SK2552003A3 - Medicinal compositions for the treatment and prevention of xanthoma and atherosclerosis - Google Patents

Medicinal compositions for the treatment and prevention of xanthoma and atherosclerosis Download PDF

Info

Publication number: SK2552003A3
Authority: SK; Slovakia
Prior art keywords: hmg; coa reductase; carboxymethyl; reductase inhibitor; dimethylindolin
Prior art date: 2000-09-01

Application number

SK255-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Takafumi Kohama

Toshimori Inaba

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-01

Filing date

2001-08-29

Publication date

2003-08-05

2001-08-29 Application filed by Sankyo Co filed Critical Sankyo Co

2003-08-05 Publication of SK2552003A3 publication Critical patent/SK2552003A3/sk

Links

201000001320 Atherosclerosis Diseases 0.000 title claims description 23
206010048214 Xanthoma Diseases 0.000 title claims description 12
206010048215 Xanthomatosis Diseases 0.000 title claims description 12
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239000000203 mixture Substances 0.000 title claims description 8
230000002265 prevention Effects 0.000 title claims description 5
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims abstract description 78
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims abstract description 77
150000003839 salts Chemical class 0.000 claims abstract description 48
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 39
TXIIZHHIOHVWJD-UHFFFAOYSA-N 2-[7-(2,2-dimethylpropanoylamino)-4,6-dimethyl-1-octyl-2,3-dihydroindol-5-yl]acetic acid Chemical compound CC(C)(C)C(=O)NC1=C(C)C(CC(O)=O)=C(C)C2=C1N(CCCCCCCC)CC2 TXIIZHHIOHVWJD-UHFFFAOYSA-N 0.000 claims abstract description 30
TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims description 47
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TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims description 47
XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims description 43
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims description 43
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-1 5-carboxymethyl-4,6-dimethylindolin-7-yl Chemical group 0.000 claims description 21
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Obesity (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

SK255-2003A 2000-09-01 2001-08-29 Medicinal compositions for the treatment and prevention of xanthoma and atherosclerosis SK2552003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2000265082		2000-09-01
PCT/JP2001/007438 WO2002020009A1 (fr)	2000-09-01	2001-08-29	Compositions medicales

Publications (1)

Publication Number	Publication Date
SK2552003A3 true SK2552003A3 (en)	2003-08-05

Family

ID=18752403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK255-2003A SK2552003A3 (en)	2000-09-01	2001-08-29	Medicinal compositions for the treatment and prevention of xanthoma and atherosclerosis

Country Status (17)

Country	Link
EP (1)	EP1314423A4 (fr)
KR (1)	KR20030029871A (fr)
CN (1)	CN1473042A (fr)
AU (2)	AU2001282541B2 (fr)
BR (1)	BR0113523A (fr)
CA (1)	CA2420951A1 (fr)
CZ (1)	CZ2003593A3 (fr)
HU (1)	HUP0301728A3 (fr)
IL (1)	IL154414A0 (fr)
MX (1)	MXPA03001857A (fr)
NO (1)	NO20030946L (fr)
NZ (1)	NZ524406A (fr)
PL (1)	PL362244A1 (fr)
RU (1)	RU2246302C2 (fr)
SK (1)	SK2552003A3 (fr)
WO (1)	WO2002020009A1 (fr)
ZA (1)	ZA200301543B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002020009A1 (fr) *	2000-09-01	2002-03-14	Sankyo Company, Limited	Compositions medicales
KR20060111898A (ko)	2003-08-29	2006-10-30	교와 가부시키가이샤	지질-풍부-플라크의 안정화 방법 및 파열 예방방법
TW200619204A (en) *	2004-12-10	2006-06-16	Kowa Co	Method for reduction, stabilization and prevention of rupture of lipid rich plaque
RU2308947C1 (ru) *	2006-02-26	2007-10-27	Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН (НИОХ СО РАН)	Лекарственное средство с гиполипидемическим эффектом "симваглизин"

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL112639A0 (en) *	1994-03-11	1995-05-26	Bristol Myers Squibb Co	A pharmaceutical composition containing pravastin
JP3720395B2 (ja) *	1994-09-20	2005-11-24	京都薬品工業株式会社	新規ヘテロ環誘導体、その製造方法およびその医薬用途
IL118778A (en) *	1995-07-03	1999-07-14	Sankyo Co	Pharmaceutical compositions for the treatment of arteriosclerosis and xanthoma containing an hmg-coa reductase inhibitor
DK0866059T3 (da) *	1995-10-05	2002-03-25	Kyoto Pharma Ind	Nye heterocykliske derivater og medicinsk anvendelse deraf
AU720853B2 (en) *	1995-11-02	2000-06-15	Warner-Lambert Company	Method and pharmaceutical composition for regulating lipid concentration
EA001539B1 (ru) *	1996-11-27	2001-04-23	Пфайзер Инк.	Амиды, ингибирующие секрецию аполипопротеина в (аро в) и/или микросомного протеина переноса триглицеридов (мтр)
WO1999021570A1 (fr) *	1997-10-28	1999-05-06	Korea Institute Of Science And Technology	Extrait d'ecorce d'agrumes en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophage-lipide sur les parois arterielles et agent de prevention ou de traitement des maladies hepatiques
CN1310629A (zh) *	1998-07-21	2001-08-29	沃尼尔·朗伯公司	用于治疗动脉粥样硬化损伤的acat和mmp抑制剂的合并给药
WO2001022962A1 (fr) *	1999-09-30	2001-04-05	Merck & Co., Inc.	Combinaison anti-hypercholesterolemique
WO2002020009A1 (fr) *	2000-09-01	2002-03-14	Sankyo Company, Limited	Compositions medicales

