SK7162001A3 - Compositions comprising cefuroxime axetil - Google Patents

Compositions comprising cefuroxime axetil Download PDF

Info

Publication number: SK7162001A3
Authority: SK; Slovakia
Prior art keywords: cefuroxime axetil; cefuroxime; aqueous liquid; axetil; contact
Prior art date: 1998-11-26

Application number

SK716-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Herwig Jennewein

Johannes Raneburger

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-26

Filing date

1999-11-24

Publication date

2001-10-08

1999-11-24 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

2001-10-08 Publication of SK7162001A3 publication Critical patent/SK7162001A3/sk

Links

KEJCWVGMRLCZQQ-YJBYXUATSA-N Cefuroxime axetil Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(=O)OC(C)OC(C)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 KEJCWVGMRLCZQQ-YJBYXUATSA-N 0.000 title claims abstract description 243
229960002620 cefuroxime axetil Drugs 0.000 title claims abstract description 242
239000000203 mixture Substances 0.000 title description 33
239000007788 liquid Substances 0.000 claims abstract description 65
229920000642 polymer Polymers 0.000 claims abstract description 45
239000004480 active ingredient Substances 0.000 claims abstract description 30
238000004519 manufacturing process Methods 0.000 claims abstract description 28
230000009246 food effect Effects 0.000 claims abstract description 12
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
239000006104 solid solution Substances 0.000 claims abstract description 10
239000006186 oral dosage form Substances 0.000 claims abstract description 9
239000007962 solid dispersion Substances 0.000 claims abstract description 9
235000021471 food effect Nutrition 0.000 claims abstract description 8
230000002411 adverse Effects 0.000 claims abstract 4
239000003826 tablet Substances 0.000 claims description 84
239000008187 granular material Substances 0.000 claims description 54
239000000843 powder Substances 0.000 claims description 51
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 49
238000004090 dissolution Methods 0.000 claims description 45
239000000546 pharmaceutical excipient Substances 0.000 claims description 45
239000003463 adsorbent Substances 0.000 claims description 35
239000002552 dosage form Substances 0.000 claims description 34
239000007941 film coated tablet Substances 0.000 claims description 34
229960001668 cefuroxime Drugs 0.000 claims description 33
JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 claims description 33
239000000725 suspension Substances 0.000 claims description 33
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
238000000034 method Methods 0.000 claims description 25
239000000243 solution Substances 0.000 claims description 21
239000006188 syrup Substances 0.000 claims description 20
235000020357 syrup Nutrition 0.000 claims description 20
239000011248 coating agent Substances 0.000 claims description 19
238000000576 coating method Methods 0.000 claims description 19
238000012360 testing method Methods 0.000 claims description 19
239000003960 organic solvent Substances 0.000 claims description 18
239000002904 solvent Substances 0.000 claims description 18
241000124008 Mammalia Species 0.000 claims description 11
239000007787 solid Substances 0.000 claims description 9
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
239000008103 glucose Substances 0.000 claims description 8
239000002253 acid Substances 0.000 claims description 7
239000012736 aqueous medium Substances 0.000 claims description 7
238000009501 film coating Methods 0.000 claims description 5
239000007888 film coating Substances 0.000 claims description 5
239000000825 pharmaceutical preparation Substances 0.000 claims description 5
230000000813 microbial effect Effects 0.000 claims description 3
238000003556 assay Methods 0.000 claims description 2
201000010099 disease Diseases 0.000 claims 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
BJHIKXHVCXFQLS-UYFOZJQFSA-N fructose group Chemical group OCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 claims 1
-1 carboxy ester Chemical class 0.000 description 35
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 21
239000000945 filler Substances 0.000 description 16
229920000036 polyvinylpyrrolidone Polymers 0.000 description 16
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 16
239000000314 lubricant Substances 0.000 description 14
239000004094 surface-active agent Substances 0.000 description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
238000005469 granulation Methods 0.000 description 12
230000003179 granulation Effects 0.000 description 12
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 11
239000000454 talc Substances 0.000 description 11
229910052623 talc Inorganic materials 0.000 description 11
235000010980 cellulose Nutrition 0.000 description 10
229920002678 cellulose Polymers 0.000 description 10
239000003795 chemical substances by application Substances 0.000 description 10
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 8
229930195725 Mannitol Natural products 0.000 description 8
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 8
238000007796 conventional method Methods 0.000 description 8
239000000594 mannitol Substances 0.000 description 8
235000010355 mannitol Nutrition 0.000 description 8
235000019333 sodium laurylsulphate Nutrition 0.000 description 8
239000011230 binding agent Substances 0.000 description 7
239000003814 drug Substances 0.000 description 7
235000013305 food Nutrition 0.000 description 7
239000001267 polyvinylpyrrolidone Substances 0.000 description 7
238000002360 preparation method Methods 0.000 description 7
239000007921 spray Substances 0.000 description 7
235000000346 sugar Nutrition 0.000 description 7
229910002012 Aerosil® Inorganic materials 0.000 description 6
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
229930091371 Fructose Natural products 0.000 description 6
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 6
239000005715 Fructose Substances 0.000 description 6
229920003083 Kollidon® VA64 Polymers 0.000 description 6
238000007922 dissolution test Methods 0.000 description 6
239000000796 flavoring agent Substances 0.000 description 6
239000012530 fluid Substances 0.000 description 6
238000000227 grinding Methods 0.000 description 6
239000002245 particle Substances 0.000 description 6
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 6
238000001694 spray drying Methods 0.000 description 6
229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
229950003588 axetil Drugs 0.000 description 5
239000001768 carboxy methyl cellulose Substances 0.000 description 5
239000008112 carboxymethyl-cellulose Substances 0.000 description 5
239000001913 cellulose Substances 0.000 description 5
239000004615 ingredient Substances 0.000 description 5
238000002156 mixing Methods 0.000 description 5
229940069328 povidone Drugs 0.000 description 5
239000003755 preservative agent Substances 0.000 description 5
238000012545 processing Methods 0.000 description 5
238000007873 sieving Methods 0.000 description 5
