SU980623A3 - Способ получени производных пурина или их солей - Google Patents

Способ получени производных пурина или их солей Download PDF

Info

Publication number: SU980623A3
Authority: SU; USSR - Soviet Union
Prior art keywords: salts; general formula; guanine; purine derivatives; anhydride
Prior art date: 1976-03-01

Application number

SU772559954A

Other languages

English (en)

Russian (ru)

Inventor

Джон Шаффер Ховард

Original Assignee

Дзе Велкам Фаундейшн Лимитед (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-03-01

Filing date

1977-12-29

Publication date

1982-12-07

1977-12-29 Application filed by Дзе Велкам Фаундейшн Лимитед (Фирма) filed Critical Дзе Велкам Фаундейшн Лимитед (Фирма)

1982-12-07 Application granted granted Critical

1982-12-07 Publication of SU980623A3 publication Critical patent/SU980623A3/ru

Links

238000000034 method Methods 0.000 title claims description 6
150000003839 salts Chemical class 0.000 title claims description 6
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title description 3
125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
239000002253 acid Substances 0.000 claims description 5
150000008064 anhydrides Chemical class 0.000 claims description 5
150000002148 esters Chemical class 0.000 claims description 4
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 3
229910052739 hydrogen Inorganic materials 0.000 claims description 3
239000001257 hydrogen Substances 0.000 claims description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
125000003277 amino group Chemical group 0.000 claims description 2
150000004820 halides Chemical class 0.000 claims description 2
238000002955 isolation Methods 0.000 claims description 2
150000002431 hydrogen Chemical class 0.000 claims 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 8
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 6
239000000203 mixture Substances 0.000 description 6
239000007787 solid Substances 0.000 description 5
-1 2-hydroxyethoxymethyl Chemical group 0.000 description 4
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 4
238000001914 filtration Methods 0.000 description 4
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 4
239000000741 silica gel Substances 0.000 description 4
229910002027 silica gel Inorganic materials 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
150000003212 purines Chemical class 0.000 description 3
JGSACAANCVVBKM-UHFFFAOYSA-N 2-[(2-amino-6-oxo-3h-purin-9-yl)methoxy]ethyl propanoate Chemical compound N1=C(N)NC(=O)C2=C1N(COCCOC(=O)CC)C=N2 JGSACAANCVVBKM-UHFFFAOYSA-N 0.000 description 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
235000019253 formic acid Nutrition 0.000 description 2
239000000047 product Substances 0.000 description 2
238000004809 thin layer chromatography Methods 0.000 description 2
238000005406 washing Methods 0.000 description 2
PGZVFRAEAAXREB-UHFFFAOYSA-N 2,2-dimethylpropanoyl 2,2-dimethylpropanoate Chemical compound CC(C)(C)C(=O)OC(=O)C(C)(C)C PGZVFRAEAAXREB-UHFFFAOYSA-N 0.000 description 1
QWXRKGCSTOAWIV-UHFFFAOYSA-N 2-(ethoxymethylamino)-3,7-dihydropurin-6-one Chemical compound N1C(NCOCC)=NC(=O)C2=C1N=CN2 QWXRKGCSTOAWIV-UHFFFAOYSA-N 0.000 description 1
CSMCRCLIPQDIKB-UHFFFAOYSA-N 2-[(2,6-diaminopurin-9-yl)methoxy]ethanol Chemical compound NC1=NC(N)=C2N=CN(COCCO)C2=N1 CSMCRCLIPQDIKB-UHFFFAOYSA-N 0.000 description 1
TYHQCBMIGOIZEH-UHFFFAOYSA-N 2-[(2,6-diaminopurin-9-yl)methoxy]ethyl formate Chemical compound NC1=NC(N)=C2N=CN(COCCOC=O)C2=N1 TYHQCBMIGOIZEH-UHFFFAOYSA-N 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
QPFYXYFORQJZEC-FOCLMDBBSA-N Phenazopyridine Chemical compound NC1=NC(N)=CC=C1\N=N\C1=CC=CC=C1 QPFYXYFORQJZEC-FOCLMDBBSA-N 0.000 description 1
125000001539 acetonyl group Chemical group [H]C([H])([H])C(=O)C([H])([H])* 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
125000004356 hydroxy functional group Chemical group O* 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
NIQQIJXGUZVEBB-UHFFFAOYSA-N methanol;propan-2-one Chemical compound OC.CC(C)=O NIQQIJXGUZVEBB-UHFFFAOYSA-N 0.000 description 1
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
229940070891 pyridium Drugs 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
239000012265 solid product Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
FJRPWCNFWGBGOF-UHFFFAOYSA-N tridecanoyl chloride Chemical compound CCCCCCCCCCCCC(Cl)=O FJRPWCNFWGBGOF-UHFFFAOYSA-N 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SU772559954A 1976-03-01 1977-12-29 Способ получени производных пурина или их солей SU980623A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7988/76A GB1561380A (en)	1976-03-01	1976-03-01	Esters of hydroxyalkoxyalkyl purines their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
SU980623A3 true SU980623A3 (ru)	1982-12-07

Family

ID=9843620

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU772559954A SU980623A3 (ru)	1976-03-01	1977-12-29	Способ получени производных пурина или их солей

Country Status (6)

Country	Link
DK (1)	DK147596C (fr)
GB (1)	GB1561380A (fr)
NO (1)	NO145339C (fr)
RO (1)	RO71410A (fr)
SU (1)	SU980623A3 (fr)
ZM (1)	ZM2577A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8725939D0 (en) *	1987-11-05	1987-12-09	Wellcome Found	Therapeutic compounds
GB8719367D0 (en) *	1987-08-15	1987-09-23	Wellcome Found	Therapeutic compounds
GB8816760D0 (en) *	1988-07-14	1988-08-17	Wellcome Found	Therapeutic compounds

1976
- 1976-03-01 GB GB7988/76A patent/GB1561380A/en not_active Expired
- 1976-03-02 DK DK88876A patent/DK147596C/da not_active IP Right Cessation
1977
- 1977-03-01 ZM ZM7825A patent/ZM2577A1/xx unknown
- 1977-03-01 RO RO7789563A patent/RO71410A/fr unknown
- 1977-03-01 NO NO770698A patent/NO145339C/no unknown
- 1977-12-29 SU SU772559954A patent/SU980623A3/ru active

Also Published As

Publication number	Publication date
ZM2577A1 (en)	1978-08-21
NO145339C (no)	1982-03-03
NO770698L (no)	1977-09-02
DK88876A (da)	1977-09-02
DK147596C (da)	1985-04-29
DK147596B (da)	1984-10-15
GB1561380A (en)	1980-02-20
RO71410A (fr)	1982-05-10
NO145339B (no)	1981-11-23

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