SU555850A3 - Способ получени производных хиназолина - Google Patents

Способ получени производных хиназолина

Info

Publication number: SU555850A3
Authority: SU; USSR - Soviet Union
Prior art keywords: quinazoline derivatives; tetrahydro; obtaining; general formula; obtaining quinazoline
Prior art date: 1972-09-09

Application number

SU2095549A

Other languages

English (en)

Russian (ru)

Inventor

Кристофер Данилевич Джон

Эдвард Глин Кемп Джон

Роберт Райт Джеймс

Original Assignee

Пфайзер Корпорейшн (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-09-09

Filing date

1975-01-08

Publication date

1977-04-25

1975-01-08 Application filed by Пфайзер Корпорейшн (Фирма) filed Critical Пфайзер Корпорейшн (Фирма)

1977-04-25 Application granted granted Critical

1977-04-25 Publication of SU555850A3 publication Critical patent/SU555850A3/ru

Links

125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
-1 2- isoindolinyl Chemical group 0.000 description 5
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
150000003839 salts Chemical class 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
239000002253 acid Substances 0.000 description 2
235000021317 phosphate Nutrition 0.000 description 2
150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
125000005055 alkyl alkoxy group Chemical group 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-M bisulphate group Chemical group S([O-])(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
238000001816 cooling Methods 0.000 description 1
229940113088 dimethylacetamide Drugs 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
230000003993 interaction Effects 0.000 description 1
150000002688 maleic acid derivatives Chemical class 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
150000003891 oxalate salts Chemical class 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
150000003892 tartrate salts Chemical class 0.000 description 1
ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SU2095549A 1972-09-09 1975-01-08 Способ получени производных хиназолина SU555850A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB4199272A GB1383409A (en)	1972-09-09	1972-09-09	Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
SU555850A3 true SU555850A3 (ru)	1977-04-25

Family

ID=10422335

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU2095549A SU555850A3 (ru)	1972-09-09	1975-01-08	Способ получени производных хиназолина

Country Status (17)

Country	Link
US (1)	US3960861A (2)
JP (1)	JPS4985078A (2)
AR (1)	AR203373A1 (2)
AT (1)	AT330785B (2)
BE (1)	BE804558A (2)
CA (1)	CA995673A (2)
DE (2)	DE2366106C2 (2)
DK (1)	DK131725C (2)
ES (1)	ES418612A1 (2)
FR (1)	FR2198751B1 (2)
GB (1)	GB1383409A (2)
IE (1)	IE38318B1 (2)
IN (2)	IN139088B (2)
LU (1)	LU68373A1 (2)
NL (1)	NL161152C (2)
SU (1)	SU555850A3 (2)
ZA (1)	ZA735660B (2)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2296757C2 (ru) *	2002-07-05	2007-04-10	Ф.Хоффманн-Ля Рош Аг	Производные хиназолина
RU2664643C2 (ru) *	2014-01-24	2018-08-21	Ф. Хоффманн-Ля Рош Аг	Способ получения n-[(3-аминооксетан-3-ил)метил]-2-(1,1-диоксо-3,5-дигидро-1,4-бензотиазепин-4ил)-6-метил-хиназолин-4-амина

