TH148528A - Tetrahydroquinoline derivatives and methods for their preparation - Google Patents

Abstract

DC60 (28/08/48) New compound of formula (I): (chemical formula) (I) where R to the power of 1 is an alkoxycarbonyl, or others; R to the power of 2 is an alkyl, or others; R to the power of 3 is a hydrogen, or others; R to the power of 4 is an alkylene, or others; R to the power of 5 is a heterocyclic group chosen to substitute; R to the power of 6, R to the power of 7, R to the power of 8, and R to the power of 9 independently are hydrogen; alkyl, alkoxy, or others; R to the power of 10 is a chosen aromatic ring, or others; or a pharmaceutically acceptable salt thereof, having activity. In the inhibitory action against cholesterol ester transfer protein (CETP), a new compound of formula (I): (chemical formula) (I) where R1 is an alkoxycarbonyl, or otherwise; R2 is an alkyl, or otherwise; R3 is a hydrogen, or otherwise; R4 is an alkylene, or otherwise; R5 is a heterocyclic group, selectively substituted; R6, R7, R8, and R9 are independently hydrogenated; alkyl, alkoxy, or otherwise; R10 is a selectively substituted aromatic ring, or otherwise; or a pharmaceutically acceptable salt thereof, having inhibitory activity against cholesterol ester transfer protein (CETP).

Claims (1)

1. Compound of formula (I): (chemical formula)(I) where R1 is a hydrogen atom, alternatively substituted alkoxycarbonyl group, alternatively substituted carbamoyl group, alternatively substituted alkyl group, alternatively substituted alkanoyl group, alternatively substituted saturated or unsaturated monocyclic or bicyclic heterocyclic group having 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic groups are alternatively substituted), or saturated or unsaturated monocyclic or bicyclic heterocyclic carbonyl group having 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic groups are alternatively substituted). R2 is a hydrogen atom or alkyl group alternatively substituted, R3 is a hydrogen atom or alkyl group alternatively substituted, R4 is an alkylene group alternatively substituted. R5 is a saturated or unsaturated monocyclic or bicyclic heterocyclic group containing 1 to 4 heteroatoms independently chosen from oxygen, sulfur and nitrogen atoms, where the heterocyclic group is replaced by 1 to 5 substituents chosen from the following groups, or the heterocyclic group is replaced by 1 to 5 substituents chosen from the following groups and further added with a halogen atom, oxo and/or hydroxy group: cyano group, cyano group, carboxyl group, sulfo group, C3-10 alkyl group, alkyl group is substituted,alternatively substituted cycloalkyl group,alkenyl group alternatively substituted,C3- 10alkoxy group,alkoxy group substituted,alternatively substituted cycloalkoxy group,alternatively substituted alkoxycarbonyl group,alternatively substituted carbamoyl group,alternatively substituted carbanimidoyl group,alkylthio group alternatively substituted,alkylsulfinyl group alternatively substituted,alkylsulfonyl group alternatively substituted,amino group alternatively substituted,alphamoyl group alternatively substituted,alkanoyl group alternatively substituted,saturated or unsaturated monocyclic or bicyclic heterocyclic group having 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic group alternatively substituted),monocyclic or bicyclic group Saturated heterocyclic oxy groups containing 1 to 4 heteroatoms independently selected from oxygen, sulfur, and nitrogen atoms (heterocyclic oxy groups are alternatively substituted), and saturated or unsaturated monocyclic or bicyclic heterocyclic carbonyl groups containing 1 to 4 heteroatoms independently selected from oxygen, sulfur, and nitrogen atoms (heterocyclic carbonyl groups are alternatively substituted). R6, R7, R8, and R9 are alternatively substituted hydrogen atoms, halogen atoms, hydroxy groups, nitro groups, cyano groups, alkyl groups, alternatively substituted alkoxy groups, alternatively substituted alkylsulfonyl oxy groups, or alternatively substituted amino groups. Or R10 is an alternatively aromatic ring containing 1 to 3 heteroatoms independently selected from oxygen, sulfur, and nitrogen atoms (aromatic ring is alternatively substituted). as an alternative), or salts of these that are accepted in pharmaceuticals 2. The compound of claim 1, wherein R5 is a saturated or unsaturated monocyclic or bicyclic heterocyclic group having 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms, wherein the heterocyclic group is replaced by 1 to 5 agents selected from the following groups, or said heterocyclic group is replaced by 1 to 5 agents selected from the following groups together with a halogen atom, oxo and/or hydroxy group: cyano group, nitro group, carboxyl group, sulfo group, C3-10 alkyl group, alkyl group substituted, cycloalkyl group alternatively substituted, alkynyl group alternatively substituted, C3-10 alkoxy group, alkoxy group substituted, cycloalkoxy group alternatively substituted, alkoxycarbonyl group alternatively substituted, carbamoyl group alternatively substituted, group Alternatively substituted mono- or tri-alkylcarbamoyl groups, alternatively substituted carbanimidoyl groups, alternatively substituted alkyl thio groups, alternatively substituted alkyl sulfinyl groups, alternatively substituted alkyl sulfonyl groups, alternatively substituted amino groups, alternatively substituted mono- or di-alkylamino groups, alternatively substituted alkanoyl amino groups, alternatively substituted alkoxycarbonyl amino groups, alternatively substituted alkylsulfonyl amino groups, alternatively substituted mono- or di-alkylcarbamoyl amino groups, saturated or unsaturated monocyclic or bicyclic carbonyl amino groups having 1 to 4 heteroatoms independently selected from the oxygen, sulfur and nitrogen atoms (heterocyclic carbonyl amino groups are alternatively substituted). Alternatively, sulfamoyl groups, alternatively substituted mono- or di-alkyl sulfamoyl groups, alternatively substituted alkanoyl groups, saturated or unsaturated monocyclic or bicyclic heterocyclic groups containing 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic groups are alternatively substituted), saturated or unsaturated monocyclic or bicyclic heterocyclic oxy groups containing 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic oxy groups are alternatively substituted), and saturated or unsaturated monocyclic or bicyclic heterocyclic carbonyl groups containing 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic carbonyl groups are alternatively substituted), and R10 is an alternative aromatic ring having 1 to 3 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms, in which the aromatic ring is alternatively substituted by 1 to 4 substituents selected from the following groups: halogen atom, carboxyl group, alternatively substituted alkoxycarbonyl group, carbamoyl group, alternatively substituted mono- or di-alkylcarbamoyl group, alternatively substituted alkyl group, alternatively substituted alkoxy group, alternatively substituted hydroxy group, nitro group, cyano group, amino group, alternatively substituted mono- or di-alkylamino group, alternatively substituted alkanoyl group, alternatively substituted alkylthio group, saturated or unsaturated monocyclic or bicyclic heterocyclic group having 1 to 4 heteroatoms independently selected from oxygen, sulfur and Nitrogen atom (heterocyclic group is alternatively substituted) 3. The compound of claim 2, wherein the alkyl group substituted, the alkyl group is alternatively substituted, the cycloalkyl group is alternatively substituted, the alkynyl group is alternatively substituted, the alkoxy group is alternatively substituted, the alkoxy group is alternatively substituted, the cycloalkoxy group is alternatively substituted, the alkoxycarbonyl group is alternatively substituted, the alkanoylamino group is alternatively substituted, the alkylsulfonylamino group is alternatively substituted, the mono- or di-alkylcarbamoylamino group is alternatively substituted, the mono- or di-alkylsulfamoyl group is alternatively substituted, the alkanoyl group is alternatively substituted, the alkaneyl group is alternatively substituted, the alkylene group is alternatively substituted, the monocyclic or bicyclic heterocyclic carbonyl amino group having 1 to 4 saturated or unsaturated monocyclic or bicyclic heterocyclic carbonyl amino group having 1 to 4 Heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic carbonyl amino groups are alternatively substituted), saturated or unsaturated monocyclic or bicyclic heterocyclic groups containing 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic groups are alternatively substituted), saturated or unsaturated monocyclic or bicyclic heterocyclic oxy groups containing 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic oxy groups are alternatively substituted), and saturated or unsaturated monocyclic or bicyclic heterocyclic carbonyl groups containing 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms (heterocyclic carbonyl groups are alternatively substituted). ) may be 1-5 groups chosen from the following groups: halogen atom, cyano group, hydroxy group, nitro group, carboxyl group, oxo group, thioxo group, sulfo group, cycloalkyl group alternatively replaced by hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl alkoxycarbonyl group alternatively replaced by hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl group or morpholinyl group, carbamoyl group, mono- or