TH25498A - Benzothiophene compounds, intermediates, composition and methods - Google Patents
Benzothiophene compounds, intermediates, composition and methodsInfo
- Publication number
- TH25498A TH25498A TH9601000616A TH9601000616A TH25498A TH 25498 A TH25498 A TH 25498A TH 9601000616 A TH9601000616 A TH 9601000616A TH 9601000616 A TH9601000616 A TH 9601000616A TH 25498 A TH25498 A TH 25498A
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- ococ6h5
- oso2
- oco
- dimethyl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 4
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims abstract 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- -1 Dimethyl amino, dimethyl amino, diisopropyl amino Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Abstract
การประดิษฐ์นี้ให้สารประกอบสูตร I ซึ่งแสดงฤทธิ์ทางเภสัชศาสตร์ R3-(CH2)n (สูตรเคมี) I ซึ่ง R1 คือ -H,OH,-O(C1-C4แอลคิล), -OCOC6H5,-OCO(C1-C6 แอลคิล), หรือ-OSO2-(C2-C6 แอลคิล); R2 คือ -H,-OH,-O(C1-C4แอลคิล), -OCOC6H5,-OCO (C1-C6 แอลคิล), หรือ-OSO2-C2-C6แอลคิล); หรือ เฮโล; R3 คือ1-พิเพอริดินิล, 1-พิโรลิดินิล,เมธิล-1-พิโรลิดินิล, ไดเมธิล-1-พิโรลิดินิล, 4-มอร์โฟลิโน, ไดเมธิลอะมิโน, ไดเมธิลอะมิโน, ไดไอโซโพรพิลอะมิโน หรือ1-เฮกซะเมธิ ลีนอิมิโน ; n คือ 2 หรือ3; และ z คือ -O- หรือ -S-; หรือเกลือของสารเหล่านั้นซึ่งเป็นที่ยอมรับทางเภสัชกรรม นอกจากนั้นยังไม่ให้สารผสมทางเภสัชศาสตร์ของสารประกอบ I สิทธิบัตรยา This invention provides compound formula I which exhibits pharmacological activity R3- (CH2) n (chemical formula) I, where R1 is -H, OH, -O (C1-C4 alkyl), -OCOC6H5, -OCO (C1- C6 alkyl), or -OSO2- (C2-C6 alkyl); R2 is -H, -OH, -O (C1-C4 alkyl), -OCOC6H5, -OCO (C1-C6 alkyl), or -OSO2-C2-C6 alkyl); Or halo; R3 is 1-piperidinil, 1-pirididinil, methyl-1-piridilidin, dimethyl-1-piridinil, 4-morfolino. , Dimethyl amino, dimethyl amino, diisopropyl amino Or 1-hexamethylene imino; n is 2 or 3; And z is -O- or -S-; Or salts of those substances, which are accepted pharmaceutical In addition, it does not provide the pharmaceutical mixtures of compound I, drug patents.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH25498A true TH25498A (en) | 1997-06-10 |
Family
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