SK19442000A3 - Tlakov inhaltory s meranmi dvkami a farmaceutick aeroslov formulcie - Google Patents

Tlakov inhaltory s meranmi dvkami a farmaceutick aeroslov formulcie Download PDF

Info

Publication number: SK19442000A3
Authority: SK; Slovakia
Prior art keywords: aerosol formulation; weight; amount; metered dose; dose inhaler
Prior art date: 1998-06-19

Application number

SK1944-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Frank E. Blondino

Michael Brucato

Maria W. Buenafe

Original Assignee

Baker Norton Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-19

Filing date

1999-06-18

Publication date

2001-09-11

1999-06-18 Application filed by Baker Norton Pharmaceuticals, Inc. filed Critical Baker Norton Pharmaceuticals, Inc.

2001-09-11 Publication of SK19442000A3 publication Critical patent/SK19442000A3/sk

Links

239000000203 mixture Substances 0.000 title claims abstract description 144
238000009472 formulation Methods 0.000 title claims abstract description 133
229940125388 beta agonist Drugs 0.000 title claims abstract description 45
239000008249 pharmaceutical aerosol Substances 0.000 title 1
239000000443 aerosol Substances 0.000 claims abstract description 131
239000003814 drug Substances 0.000 claims abstract description 70
229940079593 drug Drugs 0.000 claims abstract description 69
229940071648 metered dose inhaler Drugs 0.000 claims description 44
BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims description 36
229960002848 formoterol Drugs 0.000 claims description 36
239000002904 solvent Substances 0.000 claims description 35
239000004094 surface-active agent Substances 0.000 claims description 31
239000000725 suspension Substances 0.000 claims description 27
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
OBRNDARFFFHCGE-PERKLWIXSA-N (S,S)-formoterol fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-PERKLWIXSA-N 0.000 claims description 25
239000003795 chemical substances by application Substances 0.000 claims description 25
229960000193 formoterol fumarate Drugs 0.000 claims description 25
239000002245 particle Substances 0.000 claims description 21
LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 18
230000003381 solubilizing effect Effects 0.000 claims description 6
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
239000002202 Polyethylene glycol Substances 0.000 claims description 4
150000001298 alcohols Chemical class 0.000 claims description 4
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 4
150000002170 ethers Chemical class 0.000 claims description 4
229920001223 polyethylene glycol Polymers 0.000 claims description 4
-1 polyoxyethylene Polymers 0.000 claims description 4
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical group C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 3
125000004432 carbon atom Chemical group C* 0.000 claims description 3
229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims description 3
150000005846 sugar alcohols Polymers 0.000 claims description 3
238000002664 inhalation therapy Methods 0.000 abstract description 2
239000000463 material Substances 0.000 description 14
238000012360 testing method Methods 0.000 description 12
WPMWEFXCIYCJSA-UHFFFAOYSA-N Tetraethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCO WPMWEFXCIYCJSA-UHFFFAOYSA-N 0.000 description 11
239000010419 fine particle Substances 0.000 description 8
238000000034 method Methods 0.000 description 7
238000003860 storage Methods 0.000 description 7
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
229920001213 Polysorbate 20 Polymers 0.000 description 5
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 5
238000001816 cooling Methods 0.000 description 4
239000006184 cosolvent Substances 0.000 description 4
210000004072 lung Anatomy 0.000 description 4
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
239000002253 acid Substances 0.000 description 3
229930195733 hydrocarbon Natural products 0.000 description 3
150000002430 hydrocarbons Chemical class 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000007858 starting material Substances 0.000 description 3
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
229920002556 Polyethylene Glycol 300 Polymers 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
238000002144 chemical decomposition reaction Methods 0.000 description 2
230000008021 deposition Effects 0.000 description 2
RWRIWBAIICGTTQ-UHFFFAOYSA-N difluoromethane Chemical compound FCF RWRIWBAIICGTTQ-UHFFFAOYSA-N 0.000 description 2
239000002270 dispersing agent Substances 0.000 description 2
238000009826 distribution Methods 0.000 description 2
239000013583 drug formulation Substances 0.000 description 2
150000005828 hydrofluoroalkanes Chemical class 0.000 description 2
NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
CRSOQBOWXPBRES-UHFFFAOYSA-N neopentane Chemical compound CC(C)(C)C CRSOQBOWXPBRES-UHFFFAOYSA-N 0.000 description 2
239000007921 spray Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
230000004913 activation Effects 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
239000000556 agonist Substances 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
239000004744 fabric Substances 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
239000001282 iso-butane Substances 0.000 description 1
QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical class CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 1
230000007774 longterm Effects 0.000 description 1
238000005461 lubrication Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
BCCOBQSFUDVTJQ-UHFFFAOYSA-N octafluorocyclobutane Chemical compound FC1(F)C(F)(F)C(F)(F)C1(F)F BCCOBQSFUDVTJQ-UHFFFAOYSA-N 0.000 description 1
235000019407 octafluorocyclobutane Nutrition 0.000 description 1
QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
GTLACDSXYULKMZ-UHFFFAOYSA-N pentafluoroethane Chemical compound FC(F)C(F)(F)F GTLACDSXYULKMZ-UHFFFAOYSA-N 0.000 description 1
229960004692 perflenapent Drugs 0.000 description 1
KAVGMUDTWQVPDF-UHFFFAOYSA-N perflubutane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F KAVGMUDTWQVPDF-UHFFFAOYSA-N 0.000 description 1
229950003332 perflubutane Drugs 0.000 description 1
NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 description 1
229960004065 perflutren Drugs 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229940068886 polyethylene glycol 300 Drugs 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000000047 product Substances 0.000 description 1
239000003380 propellant Substances 0.000 description 1
239000003566 sealing material Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000002525 ultrasonication Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK1944-2000A 1998-06-19 1999-06-18 Tlakov inhaltory s meranmi dvkami a farmaceutick aeroslov formulcie SK19442000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/099,779 US6451285B2 (en)	1998-06-19	1998-06-19	Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
PCT/US1999/013863 WO1999065460A2 (fr)	1998-06-19	1999-06-18	Inhalateurs doseurs sous pression et formulations pharmaceutiques pour aerosols

