SU1003755A3 - Способ получени производных 3-нитропиррола - Google Patents
Способ получени производных 3-нитропиррола Download PDFInfo
- Publication number
- SU1003755A3 SU1003755A3 SU792772805A SU2772805A SU1003755A3 SU 1003755 A3 SU1003755 A3 SU 1003755A3 SU 792772805 A SU792772805 A SU 792772805A SU 2772805 A SU2772805 A SU 2772805A SU 1003755 A3 SU1003755 A3 SU 1003755A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- nitropyrrole
- general formula
- methyl
- methylsulfinyl
- het
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- -1 methyl-4-imidazolyl- Chemical group 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 2
- 150000005244 3-nitropyrroles Chemical class 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 14
- 229960001340 histamine Drugs 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- VNHRBDZDRWBDPB-UHFFFAOYSA-N 2-methylsulfinyl-3-nitro-1h-pyrrole Chemical compound CS(=O)C=1NC=CC=1[N+]([O-])=O VNHRBDZDRWBDPB-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 241000700198 Cavia Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- OXHNLMTVIGZXSG-UHFFFAOYSA-N 1-Methylpyrrole Chemical compound CN1C=CC=C1 OXHNLMTVIGZXSG-UHFFFAOYSA-N 0.000 description 1
- VXIBHLFYGRZKLL-UHFFFAOYSA-N 2-methylsulfinyl-3-nitro-4-phenyl-1h-pyrrole Chemical compound [O-][N+](=O)C1=C(S(=O)C)NC=C1C1=CC=CC=C1 VXIBHLFYGRZKLL-UHFFFAOYSA-N 0.000 description 1
- LOJNBPNACKZWAI-UHFFFAOYSA-N 3-nitro-1h-pyrrole Chemical compound [O-][N+](=O)C=1C=CNC=1 LOJNBPNACKZWAI-UHFFFAOYSA-N 0.000 description 1
- ZXBIXOCQHMQTFW-UHFFFAOYSA-N 4-benzyl-2-methylsulfinyl-3-nitro-1h-pyrrole Chemical compound [O-][N+](=O)C1=C(S(=O)C)NC=C1CC1=CC=CC=C1 ZXBIXOCQHMQTFW-UHFFFAOYSA-N 0.000 description 1
- QZUFZEMNMNRKRW-UHFFFAOYSA-N 4-methyl-2-methylsulfinyl-3-nitro-1h-pyrrole Chemical compound CC1=CNC(S(C)=O)=C1[N+]([O-])=O QZUFZEMNMNRKRW-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000000543 Histamine Receptors Human genes 0.000 description 1
- 108010002059 Histamine Receptors Proteins 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000002837 heart atrium Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2411778 | 1978-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1003755A3 true SU1003755A3 (ru) | 1983-03-07 |
Family
ID=10206663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU792772805A SU1003755A3 (ru) | 1978-05-30 | 1979-05-29 | Способ получени производных 3-нитропиррола |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS54157556A (de) |
| AT (1) | AT375368B (de) |
| CS (1) | CS228117B2 (de) |
| HU (1) | HU180082B (de) |
| SU (1) | SU1003755A3 (de) |
| ZA (1) | ZA792607B (de) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1419994A (en) * | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
| MW5076A1 (en) * | 1975-12-29 | 1978-02-08 | Smith Kline French Lab | Pharmacologicalle active compounds |
-
1979
- 1979-05-28 ZA ZA792607A patent/ZA792607B/xx unknown
- 1979-05-29 JP JP6740079A patent/JPS54157556A/ja active Pending
- 1979-05-29 HU HUSI001695 patent/HU180082B/hu unknown
- 1979-05-29 SU SU792772805A patent/SU1003755A3/ru active
- 1979-05-30 AT AT395279A patent/AT375368B/de not_active IP Right Cessation
- 1979-05-30 CS CS372579A patent/CS228117B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATA395279A (de) | 1983-12-15 |
| AT375368B (de) | 1984-07-25 |
| JPS54157556A (en) | 1979-12-12 |
| HU180082B (hu) | 1983-01-28 |
| ZA792607B (en) | 1980-07-30 |
| CS228117B2 (cs) | 1984-05-14 |
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