238000003756 stirring Methods 0.000 description 5
229920000168 Microcrystalline cellulose Polymers 0.000 description 4
239000002202 Polyethylene glycol Substances 0.000 description 4
229920002472 Starch Polymers 0.000 description 4
229960000913 crospovidone Drugs 0.000 description 4
230000002939 deleterious effect Effects 0.000 description 4
229940079593 drug Drugs 0.000 description 4
235000013355 food flavoring agent Nutrition 0.000 description 4
235000003599 food sweetener Nutrition 0.000 description 4
238000009472 formulation Methods 0.000 description 4
210000001035 gastrointestinal tract Anatomy 0.000 description 4
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
238000001727 in vivo Methods 0.000 description 4
150000002576 ketones Chemical class 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000000463 material Substances 0.000 description 4
235000019813 microcrystalline cellulose Nutrition 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 4
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 4
235000019698 starch Nutrition 0.000 description 4
210000002784 stomach Anatomy 0.000 description 4
239000003765 sweetening agent Substances 0.000 description 4
239000002562 thickening agent Substances 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
229920003091 Methocel™ Polymers 0.000 description 3
229920000881 Modified starch Polymers 0.000 description 3
230000002378 acidificating effect Effects 0.000 description 3
238000013019 agitation Methods 0.000 description 3
BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 3
229940063953 ammonium lauryl sulfate Drugs 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
239000003086 colorant Substances 0.000 description 3
238000005056 compaction Methods 0.000 description 3
229920001577 copolymer Polymers 0.000 description 3
239000006185 dispersion Substances 0.000 description 3
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 3
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
239000011777 magnesium Substances 0.000 description 3
229940016286 microcrystalline cellulose Drugs 0.000 description 3
239000008108 microcrystalline cellulose Substances 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
238000004806 packaging method and process Methods 0.000 description 3
239000004014 plasticizer Substances 0.000 description 3
229920006395 saturated elastomer Polymers 0.000 description 3
239000011734 sodium Substances 0.000 description 3
229910052708 sodium Inorganic materials 0.000 description 3
238000001179 sorption measurement Methods 0.000 description 3
229940032147 starch Drugs 0.000 description 3
239000008107 starch Substances 0.000 description 3
108010011485 Aspartame Proteins 0.000 description 2
244000303965 Cyamopsis psoralioides Species 0.000 description 2
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
229910010413 TiO 2 Inorganic materials 0.000 description 2
229920013820 alkyl cellulose Polymers 0.000 description 2
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
239000000605 aspartame Substances 0.000 description 2
235000010357 aspartame Nutrition 0.000 description 2
229960003438 aspartame Drugs 0.000 description 2
238000007906 compression Methods 0.000 description 2
230000006835 compression Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
238000001514 detection method Methods 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
230000002708 enhancing effect Effects 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
238000009477 fluid bed granulation Methods 0.000 description 2
239000008202 granule composition Substances 0.000 description 2
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
229920003063 hydroxymethyl cellulose Polymers 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
235000012054 meals Nutrition 0.000 description 2
239000002609 medium Substances 0.000 description 2
235000019426 modified starch Nutrition 0.000 description 2
229920006280 packaging film Polymers 0.000 description 2
239000012785 packaging film Substances 0.000 description 2
239000000049 pigment Substances 0.000 description 2
230000002335 preservative effect Effects 0.000 description 2
238000003825 pressing Methods 0.000 description 2
239000000377 silicon dioxide Substances 0.000 description 2
239000012453 solvate Substances 0.000 description 2
125000001424 substituent group Chemical group 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
150000005846 sugar alcohols Chemical class 0.000 description 2
150000008163 sugars Chemical class 0.000 description 2
150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229930186147 Cephalosporin Natural products 0.000 description 1
229920002785 Croscarmellose sodium Polymers 0.000 description 1
229920003134 Eudragit® polymer Polymers 0.000 description 1
244000307700 Fragaria vesca Species 0.000 description 1
235000016623 Fragaria vesca Nutrition 0.000 description 1
235000011363 Fragaria x ananassa Nutrition 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
229920003072 Plasdone™ povidone Polymers 0.000 description 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
239000008351 acetate buffer Substances 0.000 description 1
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
239000003929 acidic solution Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
LKDRXBCSQODPBY-ZXXMMSQZSA-N alpha-D-fructopyranose Chemical compound OC[C@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-ZXXMMSQZSA-N 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
235000013736 caramel Nutrition 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
150000001733 carboxylic acid esters Chemical group 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000005018 casein Substances 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
229960001681 croscarmellose sodium Drugs 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
229940043264 dodecyl sulfate Drugs 0.000 description 1
239000008298 dragée Substances 0.000 description 1
239000000975 dye Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003974 emollient agent Substances 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
230000037406 food intake Effects 0.000 description 1
238000001879 gelation Methods 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
229920001519 homopolymer Polymers 0.000 description 1
229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
238000003801 milling Methods 0.000 description 1
235000008935 nutritious Nutrition 0.000 description 1
239000008203 oral pharmaceutical composition Substances 0.000 description 1
229940100692 oral suspension Drugs 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
230000009993 protective function Effects 0.000 description 1
238000002390 rotary evaporation Methods 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
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229920003109 sodium starch glycolate Polymers 0.000 description 1
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150000003871 sulfonates Chemical class 0.000 description 1
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150000003952 β-lactams Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Cephalosporin Compounds (AREA)

