TH161983A - Processes and intermediates for the production of JAK inhibitors. - Google Patents
Processes and intermediates for the production of JAK inhibitors.Info
- Publication number
- TH161983A TH161983A TH1401001229A TH1401001229A TH161983A TH 161983 A TH161983 A TH 161983A TH 1401001229 A TH1401001229 A TH 1401001229A TH 1401001229 A TH1401001229 A TH 1401001229A TH 161983 A TH161983 A TH 161983A
- Authority
- TH
- Thailand
- Prior art keywords
- production
- intermediates
- processes
- jak inhibitors
- diseases
- Prior art date
Links
- 229940122245 Janus kinase inhibitor Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 102000015617 Janus Kinases Human genes 0.000 claims abstract 4
- 108010024121 Janus Kinases Proteins 0.000 claims abstract 4
- 201000010099 disease Diseases 0.000 claims abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 208000027866 inflammatory disease Diseases 0.000 claims abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
Abstract
DC60 (07/03/57) การประดิษฐ์นี้เกี่ยวข้องกับกระบวนการและสารตัวกลางสำหรับการผลิต {1- {1-[3-ฟลูออ โร -2-(ไตรฟลูออโรเมทิล) ไอโซนิโคทิโนอิล]พิเพอริดิน-4-อิล}-3-[4-(7H-ไพร์โรโล[2,3-d]ไพริมิ ดิน-4-อิล)-1H-ไพราซอล-1อิล]อะเซทิดิน-3-อิล}อะซิโตไนโทรล์ ซึ่งมีประโยชน์ในการรักษาโรค ที่เกี่ยวข้องกับฤทธิ์ของเจนัสไคเนส (JAK) ซึ่งประกอบด้วยความผิดปกติจากการอักเสบ โรคแพ้ภูมิ ตัวเอง โรคมะเร็ง และโรคชนิดอื่นๆ สิทธิบัตรยา DC60 (07/03/57) This invention involves a process and an intermediate for the production of {1- {1- [3-fluoro-2- (trifluoromethyl) isonikotino). Il] Piperidin-4-il} -3- [4- (7H-pirolo [2,3-d] pyrimi Soil-4-il) -1H-pyrazol-1 il] acetidin-3-il} acetonitrol Which is useful in treating disease Associated with the activity of Janus kinase (JAK), which includes inflammatory disorders, autoimmune diseases, cancer and other diseases.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH161983A true TH161983A (en) | 2017-04-20 |
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