TH45444A - (Methyl Sulfonyl) Phenyl-2- (5H)-Furanone That interferes with COX-2 - Google Patents

Abstract

This invention includes a novel compound, formula I, with therapeutic uses in cyclooxygenase-2-mediated disease (chemical formula). The invention also includes some pharmaceutical formulations for therapeutic use in cyclooxygenase-2-mediated disease, containing compound formula I.

Claims (54)

Revised 20/09/2016 R9 and R10 are bonded to the carbon atom to which they are attached as carbonyl or thioarbonyl groups. R11 and R12 are independent of each other, i.e. (a) hydrogen (b) mono- or thi- substituted phenyl or mono- or di- substituted benzyl or mono- or di- substituted heteroaryl or mono- or di- substituted heteroarylmethyl, where the substitute is chosen from a group consisting of (1) hydrogen (2) fluoro, chloro, bromo, and iodo (3) C1-6 alkyl (4) C1-6 alkoxy (5) C1-6 alkylthio (6) CN (7) CF3 (8) N3 (9) –C(R13)(R14-OH) (10) –C(R13)(R14)-O-C1-4 alkyl and (11) C1-6 fluoroalkyl or (c) C1-7 alkyl, CH2OR7, CN, CH2CN, C1-6 fluoroalkyl, CON(R7)2, F or OR7 or R11 and R12 combined with carbon, in which they both form a monocyclic ring. Saturated carbon of 3, 4, 5, 6 or 7 atoms. R13 and R14 are independent of each other and are chosen from the group consisting of (a) hydrogen and (b) C1-7 alkyl or R13 and R14 combined with carbon. These two are bonded together to form a carbonyl, -C(=S)-, or a saturated monocyclic carbon ring of 3, 4, 5, 6, or 7 atoms. R15 is chosen from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) phenyl or naphthyl mono-, or tri-, where the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkoxy, (4) C1-10 alkylthio, (f) benzyl or benzyl mono-, where the substitute is chosen from halo, C1-6 alkyl, C1-10 alkoxy, C1-10 alkylthio, C1-10 alkanoic acid, C1-10 alkyl amine, CN, CO2H, and CF3, or R16 and R17 combined with nitrogen. It is bound to form a saturated monocyclic ring of 5, 6, or 7 atoms, with additional O, S, or NR5 added by choice 2. Compounds according to claim 1 where R9 and R10 are bound to their carbon atoms to form carbonyl groups. 3. Compounds according to claim 2 where X is chosen from groups consisting of (a) CH2 and (b) O, Y is chosen from groups consisting of (a) CH2 and (b) O, R1 is chosen from groups consisting of (a) SO2CH3, (b) SO2NR16R17, and (c) S(O)(NH)NH2, and R2 is chosen from groups consisting of (a) C1-6 alkyl, (b) phenyl, and naphthyl, which are mono-, tri-, or tri-substituted, where the substitute is Select from the group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkoxy, (4) C1-6 alkylthio, (5) CN, (6) C1-4 fluoroalkyl, (7) C1-6 alkyl, (8) –CO2H, (9) –CO2-C1-10 alkyl, (10) –C(R5)(R6)-OH, (11) –C(R5)(R6)-O-C1-4 alkyl, (12) –C1-6 alkyl-CO2-R5, and (13) –O-(C1-6 alkyl)-CO2-R5. (C) Mono-, di-, or tri- substituted heteroaryls, where the heteroaryl is a monocyclic aromatic ring of 5 atoms. The ring contains one heteroatom, which is S, O, or N, and 1, 2, or 3 N. An alternative substitution, or heteroaryl, is a 6-atom monocyclic ring. Such a ring has one heteroatom, namely N, and 1, 2, or 3 alternative substitutions where the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthio, (6) CN, (7) CF3, and (8) –C(R5)(R6)-OH. (d) A mono- or di-substituted benzohetrocycle in which the heterocycle is a 5, 6, or 7-member ring which may have 1 or 2 heteroatoms independently chosen from O, S, and N, and which may have a carbonyl or sulfonyl group, where the substitute is chosen from. (e) A heterocycloalkyl group of 5, 6 or 7-members, which may contain 1 or 2 hetero atoms chosen independently of O, S or N and by choice of a carbonyl group or a sulfonyl group. (f) A mono- or di- substituted benzocarbocycle in which the carbocycle is a 5, 6 or 7-member ring in which by choice of a carbonyl group in which the substitute is chosen from. A group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthio, (6) CN, (7) CF3, and (8) –C(R5)(R6)-OH (g) bisoclic heteroaryls that are mono- or di- substituted of the 8, 9, or 10 members, which may contain 2 to 5 heteroatoms independently selected from O, S, or N, and which may contain at least one heteroatom. where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3 and (8) –C(R5)(R6)-OH. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, mono- or di-substituted phenyl, mono- or di-substituted benzyl, mono- or di-substituted hetero-aryl, mono- or di-substituted heteroarylmethyl where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-4 alkyl, (4) C1-4 alkoxy, (5) C1-4 Alkylthio (6) CN (7) CF3 and (8) –C(R5)(R6)-OH R4 were selected from groups consisting of (a) hydrogen (b) C1-6 alkyl (c) C1-6 alkoxy (d) C1-6 alkylthio (e) -OH (f) –OCOR7 (g) –SCOR7 (h) –OCO2R8 and (i) –SCO2R8 or R3 and R4 combined with carbon to which they both are attached to form a monocyclic ring. Saturated carbon atoms of 3, 4, 5, 6, or 7 atoms R5 and R6, each independent, are selected from a group consisting of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 are combined with the atoms they are both bound to form a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms. Each independent R7 is selected from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. R8 Each individual was independently selected from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (c) benzyl or mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls. R16 and R17 were independently selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or mono-substituted phenyl where the substitutes were chosen from... 4. Compounds according to claim 3 where X is O, Y is O, R1 is chosen from a group containing (a) SO2CH3, (b) SO2NR16R17 and (c) S(O)(NH)NH2, R2 is chosen from a group containing phenyl or naphthyl that is mono-, di- or tri- substituted. Where a replacement is chosen. From the group consisting of (1) hydrogen, (2) halo, (3) C1-4 alkoxy, (4) C1-4 alkylthio, (5) CN, (6) C1-3 fluoroalkyl, (7) C1-4 alkyl, (8) –CO2H, (9) –CO2-C1-10 alkyl, and (10) –C(R5)(R6)-OH, R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, mono- or di-substituted phenyl, mono- or di-substituted benzyl, mono- or di-substituted hetero-aryl, mono- or di-substituted heteroarylmethyl, where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-4 alkyl (4), C1-4 alkoxy (5), C1-4 alkylthio (6), CN (7), CF3 and (8) –C(R5)(R6)-OH and R4 were selected from groups containing (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkoxy, (f) benzyl or mono-substituted benzyl where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, COOH or CF3. 5. Compounds according to claim 4 where X is O, Y is O, R1 was selected from groups containing (a) SO2CH3 and (b) SO2NR16R17. R2 was selected from groups containing Mono- or di- substituted phenyls in which the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-4 alkoxy, (4) C1-4 alkylthio, (5) CN, (6) C1-3 fluoroalkyl, (7) C1-4 alkyl, (8) –CO2H and (9) –CO2-C1-10 alkyl. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, mono- or di- substituted phenyls, mono- or di- substituted benzyls, hetero-aryls. Mono- or di- substituted heteroarylmethyl, where the substitute is chosen from a group consisting of (1) hydrogen (2) halo (3) C1-3 alkyl (4) C1-3 alkoxy (5) C1-3 alkylthio (6) CN and (7) CF3. R4 is chosen from a group consisting of (a) hydrogen (b) C1-3 alkyl (c) benzyl or mono-substituted benzyl, where the substitute is chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 combine with the carbon they are attached to to form a carbonyl (a) hydrogen (b) C1-6 alkyl (c) C1-6 alkanoic acid (d) C1-6 alkyl amine (e) phenyl or (f) phenyl monosubstituted compounds in which the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkylamine, CN, CO2H or CF3; and (f) benzyl or benzyl monosubstituted compounds in which the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkylamine, CN, CO2H or CF3. 9. Compounds according to claim 8 in which X is chosen from groups containing (a) CH2 and (b) O; Y is chosen from groups containing (a) CH2 and (b) O; R1 is chosen from groups containing (a) SO2CH3 and (b) SO2NR16R17 R2. It is selected from a group consisting of mono-, di-, or tri- substituted heteroaryls, where the heteroaryl is a 5-atom monocyclic aromatic ring containing one heteroatom (S, O, or N) and 1, 2, or 3 N atoms by choice; or the heteroaryl is a 6-atom monocyclic ring containing one heteroatom (N) and 1, 2, or 3 N atoms by choice. where the substitutes are chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthio, (c) phenyl and phenyl monosubstituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (d) benzyl and benzyl monosubstituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. Each R8 is independently selected from the group consisting of (a) C1-4 alkyl, (b) phenyl and phenyl monosubstituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, (a) C1-4 alkylthio, CN, and CF3 and (c) benzyl or mono-substituted benzyl in which the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls, and R16 and R17 are independently chosen from groups consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl and mono-substituted phenyl in which the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H, or CF3 and (f) Benzyl or mono-substituted benzyl where the substitute is chosen from halo, C-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3. 10. Compounds according to claim 9 where R2 is a mono- or di-substituted heteroaryl where the heteroaryl is chosen from. Each independent group consisting of (1) furanil, (2) diazinil, (3) imidazolyl, (4) isooxazolil, (5) isothiazolyl, (6) oxadiazolil, (7) oxazolil, (8) pyrazolyl, (9) pyridyl, (10) pyrrolil R7 was selected from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3 R8 Each individual was independently selected from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (c) benzyl and mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls. R16 and R17 were independently selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or mono-substituted phenyl where the substitutes were chosen from... 21. Compounds according to claim 20 where X is O, Y is O, R1 is chosen from a group consisting of (a) SO2CH3, (b) SO2NR16R17 and (c) S(O)(NH)NH2, R2 is C1-4 alkyl, R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4fluoroalkyl, F, CON(R7)2, mono- or di-substituted phenyl, mono- or di-substituted benzyl, hetero- (a) C1-4alkyl (b) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, CN and CF3 and (c) benzyl and mono-substituted benzyl where the substitutes are chosen from halo, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, CN and CF3. R9 and R10, together with their bonded carbons, form carbonyls. R16 and R17 are independently selected from groups consisting of (a) hydrogen (b) C1-6alkyl (c). (d) C1-6 alkyl amine, (e) phenyl or mono-substituted phenyl where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3, and (f) benzyl or mono-substituted benzyl where the substitute is chosen from halo, C-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3. 