SK659090A3 - Serumfree cell cultures useful for antigens preparation and process for producing flavivirus/virus antigen or arenavirus/virus antigen - Google Patents

Serumfree cell cultures useful for antigens preparation and process for producing flavivirus/virus antigen or arenavirus/virus antigen Download PDF

Info

Publication number: SK659090A3
Authority: SK; Slovakia
Prior art keywords: virus; cells; antigen; matrix; bound
Prior art date: 1989-12-22

Application number

SK6590-90A

Other languages

English (en)

Slovak (sk)

Other versions

SK279236B6 (sk

Inventor

Wolfgang Mundt

Noel Barrett

Friedrich Dorner

Johann Eibl

Original Assignee

Immuno Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-22

Filing date

1990-12-21

Publication date

1998-08-05

1990-12-21 Application filed by Immuno Ag filed Critical Immuno Ag

1998-08-05 Publication of SK279236B6 publication Critical patent/SK279236B6/sk

1998-08-05 Publication of SK659090A3 publication Critical patent/SK659090A3/sk

Links

239000000427 antigen Substances 0.000 title claims abstract description 69
102000036639 antigens Human genes 0.000 title claims abstract description 69
108091007433 antigens Proteins 0.000 title claims abstract description 69
241000700605 Viruses Species 0.000 title claims abstract description 65
238000004113 cell culture Methods 0.000 title claims abstract description 14
238000000034 method Methods 0.000 title claims description 16
241000710831 Flavivirus Species 0.000 title claims description 13
241000712891 Arenavirus Species 0.000 title claims description 10
238000002360 preparation method Methods 0.000 title claims description 3
210000004027 cell Anatomy 0.000 claims abstract description 65
239000011159 matrix material Substances 0.000 claims abstract description 18
239000002609 medium Substances 0.000 claims abstract description 15
210000003501 vero cell Anatomy 0.000 claims abstract description 9
230000001419 dependent effect Effects 0.000 claims abstract description 5
238000000746 purification Methods 0.000 claims abstract description 5
230000002779 inactivation Effects 0.000 claims abstract description 4
210000004102 animal cell Anatomy 0.000 claims abstract description 3
210000005260 human cell Anatomy 0.000 claims abstract description 3
210000002966 serum Anatomy 0.000 claims abstract 2
238000004519 manufacturing process Methods 0.000 claims description 25
230000010412 perfusion Effects 0.000 claims description 12
230000003612 virological effect Effects 0.000 claims description 11
238000000855 fermentation Methods 0.000 claims description 10
230000004151 fermentation Effects 0.000 claims description 10
239000012679 serum free medium Substances 0.000 claims description 5
229920002307 Dextran Polymers 0.000 claims description 3
239000011521 glass Substances 0.000 claims description 3
108010010803 Gelatin Proteins 0.000 claims description 2
239000008273 gelatin Substances 0.000 claims description 2
229920000159 gelatin Polymers 0.000 claims description 2
235000019322 gelatine Nutrition 0.000 claims description 2
235000011852 gelatine desserts Nutrition 0.000 claims description 2
239000004033 plastic Substances 0.000 claims description 2
229920003023 plastic Polymers 0.000 claims description 2
230000035899 viability Effects 0.000 claims description 2
241000710771 Tick-borne encephalitis virus Species 0.000 abstract description 12
239000001963 growth medium Substances 0.000 abstract description 8
239000000203 mixture Substances 0.000 abstract description 5
206010014599 encephalitis Diseases 0.000 abstract description 4
201000011475 meningoencephalitis Diseases 0.000 abstract description 3
239000000758 substrate Substances 0.000 abstract 3
230000010261 cell growth Effects 0.000 abstract 1
230000002101 lytic effect Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 description 12
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 6
229960005486 vaccine Drugs 0.000 description 6
239000003153 chemical reaction reagent Substances 0.000 description 5
238000012258 culturing Methods 0.000 description 4
239000002054 inoculum Substances 0.000 description 4
241000287828 Gallus gallus Species 0.000 description 3
210000004556 brain Anatomy 0.000 description 3
235000013330 chicken meat Nutrition 0.000 description 3
210000002308 embryonic cell Anatomy 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
230000000694 effects Effects 0.000 description 2
235000013601 eggs Nutrition 0.000 description 2
238000011031 large-scale manufacturing process Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
230000000644 propagated effect Effects 0.000 description 2
239000000725 suspension Substances 0.000 description 2
241000282552 Chlorocebus aethiops Species 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
206010014596 Encephalitis Japanese B Diseases 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
241000710924 Togaviridae Species 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
210000000270 basal cell Anatomy 0.000 description 1
239000012620 biological material Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
230000036512 infertility Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000002245 particle Substances 0.000 description 1
244000052769 pathogen Species 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
230000002688 persistence Effects 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
210000005084 renal tissue Anatomy 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
230000000405 serological effect Effects 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000009385 viral infection Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2531/00—Microcarriers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24151—Methods of production or purification of viral material
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Virology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Peptides Or Proteins (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SK6590-90A 1989-12-22 1990-12-21 Serumfree cell cultures useful for antigens preparation and process for producing flavivirus/virus antigen or arenavirus/virus antigen SK659090A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT2928/89A AT393356B (de)	1989-12-22	1989-12-22	Verfahren zur herstellung von fsme-virus-antigen