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4044136A (en) *	1972-09-09	1977-08-23	Pfizer Inc.	Aminoquinazoline therapeutic agents
US4656174A (en) *	1982-07-24	1987-04-07	Pfizer Inc.	Quinoline therapeutic agents
EP0135469B1 (de) *	1983-06-28	1987-06-16	Ciba-Geigy Ag	Chromogene Chinazolinverbindungen
CZ400992A3 (en) *	1990-11-06	1993-12-15	Pfizer	Quinazoline derivatives for enhancing anti-tumor activity
KR0144833B1 (ko) *	1992-12-28	1998-07-15	김태훈	신규의 퀴나졸린 유도체 및 그의 제조방법
DE4338396A1 (de) *	1993-11-10	1995-05-11	Basf Ag	N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
IT1286302B1 (it) *	1996-04-10	1998-07-08	Rotta Research Lab	Chinazoline-4-amino-2-(piperidino-1-il-4-sostituite) ad attivita' anti-ipertensiva, procedimento per la loro preparazione e loro uso
IN188411B (2)	1997-03-27	2002-09-21	Yuhan Corp
KR100272471B1 (ko)	1998-11-17	2000-11-15	김선진	신규의 피리미딘 유도체 및 그의 제조방법
US6900220B2 (en)	2001-01-02	2005-05-31	Syntex (U.S.A.) Llc	Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
KR20090047450A (ko) *	2006-08-04	2009-05-12	메르츠 파마 게엠베하 운트 코. 카가아	치환된 피라졸로피리미딘, 이의 제조 방법 및 의약품으로서의 이의 용도
US8871756B2 (en) *	2011-08-11	2014-10-28	Hoffmann-La Roche Inc.	Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
WO2015018797A2 (en) *	2013-08-05	2015-02-12	Haplogen Gmbh	Antiviral compounds
CN107635999B (zh)	2015-05-20	2020-09-25	豪夫迈·罗氏有限公司	用于治疗脊髓性肌萎缩的化合物
CN108290882B (zh)	2015-07-16	2021-07-06	豪夫迈·罗氏有限公司	用于治疗呼吸道合胞病毒感染的4-喹唑啉胺衍生物的晶形
EA036399B1 (ru)	2015-11-12	2020-11-06	Ф. Хоффманн-Ля Рош Аг	Композиции для лечения спинальной мышечной атрофии
EA201800367A1 (ru)	2015-12-10	2019-02-28	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Способы лечения болезни хантингтона
WO2017097728A1 (en)	2015-12-10	2017-06-15	F. Hoffmann-La Roche Ag	Bridged piperidine derivatives
FR3061494B1 (fr)	2016-12-29	2020-07-03	Arkema France	Procede de synthese de dithiocarbamates cycliques fonctionnalises
EP3634953B1 (en)	2017-06-05	2024-01-03	PTC Therapeutics, Inc.	Compounds for treating huntington's disease
CN111182898B (zh)	2017-06-28	2024-04-16	Ptc医疗公司	用于治疗亨廷顿氏病的方法
MX2019015580A (es)	2017-06-28	2020-07-28	Ptc Therapeutics Inc	Metodos para tratar la enfermedad de huntington.
EA202092001A1 (ru)	2018-03-27	2021-01-29	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Соединения для лечения болезни гентингтона
WO2020005877A1 (en)	2018-06-27	2020-01-02	Ptc Therapeutics, Inc.	Heteroaryl compounds for treating huntington's disease
EP3814360B8 (en)	2018-06-27	2024-11-06	PTC Therapeutics, Inc.	Heteroaryl compounds for treating huntington's disease
HRP20240935T1 (hr)	2018-06-27	2024-11-22	Ptc Therapeutics, Inc.	Heterociklični i heteroaril spojevi za liječenje huntingtonove bolesti
JP7649257B2 (ja)	2019-05-13	2025-03-19	ピーティーシーセラピューティクス，インコーポレイテッド	ハンチントン病を処置するための化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2945859A (en) *		1960-07-19		Diaminoquinazolines and method of
BE501634A (2) *	1950-03-02
US3155572A (en) *	1959-04-13	1964-11-03	Merck & Co Inc	Compositions and methods for treating coccidiosis
GB1062357A (en) *	1965-03-23	1967-03-22	Pfizer & Co C	Quinazolone derivatives
GB1131126A (en) *	1966-03-10	1968-10-23	Pfizer Ltd	2-vinyl-1,4-dihydroquinazoline derivatives
US3511836A (en) *	1967-12-13	1970-05-12	Pfizer & Co C	2,4,6,7-tetra substituted quinazolines
US3637701A (en) *	1969-03-03	1972-01-25	Sandoz Ag	Certain nitrate derivatives of 4-aminoquinazolines
US3635979A (en) *	1969-09-29	1972-01-18	Pfizer	Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
US3669968A (en) *	1970-05-21	1972-06-13	Pfizer	Trialkoxy quinazolines

1972
- 1972-09-09 GB GB4199272A patent/GB1383409A/en not_active Expired
1973
- 1973-08-20 ZA ZA735660A patent/ZA735660B/xx unknown
- 1973-08-21 IN IN1920/CAL/73A patent/IN139088B/en unknown
- 1973-08-30 DK DK478273*A patent/DK131725C/da active
- 1973-08-31 CA CA180,089A patent/CA995673A/en not_active Expired
- 1973-09-03 AR AR249880A patent/AR203373A1/es active
- 1973-09-03 IE IE1560/73A patent/IE38318B1/xx unknown
- 1973-09-04 JP JP48098934A patent/JPS4985078A/ja active Pending
- 1973-09-05 US US05/394,491 patent/US3960861A/en not_active Expired - Lifetime
- 1973-09-06 AT AT774573A patent/AT330785B/de active
- 1973-09-06 DE DE2366106A patent/DE2366106C2/de not_active Expired
- 1973-09-06 DE DE2345064A patent/DE2345064C3/de not_active Expired
- 1973-09-06 BE BE135402A patent/BE804558A/xx unknown
- 1973-09-07 FR FR7332315A patent/FR2198751B1/fr not_active Expired
- 1973-09-07 LU LU68373A patent/LU68373A1/xx unknown
- 1973-09-07 NL NL7312350.A patent/NL161152C/xx not_active IP Right Cessation
- 1973-09-08 ES ES418612A patent/ES418612A1/es not_active Expired
1975
- 1975-01-08 SU SU2095549A patent/SU555850A3/ru active
- 1975-07-11 IN IN1357/CAL/75A patent/IN141109B/en unknown

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2296757C2 (ru) *	2002-07-05	2007-04-10	Ф.Хоффманн-Ля Рош Аг	Производные хиназолина
RU2664643C2 (ru) *	2014-01-24	2018-08-21	Ф. Хоффманн-Ля Рош Аг	Способ получения n-[(3-аминооксетан-3-ил)метил]-2-(1,1-диоксо-3,5-дигидро-1,4-бензотиазепин-4ил)-6-метил-хиназолин-4-амина