Publications (1)

Publication Number	Publication Date
SK19442000A3 true SK19442000A3 (sk)	2001-09-11

Family

ID=22276581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1944-2000A SK19442000A3 (sk)	1998-06-19	1999-06-18	Tlakov inhaltory s meranmi dvkami a farmaceutick aeroslov formulcie

Country Status (23)

Country	Link
US (2)	US6451285B2 (fr)
EP (2)	EP1306082B1 (fr)
JP (1)	JP2002518100A (fr)
KR (1)	KR20010053025A (fr)
CN (2)	CN1522692A (fr)
AR (1)	AR018891A1 (fr)
AT (2)	ATE260093T1 (fr)
AU (1)	AU762927B2 (fr)
BR (1)	BR9912170A (fr)
CA (1)	CA2335303A1 (fr)
CO (1)	CO5031245A1 (fr)
DE (2)	DE69915144T2 (fr)
DK (2)	DK1085856T3 (fr)
ES (2)	ES2205848T3 (fr)
HU (1)	HUP0102468A3 (fr)
IL (1)	IL140340A0 (fr)
NO (1)	NO20006466L (fr)
PL (1)	PL345399A1 (fr)
PT (2)	PT1306082E (fr)
RU (1)	RU2214230C2 (fr)
SK (1)	SK19442000A3 (fr)
WO (1)	WO1999065460A2 (fr)
ZA (1)	ZA200007455B (fr)

