TH153190A - Benzamide derivatives for inhibition of the inactivation of ABL1, ABL2 and BCR-ABL1. - Google Patents
Benzamide derivatives for inhibition of the inactivation of ABL1, ABL2 and BCR-ABL1.Info
- Publication number
- TH153190A TH153190A TH1401006797A TH1401006797A TH153190A TH 153190 A TH153190 A TH 153190A TH 1401006797 A TH1401006797 A TH 1401006797A TH 1401006797 A TH1401006797 A TH 1401006797A TH 153190 A TH153190 A TH 153190A
- Authority
- TH
- Thailand
- Prior art keywords
- abl1
- bcr
- inactivation
- abl2
- inhibition
- Prior art date
Links
- 230000002779 inactivation Effects 0.000 title claims abstract 3
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 title 1
- 101000823271 Homo sapiens Tyrosine-protein kinase ABL2 Proteins 0.000 title 1
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 title 1
- 102100022651 Tyrosine-protein kinase ABL2 Human genes 0.000 title 1
- 150000003936 benzamides Chemical class 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 4
- 206010028980 Neoplasm Diseases 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims abstract 2
- 230000035772 mutation Effects 0.000 claims abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
Abstract
DC60 (13/11/57) การประดิษฐ์นี้เกี่ยวข้องกับสารประกอบที่มีสูตร (I) ดังนี้ (สูตรเคมี) (I) โดยที่ Y, Y1, R1, R2, R3 และ R4 เป็นดังที่มีการจำกัดความไว้ในลักษณะและความมุ่งหมายของ การประดิษฐ์ที่มีความสามารถในการยับยั้งสภาพออกฤทธิ์ของ BCR-ABL1 และพันธุ์กลายของโปรตีน ดังกล่าว การประดิษฐ์นี้ยังจัดให้มีกระบวนการในการเตรียมสารประกอบตามการประดิษฐ์นี้ ยาเตรียม ทางเภสัชกรรมซึ่งประกอบรวมด้วยสารประกอบดังกล่าว และวิธีการในการใช้สารประกอบดังกล่าว ในการรักษาโรคมะเร็ง สิทธิบัตรยา DC60 (13/11/57) This invention involves compounds with the formula (I) as follows (Chemical formula) (I) where Y, Y1, R1, R2, R3 and R4 are, as they are defined in nature and The purpose of Invention with the ability to inhibit the inactivation of BCR-ABL1 and its mutations, the invention also provides a process for the preparation of the compound according to this invention, a pharmaceutical preparation consisting of such compounds. And methods for using the compound In cancer treatment, drug patent
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH153190A true TH153190A (en) | 2016-06-17 |
| TH1401006797A TH1401006797A (en) | 2016-06-17 |
Family
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