di-alkylcarbamoyl group alternatively replaced. With hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morphulinyl group.Alkyl group is alternatively replaced by hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morphulinyl group.Alkanoyl group is alternatively replaced by hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morphulinyl group.Alkoxy group is alternatively replaced by hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morphulinyl group.Alkanoyloxy group is alternatively replaced by Hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl groupThe alkylthio group is alternatively replaced by a hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl groupThe alkylsulfonyl group is alternatively replaced by a hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl groupThe alkylsulfonyl group is alternatively replaced by a hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl groupThe alkylsulfinyl group is alternatively replaced by a Alternatively replaced by a hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl groupMono- or di-alkylamino group, phenyl or morpholinyl groupAmino group Mono- or di-alkylamino group, alternatively replaced by a hydroxy group, halogen atom, carboxylic group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl groupMono- or di-alkylamino group, alternatively replaced by Hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl group. The mono- or di-alkylamino uridine group is alternatively replaced by a hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, mono- or di-alkylamino group, phenyl or morpholinyl group, and the formula group: (chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula) (chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula) (chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula),and(chemical formula) where X1 and X3 independently are CH2,NH,O,S,SO or SO2X2 and X5. independently is CH2, NH, O, S, SO or SO2 X4 is CH2, NH, O, S, SO or SO2 X6 and X7 independently is O or SX8 is S or SO and n, o, p, q and r independently are integers 1 to 4, where each group of the above formula is alternatively replaced by 1 to 3 substituents chosen from the following groups: halogen atom, carboxyl group, hydroxy group, cyano group, oxo group, thioxcho group, alkyl group, hydroxyalkyl group, alkoxycarbonyl alkyl group, carboxyalkyl group, morpholinyl alkyl group, phenyl alkyl group, alkanoyl group, hydroxyalkanoyl group, alkoxyalkanoyl group, alkoxy group, phenylalkoxy group, alkoxycarbonyl group, benzyloxycarbonyl group, mono- or Di-alkylamino, mono- or di-alkylcarbamoyl groups, mono- or di-alkylsulfamoyl groups, alkylsulfonyl groups and dedrazolyl groups 4. The compound of claim 3, wherein the "alternative aromatic ring has 1 to 3 heteroatoms independently selected from the oxygen, sulfur and nitrogen atoms" giving the beneficial effect to be a phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, furyl, pyrimidinyl, triazolyl or thienyl group; the "saturated or unsaturated monocyclic or bicyclic heterocyclic group having 1 to 4 heteroatoms independently selected from the oxygen, sulfur and nitrogen atoms giving the beneficial effect to be a phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, furyl, pyrimidinyl, triazolyl or thienyl group." Morpholinyl, thiomorpholinyl, piperazinyl, pyrrolidinyl, piperidinyl, hexahydroazepinyl, pyrrolidinyl, imidazolidinyl, oxazolidinyl, tetrahydropyranyl, tetrahydrofuranyl, dioxolanyl, oxeranyl, pyrimidinyl, pyridyl, triazolyl, tetrazolyl, oxadiazolyl, dihydropyrimidinyl, pyracinyl, thiazolyl, oxazolinyl, oxazolyl, pyridazinyl, imidazolinyl, imidazolyl, pyrazinyl, thienyl, pyrrolidinyl, furyl or dihydroxazinyl. "A saturated or unsaturated monocyclic or bicyclic heterocyclic oxy group containing one to four heteroatoms independently selected from the oxygen, sulfur and nitrogen atoms that yield Good ones are morpholinyl oxy, thiomorpholinyl oxy, piperazinyl oxy, pyrrolidinyl oxy, piperidinyl oxy, hexahydroazepinyl oxy, pyrrolidinyl oxy, imidazolidinyl oxy, oxazolidinyl oxy, tetrahydropyranyl oxy, tetrahydrofuranyl oxy, dioxolanylooxy, oxeranyl oxy, pyrimidinyl oxy, pyridyl oxy, triazolyl oxy, tetrazolyl oxy, oxadiazolyl oxy, dihydropyrimidinyl oxy, pyracinyl oxy, Thiazolyloxy, oxazolinylooxy, oxazolyloxy, pyridazinyloxy, imidazolinyloxy, imidazolylooxy, pyrazinyloxy, thienyloxy, pyrolylooxy, furyloxy or dihydroxazinylooxy "Saturated or unsaturated monocyclic or bicyclic heterocyclic carbonyl groups containing 1 to 4 independently selected heteroatoms of oxygen, sulfur and nitrogen atoms. Good results are morpholinyl carbonyl groups, thiomerolinyl carbonyl, piperazinyl carbonyl, pyrrolidinyl carbonyl, piperidinyl carbonyl, hexahydroazepinyl carbonyl, pyrrolidinyl carbonyl, imidazolidinyl carbonyl, oxazolidinyl carbonyl, tetrahydropyranyl carbonyl, tetrahydrofuranyl carbonyl, dioxolanyl carbonyl, oxeranyl carbonyl, pyrimidinyl carbonyl, pyridyl carbonyl, triazolyl carbonyl, tetrazolyl carbonyl, oxadiazolyl carbonyl, dihydropyrimidinyl carbonyl, Pyrazinyl carbonyl, thiazolyl carbonyl, oxazolinyl carbonyl, oxazolyl carbonyl, pyridazinyl carbonyl, imidazolinyl carbonyl, imidazolyl carbonyl, pyrazinyl carbonyl, thienyl carbonyl, pyrroleyl carbonyl, furyl carbonyl or dihydroxazinyl carbonyl "A saturated or unsaturated monocyclic or bicyclic heterocyclic carbonyl group containing 1 to 4 independently selected heteroatoms of oxygen, sulfur and nitrogen atoms that give good results. Morpholinyl carbonyl amino, thiomorpholinyl carbonyl amino, piperazinyl carbonyl amino, pyrrolidinyl carbonyl amino, piperidinyl carbonyl amino, hexahydroazepinyl carbonyl amino, pyrrolidinyl carbonyl amino, imidazolidinyl carbonyl amino, oxazolidinyl carbonyl amino, tetrahydropyranyl carbonyl amino, tetrahydrofuranyl carbonyl amino, dioxolanyl carbonyl amino, oxeranyl carbonyl amino, pyrimidinyl carbonyl amino, pyridyl carbonyl amino, triazolyl carbonyl amino, tetrazolyl carbonyl amino, Oxadiazolylcarbonylamino, dihydropyrimidinylcarbonylamino, pyracinylcarbonylamino, thiazolylcarbonylamino, oxazolinylcarbonylamino, oxazolylcarbonylamino, pyridazinylcarbonylamino, imidazolinylcarbonylamino, imida-zolylcarbonylamino, pyrazinylcarbonylamino, thienylcarbonylamino, pyrrolilycarbonylamino, furylcarbonyl or dihydroxazolinylcarbonyl 5. The compound of claim 1, where R1 is a hydrogen atom: the alkoxycarbonyl group is alternatively replaced by 1 to 5 independently chosen substituents from among the cyano group, hydroxy group, carboxyl group, alkoxycarbonyl group, alkoxy group (said alkoxy group is alternatively replaced by 1 to 3 independently chosen substituents). Hydroxy group, amino group, mono- or di-alkylamino group, halogen atom, carboxylic group, alkoxycarbonyl group, carboxyalkoxy and alkoxycarbonylalkoxy groups), alkylthio group, alkylsulfonyl group, alkynyl group, amino group, mono- or di-alkylamino group, tetrazolyl group, carbamoyl group, mono- or di-alkylcarbamoyl group(such mono- or di-alkylcarbamoyl group is alternatively replaced by 1 to 3 substituents that are independently chosen from the carboxyl and alkoxycarbonyl groups), alkanoylamino group(such alkanoylamino group is alternatively replaced by 1 to 3 substituents that are independently chosen from the carboxyl group, alkoxycar , hydroxy groups and halogen atoms), halogen atoms, cycloalkyl groups (such cycloalkyl groups may be alternatively replaced by one to three substituents chosen independently of the hydroxy groups, amino groups, mono- or di-alkylamino groups, halogen atoms, oxo groups, carboxyl groups, alkoxycarbonyl groups, carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarbonyl alkoxy groups), phenyl groups (such phenyl groups may be alternatively replaced by one to three substituents chosen independently of the hydroxy groups, amino groups, mono- or di-alkylamino groups, halogen atoms, carboxyl groups, alkoxycarbonyl groups, carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarbonylalkoxy groups), morpholinyl groups alternatively replaced by oxo groups, piperidinyl groups (such piperidinyl groups are alternatively replaced by 1 to 3 substituents which are independently chosen from the hydroxy groups, amino groups, mono- or di-alkylamino groups, halogen atoms, oxo groups, carboxyl groups, alkoxycarbonyl groups, carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarbonyl alkoxy groups), pyrrolidinyl groups (such pyrrolidinyl groups are alternatively replaced by 1 to 3 substituents which are independently chosen from the hydroxy groups, amino groups, mono- or di-alkylamino groups, halogen atoms Atoms, oxo groups, carboxyl groups, alkoxycarbonyl groups, carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarbonyl alkoxy groups), and pyrimidinyl groups (the pyrimidinyl groups are alternatively replaced by 1 to 3 substituents that are independent of the carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarbonyl alkoxy groups). The carbamoyl group is alternatively replaced by an alkoxy group. The dihydroxazolyl group is alternatively replaced by 1 to 2 substituents that are independent of the carboxyl group, alkoxycarbonyl group, alkyl group, carboxyalkyl group, alkoxycarbonyl alkyl group and hydroxyalkyl group. The dihydroimidazolyl group is alternatively replaced by Alternatively substituted with 1 to 3 substituents, which are independently chosen from the carboxyl group, alkoxycarbonyl group, alkyl group, carboxyalkyl group, alkoxycarbonyl alkyl group, and hydroxyalkyl group. The dihydroxazinyl group is alternatively substituted with 1 