22. Compounds according to claim 21 where X is O, Y is O, R1 is chosen from groups consisting of (a) SO2CH3 and (b) SO2NR16R17. R2 is propyl or butyl. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, mono- or di-substituted phenyl, mono- or di-substituted benzyl, mono- or di-substituted heteroaryl, mono- or di-substituted heteroarylmethyl where the substitute is chosen from a group consisting of (1) hydrogen (2) halo (3) C1-3 alkyl (4) C1-3 alkoxy (5) C1-3 alkylthio (6) CN and (7) CF3. ------------------------------------------------------- Edited 16/9/59 1. A compound with formula I (chemical formula) I or a pharmaceutically acceptable salt of such compound, where X is chosen from a group consisting of (a) CH2 (b) CHOH (c) CO (d) O (e) S and (f) N(R15) such that R3 and R4 are other than (1) both hydrogens, (2) both are C1-10 alkyls, or (3) combined with carbon in which they are both bound in a ring. Monocyclic carbon saturated with 3, 4, 5, 6, or 7 atoms, then X is chosen from CO, O, S, and N(R15). Y is chosen from the group consisting of (a) C(R11)(R12), (b) CO, (c) O, and (d) S. R1 is chosen from the group consisting of (a) SO2CH3, (b) SO2NR16R17, (c) SO2NHC(O)CF3, (d) S(O)(NH)NH2, (e) S(O)(NH)NHC(O)CF3, (f) P(O)(CH3)NH2, and (g) P(O)(CH3)2. R2 is chosen from the group consisting of (a) C1-10 alkyl, (b) phenyl, and naphthyl, which are mono-, di-, or tri- substituted, where the substitute is chosen. From the group consisting of (1) hydrogen (2) halo (3) C1-10 alkoxy (4) C1-10 alkylthio (5) CN (6) C1-6 fluoroalkyl (7) C1-10 alkyl (8) N3 (9) -CO2H (10)-CO2-C1-10 alkyl (11) -C(R5)(R6)-OH (12)-C(R5)(R6)-O-C1-4 alkyl (13)-C1-6alkyl-CO2-R5 (14) benzyloxy (15)-O-(C1-6alkyl)-CO2-R5 and (16) -O-(C1-6alkyl)-NR5R6 (c) mono-, di- or tri- substituted heteroaryls in which the heteroaryl is a 5-atom monocyclic aromatic ring in which one heteroatom, i.e., S, O or N, and 1, 2 or 3 N atoms are optionally added, or the heteroaryl is a 6-atom monocyclic ring in which one heteroatom, i.e., N, and 1, 2 or 3 N atoms are optionally added. where the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-10 alkyl and (11) C1-6 fluoroalkyl. (d) Mono- or di- substituted benzohetericycles where the heterocycle is a 5, 6 or 7-member ring which may have 1 or 2 heteroatoms independently chosen from O, S or N and which may have a carbonyl group or a sulfonyl group where the substitute is chosen from. (e) heterocycloalkyl groups of 5, 6 or 7 members, which may contain 1 or 2 hetero atoms chosen independently from O, S or N and by choice of containing a carbonyl group or a sulfonyl group; (f) benzocarbocycles that are mono- or di- substituted, where the carbocycle is a 5, 6 or 7 member ring, which by choice contains a carbonyl group where the substitute is chosen from. A group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10)-C(R5)(R6)-O-C1-4 alkyl, and (11) C1-6 fluoroalkyl. (g) Bisolic heteroaryl groups that are mono- or di- substituted of 8, 9 or 10 members with 2 to 5 hetero atoms independently chosen from O, S or N, and where each ring has at least one hetero atom. where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-10 alkyl and (11) -C1-6 fluoroalkyl. R3 is hydrogen, C1-10 alkyl, CH2OR7, CN, CH2CN, C1-6 fluoroalkyl, F, CON(R7)2, mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or di- substituted heteroaryl, or mono- or di- substituted heteroarylmethyl. Where the substitutes were chosen from the groups consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9)-C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-4 alkyl and (11) -C1-6 fluoroalkyl. R4 was chosen from the groups consisting of (a) hydrogen, (b) C1-10 alkyl, (C) C1-10 alkoxy, (d) C1-10 alkylthio, (e) -OH, (f) -OCOR7, (g) -SH, (h) -SCOR7, (i) -OCO2R8, (j) -SCO2R8, (k) OCON(R7)2, (l) SCON(R7)2, (m). C1-6 fluoroalkyl, or R3 and R4, are combined with carbon, forming a moncyclic ring. Saturated carbon atoms of 3, 4, 5, 6, or 7 atoms, R5 and R6, each independent, are selected from a group consisting of (a) hydrogen and (b) C1-10 alkyl, or R5 and R6 are combined with the atoms they are both bound to to form a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms. Each R7, each independent, is selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) phenyl and mono-substituted phenyl where the substitute is selected from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitute is selected from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, CN, and CF3, or R7. Two groups combine with the nitrogen to which they are bound to form a saturated monocyclic ring of 5, 6, or 7 atoms, with additional O, S, or NR5 as an option. Each R8 is independently selected from a group consisting of (a) C1-6 alkyl, (b) phenyl and mono-substituted phenyl where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, CN, and CF3, and (c) benzyl or mono-substituted benzyl where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, CN, and CF3. R9 and R10 are independently selected from a group consisting of (a) hydrogen and (b) C1-7 alkyl, or R9 and R10 combine with the carbon atoms to which they are bound to form a carbonyl group or thiocarbo-. The R11 and R12 pyrenes are independent of each other, namely (a) hydrogen, (b) mono- or di- substituted phenyl, or mono- or di- substituted benzyl, or mono- or di- substituted heteroaryl, or mono- or di- substituted heteroarylmethyl, where the substitute is chosen from groups consisting of (1) hydrogen, (2) fluoro, chloro, bromo, and iodo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R13)(R14)-OH, (10) -C(R13)(R14)-O-C1-4 alkyl, and (11) C1-6 fluoroalkyl, or (c) C1-7 alkyl. CH2OR7, CN, CH2CN, C1-6 fluoroalkyl, CON(R7)2, F or OR7 or R11 and R12 are combined with carbon, with both of them bonded together to form a saturated carbon ring of 3, 4, 5, 6 or 7 atoms. R13 and R14 are independently selected from the group consisting of (a) hydrogen and (b) C1-7 alkyl, or R13 and R14 are combined with carbon, with both of them bonded together to form a carbonyl, -C(=S)-, or a saturated carbon monocyclic ring of 3, 4, 5, 6 or 7 atoms. R15 is selected from the group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) phenyl or naphthyl that are mono-, di- or tri- substituted, where the substitute is Select from the group consisting of (1) hydrogen (2) halo (3) C1-10 alkoxy (4) C1-10 alkylthio (5) CN (6) C1-6 fluoroalkyl (7) C1-10 alkyl (8) N3 (9) -CO2H (10) -CO2-C1-10 alkyl (11) -C(R5)(R6)-OH (12) -C(R5)(R6)-O-C1-4 alkyl (13) -C1-6 alkyl-CO2-R5 (14) benzyloxy (15) -O-(C1-6 alkyl)-CO2-R5 and (16) -O-(C1-6 alkyl)-NR5R6 (d) heteroaryls that are substituted mono-, di- or tri- where the heteroaryl is a ring A monocyclic aromatic ring of 5 atoms, such a ring has one heteroatom, which is S, O, or N, and 1, 2, or 3 additional N atoms by choice; or a heteroaryl, which is a monocyclic ring of 6 atoms, such a ring has one heteroatom, which is N, and 1, 2, or 3 additional N atoms by choice, where the substitute is chosen from the group consisting of (1) hydrogen (2) halo (3) C1-10 alkyl (4) C1-10 alkoxy (5) C1-10 alkylthio (6) CN (7) CF3 (8) N3 (9) -C(R5)(R6)-OH. (10)-C(R5)(R6)-O-C1-10alkyl and (11)-C1-6fluoroalkyl (e) mono- or di- substituted benzohetherocycles in which the heterocycle is a 5, 6 or 7-member ring which may have 1 or 2 heteroatoms independently selected from O, S or N and which may have a carbonyl group or a sulfonyl group in which the substitute is selected from (f) heterocycloalkyl groups of 5, 6 or 7-members, which may contain 1 or 2 hetero atoms chosen independently of O, S or N and by choice of a carbonyl group or a sulfonyl group; (g) benzocarbocycles that are mono- or di-substituted, where the carbocycle is a 5, 6 or 7-member ring, which by choice contains a carbonyl group where the substitute is chosen from. Groups consisting of (1) hydrogen (2) halo (3) C1-10 alkyl (4) C1-10 alkoxy (5) C1-10 alkylthio (6) CN (7) CF3 (8) N3 (9) -C(R5)(R6)-OH (10)-C(R5)(R6)-O-C1-4alkyl and (11) C1-6fluoroalkyl. R16 and R17 were independently selected from groups consisting of (a) hydrogen, (b) C1-10alkyl, (c) C1-10alkanoic acid, (d) C1-10alkylamine, (e) phenyl or mono-substituted phenyl where the substitutes are selected from halo, C1-10alkyl, C1-10alkoxy, C1-10alkylthio, C1-10alkanoic acid, C1-10alkylamine, CN, CO2H and CF3, and (d) benzyl or mono-substituted benzyl where the substitutes are selected from halo, C1-6alkyl, C1-6alkoxy, C1-6 alkylthio, C1-10 alkanoic acid, C1-10 alkyl amine, CN, CO2H, and CF3 or R16 and R17 combine to form nitrogen, which is bound to form a saturated monocyclic ring of 5, 6, or 7 atoms, with the addition of O, S, or NR5 as an option. 2. A compound according to claim 1 in which R9 and R10 combine with the carbon atoms they are bound to, forming a carbonyl group. 