SMT201800155T1 - Derivato pirazinico - Google Patents

Derivato pirazinico

Info

Publication number
SMT201800155T1
SMT201800155T1 SM20180155T SMT201800155T SMT201800155T1 SM T201800155 T1 SMT201800155 T1 SM T201800155T1 SM 20180155 T SM20180155 T SM 20180155T SM T201800155 T SMT201800155 T SM T201800155T SM T201800155 T1 SMT201800155 T1 SM T201800155T1
Authority
SM
San Marino
Prior art keywords
pyrazine derivative
pyrazine
derivative
Prior art date
Application number
SM20180155T
Other languages
English (en)
Inventor
Akinobu Maruyama
Susumu Takeuchi
Yoshimasa Takahashi
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of SMT201800155T1 publication Critical patent/SMT201800155T1/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
SM20180155T 2014-05-13 2015-05-12 Derivato pirazinico SMT201800155T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014099677 2014-05-13
EP15792266.7A EP3144306B1 (en) 2014-05-13 2015-05-12 Pyrazine derivative
PCT/JP2015/063654 WO2015174417A1 (ja) 2014-05-13 2015-05-12 ピラジン誘導体

Publications (1)

Publication Number Publication Date
SMT201800155T1 true SMT201800155T1 (it) 2018-05-02

Family

ID=54479954

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20180155T SMT201800155T1 (it) 2014-05-13 2015-05-12 Derivato pirazinico

Country Status (28)

Country Link
US (1) US9856237B2 (it)
EP (1) EP3144306B1 (it)
JP (1) JP6173576B2 (it)
KR (1) KR20170004998A (it)
CN (1) CN106458998A (it)
AR (1) AR100403A1 (it)
AU (1) AU2015260300A1 (it)
CA (1) CA2948797A1 (it)
CY (1) CY1119876T1 (it)
DK (1) DK3144306T3 (it)
ES (1) ES2654434T3 (it)
HR (1) HRP20180122T1 (it)
HU (1) HUE035728T2 (it)
IL (1) IL248900A0 (it)
LT (1) LT3144306T (it)
ME (1) ME02978B (it)
MX (1) MX2016014693A (it)
NO (1) NO3144306T3 (it)
PH (1) PH12016502223A1 (it)
PL (1) PL3144306T3 (it)
PT (1) PT3144306T (it)
RS (1) RS56837B1 (it)
RU (1) RU2016148735A (it)
SG (1) SG11201609359WA (it)
SI (1) SI3144306T1 (it)
SM (1) SMT201800155T1 (it)
TW (1) TW201609702A (it)
WO (1) WO2015174417A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111943957B (zh) * 2019-05-17 2023-01-06 中国医学科学院药物研究所 喹啉甲酰胺类化合物及其制备方法和用途
CN116496198A (zh) * 2023-06-26 2023-07-28 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) 一种4-羟基-2'-(1-苄基-5-硝基吡咯甲叉)-苯甲酰肼衍生物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5576498A (en) * 1997-02-05 1998-08-26 Sankyo Company Limited Prophylactic or therapeutic agent for diabetic complication
JP4397875B2 (ja) 1997-02-05 2010-01-13 第一三共株式会社 糖尿病合併症予防薬又は治療薬
CN100395234C (zh) * 2003-01-02 2008-06-18 霍夫曼-拉罗奇有限公司 新cb1受体反激动剂
JP2007145786A (ja) * 2005-11-30 2007-06-14 Toray Ind Inc ピラジン誘導体及びそれを有効成分とする腎炎治療薬
MX2009010491A (es) * 2007-04-11 2009-11-09 Kissei Pharmaceutical Derivado heterociclico de 5 miembros y su uso para propositos medicos.
AR081930A1 (es) * 2010-06-16 2012-10-31 Ardea Biosciences Inc Compuestos de tioacetato
EP2944633B1 (en) * 2012-11-14 2018-01-31 Teijin Pharma Limited Pyridine derivative

Also Published As

Publication number Publication date
CY1119876T1 (el) 2018-06-27
US9856237B2 (en) 2018-01-02
SG11201609359WA (en) 2016-12-29
TW201609702A (zh) 2016-03-16
SI3144306T1 (en) 2018-02-28
ES2654434T3 (es) 2018-02-13
ME02978B (me) 2018-10-20
IL248900A0 (en) 2017-01-31
PH12016502223A1 (en) 2017-02-06
MX2016014693A (es) 2017-02-23
KR20170004998A (ko) 2017-01-11
EP3144306A4 (en) 2017-03-22
JP6173576B2 (ja) 2017-08-02
HUE035728T2 (en) 2018-05-28
WO2015174417A1 (ja) 2015-11-19
EP3144306A1 (en) 2017-03-22
PL3144306T3 (pl) 2018-04-30
AR100403A1 (es) 2016-10-05
JPWO2015174417A1 (ja) 2017-04-20
PT3144306T (pt) 2018-01-08
EP3144306B1 (en) 2017-11-15
HRP20180122T1 (hr) 2018-02-23
RU2016148735A3 (it) 2018-06-19
LT3144306T (lt) 2018-01-10
AU2015260300A1 (en) 2016-12-22
RS56837B1 (sr) 2018-04-30
US20170152242A1 (en) 2017-06-01
CN106458998A (zh) 2017-02-22
NO3144306T3 (it) 2018-04-14
RU2016148735A (ru) 2018-06-19
CA2948797A1 (en) 2015-11-19
DK3144306T3 (en) 2018-01-02

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