SK8082003A3 - Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives - Google Patents

Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives Download PDF

Info

Publication number: SK8082003A3
Authority: SK; Slovakia
Prior art keywords: pyrimidin; hal; group; chloro; pharmaceutical composition
Prior art date: 2000-12-19

Application number

SK808-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Hans-Michael Eggenweiler

Volker Eiermann

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-19

Filing date

2001-11-28

Publication date

2003-10-07

2000-12-19 Priority claimed from DE2000163223 external-priority patent/DE10063223A1/de

2000-12-21 Priority claimed from DE2000163885 external-priority patent/DE10063885A1/de

2000-12-23 Priority claimed from DE2000164992 external-priority patent/DE10064992A1/de

2001-11-28 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-10-07 Publication of SK8082003A3 publication Critical patent/SK8082003A3/sk

Links

150000003180 prostaglandins Chemical class 0.000 title claims abstract description 79
229940127291 Calcium channel antagonist Drugs 0.000 title claims abstract description 44
230000002785 anti-thrombosis Effects 0.000 title claims abstract description 31
239000008194 pharmaceutical composition Substances 0.000 title claims description 66
229960004676 antithrombotic agent Drugs 0.000 title claims description 11
229940094443 oxytocics prostaglandins Drugs 0.000 title description 6
150000001875 compounds Chemical group 0.000 claims abstract description 101
150000003839 salts Chemical class 0.000 claims abstract description 60
239000012453 solvate Substances 0.000 claims abstract description 46
239000000480 calcium channel blocker Substances 0.000 claims abstract description 31
239000003146 anticoagulant agent Substances 0.000 claims abstract description 29
206010019280 Heart failures Diseases 0.000 claims abstract description 20
239000003814 drug Substances 0.000 claims abstract description 18
206010007559 Cardiac failure congestive Diseases 0.000 claims abstract description 14
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206010039163 Right ventricular failure Diseases 0.000 claims abstract description 9
208000002815 pulmonary hypertension Diseases 0.000 claims abstract description 8
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-1 COOA Chemical group 0.000 claims description 132
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 68
125000004432 carbon atom Chemical group C* 0.000 claims description 62
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 54
125000000896 monocarboxylic acid group Chemical group 0.000 claims description 42
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 40
239000000460 chlorine Substances 0.000 claims description 39
229910052801 chlorine Inorganic materials 0.000 claims description 39
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FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 35
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KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims description 21
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JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 claims description 2
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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
150000003577 thiophenes Chemical class 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
208000019553 vascular disease Diseases 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

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- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/12—Antihypertensives
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Oncology (AREA)
Obesity (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Pregnancy & Childbirth (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

SK808-2003A 2000-12-19 2001-11-28 Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives SK8082003A3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE2000163223 DE10063223A1 (de)	2000-12-19	2000-12-19	Pharmazeutische Formulierung enthaltend Thienopyrimidine und Antithrombotica (1)
DE2000163885 DE10063885A1 (de)	2000-12-21	2000-12-21	Pharmazeutische Formulierung enthaltend Thienopyrimidine und Calcium-Antagonisten (1)
DE2000164992 DE10064992A1 (de)	2000-12-23	2000-12-23	Pharmazeutische Formulierung enthaltend Thienopyrimidine und Prostaglandine oder Prostaglandinderivate (1)
PCT/EP2001/013915 WO2002049650A2 (de)	2000-12-19	2001-11-28	Pharmazeutische formulierung enthaltend thienopyrimidine und antithrombotica, calcium-antagonisten, prostaglandine oder prostaglandinderivate

Publications (1)

Publication Number	Publication Date
SK8082003A3 true SK8082003A3 (en)	2003-10-07

Family

ID=27214207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK808-2003A SK8082003A3 (en)	2000-12-19	2001-11-28	Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives

Country Status (16)

Country	Link
US (1)	US20040072846A1 (cs)
EP (1)	EP1347761A2 (cs)
JP (1)	JP2004516269A (cs)
KR (1)	KR20030059351A (cs)
CN (1)	CN1481242A (cs)
AR (1)	AR032009A1 (cs)
AU (1)	AU2002227957A1 (cs)
BR (1)	BR0116255A (cs)
CA (1)	CA2431074A1 (cs)
CZ (1)	CZ20031754A3 (cs)
HU (1)	HUP0303289A2 (cs)
MX (1)	MXPA03005405A (cs)
NO (1)	NO20032772D0 (cs)
PL (1)	PL361805A1 (cs)
SK (1)	SK8082003A3 (cs)
WO (1)	WO2002049650A2 (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0216027D0 (en)	2002-07-10	2002-08-21	Arachnova Therapeutics Ltd	New therapeutic use
US20050107394A1 (en) *	2001-12-17	2005-05-19	Ardeschir Ghofrani	Novel use of selective pde5 inhibitors
WO2004110354A2 (en) *	2003-05-15	2004-12-23	Roskamp Research, Llc	Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis
EP2236136A1 (en) *	2005-05-17	2010-10-06	Santen Pharmaceutical Co., Ltd.	Angiogenesis inhibitor containing amine derivate as active ingredient
US20090088472A1 (en) *	2005-05-17	2009-04-02	Kouji Oohashi	Protective Agent for Neuronal Cell Comprising Amidino Derivative as Active Ingredient
JP2006348024A (ja) *	2005-05-17	2006-12-28	Santen Pharmaceut Co Ltd	アミジノ誘導体を有効成分として含む神経細胞の保護剤
CN101883564B (zh) *	2007-10-05	2013-10-16	阿尔茨海默病学会美国公司	使用(-)-尼伐地平对映体减少淀粉状蛋白沉积、淀粉状蛋白神经毒性和小神经胶质增生的方法
US20100093810A1 (en) *	2007-10-05	2010-04-15	Alzheimer's Institute Of America, Inc.	Pharmaceutical Compositions for Reducing Amyloid Deposition, Amyloid Neurotoxicity, and Microgliosis
CN102271685A (zh) *	2008-12-30	2011-12-07	斯若姆博洛捷克有限公司	鉴定发展成器官功能衰竭的风险提高的危重患者的方法及用于其治疗的化合物
US9056877B2 (en)	2011-07-19	2015-06-16	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
KR101643041B1 (ko) *	2014-04-25	2016-07-28	아주대학교산학협력단	프로테아좀 저해제 및 디히드로피리딘계 화합물을 유효성분으로 함유하는 암의 예방 또는 치료용 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2353285A1 (fr) *	1975-09-17	1977-12-30	Doms Laboratoires	Medicament vasodilatateur coronarien perfectionne
JPS5459266A (en) *	1977-10-14	1979-05-12	Ono Pharmaceut Co Ltd	Prostaglandin i2 analogs and their preparation
FR2568774B2 (fr) *	1984-05-30	1989-05-19	Choay Sa	Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
FR2672601B1 (fr) *	1991-02-08	1994-10-14	Synthelabo	Derives de benzo-1,5-thiazepine, leur preparation et leur application en therapeutique.
US6143746A (en) *	1994-01-21	2000-11-07	Icos Corporation	Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
AU734734B2 (en) *	1997-10-28	2001-06-21	Vivus, Inc.	Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
DE19752952A1 (de) *	1997-11-28	1999-06-02	Merck Patent Gmbh	Thienopyrimidine