3. Compounds according to claim 2 where X is chosen from groups containing (a) CH2 and (b) O; Y is chosen from groups containing (a) CH2 and (b) O; R1 is chosen from groups containing (a) SO2CH3, (b) SO2NR16R17 and (c) S(O)(NH)NH2; R2 is chosen from groups containing (a) C1-6 alkyl, (b) phenyl and naphthyl mono-, di- or tri- substituted where the substitute is Select from the group consisting of (1) hydrogen (2) halo (3) C1-10 alkoxy (4) C1-10 alkylthio (5) CN (6) C1-6 fluoroalkyl (7) C1-6 alkyl (8) -CO2H (9) -CO2-C1-10 alkyl (10) -C(R5)(R6)-OH (11) -C(R5)(R6)-O-C1-4 alkyl (12) -C1-6 alkyl-CO2-R5 and (13) -O-(C1-6 alkyl)-CO2-R5 (c) mono-, di- or tri- substituted heteroaryls in which the heteroaryl is a 5-atom aromatic monocyclic ring. The ring has one heteroatom, which is S, O or N, and has 1, 2 or 3 N. An alternative substitution, or heteroaryl, is a 6-atom monocyclic ring. Such ring has one heteroatom, namely N, and 1, 2, or 3 N alternative substitutions, where the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH. (d) A mono- or di-substituted benzohetrocycle, in which the heterocycle is a 5, 6, or 7-member ring which may have 1 or 2 heteroatoms chosen independently from O, S, or N, and which may have a carbonyl or sulfonyl group, where the substitute is chosen from. (e) A heterocycloalkyl group of 5, 6 or 7-members, which may contain 1 or 2 hetero atoms independently chosen from O, S or N and by choice of which there is a carbonyl group or a sulfonyl group. (f) A benzocarbocycle that is mono- or di- substituted, in which the carbocycle is a 5, 6 or 7-member ring, which by choice contains a carbonyl group in which the substitute is chosen from. A group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthio, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH (g) bisoclic heteroaryls that are mono- or di- substituted of the 8, 9, or 10 members, which may contain 2 to 5 heteroatoms independently selected from O, S, or N, and which may contain at least one heteroatom. where the substitute is chosen from the group consisting of (1) hydrogen (2) halo (3) C1-10 alkyl (4) C1-10 alkoxy (5) C1-10 alkylthio (6) CN (7) CF3 and (8) -C(R5)(R6)-OH R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, phenyl T is mono- or di-substituted, benzyl is mono- or di-substituted, hetero-aryl is mono- or di-substituted, heteroarylmethyl is mono- or di-substituted where the substitute is chosen from the group consisting of (1) hydrogen (2) halo (3) C1-10 alkyl (4) C1-10 alkoxy (5) C1-10 alkylthio (6) CN (7) CF3 and (8) -C(R5)(R6)-OH R4 were selected from groups consisting of (a) hydrogen (b) C1-6 alkyl (c) C1-6 alkoxy (d) C1-6 alkylthio (e) OH (f) -OCOR7 (g) -SCOR7 (h) -OCO2R8 and (i) -SCO2R8 or R3 and R4 combined with the carbon to which they both are attached to form a monocyclic ring. Saturated carbon atoms of 3, 4, 5, 6, or 7 atoms R5 and R6, each independent of each other, are selected from groups consisting of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 are combined with the atoms to which they are both bound to form a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms R7, each independent of each other, are selected from groups consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. R8 Each individual was independently selected from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (c) benzyl or mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10, combined with their bonded carbons, form carbonyls. R16 and R17 were independently selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or mono-substituted phenyl where the substitutes were chosen from... (d) benzyl or benzyl mono-substituted where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkylamine, CN, CO2H or CF3; 4. The compound according to claim 3, where X is O, Y is O, R1 is selected from groups containing (a) SO2CH3, (b) SO2NR16R17, and (c) S(O)(NH)NH2, R2 is selected from groups containing phenyl or naphthyl mono-, di-, or tri- substituted substituents, where the chosen substitute is selected. From the group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkoxy, (4) C1-10 alkylthio, (5) CN, (6) C1-3 fluoroalkyl, (7) C1-4 alkyl, (8) -CO2H, (9) -CO2-C1-10 alkyl, and (10) -C(R5)(R6)-H. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or di- substituted heteroaryl, mono- or di- substituted heteroarylmethyl, where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-4 alkyl (4), C1-4 alkoxy (5), C1-4 alkylthio (6), CN (7), CF3 and (8) -C(R5)(R6)-OH and R4 were selected from groups consisting of (a) hydrogen (b) C1-6 alkyl (c) C1-6 alkoxy (d) C1-6 alkylthio (e) -OH (f) -OCOR7 (g) -SCOR7 (h) -OCO2R8 and (i) -SCO2R8 or R3 and R4 combined with the carbon to which they both are attached to form a monocyclic ring. Saturated carbon atoms of 3, 4, 5, 6, or 7 atoms R5 and R6, each independent of each other, are selected from groups consisting of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 are combined with the atoms to which they are both bound to form a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms R7, each independent of each other, are selected from groups consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. R8 Each individual was independently selected from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (c) benzyl or mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls. R16 and R17 were independently selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or mono-substituted phenyl where the substitutes were chosen from... (d) benzyl or benzyl monosubstituted where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkylamine, CN, COOH or CF3; 5. Compounds according to claim 4 where X is O, Y is O, R1 is chosen from groups containing (a) SO2CH3 and (b) SO2NR16R17. R2 is chosen from groups containing mono- or di-substituted phenyls where the substitute is chosen from groups containing (1) hydrogen, (2) halo, (3) C1-4 alkoxy, (4) C1-4 alkylthio, (5) CN, (6) C1-3 fluoroalkyl, (7) C1-4 alkyl, (8) -CO2H and (9) -CO2-C1-10 alkyl. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, CH1-4 fluoroalkyl, F, mono- or di-substituted phenyls, mono- or di-substituted benzyls, hetero-aryls. Mono- or di- substituted heteroarylmethyl compounds are used where the substitute is chosen from groups consisting of (1) hydrogen, (2) halo, (3) C1-3 alkyl, (4) C1-3 alkoxy, (5) C1-3 alkylthio, (6) CN, and (7) CF3. R4 is chosen from groups consisting of (a) hydrogen, (b) C1-3 alkyl, (c) C1-3 alkoxy, (d) C1-3 alkylthio, and (e) -OH. R9 and R10 are combined with the carbon they are attached to to form a carbonyl. 6. Compounds according to claim 5 where X is O, Y is O, R1 is chosen from groups containing (a) SO2CH3 and (b) SO2NR16R17. R2 is chosen from groups containing phenyl and naphthyl that are mono- or di- substituted, where the substitute is chosen from groups containing (1) hydrogen, (2) halo, (3) CN, (4) CF3 and (5) C1-4 alkyl. R3 is hydrogen or C1-3 alkyl. R4 is hydrogen or C1-3 alkyl. R9 and R10 combine with their bonded carbons to form carbonyls. 7. Compounds according to claim 6 where X is O, Y is O, R1 is chosen from groups containing (a) SO2CH3 and (b) SO2NR16R17, R2 is chosen from groups containing phenyl and naphthyl mono- or chi- substituted where the substitute is chosen from groups containing (1) hydrogen, (2) halo, (3) CN, (4) CF3 and (5) C1-4 alkyl, R3 is methyl or ethyl, R4 is methyl or ethyl, and R9 and R10 are combined with their bonded carbons to form carbonyls. 8. Compounds according to claim 3 where X is chosen from the group consisting of (a) CH2 and (b) O; Y is chosen from the group consisting of (a) CH2 and (b) O; R1 is chosen from the group consisting of (a) SO2CH3, (b) SO2NR16R17, and (c) S(O)(NH)NH2; R2 is chosen from the group consisting of (a) mono-, di-, or tri-substituted heteroaryls where the heteroaryl is a 5-atom monocyclic aromatic ring containing one heteroatom, i.e., S, O, or N, and 1, 2, or 3 N atoms by choice; or the heteroaryl is a 6-atom monocyclic ring containing one heteroatom, i.e., N, and 1, 2, or 3 N atoms by choice. where the substitute is chosen from a group consisting of (1) hydrogen (2) halo (3) C1-6 alkyl (4) C1-6 alkoxy (5) C1-6 alkylthio (6) CN (7) CF3 and (8) –C(R5)(R6)-OH (b) mono- or di- substituted benzoheterocycles where the heterocycle is a 5, 6 or 7-member ring which may have 1 or 2 heteroatoms independently chosen from O, S or N and which may have a carbonyl group or a sulfonyl group where the substitute is chosen from (c) heterocycloalkyl groups of 5, 6 or 7-members, which may contain 1 or 2 hetero atoms chosen independently of O, S or N and by choice of containing a carbonyl group or a sulfonyl group; (d) mono- or di- substituted benzocarbocycles in which the carbocycle is a 5, 6 or 7-member ring, which by choice contains a carbonyl group in which the substitute is chosen from. A group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthio, (6) CN, (7) CF3, and (8) –C(R5)(R6)-OH (e), bicyclic heteroaryls that are mono- or di- substituted of 8, 9, or 10 members, which may contain 2, 3, 4, or 5 heteroatoms independently chosen from O, S, or N, and which may contain at least one heteroatom. where the substitute is chosen from the group consisting of (1) hydrogen (2) halo (3) C1-6 alkyl (4) C1-6 alkoxy (5) C1-6 alkylthio (6) CN (7) CF3 and (8) –C(R5)(R6)-OH. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-3 fluoroalkyl, F, CON(R7)2, mono- or di-substituted phenyl, mono- or di-substituted benzyl, mono- or chi-substituted heteroaryl, mono- or chi-substituted heteroarylmethyl where the substitute is chosen from the group consisting of (1) hydrogen (2) halo (3) C1-4 alkyl (4) C1-4 alkoxy (5) C1-4 alkylthio (6) CN (7) CF3 and (8) -C(R5)(R6)-OH R4 were selected from groups consisting of (a) hydrogen (b) C1-4 alkyl (c) C1-4 alkoxy (d) C1-4 alkylthio (e) -OH (f) -OCOR7 (g) -SCOR7 (h) -OCO2R8 and (i) -SCO2R8 or R3 and R4 combined with the carbon to which they both are attached to form a monocyclic ring. Saturated carbon atoms of 3, 4, 5, 6, or 7 atoms R5 and R6, each independent, are selected from a group consisting of (a) hydrogen and (b) C1-4 alkyl, or R5 and R6 are combined with the atoms they are both bound to form a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms. Each independent R7 is selected from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. R8 Each individual was independently selected from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (c) benzyl or mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls. R16 and R17 were independently selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or mono-substituted phenyl where the substitutes were chosen from... (d) benzyl or benzyl mono-substituted where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkylamine, CN, CO2H or CF3; 9. Compounds according to claim 8 where X is chosen from the group consisting of (a) CH2 and (b) O; Y is chosen from the group consisting of (a) CH2 and (b) O; R1 is chosen from the group consisting of (a) SO2CH3 and (b) SO2NR16R17; R2 is chosen from the group consisting of mono-, di-, or tri-substituted heteroaryls where the heteroaryl is a 5-atom monocyclic aromatic ring containing one heteroatom, i.e., S, O, or N, and 1, 2, or 3 N atoms by choice; or the heteroaryl is a 6-atom monocyclic ring containing one heteroatom, i.e., N, and 1, 2, or 3 N atoms by choice. where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthio, (6) CN, (7) CF3 and (8) -C(R5)(R6)-OH. