SK56699A3 - Novel heterocyclically substituted benzamides and their use - Google Patents

Novel heterocyclically substituted benzamides and their use Download PDF

Info

Publication number: SK56699A3
Authority: SK; Slovakia
Prior art keywords: alkyl; formula; phenyl; hydrogen; medicament
Prior art date: 1996-12-09

Application number

SK566-99A

Other languages

English (en)

Slovak (sk)

Inventor

Wilfried Lubisch

Achim Moller

Hans-Jorg Treiber

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-09

Filing date

1997-11-28

Publication date

1999-10-08

1997-11-28 Application filed by Basf Ag filed Critical Basf Ag

1999-10-08 Publication of SK56699A3 publication Critical patent/SK56699A3/sk

Links

150000003936 benzamides Chemical class 0.000 title claims abstract description 27
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201000010099 disease Diseases 0.000 claims abstract description 12
-1 CF 3 Inorganic materials 0.000 claims description 68
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239000000203 mixture Substances 0.000 claims description 25
239000001257 hydrogen Substances 0.000 claims description 23
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239000003814 drug Substances 0.000 claims description 18
238000002360 preparation method Methods 0.000 claims description 18
125000000217 alkyl group Chemical group 0.000 claims description 15
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125000000896 monocarboxylic acid group Chemical group 0.000 claims description 12
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
150000002431 hydrogen Chemical class 0.000 claims description 11
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
230000000694 effects Effects 0.000 claims description 8
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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
229960001295 tocopherol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
ZMCBYSBVJIMENC-UHFFFAOYSA-N tricaine Chemical compound CCOC(=O)C1=CC=CC(N)=C1 ZMCBYSBVJIMENC-UHFFFAOYSA-N 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
230000002792 vascular Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

SK566-99A 1996-12-09 1997-11-28 Novel heterocyclically substituted benzamides and their use SK56699A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19650975A DE19650975A1 (de)	1996-12-09	1996-12-09	Neue heterocyclisch substituierte Benzamide und deren Anwendung
PCT/EP1997/006653 WO1998025899A1 (de)	1996-12-09	1997-11-28	Neue heterocyclisch substituierte benzamide und deren anwendung bei der bekämpfung von krankheiten

Publications (1)

Publication Number	Publication Date
SK56699A3 true SK56699A3 (en)	1999-10-08

Family

ID=7814035

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK566-99A SK56699A3 (en)	1996-12-09	1997-11-28	Novel heterocyclically substituted benzamides and their use

Country Status (24)

Country	Link
US (2)	US6172072B1 (de)
EP (1)	EP0946509A1 (de)
JP (1)	JP2001505889A (de)
KR (1)	KR20000057445A (de)
CN (1)	CN1239949A (de)
AR (1)	AR010339A1 (de)
AU (1)	AU742732B2 (de)
BG (1)	BG63388B1 (de)
BR (1)	BR9713884A (de)
CA (1)	CA2273988A1 (de)
CO (1)	CO4910161A1 (de)
CZ (1)	CZ292391B6 (de)
DE (1)	DE19650975A1 (de)
HR (1)	HRP970671A2 (de)
HU (1)	HUP0000496A3 (de)
ID (1)	ID22490A (de)
IL (1)	IL129358A0 (de)
NO (1)	NO992770L (de)
NZ (1)	NZ335066A (de)
SK (1)	SK56699A3 (de)
TR (1)	TR199901282T2 (de)
TW (1)	TW420666B (de)
WO (1)	WO1998025899A1 (de)
ZA (1)	ZA9710979B (de)

