SK635190A3 - Bcrf1 protein of epstein-barr virus being capable of inhibiting synthesis of gamma-interferon, expression vector for synthesis thereof, and pharmaceutical composition containing thereof - Google Patents

Bcrf1 protein of epstein-barr virus being capable of inhibiting synthesis of gamma-interferon, expression vector for synthesis thereof, and pharmaceutical composition containing thereof Download PDF

Info

Publication number: SK635190A3
Authority: SK; Slovakia
Prior art keywords: leu; glu; lys; asp; phe
Prior art date: 1989-12-20

Application number

SK6351-90A

Other languages

English (en)

Slovak (sk)

Other versions

SK279830B6 (sk

Inventor

Kevin W Moore

Robert A Kastelein

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-20

Filing date

1990-12-18

Publication date

1999-04-13

1990-12-18 Application filed by Schering Corp filed Critical Schering Corp

1999-04-13 Publication of SK635190A3 publication Critical patent/SK635190A3/sk

1999-04-13 Publication of SK279830B6 publication Critical patent/SK279830B6/sk

Links

239000013604 expression vector Substances 0.000 title claims abstract description 16
230000015572 biosynthetic process Effects 0.000 title claims description 11
238000003786 synthesis reaction Methods 0.000 title claims description 11
239000008194 pharmaceutical composition Substances 0.000 title claims description 8
241000701044 Human gammaherpesvirus 4 Species 0.000 title claims description 5
230000002401 inhibitory effect Effects 0.000 title claims description 4
108090000623 proteins and genes Proteins 0.000 title description 23
102000004169 proteins and genes Human genes 0.000 title description 15
108010074328 Interferon-gamma Proteins 0.000 title description 2
102000008070 Interferon-gamma Human genes 0.000 title 1
229940044627 gamma-interferon Drugs 0.000 title 1
101150067964 BcRF1 gene Proteins 0.000 claims abstract description 36
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
201000004681 Psoriasis Diseases 0.000 claims abstract description 5
208000026935 allergic disease Diseases 0.000 claims abstract description 4
208000035475 disorder Diseases 0.000 claims abstract description 4
201000010099 disease Diseases 0.000 claims description 13
229940079322 interferon Drugs 0.000 claims description 9
150000001413 amino acids Chemical group 0.000 claims description 8
108010076504 Protein Sorting Signals Proteins 0.000 claims description 7
108010049041 glutamylalanine Proteins 0.000 claims description 6
UGZUVYDKAYNCII-ULQDDVLXSA-N Arg-Phe-Leu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O UGZUVYDKAYNCII-ULQDDVLXSA-N 0.000 claims description 5
JZDHUJAFXGNDSB-WHFBIAKZSA-N Glu-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(O)=O JZDHUJAFXGNDSB-WHFBIAKZSA-N 0.000 claims description 5
IDEODOAVGCMUQV-GUBZILKMSA-N Glu-Ser-Leu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O IDEODOAVGCMUQV-GUBZILKMSA-N 0.000 claims description 5
REPPKAMYTOJTFC-DCAQKATOSA-N Leu-Arg-Asp Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(O)=O REPPKAMYTOJTFC-DCAQKATOSA-N 0.000 claims description 5
AHOLTQCAVBSUDP-PPCPHDFISA-N Thr-Ile-Lys Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(O)=O AHOLTQCAVBSUDP-PPCPHDFISA-N 0.000 claims description 5
108010005233 alanylglutamic acid Proteins 0.000 claims description 5
TULNGKSILXCZQT-IMJSIDKUSA-N Cys-Asp Chemical compound SC[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O TULNGKSILXCZQT-IMJSIDKUSA-N 0.000 claims description 4
LKOAAMXDJGEYMS-ZPFDUUQYSA-N Glu-Met-Ile Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O LKOAAMXDJGEYMS-ZPFDUUQYSA-N 0.000 claims description 4
108010050904 Interferons Proteins 0.000 claims description 4
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LXKNSJLSGPNHSK-KKUMJFAQSA-N Leu-Leu-Lys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)N LXKNSJLSGPNHSK-KKUMJFAQSA-N 0.000 claims description 4
