TH21704A - New peptides with immune modulating effects - Google Patents

Abstract

A novel peptide, according to its structural formula (chemical formula), methods for its preparation and applications. In the production of pharmaceutical preparations, this novel peptide is an excellent immunomodulator.

Claims (14)

1. A peptide consisting of 4-15 amino acids according to structural formula (I) (chemical formula), where X is selected from (chemical formula), A is H, a protective group which is an L or D amino acid with or without a protected side chain and/or N-terminal protection, or an amino acid sequence with or without a protected side chain and/or N-terminal protection; N is OH, NH2, a protective group which is an L or D amino acid with or without a protected side chain and terminated with a free carboxyl amide at the C-terminal end, or an amino acid sequence with or without a protected side chain and terminated with a free carboxyl amide or protective group at the C-terminal end, with the following sequences excluded from structural formula (I) (chemical formula). The lengths of A and B can vary as long as they meet the criteria for possible lengths and amino acids, and where the peptide of structural formula (I) has multiple cisdenine regions that may be in oxidized or reducing forms, with the oxidized form having intramolecular bonds. It can be an oxidized or intermolecular disulfide monomer, either as a head-and-tail domer of the peptide of structural formula (I), as well as pharmaceutically acceptable salts of the peptide of structural formula (formula). 2. Peptide according to claim 1, where A is H, a selective shielding group from (chemical formula), B is OH, NH2, a selective shielding group from (chemical formula) of the protected side chain and terminates with an amide at the C end, which is either a free carboxyl group or a selective shielding group from (chemical formula). 3. Peptide as per claim 1, where (chemical formula) 4. Peptide according to claim 3, where (chemical formula) 5. The peptide under claim 2, where X is selected from (chemical formula). 6. Peptide according to claim 2, where (chemical formula) 7. The peptide according to claim 6 in its homodimer form. 8. The peptide according to claim 7 is (chemical formula). 9. The peptide according to claim 2 is (chemical formula). 10. Peptide under claim 1 for therapeutic use. 11. Peptide as per claim 1 for use as an immunomodulator. 12. Use of the peptides under claim 1 for the manufacture of immunomodulatory drugs. 13. Pharmaceutical preparations containing the peptides under Patent 1 as the active ingredient in combination with a pharmaceutically acceptable carrier. 14. A procedure for preparing the peptides of claim 1 by sequential amino acid pairing in the solid phase using an automated synthesizer or by individual amino acid pairing in the liquid phase with appropriately derivatized amino acids. (14 claims, 8 pages, 0 figures)