TH3258A - Vaccines for treating urinary tract infections - Google Patents

Abstract

Methods for preparing vaccines for the treatment and prevention of urinary tract infection in humans, including cultivation. Culture by itself of the bacterial strain on 8 to 14 genitourinary diseases of the genus Escherichia coli, Krebsiella pnuemonia, Proteus mirabilis, Proteus morganii, and Streptococcus faecalis, which were obtained from the patient. That is related to urinary tract infections;

Claims (6)

1. Procedures for preparing vaccines for treatment and prevention of urinary tract infection in humans. Which consists of Culture by itself of each strain 8 to 14 urinary tract bacteria of the species Escherichia coli, Klebsiclla pneumonia e. Protcus mirabilis, Proteus morganii and Streptococcus faecalis, which were isolated from the urine of patients with sepsis. urine By cultivating on food culture Suitable infection And where one-half or three-quarters of This is Escherichia coli and when finished Cultured Take the resulting biology and make Inactivated by a known method, then mixtures the different amounts of inactivated bacteria obtained from each strain. Together and dilute the mixture with an isotonic solution It has been sterilized in quantities, which yields approximately 50 million to 500 million bacteria of each strain per milliliter, and the colloidal form of aluminum phosphate is added to the consistency of A1PO4 is elevated to 1.5 to 10 mg / ml. 2. Process according to claim 1, in which the strain used to cultivate The cultures were six strains of Escherichia coli and one strains of each of the above-mentioned strains. 3. Process according to claim 1, which the germline used for culture That culture includes the following strains (Naming In house or DSM received number) Escherichia coli Ec 445 UB 525 UB 560 UB 616 UB 654 UB and 719 UB or DSM 3229 to DSM 3234 Krebisella pneumonia 16 B or DSM 3235 Proteus mirabilis 63 B or DSM 3238 Proteus morganii 58 B or DSM 3237 and Streptococcus faicalis 676 or DSM 3236 4. The process referred to in one of the claims 1 to 3, in which the resulting biologic is lethal by heating the suspension in water to a temperature of 55-60. Degrees Celsius for approximately 1 hour by formaldehyde or by gamma irradiation. 5. The procedure referred to in one of the claims from 1 to 4 in which the dead bacteria are obtained from the strain but Each string was mixed together and the resulting mixture was diluted. The resulting vaccine amount contains approximately 2 x 109 per 1 ml of bacteria. 6. Procedures referred to in any claim from 1 to 5 in which preservatives are added to the vaccine, for example, acid 0- (ethylmerithio) -benzoic ( Thiomersall) (6 claims, 2 pages, pictures)