SV2002000748A - Formas de sal de amida de acido 3-(4-bromo-2,6-difluoro-benciloxi)-5-[3-(4-pirrolidin-1-ilbutil)ureido]isotiazol-4- carboxilico y metodo de produccion ref.pc11042/700023/bb - Google Patents

Formas de sal de amida de acido 3-(4-bromo-2,6-difluoro-benciloxi)-5-[3-(4-pirrolidin-1-ilbutil)ureido]isotiazol-4- carboxilico y metodo de produccion ref.pc11042/700023/bb

Info

Publication number
SV2002000748A
SV2002000748A SV2001000748A SV2001000748A SV2002000748A SV 2002000748 A SV2002000748 A SV 2002000748A SV 2001000748 A SV2001000748 A SV 2001000748A SV 2001000748 A SV2001000748 A SV 2001000748A SV 2002000748 A SV2002000748 A SV 2002000748A
Authority
SV
El Salvador
Prior art keywords
ureido
hydrochromethylate
ilbutil
isotiazol
carboxilico
Prior art date
Application number
SV2001000748A
Other languages
English (en)
Inventor
Thomas George Gant
Glenn Robert Williams
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SV2002000748A publication Critical patent/SV2002000748A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A LAS FORMAS DE SAL HIDROCLORURO, HIDROBROMURO, HEMICITRATO, ACETATO, P-TOSILATO, L-TARTRATO, HEMISUCCINATO Y MESILATO DE AMIDA DE ACIDO 3-(4-BROMO-2, 6-DIFLUOROBENCILOXI)-5-[3-(4-PIRROLIDIN-1-ILBUTIL) UREIDO]ISOTIAZOL-4- CARBOXILICO QUE TIENEN LA FORMULA SIGUIENTE ( VER FORMULA I)LA INVENCION TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LAS SALES HIDROCLORURO, HIDROBROMURO, HEMICITRATO, ACETATO, P-TOSILATO, L-TARTRATO, HEMISUCCINATO Y MESILATO DE FORMULA I. LA INVENCION SE REFIERE ADEMAS A METODOS PARA TRATAR ENFERMEDADES HIPERPROLIFERATIVAS, TALES COMO CANCERES, EN MAMIFEROS, ESPECIALMENTE SERES HUMANOS, POR ADMINISTRACION DE LAS SALES ANTERIORES, Y A LOS METODOS PARA PREPARAR LAS FORMUAS CRISTALINAS DE LAS SALES ANTERIORES
SV2001000748A 2000-11-28 2001-11-27 Formas de sal de amida de acido 3-(4-bromo-2,6-difluoro-benciloxi)-5-[3-(4-pirrolidin-1-ilbutil)ureido]isotiazol-4- carboxilico y metodo de produccion ref.pc11042/700023/bb SV2002000748A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25351300P 2000-11-28 2000-11-28

Publications (1)

Publication Number Publication Date
SV2002000748A true SV2002000748A (es) 2002-12-02

Family

ID=22960587

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2001000748A SV2002000748A (es) 2000-11-28 2001-11-27 Formas de sal de amida de acido 3-(4-bromo-2,6-difluoro-benciloxi)-5-[3-(4-pirrolidin-1-ilbutil)ureido]isotiazol-4- carboxilico y metodo de produccion ref.pc11042/700023/bb

Country Status (49)

Country Link
US (1) US6831091B2 (es)
EP (1) EP1337521B1 (es)
JP (2) JP2004514714A (es)
KR (2) KR20050116401A (es)
CN (1) CN1231474C (es)
AP (1) AP2001002358A0 (es)
AR (1) AR031512A1 (es)
AT (1) ATE340786T1 (es)
AU (2) AU1420402A (es)
BG (1) BG107752A (es)
BR (1) BR0115621A (es)
CA (1) CA2430065C (es)
CR (1) CR6963A (es)
CY (1) CY1106240T1 (es)
CZ (1) CZ20031315A3 (es)
DE (1) DE60123461T2 (es)
DK (1) DK1337521T3 (es)
DO (1) DOP2001000288A (es)
EA (1) EA005859B1 (es)
EC (1) ECSP034628A (es)
EE (1) EE200300247A (es)
ES (1) ES2271086T3 (es)
GE (1) GEP20053652B (es)
GT (1) GT200100237A (es)
HN (1) HN2001000268A (es)
HR (1) HRP20030408A2 (es)
HU (1) HUP0302553A3 (es)
IL (1) IL155371A0 (es)
IS (1) IS6788A (es)
MA (1) MA26960A1 (es)
MX (1) MXPA03004714A (es)
MY (1) MY136686A (es)
NO (1) NO325187B1 (es)
NZ (1) NZ525788A (es)
OA (1) OA12532A (es)
PA (1) PA8533801A1 (es)
PE (1) PE20020591A1 (es)
PL (1) PL362079A1 (es)
PT (1) PT1337521E (es)
SI (1) SI1337521T1 (es)
SK (1) SK5862003A3 (es)
SV (1) SV2002000748A (es)
TN (1) TNSN01167A1 (es)
TW (1) TWI287542B (es)
UA (1) UA74221C2 (es)
UY (1) UY27039A1 (es)
WO (1) WO2002044158A1 (es)
YU (1) YU36403A (es)
ZA (1) ZA200303341B (es)

