SMT201700377T1 - Polimorfi anidri di (2r,3s,4r,5r)-5-(6-(ciclopentilammino)-9h-purin-9-il)-3,4- diidrossitetraidrofuran-2-il)}metil nitrato e processi di sua preparazione - Google Patents

Polimorfi anidri di (2r,3s,4r,5r)-5-(6-(ciclopentilammino)-9h-purin-9-il)-3,4- diidrossitetraidrofuran-2-il)}metil nitrato e processi di sua preparazione

Info

Publication number
SMT201700377T1
SMT201700377T1 SM20170377T SMT201700377T SMT201700377T1 SM T201700377 T1 SMT201700377 T1 SM T201700377T1 SM 20170377 T SM20170377 T SM 20170377T SM T201700377 T SMT201700377 T SM T201700377T SM T201700377 T1 SMT201700377 T1 SM T201700377T1
Authority
SM
San Marino
Prior art keywords
dihydroxytetrahydrofuran
cyclopentylamino
purin
processes
preparation
Prior art date
Application number
SM20170377T
Other languages
English (en)
Inventor
William K Mcvicar
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Publication of SMT201700377T1 publication Critical patent/SMT201700377T1/it

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
SM20170377T 2012-01-26 2013-01-25 Polimorfi anidri di (2r,3s,4r,5r)-5-(6-(ciclopentilammino)-9h-purin-9-il)-3,4- diidrossitetraidrofuran-2-il)}metil nitrato e processi di sua preparazione SMT201700377T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591037P 2012-01-26 2012-01-26
EP13741502.2A EP2807178B9 (en) 2012-01-26 2013-01-25 Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof
PCT/US2013/023166 WO2013112850A1 (en) 2012-01-26 2013-01-25 Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof

Publications (1)

Publication Number Publication Date
SMT201700377T1 true SMT201700377T1 (it) 2017-09-07

Family

ID=48870739

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20170377T SMT201700377T1 (it) 2012-01-26 2013-01-25 Polimorfi anidri di (2r,3s,4r,5r)-5-(6-(ciclopentilammino)-9h-purin-9-il)-3,4- diidrossitetraidrofuran-2-il)}metil nitrato e processi di sua preparazione

Country Status (26)

Country Link
US (2) US9278991B2 (it)
EP (2) EP2807178B9 (it)
JP (2) JP2015508751A (it)
KR (1) KR20140128974A (it)
CN (1) CN104093731B (it)
AU (2) AU2013211957B2 (it)
BR (1) BR112014018413A8 (it)
CA (1) CA2861009A1 (it)
CY (1) CY1119271T1 (it)
DK (1) DK2807178T3 (it)
EA (1) EA027109B1 (it)
ES (1) ES2637332T3 (it)
HR (1) HRP20171204T1 (it)
HU (1) HUE035750T2 (it)
IL (1) IL233812A0 (it)
IN (1) IN2014DN05987A (it)
LT (1) LT2807178T (it)
MX (1) MX2014009086A (it)
NZ (1) NZ627778A (it)
PL (1) PL2807178T3 (it)
PT (1) PT2807178T (it)
RS (1) RS56150B1 (it)
SG (2) SG10201701343QA (it)
SI (1) SI2807178T1 (it)
SM (1) SMT201700377T1 (it)
WO (1) WO2013112850A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011230580A1 (en) 2010-03-26 2012-10-11 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using N6 -cyclopentyladenosine (CPA), CPA derivatives or prodrugs thereof
PL2807178T3 (pl) 2012-01-26 2017-12-29 Inotek Pharmaceuticals Corporation Bezwodne polimorfy azotanu (2R,3S,4R,5R)-5-(6-(cyklopentyloamino)-9H-puryn-9-ylo)-3,4-dihydroksytetrahydrofuran-2-ylo)metylu i sposoby ich wytwarzania
WO2014152723A1 (en) * 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations

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Also Published As

Publication number Publication date
HRP20171204T1 (hr) 2017-10-06
SG10201701343QA (en) 2017-04-27
EP2807178B1 (en) 2017-05-17
SI2807178T1 (sl) 2017-09-29
EA201491393A1 (ru) 2015-01-30
US9718853B2 (en) 2017-08-01
EA027109B1 (ru) 2017-06-30
CN104093731A (zh) 2014-10-08
JP2018024636A (ja) 2018-02-15
ES2637332T3 (es) 2017-10-11
US20160137686A1 (en) 2016-05-19
CA2861009A1 (en) 2013-08-01
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HUE035750T2 (en) 2018-05-28
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KR20140128974A (ko) 2014-11-06
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