
2004
- 2004-03-30 US US10/812,440 patent/US20040186076A1/en not_active Abandoned
2006
- 2006-04-13 JP JP2006111074A patent/JP2006257091A/ja active Pending

Also Published As

Publication number	Publication date
GB9915231D0 (en)	1999-09-01
EP1189640B1 (de)	2005-03-16
WO2001000243A1 (en)	2001-01-04
PE20010346A1 (es)	2001-03-26
BR0011845A (pt)	2002-03-05
NO20016430L (no)	2002-02-26
HUP0201629A3 (en)	2003-11-28
HRP20010951A2 (en)	2005-04-30
AU4774100A (en)	2001-01-31
CA2376847A1 (en)	2001-01-04
PL352902A1 (en)	2003-09-22
CN1359303A (zh)	2002-07-17
ATE290884T1 (de)	2005-04-15
US20040186076A1 (en)	2004-09-23
US6713461B1 (en)	2004-03-30
CO5170494A1 (es)	2002-06-27
NZ515235A (en)	2003-08-29
IL146341A0 (en)	2002-07-25
OA11964A (en)	2006-04-17
JP4454900B2 (ja)	2010-04-21
ZA200110454B (en)	2002-12-20
DE60018744D1 (de)	2005-04-21
UA66932C2 (en)	2004-06-15
EA200101106A1 (ru)	2002-06-27
NO20016430D0 (no)	2001-12-28
ES2235879T3 (es)	2005-07-16
EE200100697A (et)	2003-02-17
SV2002000112A (es)	2002-02-05
MXPA01013274A (es)	2002-06-04
HUP0201629A2 (hu)	2003-03-28
YU87501A (sh)	2004-05-12
DZ3320A1 (fr)	2001-01-04
EP1189640A1 (de)	2002-03-27
TNSN00142A1 (fr)	2005-11-10
JP2006257091A (ja)	2006-09-28
TR200103827T2 (tr)	2002-05-21
AU770169B2 (en)	2004-02-12
EA003908B1 (ru)	2003-10-30
IS6163A (is)	2001-11-16
GT200000102A (es)	2001-12-14
PA8496801A1 (es)	2002-02-21
GEP20043377B (en)	2004-04-13
CN1198654C (zh)	2005-04-27
DE60018744T2 (de)	2006-05-18
MA26801A1 (fr)	2004-12-20
KR20020015067A (ko)	2002-02-27
BG106151A (en)	2002-05-31
AR033337A1 (es)	2003-12-17
JP2003503364A (ja)	2003-01-28
ECSP003551A (es)	2002-01-25
AP2001002369A0 (en)	2001-12-31
CA2376847C (en)	2007-09-25
UY26224A1 (es)	2001-01-31
CZ20014572A3 (cs)	2002-08-14

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