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-3 fluoroalkyl, F, CON(R7)2, mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or chi- substituted heteroaryl, mono- or chi- substituted heteroarylmethyl where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-4 alkyl, (4) C1-4 alkoxy, (5) C1-4 alkylthio (6) CN (7) CF3 and (8) -C(R5)(R6)-OH R4 were selected from groups consisting of (a) hydrogen (b) C1-4 alkyl (c) C1-4 alkoxy (d) C1-4 alkylthio (e) -OH (f) -OCOR7 (g) -SCOR7 (h) -OCO2R8 and (i) -SCO2R8 or R3 and R4 combined with the carbon to which they both are attached to form a monocyclic ring. Saturated carbon atoms of 3, 4, 5, 6, or 7 atoms R5 and R6, each independent of each other, are selected from groups consisting of (a) hydrogen and (b) C1-4 alkyl, or R5 and R6 are combined with the atoms they are both bound to form a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms R7, each independent of each other, are selected from groups consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. R8 Each individual was independently selected from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (c) benzyl or mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C14 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls, and R16 and R17 are independently selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3 and (d) benzyl or benzyl mono-substituted where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3. 10. Compounds under claim 9 where R2 is a mono- or di-substituted heteroaryl, where the heteroaryl is selected from. The group consisting of (1) furanil, (2) diazinil, (3) imidazolyl, (4) isooxazolil, (5) isothiazolyl, (6) oxadiazolil, (7) oxazolil, (8) pyrazolil, (9) pyridyl, (10) pyrrolil, (11) tetrazenil, (12) tetrazenil, (13) thiadiazolyl, (14) thiazolyl, (15) thienil, (16) triazinil, and (17) triazonil, and substitutes selected from the group consisting of (1) hydrogen, (2) halo, (3) C1-4 alkyl, (4) C1-4 alkoxy, (5) C1-4 alkylthio, (6) CN, and (7) CF3. 11. Compounds according to claim 10 where R2 is a mono- or di- substituted heteroaryl where the heteroaryl is chosen from the group consisting of (1) furanil, (2) diazinil, (3) imidazolyl, (4) isooxazolil, (5) isothiazolyl, (6) oxadiazolil, (7) oxazolil, (8) pyrazolyl, (9) pyridyl, (10) pyrrolil, (11) thiazolyl, (12) thienil where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-3 alkyl, (4) C1-3 alkoxy, and (5) CF3. 12. The compound according to claim 11, where X is O, Y is O, R1 is chosen from the group consisting of (a) SO2CH3 and (b) SO2NH2, R2 is a mono- or di- substituted heteroaryl where the heteroaryl is chosen from. The group consisting of (1) furanil, (2) diazinil, (3) imidazolyl, (4) oxadiazolil, (5) pyrazolil, (6) pyridyl, (7) pyrrolil, (8) thiazolil, (9) thienil, where the chosen substitutes from the group consisting of (1) hydrogen, (2) halo, (3) methyl, (4) methoxy, and (5) CF3R3 are hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, mono- or di- substituted phenyl, mono- or di- substituted benzyl, hetero-aryl substituted Mono- or di- substituted heteroarylmethyl compounds are formed where the substitute is chosen from groups consisting of (1) hydrogen, (2) halo, (3) C1-3 alkyl, (4) C1-3 alkoxy, (5) C1-3 alkylthio, (6) CN, and (7) CF3. R4 is chosen from groups consisting of (a) hydrogen, (b) C1-3 alkyl, (c) C1-3 alkoxy, (d) C1-3 alkylthio, and (e) –HO. R9 and R10 combine with the carbon they are attached to to form a carbonyl. 13. Compounds according to claim 12 where X is O, Y is O, R1 is chosen from a group consisting of (a) SO2CH3 and (b) SO2NH2, R2 is a mono- or di-substituted heteroaryl where the heteroaryl is chosen from a group consisting of (1) furanil, (2) diazinil, (3) imidazolyl, (4) oxadiazolil, (5) pyrazolyl, (6) pyridyl, (7) thiazolil and (8) thienil where the substitute is chosen from a group consisting of (1) hydrogen, (2) Br, Cl or F, (3) methyl, (4) methoxy and (5) CF3, R3 is chosen from hydrogen and C1-3 alkyl, R4 is chosen from hydrogen and C1-3 alkyl, R9 and R10 combine with the carbon to which they are attached to form carbonyls. 14. The compound according to claim 13, where X is O, Y is O, R1 is chosen from a group consisting of (a) SO2CH3 and (b) SO2NH2, R2 is a mono- or di-substituted pyridyl where the chosen representative is from a group consisting of (1) hydrogen, (2) Br, Cl or F, (3) methyl, (4) methoxy and (5) CF3, R3 is chosen from hydrogen and C1-3 alkyl, R4 is chosen from hydrogen and C1-3 alkyl, R9 and R10 combine with the carbon to which they are attached to form carbonyls. 15. The compounds according to claim 14, where X is O, Y is O, R1 is chosen from groups consisting of (a) SO2CH3 and (b) SO2NH2, R3 is chosen from methyl and ethyl, R4 is chosen from methyl and ethyl, R9 and R10 combine with the carbons to which they are bound to form carbonyls. 16. The compounds according to claim 1 are selected from the group consisting of (1) 3-(3,4-difluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (2) 3-(3-fluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (3) 3-(3,5-difluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (4) 3-phenoxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (5) 3-(2,4-difluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (6) 3-(4-chlorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (7) 3-(3,4-dichlorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (8) 3-(4-fluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (9) 3-(4-fluorophenylthio)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (10) 3-(3,5-difluorophenylthio)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (11) 3-phenylthio-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (12) 3-(N-phenylamino)-5,5-dimethyl-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (13) 3-(N-methyl-N-phenylamino)-5,5-dimethyl-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (14) 3-cyclohexyloxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (15) 3-phenylthio-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (16) 3-benzyl-5,5-dimethyl-4(4-(methylsulfonyl)phenyl)-5H-furan-2-one (17) 3-(3,4-difluorophenylhydroxymethyl)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)- 5H-furan-2-one (18) 3-(3,4-difluorobenzoyl)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (19) 3-benzoyl-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (20) 4-(4(methylsulfonyl)phenyl)-3-phenoxy-1-oxaspiro [4,4] non-3-en-2-one (21) 4-(4(methylsulfonyl)phenyl)-3-phenylthio-1-oxaspiro [4,4] non-3-en-2-one (22) 4-(2-oxo-3-phenylthio-1-oxaspiro [4,4] Non-3-en-2-one (23) 3-(4-fluorobenzyl)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (24) 3-(3,4-difluorophenoxy)–5methoxy-5-methyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (25) 3-(5-chloro-2-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (26) 3-(2-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (27) 3-(6-methyl-2-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (28) 3-(3-isoquinolinoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (29) 3-(4-(methylsulfonyl)phenyl)-2-phenoxycyclopent-2-enone and (30) 3-(4-(methylsulfonyl)phenyl)-2-(3,4-difluorophenoxy)cyclopent-2-enone 17. Pharmaceutical ingredients consisting of the compounds specified in Patent 1 in combination with pharmaceutically acceptable carriers. 18. Use of the compounds specified in Claim 1 in the preparation of pharmaceutical mixtures for the treatment of inflammatory diseases in mammalian patients. 19. Use of the compounds specified in Claim 1 in the preparation of pharmaceutical mixtures for the treatment of cyclooxygenase-mediated diseases in mammalian patients. 20. The compounds under claim 3 where X is chosen from groups containing (a) CH2 and (b) O, Y is chosen from groups containing (a) CH2 and (b) O, R1 is chosen from groups containing (a) SO2CH3, (b) SO2NR16R17 and (c) S(O)(NH)NH2, R2 is C1-6 alkyl, R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, mono- or di-substituted phenyl, mono- or di-substituted benzyl, mono- or di-substituted heteroaryl, mono- or di-substituted heteroarylmethyl where the substitute is chosen from groups containing (1) hydrogen, (2) halo, (3) C1-4 alkyl, (4) C1-4 alkoxy (5), C1-4 alkylthio (6), CN (7), CF3 and (8) –C(R5)(R6)-OH R4 was chosen from groups consisting of (a) hydrogen (b) C1-6 alkyl (c) C1-6 alkoxy (d) C1-6 alkylthio (e) -OH (f) -OCOR7 (g) -SCOR7 (h) -OCO2R8 and (i) -SCO2R8 or R3 and R4 combined with the carbon to which they both are attached to form a monocyclic ring. Saturated carbon atoms of 3, 4, 5, 6, or 7 atoms R5 and R6, each independent of each other, are selected from a group consisting of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 are combined with the atoms they are both bound to form a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms. Each R7, each independent of each other, is selected from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. R8 Each individual was independently selected from a group consisting of (a) C1-4 alkyl, (d) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (c) benzyl and mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 combine with their bonded carbons to form carbonyls. R16 and R17 were independently selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or mono-substituted phenyl where the substitutes were chosen from... (d) benzyl or benzyl mono-substituted where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3. The compounds according to claim 20 where X is O, Y is O, R1 is selected from the group consisting of (a) SO2CH3, (b) SO2NR16R17 and (c) S(O)(NH)NH2, R2 is C1-4 alkyl, R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, mono- or di-substituted phenyl, mono- or di-substituted benzyl, mono- or di-substituted heteroaryl, mono- or di-substituted heteroaryl where the substitute is selected from the group consisting of (1) hydrogen, (2) halo, (3) C1-4 alkyl, (4) C1-4 alkoxy, (5) C1-4 alkylthio, (6) CN, (7) CF3 and (8). –C(R5)(R6)-OH R4 is chosen from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkoxy, (d) C1-6 alkylthio, (e) -OH, (f) -OCOR7, (g) -SCOR7, (h) -OCO2R8, and (i) -SCO2R8, or R3 and R4 combined with the carbon to which they both are attached to form a monocyclic ring. Saturated carbon atoms of 3, 4, 5, 6, or 7 atoms R5 and R6, each independent of each other, are selected from a group consisting of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 are combined with the atoms they are both bound to form a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms. Each R7, each independent of each other, is selected from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are selected from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. R8 Each individual was independently selected from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3, and (c) benzyl and mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls. R16 and R17 were independently selected from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or mono-substituted phenyl where the substitutes were chosen from... (d) benzyl or benzyl mono-substituted where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkylamine, CN, CO2H or CF3. The compound according to claim 21, where X is O, Y is O, R1 is selected from the group consisting of (a) SO2CH3 and (b) SO2NR16R17, R2 is propyl or butyl, R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, mono- or chi- substituted phenyl, mono- or di- substituted benzyl, hetero-aryl substituted Mono- or di- substituted heteroarylmethyl compounds are formed where the substitute is chosen from groups consisting of (1) hydrogen, (2) halo, (3) C1-3 alkyl, (4) C1-3 alkoxy, (5) C1-3 alkylthio, (6) CN, and (7) CF3. R4 is chosen from groups consisting of (a) hydrogen, (b) C1-3 alkyl, (c) C1-3 alkoxy, (d) C1-3 alkylthio, and (e) –OH. R9 and R10 are combined with the carbon to which they are attached to form a carbonyl. 