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GB0219511D0 (en) *	2002-08-21	2002-10-02	Norton Healthcare Ltd	Method of preparing dry powder inhalation compositions
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GB0323685D0 (en) *	2003-10-09	2003-11-12	Jagotec Ag	Improvements in or relating to organic compounds
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EP1595531A1 (fr)	2004-05-13	2005-11-16	CHIESI FARMACEUTICI S.p.A.	Formulation d'une solution pharmaceutique stable pour aérosols doseurs sous pression
WO2007008427A2 (fr) *	2005-07-08	2007-01-18	Xemplar Pharmaceuticals, Llc	Compositions aerosol et procedes
US8367734B1 (en)	2005-08-11	2013-02-05	Amphastar Pharmaceuticals Inc.	Stable epinephrine suspension formulation with high inhalation delivery efficiency
US8815258B2 (en)	2009-05-29	2014-08-26	Pearl Therapeutics, Inc.	Compositions, methods and systems for respiratory delivery of two or more active agents
PL3111927T3 (pl) *	2009-05-29	2020-06-29	Pearl Therapeutics, Inc.	Kompozycje do wziewnego podawania środków aktywnych oraz związane z nimi sposoby i systemy
GB0918149D0 (en)	2009-10-16	2009-12-02	Jagotec Ag	Improved medicinal aerosol formulation
EP3020393B1 (fr)	2009-12-16	2020-10-07	3M Innovative Properties Company	Formulations et procédés de commande de distribution granulométrique mdi
GB201108039D0 (en)	2011-05-13	2011-06-29	Mexichem Amanco Holding Sa	Compositions
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GB9612297D0 (en)	1996-06-11	1996-08-14	Minnesota Mining & Mfg	Medicinal aerosol formulations
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US6039932A (en) *	1996-09-27	2000-03-21	3M Innovative Properties Company	Medicinal inhalation aerosol formulations containing budesonide
SE9603669D0 (sv)	1996-10-08	1996-10-08	Astra Ab	New combination
DE69734017T2 (de)	1996-12-04	2006-06-14	Link Products Ltd	Arzneimittelzusammensetzungen und vorrichtungen zu deren verabreichung
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1998
- 1998-06-19 US US09/099,779 patent/US6451285B2/en not_active Expired - Fee Related
1999
- 1999-06-18 AT AT02026980T patent/ATE260093T1/de not_active IP Right Cessation
- 1999-06-18 CN CNA2003101046076A patent/CN1522692A/zh active Pending
- 1999-06-18 HU HU0102468A patent/HUP0102468A3/hu unknown
- 1999-06-18 ES ES99931837T patent/ES2205848T3/es not_active Expired - Lifetime
- 1999-06-18 EP EP02026980A patent/EP1306082B1/fr not_active Expired - Lifetime
- 1999-06-18 WO PCT/US1999/013863 patent/WO1999065460A2/fr not_active Ceased
- 1999-06-18 PT PT02026980T patent/PT1306082E/pt unknown
- 1999-06-18 PL PL99345399A patent/PL345399A1/xx unknown
- 1999-06-18 CA CA002335303A patent/CA2335303A1/fr not_active Abandoned
- 1999-06-18 EP EP99931837A patent/EP1085856B1/fr not_active Expired - Lifetime
- 1999-06-18 DK DK99931837T patent/DK1085856T3/da active
- 1999-06-18 RU RU2001101889/14A patent/RU2214230C2/ru not_active IP Right Cessation
- 1999-06-18 BR BR9912170-0A patent/BR9912170A/pt not_active IP Right Cessation
- 1999-06-18 ES ES02026980T patent/ES2215153T3/es not_active Expired - Lifetime
- 1999-06-18 AR ARP990102934A patent/AR018891A1/es not_active Application Discontinuation
- 1999-06-18 DE DE69915144T patent/DE69915144T2/de not_active Expired - Fee Related
- 1999-06-18 SK SK1944-2000A patent/SK19442000A3/sk unknown
- 1999-06-18 DK DK02026980T patent/DK1306082T3/da active
- 1999-06-18 DE DE69911602T patent/DE69911602T2/de not_active Expired - Fee Related
- 1999-06-18 JP JP2000554340A patent/JP2002518100A/ja active Pending
- 1999-06-18 KR KR1020007014438A patent/KR20010053025A/ko not_active Ceased
- 1999-06-18 IL IL14034099A patent/IL140340A0/xx unknown
- 1999-06-18 PT PT99931837T patent/PT1085856E/pt unknown
- 1999-06-18 CN CNB998088641A patent/CN1154477C/zh not_active Expired - Fee Related
- 1999-06-18 AT AT99931837T patent/ATE250409T1/de not_active IP Right Cessation
- 1999-06-18 AU AU48259/99A patent/AU762927B2/en not_active Ceased
- 1999-06-21 CO CO99038537A patent/CO5031245A1/es unknown
2000
- 2000-12-13 ZA ZA200007455A patent/ZA200007455B/en unknown
- 2000-12-18 NO NO20006466A patent/NO20006466L/no not_active Application Discontinuation
2002
- 2002-07-02 US US10/190,094 patent/US20030077230A1/en not_active Abandoned

