SK7652003A3 - Therapeutic combination of amlodipine and benazepril - Google Patents

Therapeutic combination of amlodipine and benazepril Download PDF

Info

Publication number: SK7652003A3
Authority: SK; Slovakia
Prior art keywords: amlodipine; benazepril; pharmaceutically acceptable; acceptable salt; amount
Prior art date: 2000-12-18

Application number

SK765-2003A

Other languages

English (en)

Slovak (sk)

Inventor

William Lionel Daley

Randy Lee Webb

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-18

Filing date

2000-12-18

Publication date

2003-12-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21742073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK7652003(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-12-18 Application filed by Novartis Ag filed Critical Novartis Ag

2003-12-02 Publication of SK7652003A3 publication Critical patent/SK7652003A3/sk

Links

HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title claims abstract description 102
229960000528 amlodipine Drugs 0.000 title claims abstract description 96
XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 title claims abstract description 75
229960004530 benazepril Drugs 0.000 title claims abstract description 67
230000001225 therapeutic effect Effects 0.000 title description 3
150000003839 salts Chemical class 0.000 claims abstract description 62
VPSRQEHTHIMDQM-FKLPMGAJSA-N benazepril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 VPSRQEHTHIMDQM-FKLPMGAJSA-N 0.000 claims abstract description 26
229960003619 benazepril hydrochloride Drugs 0.000 claims abstract description 25
239000005541 ACE inhibitor Substances 0.000 claims abstract description 21
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims abstract description 21
MADRIHWFJGRSBP-ROUUACIJSA-N benazeprilat Chemical compound C([C@H](N[C@H]1CCC2=CC=CC=C2N(C1=O)CC(=O)O)C(O)=O)CC1=CC=CC=C1 MADRIHWFJGRSBP-ROUUACIJSA-N 0.000 claims abstract description 18
206010020772 Hypertension Diseases 0.000 claims abstract description 17
229960004067 benazeprilat Drugs 0.000 claims abstract description 17
239000012458 free base Substances 0.000 claims abstract description 16
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239000008194 pharmaceutical composition Substances 0.000 claims description 14
239000002552 dosage form Substances 0.000 claims description 13
ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical group OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 claims description 10
229960004005 amlodipine besylate Drugs 0.000 claims description 10
201000001320 Atherosclerosis Diseases 0.000 claims description 9
238000011161 development Methods 0.000 claims description 9
208000026106 cerebrovascular disease Diseases 0.000 claims description 8
238000009472 formulation Methods 0.000 claims description 7
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206010020880 Hypertrophy Diseases 0.000 claims 1
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201000010099 disease Diseases 0.000 abstract description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
230000002265 prevention Effects 0.000 abstract description 3
239000004480 active ingredient Substances 0.000 description 16
230000000694 effects Effects 0.000 description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
229940127291 Calcium channel antagonist Drugs 0.000 description 8
150000001875 compounds Chemical class 0.000 description 7
230000035487 diastolic blood pressure Effects 0.000 description 7
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239000000902 placebo Substances 0.000 description 5
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230000035488 systolic blood pressure Effects 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
241000124008 Mammalia Species 0.000 description 3
239000000480 calcium channel blocker Substances 0.000 description 3
230000001684 chronic effect Effects 0.000 description 3
239000008187 granular material Substances 0.000 description 3
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QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 description 2
101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
239000002220 antihypertensive agent Substances 0.000 description 2
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SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 1
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
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208000007530 Essential hypertension Diseases 0.000 description 1
206010049694 Left Ventricular Dysfunction Diseases 0.000 description 1
206010024119 Left ventricular failure Diseases 0.000 description 1
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241000288906 Primates Species 0.000 description 1
208000000924 Right ventricular hypertrophy Diseases 0.000 description 1
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239000002253 acid Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
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230000003276 anti-hypertensive effect Effects 0.000 description 1
210000002565 arteriole Anatomy 0.000 description 1
230000037396 body weight Effects 0.000 description 1
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
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238000007796 conventional method Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
230000010339 dilation Effects 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
210000002683 foot Anatomy 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
229940031705 hydroxypropyl methylcellulose 2910 Drugs 0.000 description 1
230000001631 hypertensive effect Effects 0.000 description 1
229940102223 injectable solution Drugs 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
229960001021 lactose monohydrate Drugs 0.000 description 1
229940080268 lotensin Drugs 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
150000002688 maleic acid derivatives Chemical class 0.000 description 1
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229940036132 norvasc Drugs 0.000 description 1
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235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
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229940068968 polysorbate 80 Drugs 0.000 description 1
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238000002360 preparation method Methods 0.000 description 1
230000029865 regulation of blood pressure Effects 0.000 description 1
230000036454 renin-angiotensin system Effects 0.000 description 1
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JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SK765-2003A 2000-12-18 2000-12-18 Therapeutic combination of amlodipine and benazepril SK7652003A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2000/034246 WO2002049645A1 (en)	2000-12-18	2000-12-18	Therapeutic combination of amlodipine and benazepril

