SK562006A3 - Spôsob stanovenia obsahu karbetopendecínium bromidu metódou kvapalinovej chromatografie - Google Patents
Spôsob stanovenia obsahu karbetopendecínium bromidu metódou kvapalinovej chromatografie Download PDFInfo
- Publication number
- SK562006A3 SK562006A3 SK56-2006A SK562006A SK562006A3 SK 562006 A3 SK562006 A3 SK 562006A3 SK 562006 A SK562006 A SK 562006A SK 562006 A3 SK562006 A3 SK 562006A3
- Authority
- SK
- Slovakia
- Prior art keywords
- bromide
- carbetopendecin
- component
- content
- liquid chromatography
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 26
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 title description 26
- 238000004811 liquid chromatography Methods 0.000 title description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- FXQJFHYFOGHZTB-UHFFFAOYSA-M carbethopendecinium bromide Chemical compound [Br-].CCCCCCCCCCCCCCC([N+](C)(C)C)C(=O)OCC FXQJFHYFOGHZTB-UHFFFAOYSA-M 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 4
- 238000010828 elution Methods 0.000 claims description 3
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 3
- 229910000077 silane Inorganic materials 0.000 claims description 3
- 230000005526 G1 to G0 transition Effects 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 150000001343 alkyl silanes Chemical class 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000004007 reversed phase HPLC Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 8
- 239000000499 gel Substances 0.000 description 8
- 238000000926 separation method Methods 0.000 description 7
- 238000003556 assay Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- -1 compound [1- (ethoxycarbonyl) pentadecyl] trimethylammonium bromide Chemical class 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000003889 eye drop Substances 0.000 description 4
- ACQYZSFXPXXIHL-UHFFFAOYSA-N 2-phenylmethoxycarbonyl-3,4-dihydro-1h-isoquinoline-1-carboxylic acid Chemical compound C1CC2=CC=CC=C2C(C(=O)O)N1C(=O)OCC1=CC=CC=C1 ACQYZSFXPXXIHL-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 208000031973 Conjunctivitis infective Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 201000007032 bacterial conjunctivitis Diseases 0.000 description 2
- 208000010217 blepharitis Diseases 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- UEHUZQKLOWYOMO-UHFFFAOYSA-N diethylazanium;acetate Chemical compound CC(O)=O.CCNCC UEHUZQKLOWYOMO-UHFFFAOYSA-N 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- VWQMDHRZIPQGJQ-UHFFFAOYSA-N n-ethylethanamine;formic acid Chemical compound [O-]C=O.CC[NH2+]CC VWQMDHRZIPQGJQ-UHFFFAOYSA-N 0.000 description 1
- IVQXXLUOYFEVCI-UHFFFAOYSA-N n-ethylethanamine;propanoic acid Chemical compound CC[NH2+]CC.CCC([O-])=O IVQXXLUOYFEVCI-UHFFFAOYSA-N 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical class OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000005464 sample preparation method Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 201000003826 superficial keratitis Diseases 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000005496 tempering Methods 0.000 description 1
- QBVXKDJEZKEASM-UHFFFAOYSA-M tetraoctylammonium bromide Chemical compound [Br-].CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC QBVXKDJEZKEASM-UHFFFAOYSA-M 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B61—RAILWAYS
- B61F—RAIL VEHICLE SUSPENSIONS, e.g. UNDERFRAMES, BOGIES OR ARRANGEMENTS OF WHEEL AXLES; RAIL VEHICLES FOR USE ON TRACKS OF DIFFERENT WIDTH; PREVENTING DERAILING OF RAIL VEHICLES; WHEEL GUARDS, OBSTRUCTION REMOVERS OR THE LIKE FOR RAIL VEHICLES
- B61F5/00—Constructional details of bogies; Connections between bogies and vehicle underframes; Arrangements or devices for adjusting or allowing self-adjustment of wheel axles or bogies when rounding curves
- B61F5/26—Mounting or securing axle-boxes in vehicle or bogie underframes
- B61F5/30—Axle-boxes mounted for movement under spring control in vehicle or bogie underframes
- B61F5/307—Axle-boxes mounted for movement under spring control in vehicle or bogie underframes incorporating fluid springs
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Vehicle Body Suspensions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SK56-2006U SK4560U (sk) | 2006-03-22 | 2006-03-22 | Medzičlánok spájajúci hydropružinu s pojazdom železničného vozidla |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK562006A3 true SK562006A3 (sk) | 2007-11-02 |
Family
ID=40510557
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK56-2006A SK562006A3 (sk) | 2006-03-22 | 2006-03-22 | Spôsob stanovenia obsahu karbetopendecínium bromidu metódou kvapalinovej chromatografie |
| SK56-2006U SK4560U (sk) | 2006-03-22 | 2006-03-22 | Medzičlánok spájajúci hydropružinu s pojazdom železničného vozidla |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK56-2006U SK4560U (sk) | 2006-03-22 | 2006-03-22 | Medzičlánok spájajúci hydropružinu s pojazdom železničného vozidla |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2054286A2 (de) |
| SK (2) | SK562006A3 (de) |
| WO (1) | WO2007108782A2 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008042198B4 (de) | 2008-09-18 | 2012-03-08 | Andreas Fiedler | Güterwagendrehgestell |
| CN103917428A (zh) * | 2011-08-26 | 2014-07-09 | Skf公司 | 具有用于液压悬架的两件式适配器组件的铁路转向架组件 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658471B1 (fr) * | 1990-02-21 | 1992-06-12 | Sambre & Meuse Usines | Bogie a pesee de charge pour vehicules de chemin de fer. |
| PL1727720T3 (pl) | 2004-03-26 | 2008-06-30 | Skf Ab | Kolejowy wózek zwrotny |
| DE102005004721B4 (de) * | 2005-01-10 | 2009-09-24 | Ab Skf | Verbindung an einem Drehgestell eines Schienenfahrzeugs |
-
2006
- 2006-03-22 SK SK56-2006A patent/SK562006A3/sk unknown
- 2006-03-22 SK SK56-2006U patent/SK4560U/sk unknown
-
2007
- 2007-02-16 EP EP07748758A patent/EP2054286A2/de not_active Withdrawn
- 2007-02-16 WO PCT/SK2007/050006 patent/WO2007108782A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007108782A8 (en) | 2007-12-27 |
| EP2054286A2 (de) | 2009-05-06 |
| WO2007108782A3 (en) | 2008-03-13 |
| WO2007108782A2 (en) | 2007-09-27 |
| SK4560U (sk) | 2006-09-07 |
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