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HRP20000788A2 (en) *	1998-04-20	2001-06-30	Basf Ag	Novel heterocyclically substituted amides with cysteine protease-inhibiting effect
FR2800737B1 (fr) *	1999-11-05	2006-06-30	Sod Conseils Rech Applic	Nouveaux composes heterocycliques et leur application a titre de medicaments
ES2259617T3 (es)	1999-11-05	2006-10-16	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Compuestos heterociclicos y su aplicacion como medicamentos.
GB0031302D0 (en) *	2000-12-21	2001-01-31	Glaxo Group Ltd	Napthalene derivatives
KR100962972B1 (ko)	2002-07-26	2010-06-09	주식회사유한양행	1-페닐피페리딘-3-온 유도체 및 그의 제조방법
DE60329316D1 (de)	2002-11-12	2009-10-29	Merck & Co Inc	Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
WO2005019188A1 (ja) *	2003-08-22	2005-03-03	Takeda Pharmaceutical Company Limited	縮合ピリミジン誘導体およびその用途
US7320992B2 (en) *	2003-08-25	2008-01-22	Amgen Inc.	Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
FR2863268B1 (fr) *	2003-12-09	2006-02-24	Sod Conseils Rech Applic	Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
BRPI0418026A (pt) *	2003-12-22	2007-04-17	Ajinomoto Kk	derivados de fenilalanina ou sais farmaceuticamente aceitáveis destes, composição farmacêutica, antagonista de alfa4 integrina, e, agente terapêutico ou agente preventivo para doenças
GB0416730D0 (en)	2004-07-27	2004-09-01	Novartis Ag	Organic compounds
US20070010537A1 (en) *	2004-08-20	2007-01-11	Kazumasa Hamamura	Fused pyramidine derivative and use thereof
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
US7834023B2 (en) *	2006-09-20	2010-11-16	Portola Pharmaceuticals, Inc.	Substituted dihydroquinazolines as platelet ADP receptor inhibitors
CL2007003879A1 (es)	2006-12-29	2008-07-04	Basf Ag	Compuestos derivados de aril-carboxamida; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como alzheimer, epilepsia y parkinson.
US8093265B2 (en)	2007-03-09	2012-01-10	Renovis, Inc.	Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
TWI453019B (zh)	2007-12-28	2014-09-21	Abbvie Deutschland	甲醯胺化合物
TWI519530B (zh)	2009-02-20	2016-02-01	艾伯維德國有限及兩合公司	羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途
US8236798B2 (en)	2009-05-07	2012-08-07	Abbott Gmbh & Co. Kg	Carboxamide compounds and their use as calpain inhibitors
US8598211B2 (en)	2009-12-22	2013-12-03	Abbvie Inc.	Carboxamide compounds and their use as calpain inhibitors IV
US9051304B2 (en)	2009-12-22	2015-06-09	AbbVie Deutschland GmbH & Co. KG	Carboxamide compounds and their use as calpain inhibitors V
WO2011137372A1 (en)	2010-04-30	2011-11-03	Abbott Cardiovascular Systems Inc.	Improved balloon catheter exhibiting rapid inflation and deflation
MX2013006419A (es)	2010-12-09	2013-12-16	Abbvie Inc	Compuestos carboxamida y su uso como inhibidores de calpaina v.
US9150545B2 (en)	2012-04-03	2015-10-06	AbbVie Deutschland GmbH & Co. KG	Carboxamide compounds and their use as calpain inhibitors V
WO2017156071A1 (en)	2016-03-09	2017-09-14	Blade Therapeutics, Inc.	Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
AU2017292646A1 (en)	2016-07-05	2019-02-07	Blade Therapeutics, Inc.	Calpain modulators and therapeutic uses thereof
US10934261B2 (en)	2016-09-28	2021-03-02	Blade Therapeutics, Inc.	Calpain modulators and therapeutic uses thereof
AU2019387370A1 (en)	2018-11-30	2021-06-10	Nuvation Bio Inc.	Pyrrole and pyrazole compounds and methods of use thereof