ATIPDCIQTUXABX-UWVGGRQHSA-N Lys-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN ATIPDCIQTUXABX-UWVGGRQHSA-N 0.000 claims description 4
239000003937 drug carrier Substances 0.000 claims description 4
230000009885 systemic effect Effects 0.000 claims description 4
SOBIAADAMRHGKH-CIUDSAMLSA-N Ala-Leu-Ser Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O SOBIAADAMRHGKH-CIUDSAMLSA-N 0.000 claims description 3
XKXAZPSREVUCRT-BPNCWPANSA-N Ala-Tyr-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](C)N)CC1=CC=C(O)C=C1 XKXAZPSREVUCRT-BPNCWPANSA-N 0.000 claims description 3
OANWAFQRNQEDSY-DCAQKATOSA-N Arg-Cys-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)N OANWAFQRNQEDSY-DCAQKATOSA-N 0.000 claims description 3
LVMUGODRNHFGRA-AVGNSLFASA-N Arg-Leu-Arg Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O LVMUGODRNHFGRA-AVGNSLFASA-N 0.000 claims description 3
NECWUSYTYSIFNC-DLOVCJGASA-N Asp-Ala-Phe Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 NECWUSYTYSIFNC-DLOVCJGASA-N 0.000 claims description 3
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RIYIFUFFFBIOEU-KBPBESRZSA-N Gly-Tyr-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CC=C(O)C=C1 RIYIFUFFFBIOEU-KBPBESRZSA-N 0.000 claims description 3
UWBDLNOCIDGPQE-GUBZILKMSA-N Ile-Lys Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN UWBDLNOCIDGPQE-GUBZILKMSA-N 0.000 claims description 3
WYUHAXJAMDTOAU-IAVJCBSLSA-N Ile-Phe-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O)N WYUHAXJAMDTOAU-IAVJCBSLSA-N 0.000 claims description 3
HFBCHNRFRYLZNV-GUBZILKMSA-N Leu-Glu-Asp Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O HFBCHNRFRYLZNV-GUBZILKMSA-N 0.000 claims description 3
WIDZHJTYKYBLSR-DCAQKATOSA-N Leu-Glu-Glu Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O WIDZHJTYKYBLSR-DCAQKATOSA-N 0.000 claims description 3
OTXBNHIUIHNGAO-UWVGGRQHSA-N Leu-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN OTXBNHIUIHNGAO-UWVGGRQHSA-N 0.000 claims description 3
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YCJCEMKOZOYBEF-OEAJRASXSA-N Lys-Thr-Phe Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O YCJCEMKOZOYBEF-OEAJRASXSA-N 0.000 claims description 3
RMLLCGYYVZKKRT-CIUDSAMLSA-N Met-Ser-Glu Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCC(O)=O RMLLCGYYVZKKRT-CIUDSAMLSA-N 0.000 claims description 3
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FSXRLASFHBWESK-HOTGVXAUSA-N Phe-Tyr Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CC=CC=C1 FSXRLASFHBWESK-HOTGVXAUSA-N 0.000 claims description 3
XNCUYZKGQOCOQH-YUMQZZPRSA-N Ser-Leu-Gly Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O XNCUYZKGQOCOQH-YUMQZZPRSA-N 0.000 claims description 3
GZSZPKSBVAOGIE-CIUDSAMLSA-N Ser-Lys-Ala Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O GZSZPKSBVAOGIE-CIUDSAMLSA-N 0.000 claims description 3
IOWJRKAVLALBQB-IWGUZYHVSA-N Thr-Asp Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O IOWJRKAVLALBQB-IWGUZYHVSA-N 0.000 claims description 3
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ZSPQUTWLWGWTPS-HJGDQZAQSA-N Thr-Lys-Asp Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(O)=O ZSPQUTWLWGWTPS-HJGDQZAQSA-N 0.000 claims description 3
206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 3
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JUWISGAGWSDGDH-KKUMJFAQSA-N Asp-Phe-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)CC1=CC=CC=C1 JUWISGAGWSDGDH-KKUMJFAQSA-N 0.000 claims description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SK6351-90A 1989-12-20 1990-12-18 Proteín bcrf1 vírusu epstein-barr schopný inhibova SK279830B6 (sk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45393189A	1989-12-20	1989-12-20

Publications (2)

Publication Number	Publication Date
SK635190A3 true SK635190A3 (en)	1999-04-13
SK279830B6 SK279830B6 (sk)	1999-04-13

Family

ID=23802631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK6351-90A SK279830B6 (sk)	1989-12-20	1990-12-18	Proteín bcrf1 vírusu epstein-barr schopný inhibova

Country Status (27)

