TH19066A - Method for inhibiting smooth muscle cell proliferation and stenosis - Google Patents
Method for inhibiting smooth muscle cell proliferation and stenosisInfo
- Publication number
- TH19066A TH19066A TH9401002211A TH9401002211A TH19066A TH 19066 A TH19066 A TH 19066A TH 9401002211 A TH9401002211 A TH 9401002211A TH 9401002211 A TH9401002211 A TH 9401002211A TH 19066 A TH19066 A TH 19066A
- Authority
- TH
- Thailand
- Prior art keywords
- chemical formula
- substance
- formula
- stenosis
- hydrogen
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title claims abstract 3
- 208000031481 Pathologic Constriction Diseases 0.000 title abstract 3
- 208000037804 stenosis Diseases 0.000 title abstract 3
- 230000036262 stenosis Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 title abstract 2
- 239000000126 substance Substances 0.000 claims abstract 30
- 150000001875 compounds Chemical class 0.000 claims abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
- 239000001257 hydrogen Substances 0.000 claims abstract 6
- 239000003814 drug Substances 0.000 claims abstract 3
- 229940079593 drug Drugs 0.000 claims abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010057469 Vascular stenosis Diseases 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 claims 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
Abstract
วิธีสำหรับยับยั้งการเพิ่มจำนวนเซลล์กล้ามเนื้อเรียบและภาวะตีบซึ่งประกอบ ด้วยการให้สารประกอบที่มีสูตร (I) หรือสูตร (II) ในปริมาณที่ทำให้เกิดผลแก่มนุษย์ หรือสัตว์เลี้ยงลูกด้วยนมชนิดอื่นที่จำเป็นต้องได้รับการรักษา (สูตรเคมี) (I) หรือ (สูตรเคมี) (II) ซึ่ง R1และ R3 เป็นอิสระต่อกัน คือ ไฮโดรเจน, -CH3,(สูตรเคมี)(C1-C6 แอลคิล), หรือ (สูตรเคมี) ซึ่ง Ar คือ เฟนิลที่เลือกถูกแทนที่, R2 คือ (สูตรเคมี) (สูตรเคมี) หรือ (สูตรเคมี) และ R4 คือ ไฮโดรเจน หรือ -OR1 และเกลือและโซลเวทที่ยอมรับได้ ทางเภสัชศาสตร์ของสารนั้น และยังให้วิธีสำหรับยับยั้งภาวะตีบด้วย สิทธิบัตรยา Methods for inhibiting smooth muscle cell proliferation and stenosis, which include By administering a compound with formula (I) or formula (II) at doses that were effective for humans. Or other mammals requiring treatment (chemical formula) (I) or (chemical formula) (II) where R1 and R3 are independent of hydrogen, -CH3, (chemical formula) (C1-C6 A Alkyl), or (chemical formula) where Ar is the selected phenyl is substituted, R2 is (chemical formula) (chemical formula) or (chemical formula) and R4 is hydrogen or -OR1 and salt and solve are acceptable Pharmacy of that substance And also provides a method for preventing stenosis with drug patents
Claims (6)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH19066A true TH19066A (en) | 1996-06-14 |
| TH8168B TH8168B (en) | 1998-07-07 |
Family
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