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US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE538794T1 (de) 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
MXPA04007832A (es) 2002-02-11 2005-09-08 Bayer Pharmaceuticals Corp Aril-ureas con actividad inhibitoria de angiogenesis.
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
EP1527071A1 (en) * 2002-07-25 2005-05-04 Pfizer Products Inc. Isothiazole derivatives useful as anticancer agents
CA2495962A1 (en) * 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
WO2004113274A2 (en) 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
EA010485B1 (ru) 2003-07-23 2008-10-30 Байер Фамэсьютиклс Копэрейшн Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
ATE517622T1 (de) * 2003-10-27 2011-08-15 Merck Sharp & Dohme Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten
WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
WO2005102327A1 (en) * 2004-04-20 2005-11-03 Pfizer Products Inc. Dosage forms and methods of treatment using vegfr inhibitors
CN101010315A (zh) 2004-04-30 2007-08-01 拜耳制药公司 用于治疗癌症的取代的吡唑基脲衍生物
TW200538104A (en) * 2004-05-17 2005-12-01 Pfizer Prod Inc Phenyl derivatives for the treatment of abnormal cell growth
EP1778669A2 (en) 2004-08-18 2007-05-02 Takeda San Diego, Inc. Kinase inhibitors
ATE479687T1 (de) 2004-10-15 2010-09-15 Takeda Pharmaceutical Kinaseinhibitoren
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2044043B2 (en) 2006-06-16 2021-03-03 H. Lundbeck A/S 1- ý[- (2, 4-dimethylphenylsulfanyl) -phenyl]piperazine hydrobromide as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
US7932390B2 (en) 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
WO2011073521A1 (en) 2009-12-15 2011-06-23 Petri Salven Methods for enriching adult-derived endothelial progenitor cells and uses thereof
SG187592A1 (en) 2010-07-23 2013-03-28 Univ Boston Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
PL2968650T3 (pl) * 2013-03-14 2019-05-31 Panoptica Inc Preparaty do oczu do dostarczania leku do tylnego fragmentu oka
ES2863601T3 (es) * 2014-09-17 2021-10-11 Panoptica Inc Formulaciones oculares para administración de fármacos y protección del segmento anterior del ojo
AU2023416218A1 (en) * 2022-12-28 2025-07-10 Beyang Therapeutics Co., Ltd. Protein tyrosine kinase inhibitor and medical use thereof
WO2026002133A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂的盐型
WO2026002142A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂的半琥珀酸盐晶型
WO2026002126A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂及其眼用制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця

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HRP20030408A2 (en) 2003-08-31
EP1337521B1 (en) 2006-09-27
CR6963A (es) 2003-11-25
DK1337521T3 (da) 2007-01-29
DOP2001000288A (es) 2002-12-15
TNSN01167A1 (fr) 2005-11-10
JP2008056692A (ja) 2008-03-13
EP1337521A1 (en) 2003-08-27
IL155371A0 (en) 2003-11-23
MXPA03004714A (es) 2003-08-19
AP2001002358A0 (en) 2001-12-31
CY1106240T1 (el) 2011-06-08
SI1337521T1 (sl) 2006-12-31
KR20030059275A (ko) 2003-07-07
DE60123461D1 (de) 2006-11-09
UY27039A1 (es) 2002-07-31
PA8533801A1 (es) 2002-10-31
AU1420402A (en) 2002-06-11
EA005859B1 (ru) 2005-06-30
NO20032388L (no) 2003-07-18
OA12532A (en) 2006-06-02
NZ525788A (en) 2004-11-26
JP4971946B2 (ja) 2012-07-11
HK1059085A1 (en) 2004-06-18
TWI287542B (en) 2007-10-01
CN1476439A (zh) 2004-02-18
ZA200303341B (en) 2004-04-30
EA200300424A1 (ru) 2003-10-30
CA2430065C (en) 2008-05-20
PE20020591A1 (es) 2002-07-06
MY136686A (en) 2008-11-28
JP2004514714A (ja) 2004-05-20
DE60123461T2 (de) 2007-02-15
PT1337521E (pt) 2006-12-29
CZ20031315A3 (cs) 2004-04-14
US20020151573A1 (en) 2002-10-17
US6831091B2 (en) 2004-12-14
CA2430065A1 (en) 2002-06-06
EE200300247A (et) 2003-10-15
HUP0302553A2 (hu) 2003-11-28
HN2001000268A (es) 2002-01-30
KR20050116401A (ko) 2005-12-12
CN1231474C (zh) 2005-12-14
WO2002044158A1 (en) 2002-06-06
IS6788A (is) 2003-04-14
ES2271086T3 (es) 2007-04-16
GEP20053652B (en) 2005-11-10
ECSP034628A (es) 2003-07-25
PL362079A1 (en) 2004-10-18
YU36403A (sh) 2006-08-17
GT200100237A (es) 2002-07-03
UA74221C2 (uk) 2005-11-15
AU2002214204B2 (en) 2007-05-24
NO325187B1 (no) 2008-02-11
AR031512A1 (es) 2003-09-24
BR0115621A (pt) 2003-09-02
ATE340786T1 (de) 2006-10-15
MA26960A1 (fr) 2004-12-20
BG107752A (bg) 2004-01-30
HUP0302553A3 (en) 2009-03-30
NO20032388D0 (no) 2003-05-27
SK5862003A3 (en) 2004-05-04

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