2001
- 2001-11-28 AU AU2002227957A patent/AU2002227957A1/en not_active Abandoned
- 2001-11-28 KR KR10-2003-7008155A patent/KR20030059351A/ko not_active Withdrawn
- 2001-11-28 BR BR0116255-1A patent/BR0116255A/pt not_active Application Discontinuation
- 2001-11-28 EP EP01989533A patent/EP1347761A2/de not_active Withdrawn
- 2001-11-28 CN CNA018208207A patent/CN1481242A/zh active Pending
- 2001-11-28 CA CA002431074A patent/CA2431074A1/en not_active Abandoned
- 2001-11-28 JP JP2002550990A patent/JP2004516269A/ja active Pending
- 2001-11-28 US US10/451,118 patent/US20040072846A1/en not_active Abandoned
- 2001-11-28 CZ CZ20031754A patent/CZ20031754A3/cs unknown
- 2001-11-28 MX MXPA03005405A patent/MXPA03005405A/es unknown
- 2001-11-28 WO PCT/EP2001/013915 patent/WO2002049650A2/de not_active Ceased
- 2001-11-28 HU HU0303289A patent/HUP0303289A2/hu unknown
- 2001-11-28 PL PL01361805A patent/PL361805A1/xx unknown
- 2001-11-28 SK SK808-2003A patent/SK8082003A3/sk unknown
- 2001-12-19 AR ARP010105887A patent/AR032009A1/es not_active Application Discontinuation
2003
- 2003-06-18 NO NO20032772A patent/NO20032772D0/no unknown

Also Published As

Publication number	Publication date
KR20030059351A (ko)	2003-07-07
CN1481242A (zh)	2004-03-10
WO2002049650A3 (de)	2002-10-31
NO20032772L (no)	2003-06-18
JP2004516269A (ja)	2004-06-03
CZ20031754A3 (cs)	2003-09-17
AR032009A1 (es)	2003-10-22
PL361805A1 (en)	2004-10-04
MXPA03005405A (es)	2003-09-25
CA2431074A1 (en)	2002-06-27
AU2002227957A1 (en)	2002-07-01
NO20032772D0 (no)	2003-06-18
BR0116255A (pt)	2003-12-30
HUP0303289A2 (hu)	2004-01-28
WO2002049650A2 (de)	2002-06-27
EP1347761A2 (de)	2003-10-01
US20040072846A1 (en)	2004-04-15

Publication	Publication Date	Title
SK8192003A3 (en)	2003-10-07	Pharmaceutical formulation containing pyrazolo[4,3-d]pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives
SK7352003A3 (en)	2003-11-04	Use of thienopyrimidines
AU742433B2 (en)	2002-01-03	Thienopyrimidines
JP4550361B2 (ja)	2010-09-22	スルファミドチエノピリミジン
JP2004516269A (ja)	2004-06-03	チエノピリミジンおよび抗血栓剤、カルシウム拮抗剤、プロスタグランジンまたはプロスタグランジン誘導体を含有する医薬製剤
SK8032003A3 (en)	2003-11-04	Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives
AU2001237379B2 (en)	2005-05-05	Use of benzothieno-2,3-D-pyrimidines with PDE V inhibitory effect for the treatment of erectile dysfunction
KR20020026011A (ko)	2002-04-04	티에노피리미딘의 용도
DE10063223A1 (de)	2002-06-20	Pharmazeutische Formulierung enthaltend Thienopyrimidine und Antithrombotica (1)
ZA200305548B (en)	2005-01-26	Pharmaceutical formulation containing thienopyrimidines and antithrombotics calcium antagonists prostaglandins or prostaglandin derivatives (2)
DE10063221A1 (de)	2002-06-20	Pharmazeutische Formulierung enthaltend Thienopyrimidine und Antithrombotica (2)
DE10063224A1 (de)	2002-06-20	Pharmazeutische Formulierung enthaltend Pyrazolo(4,3-d)pyrimidine und Antithrombotica