SK280407B6 - Termoplast na výrobu liekových obalov a jeho použi - Google Patents

Termoplast na výrobu liekových obalov a jeho použi Download PDF

Info

Publication number: SK280407B6
Authority: SK; Slovakia
Prior art keywords: weight; thermoplastic according; thermoplastic; methacrylic acid; drug
Prior art date: 1994-08-31

Application number

SK1062-95A

Other languages

English (en)

Slovak (sk)

Other versions

SK106295A3 (en

Inventor

Klaus Lehmann

Werner Hs

Original Assignee

R�Hm Gmbh Chemische Fabrik

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-31

Filing date

1995-08-28

Publication date

2000-01-18

1995-08-28 Application filed by R�Hm Gmbh Chemische Fabrik filed Critical R�Hm Gmbh Chemische Fabrik

1997-01-08 Publication of SK106295A3 publication Critical patent/SK106295A3/sk

2000-01-18 Publication of SK280407B6 publication Critical patent/SK280407B6/sk

Links

239000003814 drug Substances 0.000 title claims abstract description 17
229940079593 drug Drugs 0.000 title claims abstract description 14
239000012815 thermoplastic material Substances 0.000 title claims abstract 3
238000000576 coating method Methods 0.000 title abstract description 7
239000002775 capsule Substances 0.000 claims abstract description 30
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 20
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims abstract description 20
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 11
230000000968 intestinal effect Effects 0.000 claims abstract description 11
235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 10
238000004519 manufacturing process Methods 0.000 claims abstract description 7
125000005907 alkyl ester group Chemical group 0.000 claims abstract description 4
229920001169 thermoplastic Polymers 0.000 claims description 15
239000004416 thermosoftening plastic Substances 0.000 claims description 14
229920000642 polymer Polymers 0.000 claims description 12
239000000155 melt Substances 0.000 claims description 11
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
238000002347 injection Methods 0.000 claims description 4
239000007924 injection Substances 0.000 claims description 4
239000000546 pharmaceutical excipient Substances 0.000 claims description 4
239000004033 plastic Substances 0.000 claims description 4
229920003023 plastic Polymers 0.000 claims description 4
239000000126 substance Substances 0.000 claims description 3
238000003856 thermoforming Methods 0.000 claims description 3
239000002985 plastic film Substances 0.000 claims 3
229920006255 plastic film Polymers 0.000 claims 3
230000002457 bidirectional effect Effects 0.000 claims 1
229920001577 copolymer Polymers 0.000 abstract description 8
-1 dies Substances 0.000 abstract description 3
239000002700 tablet coating Substances 0.000 abstract 1
238000009492 tablet coating Methods 0.000 abstract 1
238000000034 method Methods 0.000 description 9
239000000243 solution Substances 0.000 description 8
239000000203 mixture Substances 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
238000000465 moulding Methods 0.000 description 5
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
239000006185 dispersion Substances 0.000 description 4
239000000178 monomer Substances 0.000 description 4
239000004908 Emulsion polymer Substances 0.000 description 3
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
239000000654 additive Substances 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
239000011248 coating agent Substances 0.000 description 3
238000001746 injection moulding Methods 0.000 description 3
239000007788 liquid Substances 0.000 description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
UIERETOOQGIECD-UHFFFAOYSA-N Angelic acid Natural products CC=C(C)C(O)=O UIERETOOQGIECD-UHFFFAOYSA-N 0.000 description 2
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
239000013543 active substance Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
230000001079 digestive effect Effects 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
238000007720 emulsion polymerization reaction Methods 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
238000001125 extrusion Methods 0.000 description 2
239000011888 foil Substances 0.000 description 2
210000004051 gastric juice Anatomy 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 2
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 2
239000008187 granular material Substances 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
239000012778 molding material Substances 0.000 description 2
238000006386 neutralization reaction Methods 0.000 description 2
230000003472 neutralizing effect Effects 0.000 description 2
238000004806 packaging method and process Methods 0.000 description 2
239000008188 pellet Substances 0.000 description 2
238000009512 pharmaceutical packaging Methods 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
229920000058 polyacrylate Polymers 0.000 description 2
239000000843 powder Substances 0.000 description 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
239000003826 tablet Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
239000004830 Super Glue Substances 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
238000011481 absorbance measurement Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
239000012670 alkaline solution Substances 0.000 description 1
239000012874 anionic emulsifier Substances 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
229960000503 bisacodyl Drugs 0.000 description 1
CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
230000015271 coagulation Effects 0.000 description 1
238000005345 coagulation Methods 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000007891 compressed tablet Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000006114 decarboxylation reaction Methods 0.000 description 1
239000013583 drug formulation Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 description 1
125000004494 ethyl ester group Chemical group 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000003292 glue Substances 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
239000002184 metal Chemical class 0.000 description 1
238000010137 moulding (plastic) Methods 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000035515 penetration Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000010526 radical polymerization reaction Methods 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000009757 thermoplastic moulding Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Closures For Containers (AREA)