23. The compounds according to claim 22, where X is O, Y is O, R1 is chosen from groups consisting of (a) SO2CH3 and (b) SO2NR16R17, R2 is chosen from propyl and butyl, R3 is chosen from hydrogen and C1-3 alkyl, R4 is chosen from hydrogen and C1-3 alkyl, and R9 and R10 combine with the carbon they are bound to to form carbonyl 24. The compounds according to claim 23, where X is O, Y is O, R1 is chosen from groups consisting of (a) SO2CH3 and (b) SO2NR16R17, R2 is propyl, R3 is chosen from methyl and ethyl, R4 is chosen from methyl and ethyl, and R9 and R10 combine with the carbon they are bound to to form carbonyl 25. The compounds under claim 24, where R16 and R17 are each hydrogen 26. The compound according to claim 25, where R1 is SO2CH3 27. The compounds under claim 1 are selected from a group containing (a) 5,5-dimethyl-4-(4-methylsulfonylphenyl)-3-(5-bromopyridin-2-yloxy)-5H-furan-2-one and (b) 5,5-dimethyl-4-(4-methylsulfonylphenyl)-3-(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salts. 28. The compound referred to in claim 1, which is 5,5-dimethyl-4-(4-methylsulfonylphenyl)-3-(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salt 29. Pharmaceutical ingredients consisting of the compounds specified in patent 28 in combination with pharmaceutically acceptable carriers 30. The use of the compounds under claim 28 in the preparation of pharmaceutical formulations for the treatment of inflammatory diseases in mammalian patients 31. The compounds according to claim 1 were selected from the group consisting of (1) 2-(3,4-difluorophenoxy)-3-(4-methylsulfonylphenyl)-cyclopent-2-one, (2) 3-(5-benzothiophenyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one, (3) 5,5-dimethyl-4-(4-methylsulfonyl-phenyl)-3-(pyridyl-4-oxy)-5H-furan-2-one, (4) 5,5-dimethyl-4-(4-methylsulfonyl-phenyl)-3-(pyridyl-3-oxy)-5H-furan-2-one, (5) 3-(2-methyl-5-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (6) 3-(2-fluoro-4-trifluoromethyl)phenoxy-4-(4-(methylsulfonyl)phenyl)-5,5-dimethyl-5H-furan-2-one (7) 3-(5-chloro-2-pyridylthio)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (8) 2-(3,5-difluorophenoxy)-3-(4-methylsulfonylphenyl)-cyclopent-2-one (9) 3-(2-pyrnimdyoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (10) 3-(3-methyl-2-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (11) 3-(3-chloro-5-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (12) 3-(3-(1,2,5-thiadiazolyl)oxy)-4-(4-(methylsulfonyl)phenyl)-5,5-dimethyl-5H-furan-2-one (13) 3-(5-isoquinolinoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (14) 3-(6-amino-2-pyridyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H-furan-2-one (15) 3-(3-chloro-4-fluoro)phenoxy)-4-(methylsulfonyl)phenyl)-5,5-dimethyl-5H-furan-2-one (16) 3-(6-quinolinoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (17) 3-(5-nitro-2-pyridyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (18) 3-(2-thiazolylthio)-4-(4-(methylsulfonyl)phenyl)-5,5-dimethyl-5H-furan-2-one (19) 3-(3-chloro-5-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (20) 5,5-dimethyl-4-(4-methylsulfonylphenyl)-3-(2-propoxy)-5H-furan-2-one (21) 3-(3-trifluoromethyl)phenoxy-4-(4-methylsulfonyl)phenyl-5,5-dimethyl-5H-furan-2-one (22) 5,5-dimethyl-(4-(4-methylsulfonyl)phenyl)-3-(piperidine-1-carbonyl)-5H-furan-2-one (23) 5,5-dimethyl-3-(2-butoxy)-4-(4-methylsulfonylphenyl)-5H-furan-2-one (24) 5,5-dimethyl-(4-(4-methylsulfonylphenyl)-3-(3-pentoxy)-5H-furan-2-one (25) 2-(5-chloro-2-pyridyloxy)-3-(4-methylsulfonyl)phenylcyclopent-2-one (26) 3-(4-methyl-2-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl-5H-furan-2-one (27) (5R)-3-(3,4-difluorophenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (28) (5R)-3-(4-chlorophenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (29) 3-(2-methyl-3-pyridyoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (30) 3-(4-methyl-5-nitro-2-pyridyoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (31) 3-(5-chloro-4-methyl-2-pyridyoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (32) 3-(5-fluoro-4-methyl-2-pyridyoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (33) 3-(3-chloro-2-pyridyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (34) 3-(4-fluorophenoxy)-5-methyl-4-(4-methylsulfonyl)phenyl-5-propyl-5H-furan-2-one (35) 3-(N,N-diethylamino)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5-propyl-5H-furan-2-one (36) 5,5-dimethyl-4-(4-methylsulfonyl-phenyl)-3-(3,5-dichloro-2-pyridyloxy)-5H-furan-2-one (37) (5R)-3-(4-bromophenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (38) (SR)-3-(4-methylphenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (39) (5R)-3-(5-chloro-2-pyridyloxy)-5-methyl-4-(4-methylsulfonyl)phenyl-5-(2,2,2-di Fluoroethyl)-5H-furan-2-one (40) 3-(5-chloro-2-pyridyloxy)-5-methyl-4-(4-methylsulfonyl)phenyl-5-propyl-5H-furan-2-one (41) 5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-(propoxy)-5-(2-trifluoroethyl)-5H-furan-2-one (42) S(R)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one (43) 5,5-dimethyl-3-(2,2-dimethylpropyloxy)-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (44) S(R) 3-(1-cyclopropyl-ethoxy)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)- 5H-furan-2-one (45) 5(S) S-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one (46) 3-(1-cyclopropyl-ethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (47) 3-(1-cyclopropyl ethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (48) 5,5-dimethyl-3-(isobutoxy)-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (49) 3-(4-bromophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (50) 3-(2-quinolenoxoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (51) 3-(2-chloro-5-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (52) 3-(6-benzothiazolyoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (53) 3-(6-chloro-2-pyridyloxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (54) 3-(4-quinazolilyoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (55) (5R)-3-(5-fluorophenoxy)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl-5H-furan-2-one (56) (5R)-3-(4-fluorophenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (57) (5R)-3-(5-fluorophenoxy)-5-methyl-4-(4-methylsulfonyl)phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one (58) 3-(1-isoquinolinoxy)-5,5-dimethyl-4-(methylsulfonyl)phenyl-5H-furan-2-one (59) (5R)-3-(4-fluorophenoxy)-5-methyl-4-(4-methylsulfonyl)phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one (60) 3-(3-fluoro-2-pyridyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (61) (5R)-3-(3,4-difluorophenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one (62) (5R)-3-(5-chloro-2-pyridyloxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (63) 3-(3,4-difluorophenoxy)-5-methyl-5-trifluoromethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (64) 3-(3,4-difluorophenoxy)-5-methyl-4-(4-methylsulfonyl)phenyl)-5-propyl-5H-furan-2-one (65) 3-cyclobutyloxy-5,5-dimethyl-4-(4-methylsulfonylphenyl)-5H-furan-2-one (66) 3-(1-indanyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H-furan-2-one (67) 3-(2-indanyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H-furan-2-one (68) 3-cyclopentyoxy-5,5-dimethyl-4-(4-methylsulfonylphenyl)-5H-furan-2-one (69) 3-(3,3-dimethylcyclopentyoxy)-5,5-dimethyl-4-(4-methylsulfonyl-phenyl)-5H-furan-2-one (70) 3-isopropoxy-5-methyl-4-(4-methylsulfonylphenyl)-5-propyl-5H-furan-2-one (71) 3-(2-methoxy-5-pyridylooxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (72) 3-(5-methyl-2-pyridylooxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (73) (5RS)-3-(3,4-difluorophenoxy)-5-methyl-4-(4-methylsulfonyl)phenyl-5-(2,2,2-tri-fluoroethyl)-5H-furan-2-one (74) 3-(3-chloro-4-methoxyphenoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (75) (5R)-3-(3-chloro-4-methoxyphenoxy-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (76) (5R)-3-(4-chlorophenoxy)-5-trifluoroethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (77) (5R)-3-(4-bromophenoxy)-5-trifluoroethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (78) 5-cyclopropylmethyl-3-(3,4-difluorophenoxy)-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (79) (5R)-3-(3-fluorophenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (80) (5R)-3-(4-chloro-3-fluorophenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (81) (5R)-3-phenoxy-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (82) (5R)-3-(4-chloro-3-methylphenoxy)-5-ethyl-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (83) 3-(4-chloro-3-methylphenoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (84) (5R)-3-(5-bromo-2-pyridyloxy)-5-methyl-4-(4-methylsulfonylphenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one (85) (5R)-3-(5-bromo-2-pyridyloxy)-4-(4-methylsulfonylphenyl)-5-ethyl-5-methyl-5H-furan-2-one (86) 3-(5-chloro-6-methyl-2-pyridyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (87) 3-(5-cyclopropyl-2-pyridyloxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (88) 3-(1-cyclopropylethoxy)-4-(4-methylsulfonyl)phenyl-5H-furan-2-one and (89) 3-(cyclopropylmethoxy)-4-(4-methylsulfonyl)phenyl-5H-furan-2-one 32. Compounds were selected from groups containing (5S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one, (SR)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one, and (RS) 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one, or their pharmaceutically acceptable salts or hydrates. 