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GB8524663D0 (en) *	1985-10-07	1985-11-13	Fujisawa Pharmaceutical Co	Quinazoline derivatives
DE3717828A1 (de) *	1987-05-27	1988-12-15	Hoechst Ag	Siliziumhaltige benzoesaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz
DE4000204A1 (de)	1990-01-05	1991-07-11	Steag Ag	Vorrichtung zum dosierten austragen von schuettfaehigem feststoff
EP0473551A1 (de) *	1990-08-31	1992-03-04	Ciba-Geigy Ag	3-Aryluracil-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Unkrautbekämpfungsmittel
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1996
- 1996-12-09 DE DE19650975A patent/DE19650975A1/de not_active Withdrawn
1997
- 1997-11-28 EP EP97952007A patent/EP0946509A1/de not_active Withdrawn
- 1997-11-28 BR BR9713884-3A patent/BR9713884A/pt not_active IP Right Cessation
- 1997-11-28 AU AU55580/98A patent/AU742732B2/en not_active Ceased
- 1997-11-28 KR KR1019990705071A patent/KR20000057445A/ko not_active Withdrawn
- 1997-11-28 CZ CZ19991743A patent/CZ292391B6/cs not_active IP Right Cessation
- 1997-11-28 CN CN97180437A patent/CN1239949A/zh active Pending
- 1997-11-28 IL IL12935897A patent/IL129358A0/xx unknown
- 1997-11-28 CA CA002273988A patent/CA2273988A1/en not_active Abandoned
- 1997-11-28 JP JP52615598A patent/JP2001505889A/ja active Pending
- 1997-11-28 WO PCT/EP1997/006653 patent/WO1998025899A1/de not_active Ceased
- 1997-11-28 ID IDW990486D patent/ID22490A/id unknown
- 1997-11-28 SK SK566-99A patent/SK56699A3/sk unknown
- 1997-11-28 US US09/308,350 patent/US6172072B1/en not_active Expired - Fee Related
- 1997-11-28 NZ NZ335066A patent/NZ335066A/xx unknown
- 1997-11-28 HU HU0000496A patent/HUP0000496A3/hu unknown
- 1997-11-28 TR TR1999/01282T patent/TR199901282T2/xx unknown
- 1997-12-08 TW TW086118462A patent/TW420666B/zh active
- 1997-12-08 HR HR19650975.0A patent/HRP970671A2/hr not_active Application Discontinuation
- 1997-12-08 ZA ZA9710979A patent/ZA9710979B/xx unknown
- 1997-12-09 AR ARP970105766A patent/AR010339A1/es not_active Application Discontinuation
- 1997-12-09 CO CO97071820A patent/CO4910161A1/es unknown
1999
- 1999-05-12 BG BG103399A patent/BG63388B1/bg unknown
- 1999-06-08 NO NO992770A patent/NO992770L/no unknown
2000
- 2000-09-21 US US09/666,304 patent/US6436949B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6172072B1 (en)	2001-01-09
US6436949B1 (en)	2002-08-20
JP2001505889A (ja)	2001-05-08
BR9713884A (pt)	2000-02-29
TR199901282T2 (xx)	1999-10-21
AU742732B2 (en)	2002-01-10
CZ292391B6 (cs)	2003-09-17
WO1998025899A1 (de)	1998-06-18
HUP0000496A3 (en)	2002-11-28
NO992770D0 (no)	1999-06-08
BG103399A (en)	2000-01-31
NO992770L (no)	1999-06-08
NZ335066A (en)	2000-03-27
AU5558098A (en)	1998-07-03
HRP970671A2 (en)	1998-10-31
ID22490A (id)	1999-10-21
CO4910161A1 (es)	2000-04-24
IL129358A0 (en)	2000-02-17
EP0946509A1 (de)	1999-10-06
TW420666B (en)	2001-02-01
BG63388B1 (bg)	2001-12-29
CN1239949A (zh)	1999-12-29
HUP0000496A2 (hu)	2000-09-28
ZA9710979B (en)	1999-06-18
KR20000057445A (ko)	2000-09-15
DE19650975A1 (de)	1998-06-10
AR010339A1 (es)	2000-06-07
CZ174399A3 (cs)	1999-08-11
CA2273988A1 (en)	1998-06-18

Publication	Publication Date	Title
US6172072B1 (en)	2001-01-09	Heterocyclically substituted benzamides and their use in fighting diseases
AU721620B2 (en)	2000-07-13	Novel ketobenzamides and their use
JP4621351B2 (ja)	2011-01-26	カルパインインヒビターとしての複素環式的に置換されたアミド
US6448254B1 (en)	2002-09-10	Substituted amides, their production and their use
US6630493B1 (en)	2003-10-07	Heterocyclically substituted amides, their preparation and use
SK14122000A3 (sk)	2001-05-10	Substituované benzamidy, ich príprava a použitie
JP2011063604A (ja)	2011-03-31	新規の複素環式の置換されたアミド、その製造および使用
SK15062000A3 (sk)	2001-05-10	Amidy s heterocyklickými substituentmi, ich príprava a použitie
SK14512000A3 (sk)	2001-04-09	Substituované amidy, ich príprava a použitie
CZ20003867A3 (cs)	2001-01-17	Amidy a jejich použití
CZ208499A3 (cs)	2000-09-13	Ketobenzamidy a jejich použití
HK1037371A (en)	2002-02-08	Novel heterocyclically substituted amides with cysteine protease-inhibiting effect
CZ20003868A3 (cs)	2001-03-14	Amidy a jejich použití