Country	Link
US (2)	US5627155A (de)
EP (1)	EP0506836B1 (de)
JP (1)	JP2648236B2 (de)
KR (1)	KR960015199B1 (de)
CN (1)	CN1057012C (de)
AT (1)	ATE112317T1 (de)
AU (1)	AU7899694A (de)
CA (1)	CA2071907C (de)
CZ (1)	CZ283049B6 (de)
DE (1)	DE69013011T2 (de)
DK (1)	DK0506836T3 (de)
ES (1)	ES2064082T3 (de)
FI (1)	FI104883B (de)
HK (1)	HK185396A (de)
HU (1)	HU215909B (de)
IE (1)	IE72203B1 (de)
IL (1)	IL96715A0 (de)
MX (1)	MX9203409A (de)
MY (1)	MY107449A (de)
NO (1)	NO305703B1 (de)
NZ (1)	NZ236512A (de)
OA (1)	OA09703A (de)
PH (1)	PH31669A (de)
PT (1)	PT96231B (de)
SK (1)	SK279830B6 (de)
WO (1)	WO1991009127A1 (de)
ZA (1)	ZA9010188B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL94878A (en) *	1989-06-28	2003-01-12	Schering Corp	Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same
US5632988A (en) *	1989-10-23	1997-05-27	Schering Corporation	Polypeptide inhibitors of gamma interferon
US6106823A (en) *	1991-01-16	2000-08-22	Schering Corporation	Treatment of neoplastic disease with interleukin-10
ES2068705T3 (es) *	1991-01-16	1995-04-16	Schering Corp	Tratamiento de la enfermedad neoplastica con interleuquina-10.
PT600970E (pt) *	1991-08-06	2000-05-31	Schering Corp	Utilizacao de analogos ou antagonistas da interleucina-10 para tratar toxicidade induzida por endotoxinas ou superantigenios
US5833976A (en) *	1991-08-06	1998-11-10	Schering Corporation	Use of interleukin-10 (IL-10) to treat endotoxin- or superantigen-induced toxicity
ATE380243T1 (de) *	1992-03-13	2007-12-15	Biomerieux Bv	Epstein-barr-virus verwandte peptide und nukleinsäuresegmente
US6008327A (en) *	1992-03-13	1999-12-28	Akzo Nobel, N.V.	Peptides and nucleic acid sequences related to the Epstein Barr virus
AU3801193A (en) *	1992-03-20	1993-10-21	Schering Corporation	Use of interleukin-10 to induce the production of interleukin-1 receptor antagonist
DE69330966T2 (de) *	1993-07-23	2002-06-06	Wolf, Hans	DNA-Sequenzen des Epstein-Barr Virus kodierend für ein diagnostisch relevantes Virus-Hüllprotein, durch PCR erhaltene Expressionsklone und Verwendung dieses rekombinanten Antigens in diagnostischen Tests
US5616724A (en) *	1996-02-21	1997-04-01	Cephalon, Inc.	Fused pyrrolo[2,3-c]carbazole-6-ones
AU9016998A (en) *	1997-08-08	1999-03-01	Newbiotics, Inc.	Methods and compositions for overcoming resistance to biologic and chemotherapy
EP2791168A1 (de)	2011-11-23	2014-10-22	Amgen Inc.	Behandlungsverfahren unter verwendung eines antikörpers gegen interferon-gamma
WO2022016509A1 (zh) *	2020-07-24	2022-01-27	阎忠扬	一种用以筛选药物的方法，以及该药物用于治疗牛皮癣的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0173254B1 (de) *	1984-08-23	1991-07-24	Hans Joachim Wolf	DNA-Sequenzen des EBV-Genoms, rekombinante DNA-Moleküle, Verfahren zur Herstellung von EBV-verwandten Antigenen sowie diagnostische Zusammensetzungen und pharmazeutische Zusammensetzungen, die die genannten Antigene enthalten
US5256768A (en) *	1985-12-13	1993-10-26	The Johns Hopkins University	Expression of antigenic Epstein-Barr virus polypeptides in bacteria and their use in diagnostics