Publications (2)

Publication Number	Publication Date
SK279236B6 SK279236B6 (sk)	1998-08-05
SK659090A3 true SK659090A3 (en)	1998-08-05

Family

ID=3542524

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK6590-90A SK659090A3 (en)	1989-12-22	1990-12-21	Serumfree cell cultures useful for antigens preparation and process for producing flavivirus/virus antigen or arenavirus/virus antigen

Country Status (16)

Country	Link
EP (1)	EP0506714B1 (fr)
JP (1)	JP2633391B2 (fr)
AT (2)	AT393356B (fr)
CA (1)	CA2071954C (fr)
CZ (1)	CZ281804B6 (fr)
DE (1)	DE59007659D1 (fr)
DK (1)	DK0506714T3 (fr)
ES (1)	ES2067916T3 (fr)
FI (1)	FI98377C (fr)
HR (1)	HRP921354A2 (fr)
HU (1)	HU213886B (fr)
NO (1)	NO310305B1 (fr)
RU (1)	RU2082757C1 (fr)
SK (1)	SK659090A3 (fr)
WO (1)	WO1991009935A1 (fr)
YU (1)	YU242390A (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2205015C (fr) *	1994-11-10	2003-04-08	Otfried Kistner	Procede de production d'agents biologiques dans un milieu de culture sans proteines
CN1122531C (zh) *	1995-08-01	2003-10-01	巴斯德梅诺血清和疫苗公司	抗日本脑炎疫苗的工业生产方法和所获得的疫苗
FR2737412B1 (fr) *	1995-08-01	1997-10-24	Pasteur Merieux Serums Vacc	Procede de production d'un vaccin contre le virus de l'encephalite japonaise et vaccin obtenu par ce procede
KR20010032699A (ko) *	1998-10-05	2001-04-25	무따이 마사히꼬	일본 뇌염 바이러스 감염에 대한 불활성 백신을 위한증강된 면역원 및 그 제조방법
AT409379B (de)	1999-06-02	2002-07-25	Baxter Ag	Medium zur protein- und serumfreien kultivierung von zellen
US6855535B2 (en) *	2001-12-10	2005-02-15	Baxter Healthcare S.A.	Method of large scale production of Hepatitis A virus
US6951752B2 (en)	2001-12-10	2005-10-04	Bexter Healthcare S.A.	Method for large scale production of virus antigen
JP2007068401A (ja) *	2003-08-07	2007-03-22	Chemo Sero Therapeut Res Inst	西ナイルウイルスワクチン
SG187397A1 (en) *	2007-12-27	2013-02-28	Baxter Int	Cell culture processes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT358167B (de) *	1978-12-22	1980-08-25	Immuno Ag	Verfahren zur herstellung von fruehsommer- -meningoenzephalitis-virus (fsme-virus)- -vakzinen
SE445116B (sv) *	1979-09-12	1986-06-02	Pharmacia Fine Chemicals Ab	Sett att odla celler pa mikroberare med fibronektinytskikt
NO161446C (no) *	1981-03-13	1989-08-16	Damon Biotech Inc	Fremgangsmaate for dyrking av celler som er avhengige av forankring.
SE8103138L (sv) *	1981-05-19	1982-11-20	Pharmacia Fine Chemicals Ab	Mikroberare for odling av forankringsberoende celler
CA1206900A (fr) *	1981-12-21	1986-07-02	Raymond L. Downs	Coque de verre creuse servant de support pour la culture de cellules et methode de fabrication
AT385203B (de) *	1985-04-26	1988-03-10	Immuno Ag	Verfahren zur herstellung einer fruehsommermeningoenzephalitis-virus (fsme-virus)-vakzine
DD274336A3 (de) *	1985-10-03	1989-12-20	Npo Biolar	Verfahren zur Gewinnung einer Mikroträgersubstanz für die Zellkultivierung

