SK282366B6 - Spiro-azabicyklická zlúčenina, farmaceutický prípravok s jej obsahom, spôsob prípravy, medziprodukty tohto spôsobu a jej použitie v medicíne - Google Patents

Spiro-azabicyklická zlúčenina, farmaceutický prípravok s jej obsahom, spôsob prípravy, medziprodukty tohto spôsobu a jej použitie v medicíne Download PDF

Info

Publication number: SK282366B6
Authority: SK; Slovakia
Prior art keywords: spiro; formula; compound; enantiomer; pharmaceutically acceptable
Prior art date: 1994-08-24

Application number

SK216-97A

Other languages

English (en)

Slovak (sk)

Other versions

SK21697A3 (en

Inventor

Michael Balestra

John Charles Gordon

Ronald Conrad Griffith

Robert John Murray

Original Assignee

Astra Aktiebolag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-24

Filing date

1995-08-22

Publication date

2002-01-07

1994-08-24 Priority claimed from GB9417084A external-priority patent/GB9417084D0/en

1995-03-08 Priority claimed from GBGB9504627.2A external-priority patent/GB9504627D0/en

1995-08-22 Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag

1997-09-10 Publication of SK21697A3 publication Critical patent/SK21697A3/sk

2002-01-07 Publication of SK282366B6 publication Critical patent/SK282366B6/sk

Links

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VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
LEIMLDGFXIOXMT-UHFFFAOYSA-N trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 description 1
VFJYIHQDILEQNR-UHFFFAOYSA-M trimethylsulfanium;iodide Chemical compound [I-].C[S+](C)C VFJYIHQDILEQNR-UHFFFAOYSA-M 0.000 description 1
BPLKQGGAXWRFOE-UHFFFAOYSA-M trimethylsulfoxonium iodide Chemical group [I-].C[S+](C)(C)=O BPLKQGGAXWRFOE-UHFFFAOYSA-M 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
238000010792 warming Methods 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SK216-97A 1994-08-24 1995-08-22 Spiro-azabicyklická zlúčenina, farmaceutický prípravok s jej obsahom, spôsob prípravy, medziprodukty tohto spôsobu a jej použitie v medicíne SK282366B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9417084A GB9417084D0 (en)	1994-08-24	1994-08-24	Compounds useful in therapy
GBGB9504627.2A GB9504627D0 (en)	1995-03-08	1995-03-08	Compounds for use in therapy
PCT/SE1995/000937 WO1996006098A1 (fr)	1994-08-24	1995-08-22	Composes spyro-azabicycliques utiles en therapie

Publications (2)

Publication Number	Publication Date
SK21697A3 SK21697A3 (en)	1997-09-10
SK282366B6 true SK282366B6 (sk)	2002-01-07

Family

ID=26305509

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK216-97A SK282366B6 (sk)	1994-08-24	1995-08-22	Spiro-azabicyklická zlúčenina, farmaceutický prípravok s jej obsahom, spôsob prípravy, medziprodukty tohto spôsobu a jej použitie v medicíne

Country Status (33)

Country	Link
US (2)	US5902814A (fr)
EP (1)	EP0777671B1 (fr)
JP (1)	JP3708962B2 (fr)
KR (1)	KR100366331B1 (fr)
CN (2)	CN1056846C (fr)
AR (1)	AR031828A2 (fr)
AT (1)	ATE192157T1 (fr)
AU (1)	AU690735B2 (fr)
BR (1)	BR9508751A (fr)
CA (1)	CA2196995C (fr)
CZ (1)	CZ289512B6 (fr)
DE (1)	DE69516524T2 (fr)
DK (1)	DK0777671T3 (fr)
EE (1)	EE03399B1 (fr)
EG (1)	EG24222A (fr)
ES (1)	ES2145922T3 (fr)
FI (1)	FI112868B (fr)
GR (1)	GR3033878T3 (fr)
HU (1)	HUT77352A (fr)
IL (1)	IL115039A (fr)
IS (1)	IS1852B (fr)
MX (1)	MX9701292A (fr)
NO (1)	NO307707B1 (fr)
NZ (1)	NZ292289A (fr)
PL (1)	PL183933B1 (fr)
PT (1)	PT777671E (fr)
RU (1)	RU2148058C1 (fr)
SA (1)	SA95160370B1 (fr)
SK (1)	SK282366B6 (fr)
TR (1)	TR199501053A2 (fr)
TW (1)	TW397837B (fr)
UA (1)	UA54375C2 (fr)
WO (1)	WO1996006098A1 (fr)

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US5137895A (en) *	1991-04-29	1992-08-11	A. H. Robins Company, Incorporated	3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols

1995
- 1995-08-22 AT AT95930755T patent/ATE192157T1/de not_active IP Right Cessation
- 1995-08-22 EE EE9700039A patent/EE03399B1/xx not_active IP Right Cessation
- 1995-08-22 MX MX9701292A patent/MX9701292A/es unknown
- 1995-08-22 PT PT95930755T patent/PT777671E/pt unknown
- 1995-08-22 UA UA97031329A patent/UA54375C2/uk unknown
- 1995-08-22 CZ CZ1997392A patent/CZ289512B6/cs not_active IP Right Cessation
- 1995-08-22 NZ NZ292289A patent/NZ292289A/en not_active IP Right Cessation
- 1995-08-22 CN CN95195518A patent/CN1056846C/zh not_active Expired - Fee Related
- 1995-08-22 JP JP50799596A patent/JP3708962B2/ja not_active Expired - Fee Related
- 1995-08-22 AU AU34018/95A patent/AU690735B2/en not_active Ceased
- 1995-08-22 PL PL95318760A patent/PL183933B1/pl not_active IP Right Cessation
- 1995-08-22 ES ES95930755T patent/ES2145922T3/es not_active Expired - Lifetime
- 1995-08-22 SK SK216-97A patent/SK282366B6/sk not_active IP Right Cessation
- 1995-08-22 DK DK95930755T patent/DK0777671T3/da active
- 1995-08-22 EP EP95930755A patent/EP0777671B1/fr not_active Expired - Lifetime
- 1995-08-22 BR BR9508751A patent/BR9508751A/pt not_active IP Right Cessation
- 1995-08-22 RU RU97104165A patent/RU2148058C1/ru not_active IP Right Cessation
- 1995-08-22 US US08/525,575 patent/US5902814A/en not_active Expired - Fee Related
- 1995-08-22 CA CA002196995A patent/CA2196995C/fr not_active Expired - Fee Related
- 1995-08-22 WO PCT/SE1995/000937 patent/WO1996006098A1/fr not_active Ceased
- 1995-08-22 KR KR1019970701159A patent/KR100366331B1/ko not_active Expired - Fee Related
- 1995-08-22 HU HU9701965A patent/HUT77352A/hu unknown
- 1995-08-22 DE DE69516524T patent/DE69516524T2/de not_active Expired - Fee Related
- 1995-08-23 EG EG70395A patent/EG24222A/xx active
- 1995-08-23 IL IL11503995A patent/IL115039A/xx not_active IP Right Cessation
- 1995-08-24 TR TR95/01053A patent/TR199501053A2/xx unknown
- 1995-08-24 TW TW084108836A patent/TW397837B/zh not_active IP Right Cessation
- 1995-11-08 SA SA95160370A patent/SA95160370B1/ar unknown
1997
- 1997-02-03 IS IS4424A patent/IS1852B/is unknown
- 1997-02-21 NO NO970800A patent/NO307707B1/no not_active IP Right Cessation
- 1997-02-24 FI FI970762A patent/FI112868B/fi active
1998
- 1998-11-09 US US09/188,099 patent/US6051581A/en not_active Expired - Fee Related
1999
- 1999-11-08 CN CN99123574A patent/CN1099419C/zh not_active Expired - Fee Related
2000
- 2000-04-10 AR ARP000101632A patent/AR031828A2/es unknown
- 2000-07-04 GR GR20000401563T patent/GR3033878T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2145922T3 (es)	2000-07-16
PL183933B1 (pl)	2002-08-30
JP3708962B2 (ja)	2005-10-19
FI112868B (fi)	2004-01-30
JPH10504561A (ja)	1998-05-06
IS1852B (is)	2003-02-21
PT777671E (pt)	2000-08-31
US5902814A (en)	1999-05-11
EE9700039A (et)	1997-08-15
CN1284505A (zh)	2001-02-21
GR3033878T3 (en)	2000-11-30
TW397837B (en)	2000-07-11
RU2148058C1 (ru)	2000-04-27
CA2196995A1 (fr)	1996-02-29
HK1010370A1 (en)	1999-06-17
EG24222A (en)	2008-11-10
HUT77352A (hu)	1998-03-30
CZ289512B6 (cs)	2002-02-13
FI970762L (fi)	1997-02-24
CA2196995C (fr)	2008-05-13
ATE192157T1 (de)	2000-05-15
CN1056846C (zh)	2000-09-27
AU690735B2 (en)	1998-04-30
CN1159808A (zh)	1997-09-17
FI970762A0 (fi)	1997-02-24
EP0777671A1 (fr)	1997-06-11
DE69516524D1 (de)	2000-05-31
UA54375C2 (uk)	2003-03-17
TR199501053A2 (tr)	1996-06-21
WO1996006098A1 (fr)	1996-02-29
SA95160370B1 (ar)	2006-06-04
PL318760A1 (en)	1997-07-07
IL115039A0 (en)	1995-12-08
NO307707B1 (no)	2000-05-15
MX9701292A (es)	1997-05-31
BR9508751A (pt)	1997-08-12
AR031828A2 (es)	2003-10-08
CZ39297A3 (en)	1997-12-17
CN1099419C (zh)	2003-01-22
IL115039A (en)	2001-08-26
KR100366331B1 (ko)	2003-04-10
EE03399B1 (et)	2001-04-16
NZ292289A (en)	1998-05-27
NO970800L (no)	1997-02-21
AU3401895A (en)	1996-03-14
NO970800D0 (no)	1997-02-21
SK21697A3 (en)	1997-09-10
US6051581A (en)	2000-04-18
DK0777671T3 (da)	2000-07-24
DE69516524T2 (de)	2001-01-18
IS4424A (is)	1997-02-03
EP0777671B1 (fr)	2000-04-26

Legal Events

Date	Code	Title	Description
2010-05-07	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20090822

Publication	Publication Date	Title
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EP0313393B1 (fr)	1994-03-16	Composés benzoxazines et leur utilisation pharmaceutique
US6849620B2 (en)	2005-02-01	N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
WO2003037896A1 (fr)	2003-05-08	Carboxamides hetero-bicycliques substitues par n-azabicyclo, utilises en tant qu'agonistes du recepteur de l'acetylcholine nicotinique
US20080153806A1 (en)	2008-06-26	Novel Diazabicyclic Aryl Derivatives And Their Medical Use
US20070265271A1 (en)	2007-11-15	Novel Diazabicyclic Aryl Derivatives as Cholinergy Ligands
RU2338746C2 (ru)	2008-11-20	Новые диазабициклические арильные производные, содержащие их фармацевтические композиции и их применение
HK1010370B (en)	2000-07-28	Spiro-azabicyclic compounds useful in therapy
NZ553277A (en)	2010-04-30	Novel azabicyclic aryl derivatives and their medical use