to 3 substituents, which are independently chosen from the carboxyl group, alkoxycarbonyl group, alkyl group, carboxyalkyl group, alkoxycarbonyl alkyl group, and hydroxyalkyl group. Mono- or di-alkylcarbamoyl groups are substituted. Optionally with 1 to 5 substituents independently chosen from the halogen atom, hydroxy group, carboxycarbonyl group, alkoxy group, amino group, mono- or di-alkylamino group, morpholinyl group, pyridyl group, pyridyl group, cycloalkyl group (such cycloalkyl group is alternatively replaced by 1 to 3 substituents independently chosen from the carboxyl group, alkoxycarbonyl group, halogen atom, amino group and hydroxy group), and phenyl group (such phenyl group is alternatively replaced by 1 to 3 substituents independently chosen from the carboxyl group, alkoxycarbonyl group, halogen atom, amino group and hydroxy group). The alkyl group is alternatively replaced by 1 to 5 substituents independently chosen from the halogen. atom, hydroxy group, carboxylic group, alkoxycarbonyl group, alkoxy group, amino group, mono- or di-alkylamino group, morpholinyl group, pyridyl group, cycloalkyl group (such cycloalkyl group may be alternatively replaced by 1 to 3 substituents that are independently chosen from the carboxyl group, alkoxycarbonyl group, halogen atom, amino group and hydroxy group), and phenyl group (such phenyl group may be alternatively replaced by 1 to 3 substituents that are independently chosen from the carboxyl group, alkoxycarbonyl group, halogen atom, amino group and hydroxy group). The alkanoyl group may be alternatively replaced by 1 to 5 substituents that are independently chosen from. Halogen atom, hydroxy group, carboxylic group, alkoxycarbonyl group, alkoxy group, amino group, mono- or di-alkylamino group, morpholinyl group, pyridyl group, cycloalkyl group (such cycloalkyl group may be alternatively replaced by one to three substituents that are independent of the carboxyl group, alkoxycarbonyl group, halogen atom, amino group and hydroxy group), and phenyl group (such phenyl group may be alternatively replaced by one to three substituents that are independent of the carboxyl group, alkoxycarbonyl group, halogen atom, amino group and hydroxy group). Morpholinylcarbonyl groupThe piperazinylcarbonyl group may be alternatively replaced by an alkyl group, carboxyalkyl group or alkoxycarbonylalkyl group. The pyrrolidinyl carbonyl group is alternatively replaced by 1 to 3 substituents, which are independently chosen from the carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonylalkyl group. Or the piperinyl carbonyl group is alternatively replaced by 1 to 3 substituents, which are independently chosen from the carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonylalkyl group. R5 is a saturated or unsaturated 5- to 8-membered heterocyclic group with 1 to 4 heteroatoms independently chosen from the oxygen, sulfur, and nitrogen atoms, where such heterocyclic group is replaced by 1 to 4 substituents chosen from the following groups, or such heterocyclic group is replaced by 1 to 4 substituents chosen from the following groups in combination. with halogen atoms, oxo and/or hydroxy groups: cyano group, nitro group, carboxyl group, sulfo group, cycloalkyl group alternatively replaced by carboxyl or alkoxycarbonyl group, C3-10alkyl group, alkyl group replaced by selected group from halogen atoms, cyano group, hydroxy group, carboxyl group, alkoxycarbonyl group, tetrazolyl group, mono- or di-alkylcarbamoyl group, alkoxy group (such alkoxy group is alternatively replaced by phenyl, carboxyl or hydroxy group), alkanoyl group, alkanoyloxy group, alkylthio group, alkylsulfonyl group, alkylsulfinyl group, amino group, mono- or di-alkylamino group is Alternatively replaced by a carboxylic or alkoxy group, mono- or di-alkylsulfamoylamino group, mono- or di-alkyluriido group alternatively replaced by a morpholinyl group, oxeranyl group, dioxolanyl group alternatively replaced by an alkyl group, pyrrolidinyl group alternatively replaced by an alkoxycarbonyl or carboxyl group, pyrrolidinyl group alternatively replaced by an alkoxycarbonyl alkyl or carboxyalkyl group, piperidinyl group alternatively replaced by an alkoxycarbonyl alkyl or carboxyalkyl group, piperidinyl group alternatively replaced by an alkoxycarbonyl alkyl or carboxyalkyl group, piperazinyl group alternatively replaced by an alkyl group, hexahydroazepinyl group, morpholinyl group, and piperidinyl oxy group alternatively replaced by an alkyl group. Alternatively with alkyl groups. The alkynyl groups are alternatively replaced by groups selected from cyano groups, hydroxy groups, carboxyl groups, benzyloxycarbonyl groups, tetrazolyl groups. The alkynyloxy groups are alternatively replaced by carboxyl groups, C3-10alkoxy groups. The alkoxy groups are alternatively replaced by groups selected from halogen atoms, cyano groups, hydroxy groups, carboxyl groups, alkoxycarbonyl groups, tetrazolyl groups, carbamoyl groups, mono- or di-alkylcarbamoyl groups (such mono- or di-alkylcarbamoyl groups are alternatively replaced by carboxyl, alkoxycarbonyl or hydroxy groups), alkoxy groups. (such alkoxy groups are alternatively replaced by carboxyl, formyl or hydroxy groups), alkanoyloxy groups, alkylthio groups, alkylsulfonyl groups, alkylsulfonyl groups, aminosulfonyl groups, amino groups, mono- or di-alkylamino groups are alternatively replaced by carboxyl or alkoxy groups, mono- or di-alkylsulfamoyl groups, mono- or di-alkyluriido groups are alternatively replaced by morpholinyl groups, cycloalkyl groups are alternatively replaced by carboxymethyl groups, oxeranyl groups, phenyl groups are alternatively replaced by alkoxy or carboxyl groups, morpholinyl groups, pyrrolidinyl groups are alternatively replaced by alkoxycarbonyl or carboxyl groups, pyrrolidinyl groups are alternatively replaced by alkoxycarbonyl alkyl or Carboxyl alkyl, pyrrolidinyl group replaced by oxo group, piperidinyl group alternatively replaced by alkoxycarbonyl or carboxyl group, piperidinyl group alternatively replaced by alkoxycarbonyl alkyl or carboxyl alkyl group, piperazinyl group alternatively replaced by alkyl group, hexahydroazepinyl group, pyrimidinyl group, pyridyl group, dioxolanyl group alternatively replaced by alkyl group, oxadiazolyl group alternatively replaced by oxo group, oxathiadiazolyl group alternatively replaced by oxo group, pyrrolidylcarbonyl group alternatively replaced by carboxyl group, piperidinyl oxy group alternatively replaced by alkyl group, and morpholinyl carbonyl group. The alkoxycarbonyl group is alternatively replaced by a phenyl group. Carbamoyl groups Mono- or di-alkylcarbamoyl groups are alternatively replaced by selected groups from the carboxyl, morpholinyl and alkoxy groups. Hydroxycarbanimidoyl groups Alkylthio groups are alternatively replaced by selected groups from the hydroxy, carboxyl and mono- or di-alkylcarbamoyl groups. Alkylsulfinyl groups Alkylsulfonyl groups are alternatively replaced by selected groups from the hydroxy, carboxyl, alkoxycarbonyl and mono- or di-alkylcarbamoyl groups. Alkylsulfinyl groups Alkylsulfonyl groups are alternatively replaced by selected groups from hydroxy groups, carboxyl groups, alkoxycarbonyl groups and mono- or di-alkylcarbamoyl groups. Amino groups. Mono- or di-alkylamino groups are alternatively replaced by selected groups from hydroxy groups, carboxyl groups, alkoxycarbonyl groups, alkoxy groups, mono- or di-alkylamino groups and morpholyl groups. Mono- or di-alkanoylamino groups are alternatively replaced by selected groups from hydroxy groups, alkoxy groups, carboxyl groups and amino groups. Mono- or di-alkylcarbamoylamino groups are alternatively replaced by alkoxy groups, morpholinylcarbonylamino groups, sulfamoyl groups, mono- or di-alkylsulfamoyl groups. The alkanoyl group is alternatively replaced by a group of choice from hydroxy groups, carboxyl groups, alkoxycarbonyl groups, alkoxy groups, mono- or di-alkylamino groups, and morpholinyl groups or an amino group of choice from the following groups: (chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula),(chemical formula), (chemical formula), and(chemical formula), where X1 and X3 independently are CH2, NH, O, S, SO or SO2, X2 and X5 independently are CH2, NH, O, S, SO or SO2, X4 independently is NH, O, S, SO or SO2, and n, o, p, q and r independently are integers 1 to 4, where each of the above formula groups is alternatively replaced by 1 to 3 substituents chosen from the following groups. Carboxylic group, hydroxy group, cyano group, oxo group, alkyl group, hydroxyalkyl group, alkoxycarbonyl alkyl group, carboxyalkyl group, morpholinyl alkyl group, phenylalkyl group, alkanoyl group, hydroxyalkanoyl group, alkoxyalkanoyl group, alkoxy group, phenylalkoxy group, alkoxycarbonyl group, benzyloxycarbonyl group, mono- or di-alkylamino group, mono- or di-alkylcarbamoyl group, mono- or di-alkylsulfamoyl group, alkylsulfonyl group and tetrazolyl group. R6, R7, R8 and R9 are independently hydrogen atoms, halogen atoms, hydroxy groups, nitro groups, cyano groups, alkyl groups, alkoxy groups, or mono- or di-alkylamino groups, wherein the alkyl, alkoxy, mono- or di-alkylamino groups are alternatively substituted by one to six substituents that are independently chosen from the halogen atoms, hydroxy groups, alkoxy groups, alkylthio groups, amino groups, nitro groups, cyano groups, oxo groups, carboxyl groups, alkoxycarbonyl groups and mono- or di-alkylamino groups. R6 and R7, or R7 and R8, or R8 and R9 may be combined