SK716-2001A 1998-11-26 1999-11-24 Compositions comprising cefuroxime axetil SK7162001A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0198998A AT413647B (de)	1998-11-26	1998-11-26	Verwendung eines copolymerisats aus 1-vinyl-2-pyrrolidon und vinylacetat zur herstellung von cefuroximaxetil-hältigen tabletten
PCT/EP1999/009096 WO2000030647A1 (en)	1998-11-26	1999-11-24	Compositions comprising cefuroxime axetil

Publications (1)

Publication Number	Publication Date
SK7162001A3 true SK7162001A3 (en)	2001-10-08

Family

ID=3525440

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK716-2001A SK7162001A3 (en)	1998-11-26	1999-11-24	Compositions comprising cefuroxime axetil

Country Status (30)

Country	Link
US (1)	US6727243B1 (de)
EP (1)	EP1133298B1 (de)
JP (1)	JP2002530338A (de)
KR (1)	KR20010080566A (de)
CN (1)	CN1330546A (de)
AR (1)	AR021405A1 (de)
AT (3)	AT413647B (de)
AU (1)	AU759517B2 (de)
BR (1)	BR9915694A (de)
CA (1)	CA2348876A1 (de)
CO (1)	CO5190668A1 (de)
CZ (1)	CZ20011845A3 (de)
DE (1)	DE69935609T2 (de)
ES (1)	ES2285866T3 (de)
HU (1)	HUP0104412A3 (de)
ID (1)	ID28615A (de)
IL (1)	IL142762A0 (de)
MY (1)	MY129564A (de)
NO (1)	NO20012526D0 (de)
NZ (1)	NZ511588A (de)
PE (1)	PE20001326A1 (de)
PL (1)	PL348744A1 (de)
RU (1)	RU2248794C2 (de)
SI (1)	SI1133298T1 (de)
SK (1)	SK7162001A3 (de)
TR (1)	TR200101417T2 (de)
TW (1)	TWI229603B (de)
WO (1)	WO2000030647A1 (de)
YU (1)	YU34601A (de)
ZA (1)	ZA200103927B (de)