2001
- 2001-08-29 WO PCT/JP2001/007438 patent/WO2002020009A1/fr not_active Ceased
- 2001-08-29 KR KR10-2003-7002861A patent/KR20030029871A/ko not_active Withdrawn
- 2001-08-29 SK SK255-2003A patent/SK2552003A3/sk not_active Application Discontinuation
- 2001-08-29 RU RU2003105835/15A patent/RU2246302C2/ru not_active IP Right Cessation
- 2001-08-29 AU AU2001282541A patent/AU2001282541B2/en not_active Ceased
- 2001-08-29 CN CNA018184723A patent/CN1473042A/zh active Pending
- 2001-08-29 PL PL01362244A patent/PL362244A1/xx unknown
- 2001-08-29 AU AU8254101A patent/AU8254101A/xx active Pending
- 2001-08-29 CZ CZ2003593A patent/CZ2003593A3/cs unknown
- 2001-08-29 NZ NZ524406A patent/NZ524406A/en unknown
- 2001-08-29 CA CA002420951A patent/CA2420951A1/fr not_active Abandoned
- 2001-08-29 HU HU0301728A patent/HUP0301728A3/hu unknown
- 2001-08-29 IL IL15441401A patent/IL154414A0/xx unknown
- 2001-08-29 EP EP01961177A patent/EP1314423A4/fr not_active Withdrawn
- 2001-08-29 BR BR0113523-6A patent/BR0113523A/pt not_active IP Right Cessation
- 2001-08-29 MX MXPA03001857A patent/MXPA03001857A/es unknown
2003
- 2003-02-25 ZA ZA200301543A patent/ZA200301543B/en unknown
- 2003-02-28 NO NO20030946A patent/NO20030946L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1314423A1 (fr)	2003-05-28
ZA200301543B (en)	2004-06-09
PL362244A1 (en)	2004-10-18
MXPA03001857A (es)	2003-06-04
NO20030946D0 (no)	2003-02-28
RU2246302C2 (ru)	2005-02-20
AU8254101A (en)	2002-03-22
BR0113523A (pt)	2004-06-29
NO20030946L (no)	2003-04-08
IL154414A0 (en)	2003-09-17
NZ524406A (en)	2004-06-25
CN1473042A (zh)	2004-02-04
KR20030029871A (ko)	2003-04-16
CA2420951A1 (fr)	2003-02-28
CZ2003593A3 (cs)	2003-05-14
HUP0301728A2 (hu)	2003-08-28
EP1314423A4 (fr)	2004-05-19
HUP0301728A3 (en)	2004-05-28
WO2002020009A1 (fr)	2002-03-14
AU2001282541B2 (en)	2004-06-24

Legal Events

Date	Code	Title	Description
2010-02-08	FC9A	Refused patent application

Publication	Publication Date	Title
RU2765218C2 (ru)	2022-01-26	Фиксированные комбинации и составы, содержащие етс1002 и один или более статинов, и способы лечения или уменьшения риска развития сердечно-сосудистого заболевания
CA3001627A1 (fr)	2017-05-11	Traitement de la dyslipidemie mixte
CZ286832B6 (en)	2000-07-12	Compound pharmaceutical preparation for prevention and treatment of arteriosclerosis or xanthoma
US20150272944A1 (en)	2015-10-01	Novel triglyceride reducing agent
US7776354B2 (en)	2010-08-17	Remedies for glomerular diseases
SK2552003A3 (en)	2003-08-05	Medicinal compositions for the treatment and prevention of xanthoma and atherosclerosis
US20020055533A1 (en)	2002-05-09	Pharmaceutical composition
EP1325745A1 (fr)	2003-07-09	Medicaments pour la prevention ou le traitement de complications du diabete
US7772272B2 (en)	2010-08-10	Method for enhancing glucose uptake into warm-blooded animal adipocytes
US9345671B2 (en)	2016-05-24	Adiponectin production enhancer
JP2002145774A (ja)	2002-05-22	医薬組成物
JP2006063066A (ja)	2006-03-09	抗動脈硬化作用を有する医薬組成物
US20090318496A1 (en)	2009-12-24	Preparation containing fibrate agent and process for producing the same
WO2006011551A1 (fr)	2006-02-02	Composition pharmaceutique ayant une activité anti-artériosclérose
JPWO2008123602A1 (ja)	2010-07-15	関節内投与用関節症治療剤
HK1111632B (en)	2011-07-29	Novel triglyceride reducing agent
MX2009001218A (es)	2009-02-11	Preparacion que contiene un agente de fibrato y un proceso para producir el mismo.