SK1062-95A 1994-08-31 1995-08-28 Termoplast na výrobu liekových obalov a jeho použi SK280407B6 (sk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE9414065U DE9414065U1 (de)	1994-08-31	1994-08-31	Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen

Publications (2)

Publication Number	Publication Date
SK106295A3 SK106295A3 (en)	1997-01-08
SK280407B6 true SK280407B6 (sk)	2000-01-18

Family

ID=6913070

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1062-95A SK280407B6 (sk)	1994-08-31	1995-08-28	Termoplast na výrobu liekových obalov a jeho použi

Country Status (10)

Country	Link
US (1)	US5705189A (fr)
EP (1)	EP0704207B1 (fr)
JP (1)	JPH0873378A (fr)
AT (1)	ATE203401T1 (fr)
CZ (1)	CZ286411B6 (fr)
DE (2)	DE9414065U1 (fr)
DK (1)	DK0704207T3 (fr)
ES (1)	ES2160653T3 (fr)
HU (1)	HU221431B (fr)
SK (1)	SK280407B6 (fr)

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* Cited by examiner, † Cited by third party
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1994
- 1994-08-31 DE DE9414065U patent/DE9414065U1/de not_active Expired - Lifetime
1995
- 1995-08-28 DK DK95113467T patent/DK0704207T3/da active
- 1995-08-28 AT AT95113467T patent/ATE203401T1/de not_active IP Right Cessation
- 1995-08-28 ES ES95113467T patent/ES2160653T3/es not_active Expired - Lifetime
- 1995-08-28 DE DE59509443T patent/DE59509443D1/de not_active Expired - Fee Related
- 1995-08-28 EP EP95113467A patent/EP0704207B1/fr not_active Expired - Lifetime
- 1995-08-28 SK SK1062-95A patent/SK280407B6/sk not_active IP Right Cessation
- 1995-08-29 HU HU9502529A patent/HU221431B/hu not_active IP Right Cessation
- 1995-08-30 JP JP7222098A patent/JPH0873378A/ja active Pending
- 1995-08-31 CZ CZ19952235A patent/CZ286411B6/cs not_active IP Right Cessation
- 1995-08-31 US US08/521,738 patent/US5705189A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0704207B1 (fr)	2001-07-25
JPH0873378A (ja)	1996-03-19
ES2160653T3 (es)	2001-11-16
CZ223595A3 (en)	1996-03-13
HUT75239A (en)	1997-05-28
CZ286411B6 (en)	2000-04-12
DK0704207T3 (da)	2001-09-24
EP0704207A3 (fr)	1997-08-06
DE59509443D1 (de)	2001-08-30
ATE203401T1 (de)	2001-08-15
HU221431B (en)	2002-10-28
EP0704207A2 (fr)	1996-04-03
DE9414065U1 (de)	1994-11-03
HU9502529D0 (en)	1995-10-30
US5705189A (en)	1998-01-06
SK106295A3 (en)	1997-01-08

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2010-05-07	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20090828

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