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KR100342943B1 (ko) *	1999-08-04	2002-07-02	민경윤	비결정질 세푸록심 악세틸 고형분산체, 이의 제조 방법 및 이를 포함하는 경구투여용 조성물
US7527807B2 (en) *	2000-06-21	2009-05-05	Cubist Pharmaceuticals, Inc.	Compositions and methods for increasing the oral absorption of antimicrobials
EP1414417A4 (de) *	2000-12-01	2004-05-06	Abdul Rehman Khan	Pharmazeutische formulierung
EP1911462A3 (de) *	2001-01-26	2011-11-30	Schering Corporation	Zusammensetzungen enthaltend einen Sterolabsorptionshemmer
US6524617B1 (en) *	2001-07-25	2003-02-25	Isp Investments Inc.	Synergistic filler composition
MY148466A (en)	2001-10-26	2013-04-30	Merck Frosst Canada Ltd	Granule formulation
ES2201932B2 (es) *	2001-11-23	2005-03-16	Glaxo Group Limited	Composicion farmaceutica.
JP4526247B2 (ja) *	2002-07-08	2010-08-18	第一三共株式会社	経口用セファロスポリン製剤
TW200404550A (en) *	2002-07-08	2004-04-01	Sankyo Co	Cepharospolin formulation for oral use
AU2003260803A1 (en) *	2002-08-30	2004-03-19	Orchid Chemicals And Pharmaceuticals Ltd.	Sustained release pharmaceutical composition
WO2005002540A2 (en) *	2003-07-01	2005-01-13	Ranbaxy Laboratories Limited	Dry powder pharmaceutical suspension compositions of cefuroxime axetil
KR100552567B1 (ko) *	2003-08-23	2006-02-15	한국유나이티드제약 주식회사	수분 흡수에 안정하고 빠르게 붕해되는 세푸록심 악세틸을포함하는 정제의 조성물 및 제조 방법
NZ580951A (en) *	2005-04-29	2011-06-30	Cubist Pharm Inc	Therapeutic compositions
CN100402035C (zh) *	2005-07-07	2008-07-16	石药集团中奇制药技术（石家庄）有限公司	一种微囊化头孢呋辛酯的药物组合物
US8900605B2 (en)	2010-06-14	2014-12-02	Ratiopharm Gmbh	Solid ivabradine-containing composition
WO2014023710A1 (en) *	2012-08-07	2014-02-13	Sandoz Ag	UNCOATED TABLET COMPRISING GRANULES INCLUDING A β-LACTAM ANTIBIOTIC AND HIGHLY DISPERSED SILICONE DIOXIDE
US9687453B2 (en)	2013-04-25	2017-06-27	Kyorin Pharmaceutical Co., Ltd.	Solid pharmaceutical composition
CN105338982B (zh)	2013-04-25	2017-10-10	杏林制药株式会社	固体药用组合物
JP6018334B2 (ja)	2014-10-23	2016-11-02	杏林製薬株式会社	固形医薬組成物