33. The compound according to claim 32 is named (5S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salt or hydrate (chemical formula) SO2CH334. The compound according to claim 32 is named (5R)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salts or hydrates. 35. The compound according to claim 32 is named (RS)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salts or hydrates. 36. Pharmaceutical ingredients, consisting of the compounds specified in claim 32, combined with pharmaceutically acceptable carriers 37. The use of the compounds described in claim 32 in the preparation of pharmaceutical mixtures for the treatment of inflammatory diseases in mammalian patients requiring such treatment. 38. The use of the compounds described in claim 32 in the preparation of pharmaceutical mixtures for therapeutic use in cyclooxygenase-mediated diseases in mammalian patients requiring such treatment. 39. The use of the compounds described in claim 32 in the preparation of pharmaceutical formulations for the treatment of arthritis in mammalian patients requiring such treatment 40. The use of the compounds under claim 39, where arthritis is osteoarthritis 41. The use of the compounds under claim 39, where the arthritis is rheumatoid arthritis 42. The use of the compounds described in Claim 30 in the preparation of pharmaceutical mixtures for the treatment of pain in mammalian patients. ------------------------------------------------------- 1. The compound formula 1 (chemical formula) or the pharmaceutically acceptable salt of such substance, where X is chosen from a group consisting of ( a ) CH2 ( b ) CHOH ( c ) CO ( d ) O ( e ) S and ( f ) N (R15) such that when R3 and R4 are other than ( 1 ), both are hydrogen, ( 2 ) both are C1-10 alkyl, or ( 3 ) combined with carbon. Both are bound together to form a saturated monocyclic carbon ring of 3, 4, 5, 6, or 7 atoms. X is chosen from CO, O, S, and N(R15). Y is chosen from groups consisting of (a) C(R11)(R12), (b) CO, (c) O, and (d) S. R1 is chosen from groups consisting of (a) SO2CH3, (b) CO2NR16R17, (c) SO2NHC(O)CF3, (d) S(O)(NH)NH2, (e) S(O)(NH)NH2NHC(O)CF3, (f) P(O)(CH3)NH2, and (g) P(O)(CH3)2. R2 is chosen from groups consisting of (a) C1-10 alkyls, (b) phenyls, and naphthyls that are substituted mono-, di-, or Tri- where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkoxy, (4) C1-10 alkylthio, (5) CN, (6) C1-6 fluoroalkyl, (7) C1-6 alkyl, (8) N3, (9) -CO2H, (10) -CO2-C1-10 alkyl, (11) -C(R5)(R6)-OH, (12) -C(R5)(R6)-O-C1-4 alkyl, (13) -C1-6 alkyl-CO2-R5, (14) benzyloxy, (15) -O-(C1-6 alkyl)-CO2-R and (16) -O-(C1-6 alkyl). -NR5R6 (c) Mono-, di-, or tri- substituted heteroaryls where the heteroaryl is a 5-atom aromatic monocyclic ring containing one heteroatom, i.e., S, O, or N, and 1, 2, or 3 N atoms by choice; or the heteroaryl is a 6-atom monocyclic ring containing one heteroatom, i.e., N, and 1, 2, or 3 N atoms by choice, where the substitute is Select from a group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-10 alkyl, and (11) C1-6 fluoroalkyl. (g) Mono- or di- substitution bicyclic heteroaryl groups of 8, 9, or 10 members with 2 to 5 hetero atoms independently selected from O, S, or N, where each ring contains at least one hetero atom. where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-10 alkyl and (11) C1-6 fluoroalkyl. R3 is hydrogen, C1-10 alkyl, CH2OR7, CN, CH2CN1 C1-6 fluoroalkyl, F, CON(R7)2, mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or di- substituted heteroaryl. Di- or heteroarylmethyl, which are mono- or di- substituted, where the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-4 alkyl and (11) C1-6 fluoroalkyl R4 are chosen from a group consisting of (a) hydrogen, (b) C1-10 alkyl, (c) C1-10 alkoxy, (d) C1-10 alkylthio, (e) -OH, (f) -OCOR7, (g) -SH, (h) ) -SCOR7 ( i ) -OCO2R8 ( i ) -SCO2R8 ( k ) OCON ( R 7)2 ( l ) SCON(R7)2 and ( m ) C1-6 fluoroalkyl or R3 and R4 combined with the atom to which they are both attached to form a saturated monocyclic carbon ring of 3, 4, 5, 6 or 7 atoms. R5 and R6 are independently selected from the group consisting of ( a ) hydrogen and ( b ) C1-10 alkyl or R5 and R6 combined with the atom to which they are both attached to form It is a saturated monocyclic ring of 3, 4, 5, 6, or 7 atoms. Each R7 atom is independent and chosen from a group consisting of (a) hydrogen, (b) C1-10 alkyl, (c) phenyl and mono-substituted phenyl where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, CN, and CF3, or two R7 groups combined with the nitrogen to which it is bound to form a ring. Saturated monocyclic rings of 5, 6, or 7 atoms, with additional O, S, or NR5 as an option, are chosen from groups consisting of (a) C1-6 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, CN, and CF3, and (c) benzene or mono-substituted benzyl where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, CN, and CF3. R9 and R10 are independently chosen from groups consisting of (a) hydrogen and (b) C1-7 alkyl, or R9 and R10 are combined with their bonded carbon atoms to form carbonyl or thiocarbonyl groups. R11 And R12 are independent of each other, namely (a) hydrogen, (b) mono- or di- substituted phenyl, or mono- or di- substituted benzyl, or mono- or di- substituted heteroaryl, or mono- or di- substituted heteroarylmethyl, where the substitute is chosen from the group consisting of (1) hydrogen, (2) fluoro, chloro, bromo, and iodo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R13)(R14)-OH, (10) -C(R13)(R14)-O-C1-4 alkyl, and (11) C1-6 fluoroalkyl or (c) C1-7 alkyl, CH2OR7, CN, CH2CN, C1-6 fluoroalkyl, CON(R7)12, F or OR7 or R11 and R12 are bonded to carbon, with which they both form a saturated carbon mocyclic ring of 3, 4, 5, 6 or 7 atoms. R13 and R14 are bonded to carbon. These two are bonded together to form a carbonyl, -C(=S)-, or a saturated monocyclic carbon ring of 3, 4, 5, 6, or 7 atoms. R15 is chosen from a group consisting of (a) hydrogen, (b) C1-6 alkyl, (c) phenyl, or naphthyl that is mono-, di-, or tri- substituted, where the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkoxy, (4) C1-10 alkylthio, (5) CN, (6) C1-6 fluoroalkyl, (7) C-10 alkyl, (8) N3, (9) -CO2H, (10) -CO2-C1-10 alkyl, (11) C(R5)(R6)-OH. 12 ) C ( R 5)( R 6)-O-C1-4 alkyl ( 13 ) C 1-6 alkyl -CO2-R5 ( 14 ) benzyloxy ( 15 ) -O-(C1-6 alkyl) -CO2-R5 and ( 16 ) -O-(C1-6 alkyl) -NR5R6 ( d ) Mono-, di- or tri- substituted heteroaryls where the heteroaryl is a 5-atom aromatic monocyclic ring, such ring has one hetero atom, which is S, O or N, and 1, 2 or 3 N atoms are added by choice, or the heteroaryl is a 6-atom monocyclic ring, such ring has one hetero atom, which is N and 1, 2 or 3 N atoms are added by choice, where the substitute is Select from groups consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-10 alkyl, and (11) C1-6 fluoroalkyl. (e) Mono- or di- substituted basohetherocycles in which the heterocycle is a 5, 6 or 7-member ring which may have 1 or 2 heteroatoms chosen independently of O, S or N and which may have a carbonyl group or a sulfonyl group in which the substitute is chosen from the group. Containing (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-10 alkyl and (11) C1-6 fluoroalkyl. (f) heterocycloalkyl groups of 5, 5 or 7 members, which may contain 1 or 2 heteroatoms independently chosen from O, S or N and by choice contain a carbonyl group or a sulfonyl group. (g) benzocarbocycles. Replaced in a mono- or di- configuration, where the carbohydrate is a 5, 6, or 7-member ring, which, by choice, has a carbonyl group where the replacer... The substitutes were chosen from groups consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, (8) N3, (9) -C(R5)(R6)-OH, (10) -C(R5)(R6)-O-C1-4 alkyl, and (11) C1-6 fluoroalkyl. R16 and R17 were independently chosen from groups consisting of (a) hydrogen, (b) C1-10 alkyl, (c) C1-10 alkanoic acid, (d) C1-10 alkylamine, (e) phenyl or mono-substituted phenyl where the substitutes were chosen from. (d) Benzyl or mono-substituted benzyl, where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-10 alkanoic acid, C1-10 alkyl amine, CN, CO2H and CF3 or R16 and R17 combined to form nitrogen, which it forms as a saturated monocyclic ring of 5, 6 or 7 atoms with additional O, S or NR5 by choice 2. The compounds under claim 1 are those in which R9 and R10 combine with the carbon atoms to which they are bound to form carbonyl groups 3. The compounds under claim 2 where X is selected from groups containing (a) CH2 and (b) O, Y is selected from groups containing (a) CH2 and (b) O, R1 is selected from groups containing (a) SO2CH3, (b) SO2NR16R17 and (c) S(O)(NH)NH2, R2 is selected from groups containing (a) C1-6 alkyl, (b) phenyl and naphthyl mono-, di- or tri- substituted, where the substitute is selected from Groups consisting of (1) hydrogen, (2) halo, (3) C1-6 alkoxy, (4) C1-6 alkylthio, (5) CN, (6) C1-4 fluoroalkyl, (7) C1-6 alkyl, (8) -CO2H, (9) -C O2-C1-10 alkyl, (10) -C( R 5)(R6)-OH, (11) -C(R5)(R6)-O-C1-4 alkyl, (12) -C1-6 alkyl -CO2-R5 and (13) - O - (C1-6 alkyl) -CO2-R5. (c) mono-, di- or tri- substituted heteroaryls where the heteroaryl is a monocyclic aromatic ring of 5. The ring has one heteroatom, which is S, O, or N, and 1, 2, or 3N atoms are added by choice, or the heteroaryl is a monocyclic ring of 6 atoms. The ring has one heteroatom, which is N, and 1, 2, or 3N atoms are added by choice, where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH. (d) Mono- or di- substituted benzohetrocycles where the heterocycle (e) A 5, 6 or 7-member ring which may contain 1 or 2 hetero atoms independently selected from O, S or N and which may contain a carbonyl or sulfonyl group in which the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3 and (8) -C(R5)(R6)-OH. (e) A 5, 6 or 7-member heterocycloalkyl group which may contain 1 or 2 hetero atoms independently selected from O, S or N and which, by choice, contain a carbonyl or sulfonyl group. (f) A benzocarbocycle. Mono- or di- substituted bicyclic heteroaryls of 8, 9 or 10 members, which may have 2 to 5 hetero atoms chosen independently from O, S and N, and which may have at least one hetero atom where the substitute is chosen. Selected from the group consisting of (1) hydrogen, (2) halo, (3) C1-10 alkyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) CN, (7) CF3 and (8) -C(R5)(R6)-OH. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, phenyl substituted in mono- or di-, benzyl substituted in mono- or di-, heteroaryl substituted in mono- or di-, heteroarylmethyl substituted in mono- or di- where the substitute is selected from the group consisting of (1) hydrogen, (2) halo, 3) C1-10 alkyl ( 4 ) C1-10 alkoxy ( 5 ) C1-10 alkylthio ( 6 ) CN ( 7 ) CF3 and ( 8 ) -C( R 5) (R6) -OH R4 were selected from groups consisting of ( a ) hydrogen ( b ) C1-6 alkyl ( c ) C1-6 alkoxy ( d ) C1-6 alkylthio ( e ) -OH ( f ) -OCOR7 ( g ) -SCOR7 ( h ) -OCO2R8 and ( i ) -SCO2R8 or R3 and R4 combined with the carbon to which they both are attached. It is a saturated monocyclic carbon ring of 3, 4, 5, 6, or 7 atoms. R5 and R6 are independent of each other and are chosen from groups consisting of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 are bonded to the atoms to which they are both attached. Each R7 is an independent monocyclic ring of 3, 4, 5, 6, or 7 atoms, chosen from a group consisting of (a) hydrogen and (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkythio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkythio, CN, and CF3. Each R8 is an independent R8, chosen from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, C1-4 alkyl, (a) C1-4 alkyl, C1-4 alkyl, C1-4 alkylthio, CN and CF3 and (c) benzyl or benzyl mono-substituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkyl, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls. R16 and R17 are independently chosen from groups consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or phenyl mono-substituted where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkyl, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3 and (d) benzyl or benzyl monosubstituted where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkydthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3. 4. The compounds according to claim 3, where X is O, Y is O, R1 is chosen from groups containing (a) SO2CH3, (b) SO2NR16R17, and (c) S(O)(NH)NH2. R2 is chosen from groups containing phenyl or naphthyl substituted mono-, di-, or tri-, where the substitute is chosen from groups containing (1) hydrogen, (2) halo, (3) C1-10 alkoxy, (4) C1-10 alkylthio, (5) CN, (6) C1-3 fluoroalkyl, (7) C1-4 alkyl, (8) -CO2H, (9) -CO2-C1-10 alkyl, and (10) -C(R5)(R6)-OH. R3 is hydrogen, C1-6 alkyl, CH2OR7. CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, phenyl substituted in mono- or di- form, benzyl substituted in mono- or di- form, heteroaryl substituted in mono- or di- form, heteroarylmethyl substituted in mono- or di- form where the substitute is chosen from a group consisting of (1) hydrogen (2) halo (3) C1-4 alkyl (4) C1-4 alkoxy (5) C1-4 alkylthio (6) CN (7) CF3 and (8) -C(R5)(R6)-OH and R4 are chosen from a group consisting of (a) hydrogen (b) C1-6 alkyl (c) C1-6 alkoxy (d) C1-6 Alkylthio(e)-OH(f)-OCOR7(g)-SCOR7(h)-OCO2R8 and (i)-SCOR8, or R3 and R4 are combined with the carbon to which they are both attached, forming a saturated monocyclic carbon ring of 3, 4, 5, 6, or 7 atoms. R5 and R6 are independent and chosen from the groups composed of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 are combined with the atoms to which they are both attached. Each R7 is an independent monocyclic ring of 3, 4, 5, 6, or 7 atoms, chosen from a group consisting of (a) hydrogen and (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. Each R8 is an independent R8, chosen from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, C1-4 alkyl. (a) , C1-4 alkyl, C1-4 alkyl, C1-4 alkylthio, CN and CF3 and (c) benzyl or benzyl mono-substituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkyl, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with their bonded carbons to form carbonyls. R16 and R17 are independently chosen from groups consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or phenyl mono-substituted where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkyl, C1-6 alkylthio, C1-6 alkanoic. (d) benzyl or benzyl mono-substituted where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkylamine, CN, COOH or CF3. The compounds according to claim 4, where X is O, Y is O, R1 is selected from groups containing (a) SO2CH3 and (b) SO2NR16R17. R2 is selected from groups containing mono- or di- substituted phenyls where the substitute... Substitutes are selected from groups consisting of (1) hydrogen, (2) halo, (3) C1-4 alkoxy, (4) C1-4 alkylthio, (5) CN, (6) C1-3 fluoroalkyl, (7) C1-4 alkyl, (8) -CO2H and (9) -CO2-C1-10 alkyl. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or di- substituted heteroaryl, mono- or di- substituted heteroarylmethyl, where the substitute is selected from groups consisting of (1 (a) hydrogen, (b) C1-3 alkyl, (c) C1-3 alkoxy, (d) C1-3 alkylthio, (6) CN, and (7) CF3. R4 was selected from the groups consisting of (a) hydrogen, (b) C1-3 alkyl, (c) C1-3 alkoxy, (d) C1-3 alkylthio, and (e) -OH. R9 and R10 are combined with the carbon they are bound to to form carbonyl 6. The compounds according to claim 5, where X is O, Y is O, R1 is chosen from groups containing (a) SO2CH3 and (b) SO2NR16R17. R2 is chosen from groups containing phenyl and naphthyl that are mono- or di- substituted, where the substitute is chosen from groups containing (1) hydrogen, (2) halo, (3) CN, (4) CF3 and (5) C1-4 alkyl. R3 is hydrogen or C1-3 alkyl. R4 is hydrogen or C1-3 alkyl. R9 and R10 combine with the carbon they are bound to to form carbonyls. 7. The compounds according to claim 6, where X is O, Y is O, R1 is chosen from groups containing (a) SO2CH3 and (b) SO2NR16R17. R2 is chosen from groups containing phenyl and naphthyl that are mono- or di- substituted, where the substitute is chosen from groups containing (1) hydrogen, (2) halo, (3) CN, (4) CF3 and (5) C1-4 alkyl. R3 is methyl or ethyl, R4 is methyl or ethyl, and R9 and R10 are combined with the carbon they are attached to to form carbonyls. 8. The compounds under claim 3 are chosen from groups consisting of (a) CH2 and (b) O; Y is chosen from groups consisting of (a) CH2 and (b) O; R1 is chosen from groups consisting of (a) SO2CH3, (b) SO2NR16, R17, and (c) S(O)(NH)NH2; R2 is chosen from groups consisting of (a) mono-, di-, or tri- substituted heteroaryls where the heteroaryl is a 5-atom aromatic monocyclic ring containing one heteroatom, which is S, O, or N, and 1, 2, or 3N atoms by choice; or the heteroaryl is a 6-atom monocyclic ring containing one heteroatom, which is N, and 1, 2, or 3N atoms by choice, where the substitute is chosen. Select from groups consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthione, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH. (b) Mono- or di- substituted benzoheterocycles in which the heterocycle is a 5-, 6- or 7-member ring which may contain 1 or 2 heteroatoms chosen independently of O, S, or N and which may contain carbonyl or sulfonyl groups in which the substitute is chosen from. (1) Hydrogen, (2) Halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthione, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH. (c) Heterocycloalkyl groups of 5, 6, or 7-members, which may contain 1 or 2 hetero atoms independently chosen from O, S, or N, and by choice contain a carbonyl group or a sulfonyl group. (d) Mono- or di- substituted benzocarbocycles in which the caryocycle is a 5, 6, or 7-member ring, which by choice contains a carbonyl group in which the substitute A bicyclic heteroaryl substituent is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthio, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH. (e) Bicyclic heteroaryls are mono- or di-substituted of 8, 9, or 10 members, which may have 2, 3, 4, or 5 heteroatoms chosen independently of O, S, or N, and may have at least one heteroatom where the substituent is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthio, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH. ) CN ( 7 ) CF 3 and ( 8 ) -C (R5) (R6) -OH R3 is hydrogen, C1-6 alkyl, CH2OR7 , CN , CH2CN , C1-3 fluoroalkyl , F , CON(R7)2 , mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or di- substituted heteroaryl, mono- or di- substituted heteroarylmethyl where the substitute is chosen from the group. Containing (1) hydrogen, (2) halo, (3) C1-4 alkyl, (4) C1-4 alkoxy, (5) C1-4 alkylthione, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH, R4 was selected from the group containing (a) hydrogen, (b) C1-4 alkyl, (c) C1-4 alkoxy, (d) C1-4 alkylthione, (e) -OH, (f) -OCOR7, (g) -SCOR7, (h) -OCO2R8, and (i) -SCO2R8, or R3 and R4 combined with the carbon to which they both are attached. It is a saturated monocyclic carbon ring of 3, 4, 5, 6, or 7 atoms. R5 and R6 are independent of each other and are chosen from groups consisting of (a) hydrogen and (b) C1-4 alkyl, or R5 and R6 are bonded to the atoms to which they are both attached. Each R7 is an independent monocyclic ring of 3, 4, 5, 6, or 7 atoms, chosen from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitute is chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkydthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitute is chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkydthio, CN, and CF3. Each R8 is an independent R8, chosen from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitute is chosen from halo, C1-4 (a) alkyl, C1-4 alkoxy, C1-4 alkythio, CN and CF3 and (c) benzyl or benzyl mono-substituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkythio, CN and CF3. R9 and R10, combined with their bonded carbons, form carbonyls R16 and R17, which are independent of each other, are chosen from groups consisting of (a) hydrogen, (b) C1-4 alkyl, (c) C1-4 alkanoic acid, (d) C1-4 alkyl amine, (e) phenyl or phenyl mono-substituted where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkythio, C1-6 alkanoic. Acid, C1-6 alkyl amine, CN, CO2H or CF3 9. The compounds according to claim 8 where X is selected from the groups consisting of (a) CH2 and (b) O, Y is selected from the groups consisting of (a) CH2 and (b) O, R1 is selected from the groups consisting of (a) SO2CH and (b) SO2NR16R17, R2 is selected from the groups consisting of... Mono-, di-, or tri- substituted heteroaryls, where the heteroaryl is a 5-atom aromatic monocyclic ring containing one hetero atom, i.e., S, O, or N, and one, two, or three N atoms added by choice; or a 6-atom monocyclic ring containing one hetero atom, i.e., N, and one, two, or