SMT202000385T1 - Composizione farmaceutica iniettabile stabile di un antagonizta dei recettori della neurochinina 1 e processo per la sua preparazione - Google Patents

Composizione farmaceutica iniettabile stabile di un antagonizta dei recettori della neurochinina 1 e processo per la sua preparazione

Info

Publication number
SMT202000385T1
SMT202000385T1 SM20200385T SMT202000385T SMT202000385T1 SM T202000385 T1 SMT202000385 T1 SM T202000385T1 SM 20200385 T SM20200385 T SM 20200385T SM T202000385 T SMT202000385 T SM T202000385T SM T202000385 T1 SMT202000385 T1 SM T202000385T1
Authority
SM
San Marino
Prior art keywords
neurokinin
preparation
pharmaceutical composition
receptor antagonist
injectable pharmaceutical
Prior art date
Application number
SM20200385T
Other languages
English (en)
Inventor
Evangelos Karavas
Amalia Diakidou
Louiza Konstanti
Efthimos Koutris
Dimitrios Bikiaris
Sotiria Chatidou
Panagiotis Barmpalexis
Katerina Minioti
Original Assignee
Pharmathen Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmathen Sa filed Critical Pharmathen Sa
Publication of SMT202000385T1 publication Critical patent/SMT202000385T1/it

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015Drug-containing film-forming compositions, e.g. spray-on

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fencing (AREA)
SM20200385T 2012-07-06 2012-07-06 Composizione farmaceutica iniettabile stabile di un antagonizta dei recettori della neurochinina 1 e processo per la sua preparazione SMT202000385T1 (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2012/002854 WO2014005606A1 (en) 2012-07-06 2012-07-06 Stable injectable pharmaceutical composition of neurokinin 1 receptor antagonist and process for preparation thereof
EP12756353.4A EP2866797B1 (en) 2012-07-06 2012-07-06 Stable injectable pharmaceutical composition of neurokinin 1 receptor antagonist and process for preparation thereof

Publications (1)

Publication Number Publication Date
SMT202000385T1 true SMT202000385T1 (it) 2020-11-10

Family

ID=46826407

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20200385T SMT202000385T1 (it) 2012-07-06 2012-07-06 Composizione farmaceutica iniettabile stabile di un antagonizta dei recettori della neurochinina 1 e processo per la sua preparazione

Country Status (14)

Country Link
US (2) US20150165045A1 (it)
EP (1) EP2866797B1 (it)
CY (1) CY1123370T1 (it)
DK (1) DK2866797T3 (it)
ES (1) ES2798103T3 (it)
HR (1) HRP20201138T1 (it)
HU (1) HUE051147T2 (it)
LT (1) LT2866797T (it)
PL (1) PL2866797T3 (it)
PT (1) PT2866797T (it)
RS (1) RS60599B1 (it)
SI (1) SI2866797T1 (it)
SM (1) SMT202000385T1 (it)
WO (1) WO2014005606A1 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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JP2016532660A (ja) 2013-10-08 2016-10-20 イノファーマ インク アプレピタント経口液体製剤
EP3091977A2 (en) * 2013-12-30 2016-11-16 Oncoprevent GmbH Neurokinin-1 receptor antagonists for use in a method of prevention of cancer
EP3171894B1 (en) * 2014-07-24 2021-03-24 Plus Vitech, S.L. Neurokinin-1 receptor antagonist composition for treatment of diseases and conditions of the respiratory tract
KR102424837B1 (ko) * 2014-09-19 2022-07-25 헤론 테라퓨틱스 인코포레이티드 아프레피탄트의 에멀젼 제형
WO2017021880A1 (en) * 2015-08-03 2017-02-09 Leiutis Pharmaceuticals Pvt Ltd Liquid formulations of fosaprepitant
US9913853B2 (en) 2015-11-03 2018-03-13 Cipla Limited Stabilized liquid fosaprepitant formulations
US9974742B2 (en) 2016-02-01 2018-05-22 Heron Therapeutics, Inc. Emulsion formulations of an NK-1 receptor antagonist and uses thereof
EP3411013A1 (en) * 2016-02-01 2018-12-12 Heron Therapeutics, Inc. Emulsion comprising an nk-1 receptor antagonist
CA3025837C (en) 2016-06-06 2024-02-13 Helsinn Healthcare Sa Physiologically balanced injectable formulations of fosnetupitant
US20190175702A1 (en) * 2016-08-03 2019-06-13 Zhuhai Beihai Biotech Co., Ltd. Formulations of fosaprepitant and aprepitant
AU2019214872A1 (en) * 2018-01-30 2020-08-06 Heron Therapeutics, Inc. Method of administering emulsion formulations of an NK-1 receptor antagonist
US11654154B2 (en) 2019-01-29 2023-05-23 Navinta Iii Inc Process for preparing injectable Fosaprepitant Dimeglumine compositions having improved storage stability
CN112168788B (zh) * 2019-07-01 2022-07-19 中国医学科学院药物研究所 静脉注射用阿瑞匹坦胶束无菌冻干制剂及其制备方法
CN110559255B (zh) * 2019-09-06 2022-08-19 南京医科大学 Zl006温敏凝胶及其制备方法
JP7606633B2 (ja) * 2022-04-14 2024-12-25 ウィズダム・ファーマスーティカル・カンパニー・リミテッド 医薬組成物及びアプレピタント注射液並びに凍結乾燥粉末注射剤
CN115944745B (zh) * 2022-12-01 2024-03-22 石河子大学 一种具有聚集诱导发光性质的活性氧响应型药物控释体系及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69231395T3 (de) 1991-09-20 2005-07-21 Glaxo Group Ltd., Greenford Neue medizinische Indikation für Tachykinin-Antagonisten
IL112778A0 (en) 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US8940311B2 (en) * 2004-10-21 2015-01-27 Tae-Hong Lim In situ controlled release drug delivery system
EP1984359A1 (en) * 2006-02-03 2008-10-29 Glenmark Pharmaceuticals Limited Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
US20090285862A1 (en) * 2006-05-03 2009-11-19 Cnsbio Pty Ltd. Methods and composition for treatment of inflammatory pain
US20070265329A1 (en) 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
WO2008110534A1 (en) * 2007-03-13 2008-09-18 Sandoz Ag Pharmaceutical compositions of poorly soluble drugs
EP3090743A1 (en) * 2008-01-09 2016-11-09 Charleston Laboratories, Inc. Pharmaceutical compositions for treating headache and eliminating nausea
KR101653707B1 (ko) * 2008-05-29 2016-09-02 알바니 몰레큘라 리써치, 인크. 5-ht3 수용체 조절제, 이의 제조 방법, 및 그의 용도
CA2767576C (en) * 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
HUP1000325A2 (en) * 2010-06-18 2012-01-30 Druggability Technologies Ip Holdco Jersey Ltd Nanostructured aprepitant compositions and process for their preparation

Also Published As

Publication number Publication date
RS60599B1 (sr) 2020-08-31
EP2866797B1 (en) 2020-04-29
LT2866797T (lt) 2020-06-25
ES2798103T3 (es) 2020-12-09
PT2866797T (pt) 2020-07-22
PL2866797T3 (pl) 2020-11-02
CY1123370T1 (el) 2021-12-31
WO2014005606A1 (en) 2014-01-09
HRP20201138T1 (hr) 2020-10-30
US20200237920A1 (en) 2020-07-30
US20150165045A1 (en) 2015-06-18
HUE051147T2 (hu) 2021-03-01
SI2866797T1 (sl) 2020-08-31
EP2866797A1 (en) 2015-05-06
DK2866797T3 (da) 2020-08-03

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