Also Published As

Publication number	Publication date
AR203373A1 (es)	1975-09-08
DK131725C (da)	1976-01-26
IN141109B (2)	1977-01-22
IE38318L (en)	1974-03-09
ATA774573A (de)	1975-10-15
NL161152C (nl)	1980-01-15
NL7312350A (2)	1974-03-12
CA995673A (en)	1976-08-24
DE2345064B2 (de)	1979-03-08
FR2198751A1 (2)	1974-04-05
AT330785B (de)	1976-07-26
AU5960673A (en)	1975-02-27
DE2366106C2 (de)	1980-02-14
NL161152B (nl)	1979-08-15
ZA735660B (en)	1974-07-31
DK131725B (da)	1975-08-25
DE2366106B1 (de)	1979-06-21
DE2345064A1 (de)	1974-04-11
DE2345064C3 (de)	1979-10-25
FR2198751B1 (2)	1977-01-28
GB1383409A (en)	1974-02-12
IE38318B1 (en)	1978-02-15
BE804558A (fr)	1974-03-06
US3960861A (en)	1976-06-01
LU68373A1 (2)	1975-05-21
JPS4985078A (2)	1974-08-15
ES418612A1 (es)	1976-07-16
IN139088B (2)	1976-05-08

Publication	Publication Date	Title
SU555850A3 (ru)	1977-04-25	Способ получени производных хиназолина
Nesterova et al.	1995	Synthesis and study the pharmacological activity of derivatives of 5-dimethylaminopyrano [3, 2-c] quinolin-2-ones
NO179748B (no)	1996-09-02	Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-(1H-indol-3-yl)-maleinimidderivater
GB1573809A (en)	1980-08-28	Basically substituted indole derivative and process for their manufacture
SU1609449A3 (ru)	1990-11-23	Способ получени индентиазола
ES382550A1 (es)	1973-04-16	Procedimiento para la preparacion de nuevas 2-aminoalcohi- lamino-tieno (3,2-d) pirimidinas.
ES439811A1 (es)	1977-04-16	Procedimiento para la preparacion de derivados de bencimida-zol.
CA2107485C (fr)	2001-02-27	Nouveaux derives d'ellipticine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
Markgraf et al.	1969	Strained heterocyclic systems. IV. 1, 2-Dihydrocyclobuta [b] quinoline and derivatives
Jones et al.	1955	Vic-dicarboxylic acid derivatives of pyrazole, isoxazole, and pyrimidine
KR880011122A (ko)	1988-10-26	4-티오퀴나졸린 유도체, 이의 제조방법 및 약제학적 조성물
SU1487811A3 (ru)	1989-06-15	СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 12-АМИНО-ПИРИДАЗИНО [4 ’, 51 : 3,4 )ПИРРОЛО[2,1—а)ИЗОХИНОЛИНА,ИЛИ ИХ ФИЗИОЛОГИЧЕСКИ ПЕРЕНОСИМЫХ КИСЛОТНО-, АДДИТИВНЫХ СОЛЕЙ '
FI58118C (fi)	1980-12-10	Foerfarande foer framstaellning av n-(1-etyl-alfa-pyrrolidylmetyl)-2-metoxi-5-sulfamidobensamid
Glushkov et al.	2005	Synthesis and antiinflammatory and analgesic activity of amidines of 3, 4-dihydroisoquinoline series
US3072650A (en)	1963-01-08	Amides of 2-(aminomethyl)-oxacycloalkanes
US3320272A (en)	1967-05-16	Process for preparing z-alkoxycyclo- heptimidazole derivatives
SU432718A3 (ru)	1974-06-15	Способ получения2-замещенных производных1-циннамилбензимидазола
US5098919A (en)	1992-03-24	Pyrrolo(2,1-b)thiazole derivatives
FUJII et al.	1971	Lactams. II. Synthesis and Acid Hydrolysis of 1-Benzyl-2-piperidone Derivatives Possessing the Carboxyl Function: Equilibrium between 6-and 5-Membered Lactams
Saldabol et al.	1967	Synthesis and transformations of furan derivatives: VI. Amides of β-(2-furyl)-and β-(5-nitro-2-furyl-α-acylamdoacrylic acids) and 1-substituted 2-phenyl-4-(5′ nitro-2′-furfuryliden)-5-imidazolones
SU655307A3 (ru)	1979-03-30	Способ получени производных гуанидинов или их солей
US3647785A (en)	1972-03-07	Novel 3-indolylaliphatic acid anhydrides
Liu et al.	1977	Reactions of Cyclic Pseudothioureas with Acetylenedicarboxylates
Craig et al.	1949	Curariform activity and chemical structure. III. Syntheses in the 3-indolylmethylamine series
Zakhs et al.	1972	Synthesis and properties of salts of 2-substituted derivatives of 1, 6-dimethyl-7-chloro-1, 6-diazaphenalenium salts, III

SU555850A3 - Способ получени производных хиназолина - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (1)

Publications (1)

Family

ID=10422335

Family Applications (1)

Country Status (17)

Cited By (2)

Families Citing this family (27)

Family Cites Families (9)

Cited By (2)

Also Published As

Similar Documents