Also Published As

Publication number	Publication date
BR9912170A (pt)	2001-10-23
IL140340A0 (en)	2002-02-10
PT1306082E (pt)	2004-05-31
HUP0102468A3 (en)	2002-12-28
AR018891A1 (es)	2001-12-12
ATE260093T1 (de)	2004-03-15
US20030077230A1 (en)	2003-04-24
ES2205848T3 (es)	2004-05-01
EP1306082B1 (fr)	2004-02-25
AU762927B2 (en)	2003-07-10
NO20006466L (no)	2001-02-16
NO20006466D0 (no)	2000-12-18
RU2214230C2 (ru)	2003-10-20
DK1306082T3 (da)	2004-06-01
CA2335303A1 (fr)	1999-12-23
CN1310611A (zh)	2001-08-29
CO5031245A1 (es)	2001-04-27
CN1522692A (zh)	2004-08-25
ES2215153T3 (es)	2004-10-01
WO1999065460A2 (fr)	1999-12-23
EP1085856B1 (fr)	2003-09-24
KR20010053025A (ko)	2001-06-25
ZA200007455B (en)	2002-06-13
EP1085856A2 (fr)	2001-03-28
PL345399A1 (en)	2001-12-17
DE69915144T2 (de)	2004-12-09
CN1154477C (zh)	2004-06-23
PT1085856E (pt)	2004-01-30
AU4825999A (en)	2000-01-05
EP1306082A1 (fr)	2003-05-02
JP2002518100A (ja)	2002-06-25
US20020018753A1 (en)	2002-02-14
US6451285B2 (en)	2002-09-17
WO1999065460A3 (fr)	2000-04-27
HUP0102468A2 (hu)	2002-03-28
ATE250409T1 (de)	2003-10-15
DE69911602T2 (de)	2004-07-01
DK1085856T3 (da)	2003-12-08
DE69915144D1 (de)	2004-04-01
DE69911602D1 (de)	2003-10-30

Publication	Publication Date	Title
SK19442000A3 (sk)	2001-09-11	Tlakov inhaltory s meranmi dvkami a farmaceutick aeroslov formulcie
US6004537A (en)	1999-12-21	Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol
CA2352484C (fr)	2010-05-04	Aerosols doseurs sous pression
US6290930B1 (en)	2001-09-18	Pharmaceutical solution aerosol formulations containing fluoroalkanes and budesonide
SK16062002A3 (sk)	2003-04-01	Farmaceutický prostriedok na použitie v aerosólovom inhalátore s odmeranou dávkou a spôsob jeho výroby
Murata et al.	2012	Effect of the moisture content in aerosol on the spray performance of Stmerin® D hydrofluoroalkane preparations (2)
CZ20004793A3 (cs)	2001-05-16	Tlakové inhalátory s odměřenými dávkami a farmaceutické aerosolové přípravky
AU2003235032A1 (en)	2003-09-11	Pressurized metered dose inhalers and pharmaceutical aerosol formulations
MXPA00012655A (en)	2001-12-13	Pressurized metered dose inhalers and pharmaceutical aerosol formulations
MXPA01006082A (en)	2002-06-05	Pharmaceutical aerosol formulations containing fluoroalkanes, budesonide and formoterol
MXPA01006083A (en)	2002-06-05	Pharmaceutical aerosol formulations containing fluoroalkanes and budesonide