Publications (1)

Publication Number	Publication Date
SK7652003A3 true SK7652003A3 (en)	2003-12-02

Family

ID=21742073

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SK765-2003A SK7652003A3 (en)	2000-12-18	2000-12-18	Therapeutic combination of amlodipine and benazepril
SK764-2003A SK7642003A3 (en)	2000-12-18	2001-12-17	Therapeutic combination of amlodipine and benazepril/benazeprilat

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SK764-2003A SK7642003A3 (en)	2000-12-18	2001-12-17	Therapeutic combination of amlodipine and benazepril/benazeprilat

Country Status (26)

Country	Link
EP (3)	EP1365761A1 (cs)
JP (3)	JP2004516266A (cs)
KR (3)	KR20040007420A (cs)
CN (2)	CN1461218A (cs)
AT (1)	ATE338549T1 (cs)
AU (4)	AU2001225816B2 (cs)
BR (2)	BR0017386A (cs)
CA (2)	CA2432638A1 (cs)
CY (1)	CY1106275T1 (cs)
CZ (2)	CZ20031678A3 (cs)
DE (1)	DE60122928T2 (cs)
DK (1)	DK1345607T3 (cs)
EC (1)	ECSP034658A (cs)
ES (1)	ES2272565T3 (cs)
HU (2)	HUP0302455A3 (cs)
IL (4)	IL156136A0 (cs)
MX (2)	MXPA03005462A (cs)
NO (2)	NO20032766L (cs)
NZ (1)	NZ526467A (cs)
PL (2)	PL362252A1 (cs)
PT (1)	PT1345607E (cs)
RU (1)	RU2292206C2 (cs)
SI (1)	SI1345607T1 (cs)
SK (2)	SK7652003A3 (cs)
WO (2)	WO2002049645A1 (cs)
ZA (1)	ZA200304514B (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA04004844A (es) *	2001-11-23	2004-07-30	Solvay Pharm Gmbh	Tratamiento de hipertonia durante la fase aguda de un accidente cerebrobascular.
US20040229901A1 (en) *	2003-02-24	2004-11-18	Lauren Otsuki	Method of treatment of disease using an adenosine A1 receptor antagonist
CA2522971A1 (en)	2003-04-25	2004-11-11	Novacardia, Inc.	Method of improved diuresis in individuals with impaired renal function
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2000
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2001
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2003
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2006
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2008
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Publication number	Publication date
DE60122928D1 (de)	2006-10-19
MXPA03005463A (es)	2003-09-25
HUP0302456A3 (en)	2004-05-28
ATE338549T1 (de)	2006-09-15
NO20032766D0 (no)	2003-06-17
EP1345607A1 (en)	2003-09-24
PT1345607E (pt)	2007-01-31
IL190802A0 (en)	2008-11-03
EP1674099A1 (en)	2006-06-28
ECSP034658A (es)	2003-07-25
JP2004519440A (ja)	2004-07-02
PL360989A1 (en)	2004-09-20
ES2272565T3 (es)	2007-05-01
AU2581601A (en)	2002-07-01
BR0116228A (pt)	2003-12-30
CZ20031677A3 (cs)	2003-10-15
NO20032766L (no)	2003-08-14
NZ526467A (en)	2005-04-29