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GB1571683A (en) *	1976-02-16	1980-07-16	Glaxo Operations Ltd	Ester derivatives of cefuroxime
GB1572993A (en) *	1976-02-16	1980-08-13	Glaxo Operations Ltd	Ester derivatives of cefuroxime
YU44680B (en) *	1982-07-30	1990-12-31	Glaxo Lab Ltd	Process for obtaining very pure amorphous form of cephuroxim axetile
GB8524001D0 (en) *	1985-09-30	1985-11-06	Glaxo Group Ltd	Pharmaceutical composition
IL85538A (en) *	1987-02-27	1991-09-16	Lilly Co Eli	Sustained release matrix tablet formulations containing hydrophilic and enteric polymers
NL193682C (nl) *	1987-05-14	2000-07-04	Glaxo Group Ltd	Beklede cefuroximaxetilsamenstelling.
DE3810343A1 (de) *	1988-03-26	1989-10-05	Basf Ag	Verfahren zur herstellung von festen pharmazeutischen retardformen
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DE19602757A1 (de) *	1996-01-26	1997-07-31	Boehringer Mannheim Gmbh	Feste Instant-Release-Darreichungsformen und Verfahren zu ihrer Herstellung
US5663258A (en) *	1996-02-20	1997-09-02	Isp Investments Inc.	Strongly swellable, moderately crosslinked copolymers of vinylpyrrolidone and vinyl acetate
DE19631085A1 (de) *	1996-08-01	1998-02-05	Basf Ag	Verwendung von (Meth)acrylsäure-Maleinsäure-Copolymeren zur Verbesserung der Permeabilität der Schleimhaut
ATE277739T1 (de) *	1996-10-28	2004-10-15	Gen Mills Inc	Einbettung und einkapselung von teilchen zur kontrollierten abgabe
IL119627A (en) *	1996-11-17	2002-03-10	Yissum Res Dev Co	PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED-RELEASE OF AN ACTIVE AGENT COMPRISING AT LEAST ONE β-LACTAM ANTIBIOTIC AGENT
CA2209868C (en) *	1997-08-15	2001-08-14	Bernard Charles Sherman	Pharmaceutical compositions comprising cefuroxime axetil
AU3277899A (en) *	1998-03-03	1999-09-20	Dae Woong Chemical Co., Ltd.	Pharmaceutical composition containing cefuroxime axetil stable for moisture absorption
CA2239331C (en) *	1998-05-29	1999-11-30	Bernard Charles Sherman	Pharmaceutical tablets comprising cefuroxime axetil
DE19835823A1 (de) *	1998-08-10	1999-10-07	Lindopharm Gmbh	Pharmazeutische Zusammensetzung, Verfahren zu ihrer Herstellung und ihre Verwendung sowie aus ihr hergestellte wässerige Suspension
KR100342943B1 (ko)	1999-08-04	2002-07-02	민경윤	비결정질 세푸록심 악세틸 고형분산체, 이의 제조 방법 및 이를 포함하는 경구투여용 조성물

1998
- 1998-11-26 AT AT0198998A patent/AT413647B/de not_active IP Right Cessation
1999
- 1999-11-20 TW TW088120315A patent/TWI229603B/zh not_active IP Right Cessation
- 1999-11-24 RU RU2001117518/15A patent/RU2248794C2/ru not_active IP Right Cessation
- 1999-11-24 DE DE69935609T patent/DE69935609T2/de not_active Expired - Lifetime
- 1999-11-24 IL IL14276299A patent/IL142762A0/xx unknown
- 1999-11-24 BR BR9915694-6A patent/BR9915694A/pt not_active IP Right Cessation
- 1999-11-24 AU AU16544/00A patent/AU759517B2/en not_active Ceased
- 1999-11-24 ES ES99959327T patent/ES2285866T3/es not_active Expired - Lifetime
- 1999-11-24 HU HU0104412A patent/HUP0104412A3/hu unknown
- 1999-11-24 ID IDW00200101088A patent/ID28615A/id unknown
- 1999-11-24 EP EP99959327A patent/EP1133298B1/de not_active Expired - Lifetime
- 1999-11-24 CA CA002348876A patent/CA2348876A1/en not_active Abandoned
- 1999-11-24 AT AT99959327T patent/ATE357237T1/de active
- 1999-11-24 CN CN99813759A patent/CN1330546A/zh active Pending
- 1999-11-24 NZ NZ511588A patent/NZ511588A/en unknown
- 1999-11-24 US US09/445,741 patent/US6727243B1/en not_active Expired - Fee Related
- 1999-11-24 CZ CZ20011845A patent/CZ20011845A3/cs unknown
- 1999-11-24 SI SI9930969T patent/SI1133298T1/sl unknown
- 1999-11-24 TR TR2001/01417T patent/TR200101417T2/xx unknown
- 1999-11-24 PL PL99348744A patent/PL348744A1/xx unknown
- 1999-11-24 SK SK716-2001A patent/SK7162001A3/sk unknown
- 1999-11-24 YU YU34601A patent/YU34601A/sh unknown
- 1999-11-24 WO PCT/EP1999/009096 patent/WO2000030647A1/en not_active Ceased
- 1999-11-24 KR KR1020017006542A patent/KR20010080566A/ko not_active Ceased
- 1999-11-24 JP JP2000583530A patent/JP2002530338A/ja not_active Withdrawn
- 1999-11-25 PE PE1999001186A patent/PE20001326A1/es not_active Application Discontinuation
- 1999-11-25 AR ARP990106024A patent/AR021405A1/es not_active Application Discontinuation
- 1999-11-26 MY MYPI99005158A patent/MY129564A/en unknown
- 1999-11-26 CO CO99074648A patent/CO5190668A1/es not_active Application Discontinuation
2001
- 2001-05-15 ZA ZA200103927A patent/ZA200103927B/en unknown
- 2001-05-23 NO NO20012526A patent/NO20012526D0/no not_active Application Discontinuation
2004
- 2004-02-23 AT AT0028104A patent/AT500135A1/de not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20010080566A (ko)	2001-08-22
US6727243B1 (en)	2004-04-27
ID28615A (id)	2001-06-21
AT500135A1 (de)	2005-11-15
ES2285866T3 (es)	2007-11-16
AU759517B2 (en)	2003-04-17
AT413647B (de)	2006-04-15
CO5190668A1 (es)	2002-08-29
HUP0104412A2 (hu)	2002-04-29
CA2348876A1 (en)	2000-06-02
JP2002530338A (ja)	2002-09-17
NO20012526L (no)	2001-05-23
PE20001326A1 (es)	2000-12-12
YU34601A (sh)	2004-09-03
DE69935609D1 (de)	2007-05-03
TR200101417T2 (tr)	2001-11-21
AU1654400A (en)	2000-06-13
SI1133298T1 (sl)	2007-10-31
AR021405A1 (es)	2002-07-17
EP1133298A1 (de)	2001-09-19
WO2000030647A1 (en)	2000-06-02
EP1133298B1 (de)	2007-03-21
NO20012526D0 (no)	2001-05-23
NZ511588A (en)	2003-08-29
DE69935609T2 (de)	2007-12-06
ATE357237T1 (de)	2007-04-15
HUP0104412A3 (en)	2002-08-28
ATA198998A (de)	2005-09-15
CZ20011845A3 (cs)	2001-08-15
TWI229603B (en)	2005-03-21
BR9915694A (pt)	2001-08-14
IL142762A0 (en)	2002-03-10
MY129564A (en)	2007-04-30
ZA200103927B (en)	2002-05-15
PL348744A1 (en)	2002-06-03
RU2248794C2 (ru)	2005-03-27
CN1330546A (zh)	2002-01-09