at the end to form an alkylene group in which the alkylene group may have one to three heteroatoms independently chosen from the nitrogen, sulfur and oxygen atoms. R10 is an alternative aromatic ring having 1 to 3 heteroatoms independently chosen from oxygen, sulfur and nitrogen atoms, where the monocyclic aromatic ring is alternatively substituted by 1 to 4 substituents independently chosen from halogen atoms, carboxyl group, alkoxycarbonyl group, carbamoyl group, mono- or dialkylcarbamoyl group, alkyl group, alkoxy group, hydroxy group, nitro group, cyano group, amino group, mono- or di-alkylamino group, alkanoyl group, alkylthio group, tetrazolyl group and trihydroxazolyl group, where the alkyl, alkoxy, mono- or dialkylamino, mono- or di-alkylcarbamoyl, alkanoyl and alkylthio groups are independently substituted. Alternatively, the agents are selected independently of the halogen atoms, and the hydroxy, alkoxy, amino, morpholinyl, piperidinyl, pyrrolidinyl, piperazinyl, alkylpiperazinyl, and alkanoylpiperazinyl groups, 6. The compound of claim 5, wherein the "alternatively monocyclic aromatic ring having 1 to 3 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms" is a phenyl group, pyridyl group, pyrimidinyl group, feryl group or thienyl group and the "5- to 8-membered saturated or unsaturated heterocyclic group having 1 to 4 heteroatoms independently selected from oxygen, sulfur and nitrogen atoms" is a pyrimidinyl group, pyridyl group, diazolyl group, tetrazolyl group, oxadiazolyl group, dihydropyrimidinyl group, pyrazinyl group, thiazolyl group, oxazolyl group, imidazolyl group, dihydroxazinyl group, dihydropyrazinyl group or pyrazolyl group. The compound of claim 6, where R1 is a hydrogen atom, the alkoxycarbonyl group is alternatively replaced by 1 to 5 independently chosen substituents, from a cyano group, a hydroxy group, a carboxyl group, a carboxyl group, an alkoxycarbonyl group, an alkoxy group (said alkoxy group is alternatively replaced by 1 to 3 independently chosen substituents). From hydroxy groups, amino groups, mono- or di-alkylamino groups, halogen atoms, carboxylic groups, alkoxycarbonyl groups, carboxyalkoxy and alkoxycarbonylalkoxy groups), alkylthio groups, alkylsulfonyl groups, alkynyl groups, amino groups, mono- or di-alkylamino groups, tetrazolyl groups, carbamoyl groups, mono- or di-alkylcarbamoyl groups (such mono- or di-alkylcarbamoyl groups are alternatively replaced by one to three substituents which are independently chosen from the carboxyl and alkoxycarbonyl groups), alkanoylamino groups (such alkanoylamino groups are Alternatively replaced by 1 to 3 substituents chosen independently of the carboxyl group, alkoxycarbonyl group, hydroxy group and halogen atom), halogen atom, cycloalkoxy group (such cycloalkyl group is alternatively replaced by 1 to 3 substituents chosen independently of the hydroxy group, amino group, mono- or di-alkylamino group, halogen atom, oxo group, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, alkoxycarbonyl alkyl group, carboxyalkoxy group and alkoxycarbonyl alkoxy group), phenyl group (such phenyl group is substituted Optionally with 1 to 3 substituents which are independently chosen from the hydroxy group, amino group, mono- or di-alkylamino group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, alkoxycarbonyl alkyl group, carboxyalkoxy group and alkoxycarbonyl alkoxy group), the morpholinyl group is alternatively replaced by an oxo group, piperidinyl group (the piperidin group is alternatively replaced by 1 to 3 substituents which are independently chosen from the hydroxy group, amino group, mono- or di-alkylamino group, halogen atoms, oxo groups, carboxyl groups, alkoxycarbonyl groups, carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarbonyl alkoxy groups), pyrrolidinyl groups (such pyrrolidinyl groups are alternatively replaced by 1 to 3 substituents which are independently chosen from the hydroxy group, amino group, mono- or di-alkylamino group, halogen atoms, oxo groups, carboxyl groups, alkoxycarbonyl groups, carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarbonyl alkoxy groups), and pyrimidinyl groups (such pyrimidinyl groups are alternatively replaced by 1 to 3 substituents which are independently chosen from the carboxyalkyl group, alkoxycarbonyl alkyl group, carboxyalkoxy group And alkoxycarbonyl alkoxy groups) The dihydroxazolyl group is alternatively replaced by 1 to 2 substituents, which are independently chosen from the carboxyl group, alkoxycarbonyl group, alkyl group, carboxyalkyl group, alkoxycarbonyl alkyl group and hydroxyalkyl group. The mono- or di-alkylcarbamoyl group is alternatively replaced by 1 to 5 substituents, which are independently chosen from the halogen atom, hydroxy group, carboxyl group, alkoxycarbonyl group, alkoxy group, amino group, mono- or di-alkylamino group, morpholinyl group, pyridyl group, cycloalkyl group (The cycloalkyl group is alternatively replaced by 1 to 3 substituents, which are independently chosen from the carboxyl group, alkoxycarbonyl group, halogen atom, amino group and hydroxy group) and phenyl group (the phenyl group may be alternatively replaced by one to three substituents, independently chosen from the carboxylic group, alkoxycarbonyl group, halogen atom, amino group, and hydroxy group). R2 is an alkyl group, R3 is a hydrogen atom, R4 is an alkylene group, R5 is a heterocyclic group chosen from among pyrimidinyl groups, pyridyl groups, triazolyl groups, tetrazolyl groups, oxadiazolyl groups, dihydropyrimidinyl groups, pyrazinyl groups, thiazolyl groups, oxazolyl groups, imidazolyl groups, dihydroxazinyl groups, pyrazolyl groups, and dihydropyrazinyl groups, wherein the heterocyclic group may be replaced by one to four substituents, such that Select from the following groups, or 1 to 4 substituents selected from the following groups and an oxo group: cyano group, nitro group, carboxyl group, sulfo group, C3-10alkyl group. The alkyl group is replaced by a group chosen from the halogen atom, cyano group, hydroxy group, carboxyl group, alkoxycarbonyl group, tetrazolyl group, mono- or di-alkylcarbamoyl group, alkoxy group (such alkoxy group is alternatively replaced by a phenyl, carboxyl or hydroxy group), alkanoyloxy group, alkylthio group, alkylsulfonyl group, alkylsulfinyl group, amino group, mono- or di-alkylamino group is alternatively replaced by a carboxyl or alkoxy group, mono- or di-alkylsulfamoyl group. The mono- or di-alkyl uriido group is alternatively replaced by a morpholinyl group, the oxeranyl group, the dioxolanyl group is alternatively replaced by an alkyl group, the pyrrolidinyl group is alternatively replaced by an alkoxycarbonyl or carboxylic group, the pyrrolidinyl group is alternatively replaced by an alkoxycarbonyl alkyl or carboxyalkyl group, the piperidinyl group is alternatively replaced by an alkoxycarbonyl or carboxyalkyl group, the piperidinyl group is alternatively replaced by an alkoxycarbonyl alkyl or carboxyalkyl group, the piperazinyl group is alternatively replaced by an alkyl group, the hexahydroazepinyl group, the morpholinyl group, and the piperidinyl oxy group is alternatively replaced by an alkyl group. Alkenyl groups are alternatively replaced by groups selected from cyano groups, hydroxy groups, carboxyl groups, benzyloxycarbonyl groups, tetrazolyl groups. Alkenylkoxy groups are alternatively replaced by carboxyl groups, C3-10alkoxy groups. Alkoxy groups are alternatively replaced by groups selected from halogen atoms, cyano groups, hydroxy groups, carboxyl groups, alkoxycarbonyl groups, tetrazolyl groups, carbamoyl groups, mono- or di-alkylcarbamoyl groups are alternatively replaced by hydroxy groups, alkoxy groups are, alternatively replaced by carboxyl or hydroxy groups, alkanoyloxy groups, alkylthio groups, alkylsulfonyl groups, alkylsulfinyl groups, aminosulfonyl groups, amino groups, mono- or di-alkylamino groups. substituted by a carboxylic or alkoxy group, mono- or di-alkylsulfamoylamino group, mono- or di-alkyluriido group alternatively substituted by a morpholinyl group, cycloalkyl group alternatively substituted by a carboxymethyl group, oxeranyl group, phenyl group alternatively substituted by an alkoxy or carboxyl group, morpholinyl group, pyrrolidinyl group alternatively substituted by an alkoxycarbonyl or carboxyl group, pyrrolidinyl group alternatively substituted With alkoxycarbonyl alkyl or carboxyl alkyl groups, pyrrolidinyl groups are replaced by oxo groups, piperidinyl groups are alternatively replaced by alkoxycarbonyl or carboxyl groups, piperidinyl groups are alternatively replaced by alkoxycarbonyl alkyl or carboxyl alkyl groups, piperazinyl groups are alternatively replaced by alkyl groups, hexahydroazepinyl groups, pyrimidinyl groups, pyridyl groups, dioxolanyl groups are alternatively replaced by alkyl groups, oxadiazolyl groups are alternatively replaced by oxo groups, oxathiadiazolyl groups are alternatively replaced by oxo groups, pyrrolidylcarbonyl groups are alternatively replaced by carboxyl groups, piperidinyl oxy groups are alternatively replaced by phenyl groups, carbamoyl groups. Mono- or di-alkylcarbamoyl groups are alternatively replaced by selected groups from carboxyl, morpholinyl, and alkoxy groups. Hydroxycarbanimidoyl groups. Alkylthio groups are alternatively replaced by selected groups from hydroxy, carboxyl, and mono- or di-alkylcarbamoyl groups. Alkylsulfinyl groups. Alkylsulfonyl groups are alternatively replaced by selected groups from hydroxy, carboxyl, and mono- or