SK278528B6 - 5-(2-methyl-4,4,4-trifluorobutylcarbamoyl)indole derivatives, preparation method thereof and pharmaceutical compositions containing them - Google Patents

5-(2-methyl-4,4,4-trifluorobutylcarbamoyl)indole derivatives, preparation method thereof and pharmaceutical compositions containing them Download PDF

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Publication number
SK278528B6
SK278528B6 SK6146-90A SK614690A SK278528B6 SK 278528 B6 SK278528 B6 SK 278528B6 SK 614690 A SK614690 A SK 614690A SK 278528 B6 SK278528 B6 SK 278528B6
Authority
SK
Slovakia
Prior art keywords
methyl
formula
acid
compound
ylmethyl
Prior art date
Application number
SK6146-90A
Other languages
English (en)
Slovak (sk)
Other versions
SK614690A3 (en
Inventor
Robert T Jacobs
Original Assignee
Jacobs Robert T.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jacobs Robert T. filed Critical Jacobs Robert T.
Publication of SK278528B6 publication Critical patent/SK278528B6/sk
Publication of SK614690A3 publication Critical patent/SK614690A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK6146-90A 1989-12-11 1990-12-10 5-(2-methyl-4,4,4-trifluorobutylcarbamoyl)indole derivatives, preparation method thereof and pharmaceutical compositions containing them SK614690A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898927981A GB8927981D0 (en) 1989-12-11 1989-12-11 Carbamoyl derivative

Publications (2)

Publication Number Publication Date
SK278528B6 true SK278528B6 (en) 1997-08-06
SK614690A3 SK614690A3 (en) 1997-08-06

Family

ID=10667774

Family Applications (1)

Application Number Title Priority Date Filing Date
SK6146-90A SK614690A3 (en) 1989-12-11 1990-12-10 5-(2-methyl-4,4,4-trifluorobutylcarbamoyl)indole derivatives, preparation method thereof and pharmaceutical compositions containing them

Country Status (32)

Country Link
EP (1) EP0432984B1 (cs)
JP (1) JPH0822849B2 (cs)
KR (1) KR100192999B1 (cs)
CN (1) CN1025786C (cs)
AP (1) AP192A (cs)
AT (1) ATE163641T1 (cs)
AU (1) AU642182B2 (cs)
BG (2) BG50606A3 (cs)
CA (1) CA2031897C (cs)
CZ (1) CZ614690A3 (cs)
DE (1) DE69032083T2 (cs)
DK (1) DK0432984T3 (cs)
ES (1) ES2112832T3 (cs)
FI (1) FI95029C (cs)
GB (2) GB8927981D0 (cs)
GR (1) GR3026279T3 (cs)
HK (1) HK1003830A1 (cs)
HR (1) HRP930326B1 (cs)
HU (2) HU210441B (cs)
IE (1) IE904448A1 (cs)
IL (1) IL96621A (cs)
MY (1) MY106363A (cs)
NO (1) NO174198C (cs)
PL (2) PL166516B1 (cs)
PT (1) PT96154B (cs)
RO (1) RO108562B1 (cs)
RU (1) RU2002740C1 (cs)
SI (1) SI9012330A (cs)
SK (1) SK614690A3 (cs)
TW (1) TW219329B (cs)
YU (1) YU48218B (cs)
ZA (1) ZA909898B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE113581T1 (de) * 1990-05-04 1994-11-15 Ciba Geigy Ag Substituierte indole.
GB9020338D0 (en) * 1990-09-18 1990-10-31 Lilly Industries Ltd Pharmaceutical compounds
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
ES2050611B1 (es) * 1992-10-08 1994-12-16 Ici Plc Una nueva forma fisica de un derivado de carbamoilindol con propiedades antagonistas de leucotrienos.
GR1001368B (el) * 1992-10-08 1993-10-29 Ici Plc Φαρμακευτικοί φορείς.
WO1996008496A1 (en) * 1994-09-16 1996-03-21 Takeda Chemical Industries, Ltd. Triazolopyridazines process and intermediates for their preparation and their use as medicaments
US7166638B2 (en) * 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
KR20070091607A (ko) * 2004-10-12 2007-09-11 디코드 제네틱스, 아이엔씨. 폐쇄성 동맥 질환용의 설폰아미드 주변 치환된바이사이클릭 화합물
JP5024039B2 (ja) * 2005-02-25 2012-09-12 小野薬品工業株式会社 インドール化合物およびその用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524152A (en) * 1982-12-30 1985-06-18 Pennwalt Corporation 1-Cyano-3-(fluoroalkyl)guanidines for lowering blood pressure
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
IE862737L (en) * 1985-10-17 1987-04-17 Staehler Theo Heterocyclic compounds
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
GB8906032D0 (en) * 1988-04-14 1989-04-26 Ici America Inc Hetera-aliphatic carboxamides
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process

Also Published As

Publication number Publication date
AU6791790A (en) 1991-06-13
CA2031897C (en) 2001-12-18
NO905327L (no) 1991-06-12
FI95029B (fi) 1995-08-31
RU2002740C1 (ru) 1993-11-15
TW219329B (cs) 1994-01-21
CN1053604A (zh) 1991-08-07
DK0432984T3 (da) 1998-11-30
JPH0770061A (ja) 1995-03-14
DE69032083D1 (de) 1998-04-09
IE904448A1 (en) 1991-06-19
NO174198B (no) 1993-12-20
ZA909898B (en) 1991-08-28
AU642182B2 (en) 1993-10-14
IL96621A0 (en) 1991-09-16
EP0432984B1 (en) 1998-03-04
EP0432984A3 (en) 1992-04-22
HRP930326A2 (en) 1996-06-30
IL96621A (en) 1994-11-28
CN1025786C (zh) 1994-08-31
AP192A (en) 1992-06-30
MY106363A (en) 1995-05-30
PL166516B1 (pl) 1995-05-31
KR100192999B1 (ko) 1999-06-15
GB9026797D0 (en) 1991-01-30
HU210441B (en) 1995-04-28
YU48218B (sh) 1997-08-22
BG60015B2 (bg) 1993-06-30
CA2031897A1 (en) 1991-06-12
RO108562B1 (ro) 1994-06-30
PT96154A (pt) 1991-09-30
JPH0822849B2 (ja) 1996-03-06
SI9012330A (en) 1997-12-31
PT96154B (pt) 1998-05-29
ES2112832T3 (es) 1998-04-16
CZ282068B6 (cs) 1997-05-14
AP9000230A0 (en) 1991-01-31
YU233090A (sh) 1993-05-28
GB2238790A (en) 1991-06-12
BG50606A3 (bg) 1992-09-15
GR3026279T3 (en) 1998-06-30
HK1003830A1 (en) 1998-11-06
NO174198C (no) 1994-04-06
EP0432984A2 (en) 1991-06-19
FI95029C (fi) 1995-12-11
HU210877A9 (en) 1995-09-28
HU908137D0 (en) 1991-06-28
ATE163641T1 (de) 1998-03-15
PL167449B1 (pl) 1995-09-30
SK614690A3 (en) 1997-08-06
KR910011780A (ko) 1991-08-07
GB8927981D0 (en) 1990-02-14
HRP930326B1 (en) 1998-12-31
FI906084L (fi) 1991-06-12
PL288184A1 (en) 1992-04-21
NO905327D0 (no) 1990-12-10
FI906084A0 (fi) 1990-12-11
DE69032083T2 (de) 1998-07-16
HUT56345A (en) 1991-08-28
GB2238790B (en) 1993-06-30
CZ614690A3 (en) 1997-05-14

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