BR0017386A (pt)	2004-01-13
NO20032765L (no)	2003-08-14
PL362252A1 (en)	2004-10-18
SI1345607T1 (sl)	2007-02-28
AU2002232620B2 (en)	2005-11-03
IL190801A0 (en)	2008-11-03
CN1481241A (zh)	2004-03-10
SK7642003A3 (en)	2003-11-04
CN1461218A (zh)	2003-12-10
IL156136A0 (en)	2003-12-23
HUP0302456A2 (hu)	2003-11-28
JP2010043111A (ja)	2010-02-25
EP1345607B1 (en)	2006-09-06
JP2004516266A (ja)	2004-06-03
CA2432638A1 (en)	2002-06-27
CZ301424B6 (cs)	2010-02-24
CA2432282A1 (en)	2002-06-27
DK1345607T3 (da)	2006-12-27
WO2002049645A1 (en)	2002-06-27
RU2292206C2 (ru)	2007-01-27
AU3262002A (en)	2002-07-01
HUP0302455A2 (hu)	2003-11-28
CY1106275T1 (el)	2011-10-12
CZ20031678A3 (cs)	2003-10-15
WO2002049646A1 (en)	2002-06-27
ZA200304514B (en)	2004-05-10
HK1059566A1 (en)	2004-07-09
KR20040007420A (ko)	2004-01-24
DE60122928T2 (de)	2007-09-06
AU2002232620B9 (en)	2005-11-24
IL156267A0 (en)	2004-01-04
KR20090033914A (ko)	2009-04-06
NO20032765D0 (no)	2003-06-17
AU2001225816B2 (en)	2005-10-13
HUP0302455A3 (en)	2005-05-30
MXPA03005462A (es)	2003-09-25
EP1365761A1 (en)	2003-12-03
RU2003121019A (ru)	2005-01-20
KR20030061840A (ko)	2003-07-22

Legal Events

Date	Code	Title	Description
2010-04-07	FC9A	Refused patent application

Publication	Publication Date	Title
SK7652003A3 (en)	2003-12-02	Therapeutic combination of amlodipine and benazepril
CZ117396A3 (en)	1996-09-11	Novel pharmaceutical composition containing ace inhibitor ramipril and dyhydropyridine compound
SK14642002A3 (sk)	2003-05-02	Kombinované farmaceutické prostriedky obsahujúce antagonistu AT1-receptora a/alebo inhibítor HMG-CoA reduktázy a/alebo ACE inhibítor
US6162802A (en)	2000-12-19	Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor
US7560446B2 (en)	2009-07-14	Use of angiotensin II receptor antagonists for treating acute myocardial infarction
RU2182002C2 (ru)	2002-05-10	Композиция с фиксированной дозой ингибитора ангиотензин-превращающего фермента и антагониста кальциевых каналов, способ ее изготовления и применение для лечения сердечно-сосудистых заболеваний
US20080287412A1 (en)	2008-11-20	Therapeutic combination of amlodipine and benazepril/benazeprilat
US20040048905A1 (en)	2004-03-11	Therapeutic combination of amlodipine and benazepril
NZ526385A (en)	2005-04-29	High dose therapeutic combination of amlodipine and benazepril
ZA200304330B (en)	2005-02-23	Therapeutic combination of amlodipine and benazepril.
HK1094147A (en)	2007-03-23	Therapeutic combination of amlodipine and benazepril/benazeprilat
HK1059566B (en)	2007-03-23	Therapeutic combination of amlodipine and benazepril/benazeprilat