di-alkylcarbamoyl groups. Amino groups. Mono- or di-alkylamino groups are alternatively replaced by selected groups from hydroxy, carboxyl, alkoxycarbonyl, alkoxy, mono- or di-alkylamino, and morpholinyl groups. Alkanoylamino groups are alternatively replaced by selected groups from hydroxy, alkoxy, carboxyl and amino groups. Mono- or di-alkyluriido groups are alternatively replaced by selected groups from alkoxy groups, morpholinylcarbonylamino groups, sulfamoyl groups, mono- or di-alkylsulfamoyl groups. Morpholinyl groups are alternatively replaced by selected groups from oxo and carboxyl groups. Thiomorpholinyl groups are alternatively oxidized. Piperazinyl groups are alternatively replaced by selected groups from cyano groups, alkyl groups, hydroxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkyl groups, alkanoyl groups, hydroxyalkanoyl groups, alkoxyalkanoyl groups, benzyloxycarbonyl groups, mono- or di-alkylcarbamoyl groups, mono- or di-alkylsulfamoyl groups, alkylsulfonyl groups and tetrazolyl groups. Piperidinyl groups are alternatively replaced by selected groups from carboxyl groups, hydroxy groups, oxo groups, alkyl groups, hydroxyalkyl groups, carboxyalkyl groups, alkanoyl groups, alkoxy groups, phenylalkoxy groups, alkoxycarbonyl groups and alkoxycarbonyl alkyl groups. The pyrrolidinyl group is alternatively replaced by a group chosen from oxo groups, carboxyl groups, alkanoyl groups, and mono- or di-alkylamino groups. The pyrrolidinyl group is alternatively replaced by an oxo group. The hexahydrodiazepine group is alternatively replaced by an alkanoyl group. The diazolininyl group is alternatively replaced by an oxo group. The dioxolanyl group is alternatively replaced by an alkyl group. The pyridyl group is alternatively replaced by a carboxyl group, hydroxy group, or hydroxyalkyl group (the pyridyl group is further oxidized alternatively). The tetrazolyl group is replaced by a hydroxy or alkyl group alternatively replaced by a morpholinyl group. The dihydroxadiazolyl group is alternatively replaced by an oxo group. The dihydroimitazolyl group. The dihydroxazolyl group. Oxazolidinyl group is alternatively replaced by an oxo group. Tetrahydropyridyl group is alternatively replaced by a benzyl group. Pyrimidinyl group. Tetrahydropyranyl group. Piperidinyl oxy group is alternatively replaced by a selected group from alkyl groups, carboxyl groups, carboxyl alkyl groups and alkanoyl groups. Pyrrolidinyl oxy group is alternatively replaced by a selected group from alkyl groups, carboxyl groups, carboxyl alkyl groups and alkanoyl groups. Tetrahydropyranyl oxy group. Tetrahydrofuranyl oxy group. Thienyl oxy group is alternatively oxidized. Morpholinyl carbonyl group. Piperazinyl carbonyl group is alternatively replaced by a selected group from alkanoyl and alkyl groups and pyrrolidinyl carbonyl group. R6 and R9 are hydrogen atoms, R7 and R9 independently are hydrogen atoms, alkyl groups alternatively substituted by halogen atoms, alkoxy groups, mono- or di-alkylamino groups or halogen atoms, or R7 and R8 may be combined terminally to form alkylene deoxy groups, and R10 is a phenyl or pyridyl group in which the phenyl or pyridyl group is alternatively substituted by one to four substituents, where the alkyl groups are alternatively substituted by halogen atoms, alkoxy groups, hydroxy groups, halogen atoms, cyano groups, amino groups and mono- or di-alkylamino groups. The compound of claim 7, wherein, R1 is an alkoxycarbonyl group alternatively replaced by 1 to 5 substituents independently chosen from the hydroxy group, carboxyl group, alkoxycarbonyl group, alkoxy group (said alkoxy group is alternatively replaced by 1 to 3 substituents independently chosen from the hydroxy group, halogen atom, carboxyl group, and alkoxycarbonyl group), an alkynyl group, a halogen atom, a cycloalkyl group (said cycloalkyl group is alternatively replaced by 1 to 3 substituents independently chosen from the hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonyl alkyl group), a phenyl group (said phenyl group is alternatively replaced by 1 to 3 Substituents that are independently chosen from the hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonyl alkyl group), piperidinyl group (such piperidinyl group is alternatively replaced by one to three substituents that are independently chosen from the hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonyl alkyl group), and pyrrolidinyl group (such pyrrolidinyl group is alternatively replaced by one to three substituents that are independently chosen from the hydroxy group, amino group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonyl alkyl group), or dihydroxazolyl group is alternatively replaced. Alternatively, one to two substituents are substituted by a choice of the carboxylic group, alkoxycarbonyl group, carboxyalkyl group, alkoxycarbonyl alkyl group, and hydroxyalkyl group. R5 is a pyrimidinyl group, pyridyl group, diazolyl group, tetrazolyl group, oxadiazolyl group, dihydropyrimidinyl group, pyrazinyl group, thiacyl group, oxazolyl group, dihydroxazinyl group, pyrazolyl group, or dihydropyrazinyl group, such groups are substituted by one to four substituents selected from the following groups: cyano group, nitro group, carboxyl group, sulfo group. The alkyl group is substituted by a group selected from the halogen atom, cyano group, hydroxy group, carboxyl group, alkoxycarbonyl group, the alkoxy group is alternatively substituted by Carboxylic or hydroxy group, alkanoyloxy group, alkylthio group, alkylsulfonyl group, alkylsulfonyl group, amino group, mono- or di-alkylamino group, mono- or di-alkylsulfamoylamino group, mono- or di-alkyluriido group alternatively replaced by morpholinyl group, oxeranyl group, di-alkylisoxolanyl group, pyrrolidinyl group alternatively replaced by alkoxycarbonyl or carboxyl group, piperidinyl group alternatively replaced by alkoxycarbonyl or carboxyl group, piperazinyl group alternatively replaced by alkyl group, hexahydroazepinyl group and morpholinyl group. Alkenyl group alternatively replaced by carboxyl group, cyano- or Benzyloxycarbonyl group, alkoxy group replaced by selected groups from halogen atoms, cyano group, hydroxy group, carboxyl group, alkoxycarbonyl group, alkoxy group alternatively replaced by carboxyl or hydroxy groups, alkanoyloxy group, alkylthio group, alkylsulfonyl group, alkylsulfinyl group, amino group, mono- or di-alkylamino group, mono- or di-alkylsulfamoylamino group, mono- or di-alkyluriido group alternatively replaced by morpholinyl group, oxeranyl group, di-alkyldioxolanyl group, pyrrolidinyl group alternatively replaced by alkoxycarbonyl or carboxyl group, piperidinyl group alternatively replaced. Optionally with alkoxycarbonyl or carboxylic groups, piperazinyl groups are alternatively replaced by alkyl, hexahydroazepinyl, and morpholinyl groups. Alkoxycarbonyl groups are alternatively replaced by phenyl groups. Mono- or di-alkylcarbamoyl groups are alternatively replaced by carboxyl groups. Hydroxycarbanimidoyl groups. Alkylthio groups. Alkylsulfonyl groups. Alkylsulfonyl groups are alternatively replaced by carboxyl groups. Mono- or di-alkylamino groups are alternatively replaced by groups chosen from. Hydroxy groups, carboxyl groups, alkoxycarbonyl groups, alkoxy groups, mono- or di-alkylamino groups, and morpholinyl groups. Mono- or di-alkylsulfamoyl groups. Morpholinyl groups. The thiomorpholinyl group is alternatively oxidized. The piperazinyl group is alternatively replaced by a selection of alkyl, alkanoyl and hydroxyalkanoyl groups. The piperidinyl group is alternatively replaced by an alkyl group. The tetrazolyl group is alternatively replaced by an alkyl, hydroxyalkyl or morpholinyl alkyl group. The dihydroxadiazolyl group is alternatively replaced by an oxo group. The pyrimidinyl group, tetrahydropyranyl group and R10 are phenyl or pyridyl groups in which the phenyl or pyridyl group is alternatively replaced by 1 to 4 selected substituents from the alkyl group are alternatively replaced by a halogen atom, alkoxy group, hydroxy group, halogen atom, cyano group, amino group and Mono or di-alkylamino group 9. The compound of claim 1, where R1 is a hydrogen atom, the alkoxycarbonyl group is alternatively replaced by 1 to 5 independently chosen substituents, from a cyano group, a hydroxy group, a carboxyl group, a carboxyl group, an alkoxycarbonyl group, an alkoxy group (said alkoxy group is alternatively replaced by 1 to 3 independently chosen substituents). From hydroxy groups, amino groups, mono- or di-alkylamino groups, halogen atoms, carboxylic groups, alkoxycarbonyl groups, carboxyalkoxy and alkoxycarbonylalkoxy groups), alkylthio groups, alkylsulfonyl groups, alkynyl groups, amino groups, mono- or di-alkylamino groups, tetrazolyl groups, carbamoyl groups, mono- or di-alkylcarbamoyl groups (such mono- or di-alkylcarbamoyl groups are alternatively replaced by one to three substituents which are independently chosen from the carboxyl and alkoxycarbonyl groups), alkanoylamino groups (such alkanoylamino groups are Alternatively replaced by 1 to 3 substituents chosen independently of the carboxyl group, alkoxycarbonyl group, hydroxy group and halogen atom), halogen atom, cycloalkoxy group (such cycloalkyl group is alternatively replaced by 1 to 3 substituents chosen independently of the hydroxy group, amino group, mono- or di-alkylamino group, halogen atom, oxo group, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, alkoxycarbonyl alkyl group, carboxyalkoxy group and