1990
- 1990-12-18 DE DE69013011T patent/DE69013011T2/de not_active Expired - Fee Related
- 1990-12-18 PT PT96231A patent/PT96231B/pt not_active IP Right Cessation
- 1990-12-18 WO PCT/US1990/007288 patent/WO1991009127A1/en not_active Ceased
- 1990-12-18 CA CA002071907A patent/CA2071907C/en not_active Expired - Fee Related
- 1990-12-18 ES ES91902258T patent/ES2064082T3/es not_active Expired - Lifetime
- 1990-12-18 NZ NZ236512A patent/NZ236512A/en unknown
- 1990-12-18 DK DK91902258.2T patent/DK0506836T3/da active
- 1990-12-18 HU HU9202075A patent/HU215909B/hu not_active IP Right Cessation
- 1990-12-18 ZA ZA9010188A patent/ZA9010188B/xx unknown
- 1990-12-18 JP JP3502513A patent/JP2648236B2/ja not_active Expired - Fee Related
- 1990-12-18 SK SK6351-90A patent/SK279830B6/sk unknown
- 1990-12-18 CZ CS906351A patent/CZ283049B6/cs not_active IP Right Cessation
- 1990-12-18 EP EP91902258A patent/EP0506836B1/de not_active Expired - Lifetime
- 1990-12-18 IL IL96715A patent/IL96715A0/xx unknown
- 1990-12-18 PH PH41744A patent/PH31669A/en unknown
- 1990-12-18 KR KR1019920701474A patent/KR960015199B1/ko not_active Expired - Fee Related
- 1990-12-18 MX MX9203409A patent/MX9203409A/es unknown
- 1990-12-18 AT AT91902258T patent/ATE112317T1/de not_active IP Right Cessation
- 1990-12-19 IE IE458890A patent/IE72203B1/en not_active IP Right Cessation
- 1990-12-19 MY MYPI90002207A patent/MY107449A/en unknown
- 1990-12-19 CN CN90110079A patent/CN1057012C/zh not_active Expired - Fee Related
1992
- 1992-06-16 FI FI922770A patent/FI104883B/fi active
- 1992-06-19 OA OA60232A patent/OA09703A/en unknown
- 1992-06-19 NO NO922456A patent/NO305703B1/no not_active IP Right Cessation
1994
- 1994-11-23 AU AU78996/94A patent/AU7899694A/en not_active Abandoned
1995
- 1995-05-26 US US08/450,749 patent/US5627155A/en not_active Expired - Lifetime
- 1995-06-06 US US08/466,950 patent/US5736390A/en not_active Expired - Lifetime
1996
- 1996-01-03 HK HK185396A patent/HK185396A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0506836B1 (de)	1994-09-28
NZ236512A (en)	1997-07-27
HU9202075D0 (en)	1992-10-28
US5627155A (en)	1997-05-06
ATE112317T1 (de)	1994-10-15
CN1057012C (zh)	2000-10-04
NO922456D0 (no)	1992-06-19
WO1991009127A1 (en)	1991-06-27
FI922770L (fi)	1992-06-16
PT96231B (pt)	1998-09-30
SK279830B6 (sk)	1999-04-13
ZA9010188B (en)	1991-08-28
DE69013011T2 (de)	1995-02-23
KR960015199B1 (ko)	1996-11-01
IE72203B1 (en)	1997-04-09
CZ635190A3 (en)	1997-09-17
HUT65369A (en)	1994-05-02
OA09703A (en)	1993-08-30
AU7063691A (en)	1991-07-18
EP0506836A1 (de)	1992-10-07
NO305703B1 (no)	1999-07-12
AU7899694A (en)	1995-02-09
AU652732B2 (en)	1994-09-08
US5736390A (en)	1998-04-07
HK185396A (en)	1996-10-11
CA2071907C (en)	2000-08-08
MY107449A (en)	1995-12-31
MX9203409A (es)	1992-07-01
JP2648236B2 (ja)	1997-08-27
DK0506836T3 (da)	1994-11-28
NO922456L (no)	1992-06-19
DE69013011D1 (de)	1994-11-03
PH31669A (en)	1999-01-18
FI104883B (fi)	2000-04-28
ES2064082T3 (es)	1995-01-16
IE904588A1 (en)	1991-07-03
CZ283049B6 (cs)	1997-12-17
CA2071907A1 (en)	1991-06-21
CN1052608A (zh)	1991-07-03
HU215909B (hu)	1999-03-29
IL96715A0 (en)	1991-09-16
JPH05503846A (ja)	1993-06-24
PT96231A (pt)	1991-09-30
FI922770A0 (fi)	1992-06-16

Publication	Publication Date	Title
DE69201128T2 (de)	1995-05-24	Behandlung von neoplastischen krankenheiten mit interleukin-10.
SK279897B6 (sk)	1999-05-07	Spôsob izolácie ľudského nekrotizujúceho faktora (
SK8396A3 (en)	1997-03-05	Antagonists and agonists of human interleukin-10
CA2071907C (en)	2000-08-08	Bcrf1 proteins as inhibitors of interferon-y
US20040105841A1 (en)	2004-06-03	Interferons, uses and compositions related thereto
WO1993018783A1 (en)	1993-09-30	Use of interleukin-10 to induce the production of interleukin-1 receptor antagonist
PT97107A (pt)	1991-12-31	Metodo para aumentar o crescimento e proliferacao de mastocitos utilizando interleuquina-9-purificada
EP0912741B1 (de)	2004-07-28	T-zell selektive interleukin-4 agoniste
AU652732C (en)	1995-05-25	BCRF1 proteins as inhibitors of interferon-gamma
AU650013B2 (en)	1994-06-09	BCRF1 antagonists for treating Epstein-Barr virus infections