1989
- 1989-12-22 AT AT2928/89A patent/AT393356B/de not_active IP Right Cessation
1990
- 1990-12-21 DK DK91900666T patent/DK0506714T3/da not_active Application Discontinuation
- 1990-12-21 ES ES91900666T patent/ES2067916T3/es not_active Expired - Lifetime
- 1990-12-21 WO PCT/AT1990/000128 patent/WO1991009935A1/fr not_active Ceased
- 1990-12-21 RU SU905052769A patent/RU2082757C1/ru not_active IP Right Cessation
- 1990-12-21 HU HU9202009A patent/HU213886B/hu unknown
- 1990-12-21 AT AT91900666T patent/ATE113652T1/de not_active IP Right Cessation
- 1990-12-21 JP JP50113291A patent/JP2633391B2/ja not_active Expired - Fee Related
- 1990-12-21 CA CA 2071954 patent/CA2071954C/fr not_active Expired - Lifetime
- 1990-12-21 CZ CS906590A patent/CZ281804B6/cs not_active IP Right Cessation
- 1990-12-21 DE DE59007659T patent/DE59007659D1/de not_active Expired - Fee Related
- 1990-12-21 SK SK6590-90A patent/SK659090A3/sk not_active IP Right Cessation
- 1990-12-21 YU YU242390A patent/YU242390A/sh unknown
- 1990-12-21 EP EP19910900666 patent/EP0506714B1/fr not_active Expired - Lifetime
1992
- 1992-06-18 FI FI922851A patent/FI98377C/fi active
- 1992-06-19 NO NO19922422A patent/NO310305B1/no not_active IP Right Cessation
- 1992-11-25 HR HRP921354 patent/HRP921354A2/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATE113652T1 (de)	1994-11-15
HU9202009D0 (en)	1992-10-28
WO1991009935A1 (fr)	1991-07-11
AT393356B (de)	1991-10-10
ES2067916T3 (es)	1995-04-01
NO922422L (no)	1992-08-17
YU242390A (sh)	1993-05-28
NO922422D0 (no)	1992-06-19
HU213886B (en)	1997-11-28
HUT65410A (en)	1994-06-28
DK0506714T3 (da)	1995-04-18
DE59007659D1 (de)	1994-12-08
RU2082757C1 (ru)	1997-06-27
FI922851A0 (fi)	1992-06-18
SK279236B6 (sk)	1998-08-05
ATA292889A (de)	1991-03-15
CA2071954C (fr)	1996-06-18
JP2633391B2 (ja)	1997-07-23
HRP921354A2 (en)	1996-02-29
EP0506714A1 (fr)	1992-10-07
FI922851A7 (fi)	1992-06-18
JPH05502581A (ja)	1993-05-13
FI98377C (fi)	1997-06-10
CA2071954A1 (fr)	1991-06-23
EP0506714B1 (fr)	1994-11-02
NO310305B1 (no)	2001-06-18
CZ659090A3 (en)	1996-11-13
CZ281804B6 (cs)	1997-02-12
FI98377B (fi)	1997-02-28

Legal Events

Date	Code	Title	Description
2010-09-07	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20091221

Publication	Publication Date	Title
AU2008207588B2 (en)	2012-01-19	Methods for producing an active constituent of a pharmaceutical or a diagnostic agent in an MDCK cell suspension culture
Van Hemert et al.	1969	Homogeneous cultivation of animal cells for the production of virus and virus products
AU2002338666B2 (en)	2008-11-20	Multiplication of viruses in a cell culture
US4024020A (en)	1977-05-17	Method of cell culture on polyacrylonitrile surface
CN1147833A (zh)	1997-04-16	甲型肝炎病毒培养工艺
SK659090A3 (en)	1998-08-05	Serumfree cell cultures useful for antigens preparation and process for producing flavivirus/virus antigen or arenavirus/virus antigen
US3520972A (en)	1970-07-21	Feline virus vaccines obtained by propagation and serial passage attenuation of virulent feline viruses in diploid feline embryo tissue cell serial passage subculture strains
US7666654B2 (en)	2010-02-23	Method for preparing viral material
IE51454B1 (en)	1986-12-24	High titer production of hepatitis a virus
US5719051A (en)	1998-02-17	Perfusion system and a method for the large scale production of virus or virus antigen
US3935066A (en)	1976-01-27	Cell lines
US4169761A (en)	1979-10-02	Process for the cultivation of viruses
KR20120027381A (ko)	2012-03-21	일본뇌염 백신 및 그것의 제조 방법
KR20010033558A (ko)	2001-04-25	생물학적 제제를 생산하기 위한 세포의 제조
JPH0998778A (ja)	1997-04-15	マレク病ワクチン
Moran	1999	A microcarrier-based cell culture process for the production of a bovine respiratory syncytial virus vaccine
NO860180L (fr)	1986-01-20
Nicholson	1980	Growth of fish cell lines on microcarriers
US3616203A (en)	1971-10-26	Virus culture and method
RU2142816C1 (ru)	1999-12-20	Способ получения антигерпетической вакцины и лекарственная форма на ее основе
Schmidt et al.	1986	Morphology and in vivo growth characteristics of an atypical murine proliferative osseous lesion induced in vitro
RU2816765C1 (ru)	2024-04-04	Способ получения культуральной инактивированной вакцины против вируса бешенства
RU2014084C1 (ru)	1994-06-15	Способ получения вирионной герпетической вакцины
EP0727484A1 (fr)	1996-08-21	Procédé pour la croissance de virus
RU2616245C2 (ru)	2017-04-13	Композиция для профилактики заболеваний, вызываемых цитомегаловирусной инфекцией