alkoxycarbonyl alkoxy group), phenyl group (such phenyl group is substituted Optionally with 1 to 3 substituents which are independently chosen from the hydroxy group, amino group, mono- or di-alkyl amino group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, alkoxycarbonyl alkyl group, carboxyalkoxy group and alkoxycarbonyl alkoxy group), the morpholinyl group is alternatively replaced by an oxo group, piperidinyl group (such piperidinyl group is alternatively replaced by 1 to 3 substituents which are independently chosen from the hydroxy group, amino group, mono- or di-alkyl amino group, halogen atom, oxyl group, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, alkoxy carbonyl alkyl group, carboxyalkoxy group and alkoxycarbonyl alkoxy group), pyrrolidinyl group. (The pyrimidinyl group may be alternatively replaced by one to three substituents independently chosen from among the hydroxy groups, amino groups, mono- or di-alkylamino groups, halogen atoms, oxo groups, carboxyl groups, alkoxycarbonyl groups, carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarbonyl alkoxy groups), and pyrimidinyl groups. (The pyrimidinyl group may be alternatively replaced by one to three substituents independently chosen from among the carboxyalkyl groups, alkoxycarbonyl alkyl groups, carboxyalkoxy groups and alkoxycarboxylalkoxy groups.) The dihydroxazolyl group may be alternatively replaced by 1 to 2 substituents, independently chosen from the carboxylic group, alkoxycarbonyl group, alkyl group, carboxyalkyl group, alkoxycarbonylalkol group, and hydroxyalkyl group. The mono- or di-alkylcarbamoyl group is alternatively replaced by 1 to 5 substituents, independently chosen from the halogen atom, hydroxy group, carboxylic group, alkoxycarbonyl group, alkoxy group, amino group, mono- or di-alkylamino group, morpholinyl group, pyridyl group, cycloalkyl group (such cycloalkyl group is alternatively replaced by 1 to 3 substituents, independently chosen from the carboxylic group, alkoxycarbonyl group, halogen atom, amino group, and hydroxy group), and phenyl group (such phenyl group is alternatively replaced by 1 to 3 substituents, independently chosen from the which is selected independently of the carboxylic group, alkoxycarbonyl group, halogen atom, amino group, and hydroxy group) R2 is the alkyl group, R3 is the hydrogen atom, R4 is the alkylene group, R5 is the formula group (chemical formula), where ring A is a saturated or unsaturated 5- to 8-membered heterocyclic group containing 1 to 4 heteroatoms independently selected from the oxygen, sulfur, and nitrogen atoms, and R11 is a group selected from the following groups: cyano group, nitro group, carboxyl group, sulfo group. The alkyl group is replaced by a group selected from the halogen atom, cyano group, hydroxy group, carboxyl group, alkoxycarbonyl group, alkoxy group (the alkoxy group is substituted). Alternatively with phenyl, hydroxy or carboxyl groups), alkanoyloxy groups, alkylthio groups, alkylsulfonyl groups, alkylsulfinyl groups, amino groups, mono- or di-alkylamino groups, mono- or di-alkylsulfamoylamino groups, mono- or di-alkyluriido groups alternatively replaced by morpholinyl groups, oxeranyl groups, di-alkyldioxo-lanyl groups, pyrrolidinyl groups alternatively replaced by alkoxycarbonyl or carboxyl groups, piperacinyl groups alternatively replaced by alkoxycarbonyl or carbonyl groups, piperacinyl groups alternatively replaced by alkyl groups, hexahydroazepinyl groups and morpholinyl groups. Alkenyl groups are alternatively replaced by carboxyl, cyano or benzyloxycarbonyl groups. The alkoxy groups are alternatively replaced by groups selected from the halogen atoms, cyano groups, hydroxy groups, carboxyl groups, alkoxycarbonyl groups, alkoxy groups (the alkoxy groups are alternatively replaced by phenyl, hydroxy or carboxyl groups), alkanoyloxy groups, alkylthio groups, alkylsulfonyl groups, alkylsulfinyl groups, amino groups, mono- or di-alkylamino groups, mono- or di-alkylsulfamoylamino groups, mono- or di-alkyluriido groups are alternatively replaced by morpholinyl groups, oxeranyl groups, di-alkyldioxo-lanyl groups, pyrrolidinyl groups are Alternatively replaced by alkoxycarbonyl or carboxyl groups, piperidinyl group alternatively replaced by alkoxycarbonyl or carboxyl groups, piperazinyl group alternatively replaced by alkyl, hexa-hydroazepinyl, and morpholinyl groups. Alkoxycarbonyl group alternatively replaced by phenyl group. Mono- or di-alkylcarbamoyl group alternatively replaced by carboxyl group. Hydroxycarbanimidoyl group. Alkylthio group. Alkylsulfonyl group. Alkylsulfonyl group alternatively replaced by carboxyl group. Mono- or di-alkylamino groups alternatively replaced by hydroxy groups, carboxyl groups, alkoxycarbonyl groups, alkoxy groups, mono- or di-alkylamino groups, and morpholinyl groups. Mono- or di-alkylsulfamoyl groups, morpholinyl groups, thiomorpholinyl groups are alternatively oxidized. Piperazinyl groups are alternatively replaced by alkyl, alkanoyl and hydroxyalkanoyl groups. Pyrrolidine groups are alternatively replaced by carboxyl, carboxyalkyl groups, alkyl groups, alkoxycarbonyl groups or alkoxycarbonyl alkyl groups. Piperidinyl groups are alternatively replaced by carboxyl, carboxy alkyl groups, alkyl groups, alkoxycarbonyl groups or alkoxycarbonyl alkyl groups. Dioxolanyl groups are alternatively replaced by alkyl groups. Tetrazolyl groups are alternatively replaced by alkyl, hydroxyalkyl or morpholinyl alkyl groups. Dihydroxadiazolyl groups are alternatively replaced by oxo groups. Pyrimidinyl group, tetrahydropyranyl group R6 and R9 are hydrogen atoms, R7 and R8 are independent hydrogen atoms, alkyl groups are alternatively substituted with halogen atoms, alkoxy groups, mono- or di-alkylamino groups or in combination at the end to form alkylene deoxy groups, and R10 is a phenyl or pyridyl group in which the phenyl or pyridyl group is alternatively substituted with 1 to 4 substituents, where the alkyl groups are alternatively substituted with halogen atoms, alkoxy groups, hydroxy groups, halogen atoms, cyano groups, amino groups and mono- or di-alkylamino groups. 10. The compound of claim 9, wherein ring A is a pyrimidinyl group, pyrimidinyl group, pyridyl group, triazolyl group, tetrazolyl group, oxadiazolyl group, dihydropyrimidinyl group, pyrazinyl group, thiazolyl group, oxazolyl group, dihydroxazinyl group, imidazolyl group, pyrazolyl group, or dihydropyrazinyl group11. The compound of claim 10, wherein ring A is a pyrimidinyl group, pyridyl group, pyridinyl group, tetrazolyl group, oxadiazolyl group, pyrazinyl group, thiazolyl group or oxazolyl group and R11 is a carboxyl group, cyano group, nitro group, alkyl group or hydroxy alkoxy group is substituted by a group selected from among hydroxy group, cyano group, carboxyl group, alkoxycarbonyl group, alkoxy group, phenylalkoxy group, hydroxyalkoxy group, carboxyalkoxy group, alkylthio group, alkylsulfonyl group, alkylsulfinyl group, amino group, mono- or di-alkylamino group, mono- or di-alkylsulfamoylamino group, mono- or di-alkyluriido group is substituted. Alternatively replaced by a morpholinyl group, an oxeranyl group, a di-alkyldioxolanyl group, a pyrrolidinyl group is alternatively replaced by a carboxyl group, a piperidinyl group is alternatively replaced by a carboxyl group, a piperazinyl group is alternatively replaced by an alkyl group, and a morpholinyl group. The alkynyl group is alternatively replaced by a carboxyl group. The alkoxy group is replaced by selected groups. From hydroxy group, cyano group, carboxyl group, alkoxycarbonyl group, alkoxy group, phenylalkoxy group, hydroxyalkoxy group, carboxyalkoxy group, alkylthio group, alkylsulfonyl group, alkylsulfinyl group, amino group, mono- or di-alkylamino group, mono- or di-alkylsulfamoylamino group, mono- or di-alkyluriido group alternatively replaced by morpholinyl group, oxeranyl group, di-alkyldi-oxolanyl group, pyrrolidinyl group alternatively replaced by carboxyl group, piperidinyl group alternatively replaced by carboxyl group, piperazinyl group alternatively replaced by alkyl and morpholinyl group. Alkoxycarbonyl groupHydroxycarbanimidoyl groupAlkyl thiogroupAlkylsulfonyl group is alternatively replaced by a carboxylMono- or di-alkylamino group is alternatively replaced by a hydroxy, carboxyl, alkoxy group or mono- or di-alkylamino groupMorpholinyl groupThiomorpholinyl group is alternatively oxidizedPiperachinyl group is alternatively replaced by a group selected from alkyl, alkanoyl and hydroxyalkanoyl groupsPyrrolidine group is alternatively replaced by a carboxyl, alkyl group, carboxyalkyl group or alkoxycarbonyl groupPiperinyl group is alternatively replaced by a carboxyl, alkyl group, carboxyalkyl group or alkoxycarbonyl groupTetrazolyl group is alternatively replaced by Alkyl group, hydroxyalkyl group or morpholinyl alkyl group and oxodihydroxadiazolyl group, pyrimidinyl group or tetrahydropyranyl group 12. The compound of claim 11, wherein R1 is an alkoxycarbonyl group alternatively replaced by 1 to 5 substituents independently chosen from the hydroxy group, carboxyl group, alkoxycarbonyl group, alkoxy group (said alkoxy group is alternatively replaced by 1 to 3 substituents independently chosen from the hydroxy group, halogen atom, carboxyl group, and alkoxycarbonyl group), an alkynyl group, a halogen atom, a cycloalkyl group (said cycloalkyl group is alternatively replaced by 1 to 3 substituents independently chosen from the hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonyl alkyl group), a phenyl group (said phenyl group is alternatively replaced by 1 to 3 Substituents that are independently chosen by the hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonyl alkyl group), piperidinyl group (such piperidinyl group is alternatively replaced by 1 to 3 substituents that are independently chosen by the hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonyl alkyl group), and pyrrolidinyl group (such pyrrolidinyl group is alternatively replaced by 1 to 3 substituents that are independently chosen by the hydroxy group, halogen atom, carboxyl group, alkoxycarbonyl group, carboxyalkyl group, and alkoxycarbonyl alkyl group), or dihydroxazolyl group is alternatively replaced by 1 to 2 substituents, which are independently chosen from the carboxylic group, alkoxycarbonyl group, carboxyalkyl group, alkoxycarbonyl alkyl group, and hydroxyalkyl group. R10 is a phenyl group alternatively replaced by 1 to 3 substituents, which are alternatively chosen from. The alkyl groups are alternatively replaced by a halogen atom, alkoxy group, halogen atom, and cyano group. Ring A is a pyrimidinyl group, pyridyl group, pyridinyl group, tetrazolyl group, oxadiazolyl group, or thiazolyl group, and R11 is a carboxyl group, cyano group, nitro group, alkyl group, and hydroxyalkyl group. Select from hydroxy groups, carboxyl groups, alkoxycarbonyl groups, alkoxy groups, phenylalkoxy groups, carboxyalkoxy groups, alkylthio groups, alkylsulfonyl groups, alkylsulfinyl groups, amino groups, mono- or di-alkylamino groups, mono- or di-alkylsulfamoylamino groups, mono- or di-alkyluriido groups alternatively replaced by morpholinyl groups, oxeranyl groups, di-alkyldioxolanyl groups, piperazinyl groups alternatively replaced by alkyl groups, and morpholinyl groups. Alkenyl groups alternatively replaced by carboxyl groups. Alkoxy groups are substituted. With selected groups of cyano group, hydroxy group, carboxyl group, alkoxycarbonyl group, alkoxy group, phenylalkoxy group, carboxyalkoxy group, alkylthio group, alkylsulfonyl group, alkylsulfonyl group, amino group, mono- or di-alkylamino group, mono- or di-alkylsulfamoylamino group, mono- or di-alkyluriido group alternatively replaced by morpholinyl group, oxeranyl group, di-alkyldioxolanyl group, piperazinyl group alternatively replaced by alkyl group, and morpholinyl group, hydroxycarbanimidoyl group, alkylthio group, alkylsulfonyl group alternatively replaced by alkoxycarbonyl group. The mono- or di-alkylamino group is alternatively replaced by a hydroxy group, carboxyl group, alkoxy group, morpholinyl group. The thiomorpholinyl group is alternatively oxidized. The piperazinyl group is alternatively replaced by alkyl, alkanoyl and hydroxyalkanoyl groups. The pyrrolidinyl group is alternatively replaced by a carboxyl group, alkyl group, carboxyalkyl group or alkoxycarbonyl group. The piperidinyl group is alternatively replaced by a carboxyl group, alkyl group, carboxyalkyl group or alkoxycarbonyl group. The tetrazolyl group is alternatively replaced by an alkyl group, hydroxyalkyl or morpholinyl alkyl group and an oxodihydroxadiazolyl group. The pyrimidinyl group or tetrahydropyranyl group. 13. The compound of claim 12, wherein R1 is an alkoxycarbonyl group alternatively replaced by 1 to 5 substituents independently chosen from the carboxylic group, alkoxycarbonyl group, halogen atom, hydroxy group, and cycloalkyl group. R10 is a phenyl group alternatively replaced by 1 to 3 substituents independently chosen from the cyano group, the alkyl group alternatively replaced by a halogen atom, and the alkoxy group on ring A is a pyrimidinyl group, pyridyl group, tetrazolyl group, or oxadiazolyl group. R11 is a carboxyl group. The alkyl group is replaced by a hydroxy group, carboxyl group, alkoxy group, or alkylsulfonyl group. The alkynyl group is alternatively replaced by a carboxyl group. The alkoxy group is replaced by a cyano group, carboxyl group, hydroxy group, alkoxy group, alkyl thio or alkyl sulfonyl group. The mono- or di-alkylamino group is alternatively replaced by a carboxyl group or alkoxy group. The morpholinyl group, piperidinyl group is replaced by a carboxyl group. The tetrazolyl group is replaced by a hydroxyalkyl group. R7 is the alkyl group alternatively replaced by a halogen atom, alkoxy group or a mono- or di-alkylamino group and R8 is the hydrogen atom. 14. The compound of claim 13, wherein R1 is an ethoxycarbonyl group, a hydroxyethoxycarbonyl group, a 2-fluoroethoxycarbonyl group, a 2,2-difluoroethoxycarbonyl group or a 2,2,2-trifluoroethoxycarbonyl group, R2 is an ethyl group, R10 is a phenyl group replaced by one to two substituents selected from among a cyano group, a trifluoromethyl group and a methoxy group, R7 is a trifluoromethyl group and a methoxy group. The compound of claim 13, wherein R1 is a carboxy (C2-10alkoxy) carbonyl or alkoxycarbonyl (C2-10alkoxy) carbonyl group, R2 is an ethyl group, R10 is a phenyl group replaced by one to two substituents selected from among a cyano group, a trifluoromethyl group and a methoxy group, R7 is a trifluoromethyl or methoxy group. Selected compounds from the following compounds or salts thereof that are pharmaceutically accepted. (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholine-4-yl)-pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-{[methyl-(2-methoxyethyl)]- amino}pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1- carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)- pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-(5-carboxypyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-carboxyethyl)pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-[2-(2-hydroxyethyl)-2H- tetrazol-5-yl]pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline- 1-carboxylic acid ethyl ester. (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholine-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{(3,5-dimethoxybenzyl)-[5-(morpholine-4-yl)pyrimidine-2-yl]}amino-2- ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{(3,5-dicyanobenzyl)-[5-(morpholine-4-yl)pyrimidine-2-yl]}amino-2- ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{(3-cyanobenzyl)-[5-(morpholine-4-yl)pyrimidine-2-yl]}amino-2-ethyl- 6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R*,4S*)-4-([3,5-bis(trifluoromethyl)benzyl)-{5-[2-(2-hydroxyethyl)-2H- tetrazol-5-yl]pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin- 1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[2-(2-hydroxyethyl)-2H- tetrazol-5-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[2-(2-methanesulfonylethyl)-2H- tetrazol-5-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethyl)benzyl]-[5-(morpholine-4-yl)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R*,4S*)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholine-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(4-carboxypiperidin-1-yl)pyrimidine-2-yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(2-carboxyethyl)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-(5-{[methyl-(2-carboxyethyl)]- amino}pyrimidine-2-yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1- carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-carboxypropoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-{5-[3-(tetrazol-5-yl)propoxy] pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(4-carboxybutoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(5-carboxypentyoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-carboxyethyl)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(4-carboxymethyl-piperidin- 1-yl)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1- carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-carboxypropoxy)pyridine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(4-carboxybutoxy)pyridine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-[(3-cyano-5-trifluoromethylbenzyl]-[5-(4-carboxybutoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-carboxypropoxy)pyrimidine-2-yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-carboxypropoxy)pyrimidine-2-yl]}amino-2-ethyl-6-dimethylamino-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(4-carboxypiperidin-1-yl)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(4-carboxypiperidin-1-yl)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid ethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-carboxypropoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2,2,2-trifluoroethyl ester (2R,4S)-4-{[3-cyano-5-trifluoromethylbenzyl]-[5-(3-carboxypropoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2,2,2-trifluoroethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(4-carboxypiperidin-1-yl)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2-hydroxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholine-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholine-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid3- carboxypropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholine-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholine-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholine-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid5- carboxypentyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-hydroxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-hydroxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid5- carboxypentyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid3- carboxypropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-cyanopropoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester or (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-dimethylaminopyrimidine-2-yl)}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester 17. Selected compounds from the following compounds or salts thereof that are pharmaceutically accepted (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-hydroxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid 3- carboxypropyl ester. (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-hydroxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-hydroxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid5- carboxypentyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-cyanopropoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid 3- carboxypropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-cyanopropoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid 4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-cyanopropoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-cyanopropoxy)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid5- carboxypentyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-(5-dimethylaminopyrimidine-2-yl)} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid 3- carboxypropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-(5-dimethylaminopyrimidine-2-yl)} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid 4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-(5-dimethylaminopyrimidine-2-yl)} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-(5-dimethylaminopyrimidine-2-yl)} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid5- carboxypentyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid3- carboxypropyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyrimidine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(2-methoxyethoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxyethyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(2-methoxyethoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid3-carboxypropyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(2-methoxyethoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxybutyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(2-methoxyethoxy)pyrimidine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyridine-2-yl]} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyridine-2-yl]} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid3- carboxypropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyridine-2-yl]} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyridine-2-yl]} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-hydroxyethoxy)pyridine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyridine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyridine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid3- carboxypropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyridine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(2-methoxyethoxy)pyridine- 2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(3-cyanopropoxy)pyridine-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-dimethylaminopyridine-2-yl]} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-dimethylaminopyridine-2-yl]} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid3- carboxypropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-(5-dimethylaminopyridine-2-yl)} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-dimethylaminopyridine-2-yl]} amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyridin-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxyethyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyridin-2- yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid3- carboxypropyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyridine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid4-carboxybutyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyridine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxy-2-methylpropyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(2-methoxyethoxy)pyridine-2-yl]}amino-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid3- carboxypropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyrimidin-2- yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyrimidin-2-yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyrimidine-2-yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinoline-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyridine-2-yl]} amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxyethyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyridine-2-yl]} amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid3-carboxy-propyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyridine-2-yl]} amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid4-carboxy-butyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyridine-2-yl]} amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxy-2- methylpropyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyridine-2-yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid4- carboxybutyl ester (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(morpholin-4-yl)pyridine-2-yl]}amino-2-ethyl-6-methoxy-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxy-2-methylpropyl ester (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl]-[5-(morpholin-4-yl)pyrimidine-2- yl]}amino-2-ethyl-6,7-ethylenedioxy-3,4-dihydro-2H-quinolin-1-carboxylic acid2- carboxyethyl ester or (2R,4S)-4-{(3-cyano-5-trifluoromethylbenzyl)-[5-(2-methoxyethoxy)pyrimidine-2-yl]}amino-2-ethyl-6,7-ethylenedioxy-3,4-dihydro-2H-quinolin-1-carboxylic acid2-carboxyethyl ester 18. A method for preparing a tetrahydroquinoline derivative of formula (I): (chemical formula)(I), wherein each of the symbols R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 has the same meaning as stated above in claim 1, comprising condensing a compound of formula (II): (chemical formula)(II), wherein each of the symbols has the same meaning as stated above, with a compound of formula (III): R10-R4-Z1(III), wherein Z1 is a Lifting group and other symbols have the same meaning as stated above. 19. Compound of formula(II): (chemical formula)(II), wherein each of the symbols R1, R2, R3, R4, R5, R6, R7, R8, and R9 has the same meaning as in claim 1, or a salt thereof. 20. A diesteriomer mixture of formula (XIII-a): (chemical formula)(XIII-a) where R15 is an optically active protecting group for the amino groups and the symbols R2,R3,R6,R7,R8, and R9 have the same meaning as in claim 1, or salts thereof 21. A method for preparing a diesteriomeric mixture of formula (XIII-a): (chemical formula)(XIII-a), wherein R15 is an optically active protecting group for the amino groups and the symbols R2, R3, R6, R7, R8, and R9 have the same meaning as stated in claim 1, comprising the reaction of the compound of formula (XV): (chemical formula)(XV), wherein each symbol has the same meaning as stated above, with the compound of formula (XIV-a): (chemical formula)(XIV-a), wherein each symbol has the same meaning as stated above. 22. A method for preparing an optically active compound of formula (XIII-b): (chemical formula)(XIII-b), wherein the symbols R2, R3, R6, R7, R8, and R9 have the same meaning as stated in claim 1, consisting of reacting the compound of formula (XV): (chemical formula)(XV), wherein each symbol has the same meaning as stated above, with the compound of formula (XIV-a): (chemical formula)(XIV-a), wherein R15 is an optically active protecting group for the amino group and R3 has the same meaning as stated above, dissolving the diesteriomer mixture of formula (XIII-a) to yield C(XIII-a), wherein each symbol has the same meaning as stated above, and eliminating the optically active protecting group for the amino group 23. The process of claim 21 or 22, wherein the compound of formula (XVIII): (chemical formula)(XVIII), wherein the symbols R2, R6, R7, R8 and R9 having the same meaning as stated in claim 1 are used in place of the compound (XV): (chemical formula)(XV), wherein each symbol has the same meaning as stated above 24. A pharmaceutical mixture, comprising any one of claims 1 to 17, or a salt thereof, pharmaceutically acceptable as an active ingredient. 25. A method for the prevention or treatment of arterial hypertrophy, peripheral arterial disease, dyslipidemia, hyperlipidemia, hypolipidemia, hypertriglycerideemia, hereditary hyperlipidemia, cardiovascular disease, angina pectoris, localized ischemic heart disease, acute episodes, myocardial infarction, reperfusion injury, postoperative valvular stenosis, hypertension, cerebral infarction, acute episodes of cerebral infarction, diabetes mellitus, vascular complications of diabetes, thrombophlebitis, obesity or intrinsic toxicity, comprising administering an effective amount of any of the compounds of claims 1 to 17, or a pharmaceutically acceptable salt thereof, to a patient who requires any of the following 28. The use of any one of the compounds of claims 1 to 17, or a pharmaceutically acceptable salt thereof, in the treatment of patients suffering from arterial hyperplasia, peripheral vascular disease, dyslipidemia, hyperlipidemia, hypertriglycerideemia, hypertriglycerideemia, hereditary hyperlipidemia, cardiovascular disease, angina pectoris, localized ischemic attack, acute episodes, myocardial infarction due to ischemia, reperfusion injury, postoperative vascular stenosis, hypertension, cerebral infarction due to ischemia, acute episodes of brain, diabetes, vascular complications of diabetes, thrombophlebitis, obesity, or conditions in which the blood is toxic.