Publication	Publication Date	Title
CA2258841C (en)	2006-05-30	Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug
KR100767928B1 (ko)	2007-10-17	활성 성분의 맛이 차폐되고 활성 성분이 즉시 방출되는 코팅된 과립의 제조 방법
CA2272586C (en)	2005-11-22	Rapidly disintegrable pharmaceutical composition
EP1341527B1 (de)	2011-08-10	Pharmazeutische zubereitung mit einem auf einer matrix dispergierten wirkstoff
US20220105131A1 (en)	2022-04-07	Pharmaceutical compositions
AU759517B2 (en)	2003-04-17	Compositions comprising cefuroxime axetil
TWI228414B (en)	2005-03-01	Pharmaceutical composition comprising carvedilol and hydrochlorothiazide, solid dosage form comprising it, and process for the production of the same
UA81781C2 (uk)	2008-02-11	Фармацевтична композиція, яка включає телмісартан, спосіб її одержання (варіанти), двошарова фармацевтична таблетка та спосіб її одержання
HU226492B1 (en)	2009-03-02	Enteric coated pharmaceutical tablet containing didanoside
CZ20021765A3 (cs)	2002-08-14	Způsob potahování jader tablet a tablety tímto způsobem získané
JPH05246861A (ja)	1993-09-24	ポリカルボフィルカルシウム含有製剤
CA2253769C (en)	2000-09-26	Pharmaceutical compositions comprising fenofibrate
KR0133526B1 (ko)	1998-04-23	Nb-818의 용이흡수성 약제
KR20000015865A (ko)	2000-03-15	칼륨, 나트륨 및 트리스옥사프로진염의 약학적 제제
JP3836893B2 (ja)	2006-10-25	ポリカルボフィルカルシウム含有製剤
JP2000516601A (ja)	2000-12-12	水溶性化合物及びセルロースを含有する粒状物
WO1999020277A1 (en)	1999-04-29	Rapidly soluble drug composition
KR100464210B1 (ko)	2005-01-03	세푸록심 악세틸 함유 약제학적 조성물 및 그의 제조방법
MXPA01005274A (en)	2002-03-26	Compositions comprising cefuroxime axetil
AU3341301A (en)	2001-06-14	Pharmaceutical formulations comprising amoxocyllin and clavulanate