three N atoms added by choice, where the substitute is chosen from a group consisting of (1) hydrogen, (2) halo, (3) C1-6 alkyl, (4) C1-6 alkoxy, (5) C1-6 alkylthione, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH. R3 is hydrogen, C1-6 alkyl, CH2OR7 , CN , CH2CN , C1-3 fluoroalkyl , F , CON(R7)2 , mono- or di- substituted phenyl , mono- or di- substituted benzyl , mono- or di- substituted heteroaryl , mono- or di- substituted heteroarylmethyl where the substitute is chosen from a group consisting of ( 1 ) hydrogen ( 2 ) halo ( 3 ) C1-4 alkyl ( 4 ) C1-4 alkoxy ( 5 ) C1-4 alkylthione ( 6 ) CN ( 7 ) CF 3 and ( 8 ) -C(R5)(R6)-OH R4 is chosen from a group consisting of ( a ) hydrogen ( b ) C1-4 alkyl ( c ) C1-4 alkoxy ( d ) ) C1-4 alkylthio (e)-OH (f)-OCOR7 (g)-SCOR7 (h)-OCO2R8 and (i)-SCO2R8 or R3 and R4 are combined with the atoms to which they are both attached to form a saturated monocyclic carbon ring of 3, 4, 5, 6 or 7 atoms. R5 and R6 are independent and chosen from the groups consisting of (a) hydrogen and (b) C1-4 alkyl or R5 and R6 combined with the atoms to which they are both attached to form Each R7 is an independent monocyclic ring of 3, 4, 5, 6, or 7 atoms, chosen from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. Each R8 is an independent R8, chosen from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, (a) C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3 and (c) benzyl and benzyl monosubstituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with the carbons they are attached to to form carbonyls, and R16 and R17 are independently chosen from groups consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl and phenyl monosubstituted where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkyl amine, CN, CO2H or CF3 10. The compounds according to claim 9 where R2 is a mono- or di-substituted heteroaryl, where the heteroaryl is selected from the group consisting of (1) furanil, (2) diazinil, (3) imidazolyl, (4) isooxazolil, (5) isothiazolyl, (6) oxadiazolil, (7) oxazolil, (8) pyrazolil, (9) pyridyl, (10) pyrrolil, (11) tetrazenil, (12) tetrazolyl, (13) thiadiazolyl, (14) thiazolyl, (15) thienil, (16) triazinil, and (17) thiazolil. and the chosen substitute from the group consisting of (1) hydrogen (2) halo (3) C1-4 alkyl (4) C1-4 alkoxy (5) C1-4 alkylthio (6) CN and (7) CF3 11. The compounds under claim 10 where R2 is a mono- or di-substituted heteroaryl where the heteroaryl is chosen from the group consisting of (1) furanil, (2) diazinil, (3) imidazolyl, (4) isooxazolil, (5) isothiazolyl, (6) oxadiazolil, (7) oxazolil, (8) pyrazolyl, (9) pyridyl, (10) pyrrolil, (11) thiazolyl, (12) thienil where the substitute is chosen from the group consisting of (1) hydrogen, (2) halo, (3) C1-3 alkyl, (4) C1-3 alkoxy, and (5) CF3. 12. The compound according to claim 11, where X is O, Y is O, R1 is chosen from the groups consisting of (a) SO2CH3 and (b) SO2NH2. R2 is a mono- or di-substituted heteroaryl where the heteroaryl is chosen from the groups consisting of (1) furanil, (2) diazinil, (3) imidazolyl, (4) oxadiazolil, (5) pyrazolyl, (6) pyridyl, (7) pyrrolil, (8) thiazolyl, (9) thienil, where the substitute is chosen from the groups consisting of (1) hydrogen, (2) halo, (3) methyl, (4) methoxy and (5) CF3. R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or di- substituted heteroaryl, mono- or di- substituted heteroarylmethyl where the substitute is chosen from groups consisting of (1) hydrogen, (2) halo, (3) C1-3 alkyl, (4) C1-3 alkoxy, (5) C1-3 alkylthio, (6) CN and (7) CF3. R4 is chosen from groups consisting of (a) hydrogen, (b) C1-3 alkyl, (c) C1-3 alkoxy, (d) C1-3 alkylthio and (e) -OH and R9 and R10. It combines with the carbon it's bound to to form carbonyl 12. The compound according to claim 12, where X is O, Y is O, R1 is selected from the group consisting of (a) SO2CH3 and (b) SO2NH2, R2 is a mono- or di-substituted heteroaryl where the heteroaryl is selected from the group consisting of (1) furanil, (2) diazinil, (3) imitazolyl, (4) oxadiazolil, (5) pyrazolyl, (6) pyridyl, (7) thiazolil and (8) thienil, where the substitute selected from the group It consists of (1) hydrogen, (2) Br, Cl or F, (3) methyl, (4) methoxy and (5) CF3. R3 is chosen from hydrogen and C1-3 alkyl. R4 is chosen from hydrogen and C1-3 alkyl. R9 and R10 combine with the carbon they are bound to to form carbonyl 14. The compound according to claim 13, where X is O, Y is O, R1 is chosen from groups consisting of (a) SO2CH3 and (b) SO2NH2. R2 is a mono- or di-substituted pyridyl where the substitute is chosen from groups consisting of (1) hydrogen, (2) Br, Cl or F, (3) methyl, (4) methoxy and (5) CF3. R3 is chosen from hydrogen and C1-3 alkyl. R4 is chosen from hydrogen and C1-3 alkyl. R9 and R10 combine with the carbon they are bound to to form carbonyls. 15. The compounds according to claim 14, where X is O, Y is O, R1 is chosen from groups consisting of (a) SO2CH3 and (b) SO2NH2. R3 is chosen from methyl and ethyl. R4 is chosen from methyl and ethyl. R9 and R10 combine with the carbons they are bound to to form carbonyl 16. The compounds according to claim 1 are selected from the group consisting of (1) 3-(3,4-difluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one, (2) 3-(3-fluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one, (3) 3-(3,5-difluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one, (4) 3-phenoxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl ( 5 ) 3-(2,4-difluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 6 ) 3-(4-chlorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 7 ) 3-(3,4-dichlorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 8 ) 3-(4-fluorophenoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one nyl)phenyl)-5H-furan-2-one ( 9 ) 3-(4-fluorophenylthio)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 10 ) 3-(3,5-difluorophenylthio)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 11 ) 3-phenylthio-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 12 ) 3-( N-phenylamino)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one nil)phenyl)-5H-furan-2-one ( 13 ) 3-( N-methyl-N-phenylamino)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 14 ) 3-cyclohexyloxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one (b)O R1 was selected from the group consisting of (a) SO2CH3, (b) SO2NR16R17 and (c) S(O)(NH)NH2. R2 is C1-6 alkyl, R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or di- substituted heteroaryl, mono- or di- substituted heteroarylmethyl, where the substitute was selected from Groups consisting of (1) hydrogen, (2) halo, (3) C1-4 alkyl, (4) C1-4 alkoxy, (5) C1-4 alkylthio, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH R4 were selected from groups consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkoxy, (d) C1-6 alkylthio, (e) -OH, (f) -OCOR7, (g) -SCOR7, (h) -OCO2R8, and (i) -SCO2R8, or R3, or R4, bonded to the carbon with which they both are attached. They form saturated monocyclic carbon rings of 3, 4, 5, 6, or 7 atoms. R5 and R6 are independent and chosen from groups consisting of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 combine with the atoms to which they are both bonded. Each R8 is an independent monocyclic ring of 3, 4, 5, 6, or 7 atoms, chosen from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. (a) nitrogen, (b) C1-6 alkyl, (c) C1-6 alkyl amine, (d) C1-6 alkyl amine, (e) phenyl or phenyl monosubstituted where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-4 alkyl thio, CN and CF3. R9 and R10, combined with their bonded carbons, form carbonyls. R16 and R17 are independently selected from groups consisting of (a) nitrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or phenyl monosubstituted where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl thio, C1-6 alkanoic. (d) benzyl or mono-substituted benzyl, where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkanoic acid, C1-6 alkylamine, CN, CO2H or CF3. 21. The compound according to claim 20 where X is O, Y is O, R1 is selected from the group consisting of (a) SO2CH3, (b) SO2NR16R17, and (c) S(O)(NH)NH2, R2 is C1-4 alkyl, R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, CON(R7)2, mono- or di- substituted phenyl, mono- or di- substituted benzyl, mono- or di- substituted heteroaryl, mono- or di- substituted heteroarylmethyl, where the substitute is selected from. Groups consisting of (1) hydrogen, (2) halo, (3) C1-4 alkyl, (4) C1-4 alkoxy, (5) C1-4 alkylthio, (6) CN, (7) CF3, and (8) -C(R5)(R6)-OH. R4 was selected from groups consisting of (a) hydrogen, (b) C1-6 alkyl, (c) C1-6 alkoxy, (d) C1-6 alkylthio, (e) -OH, (f) -OCOR7, (g) -SCOR7, (h) -OCO2R8, and (i) -SCO2R8, or R3 and R4 combined with the carbon to which they both are attached. They form monosaccharide rings of saturated carbon of 3, 4, 5, 6, or 7 atoms. R5 and R6 are independent of each other and are chosen from groups consisting of (a) hydrogen and (b) C1-6 alkyl, or R5 and R6 combine with the atoms to which they are both bonded to form a ring. Each independent R7 atom was selected from a group consisting of (a) hydrogen, (b) C1-4 alkyl, (c) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3, and (d) benzyl and mono-substituted benzyl where the substitutes were chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN, and CF3. Each independent R8 atom was selected from a group consisting of (a) C1-4 alkyl, (b) phenyl and mono-substituted phenyl where the substitutes were chosen from halo, C1-4 alkyl. (a) phenyl or phenyl mono-substituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3 and (c) benzyl and benzyl mono-substituted where the substitutes are chosen from halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, CN and CF3. R9 and R10 are combined with the carbons they are attached to to form carbonyls. R16 and R17 are independently selected from groups consisting of (a) nitrogen, (b) C1-6 alkyl, (c) C1-6 alkanoic acid, (d) C1-6 alkyl amine, (e) phenyl or phenyl mono-substituted where the substitutes are chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 (d) benzene and benzyl mono-replaced where the substitute is chosen from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkyl acid, C1-6 alkylamine, CN, CO2H or CF3. 22. Compounds according to claim 21 where X is O, Y is O, R1 is chosen from groups consisting of (a) SO2CH3 and (b) SO2NR16R17, R2 is propyl or butyl, R3 is hydrogen, C1-6 alkyl, CH2OR7, CN, CH2CN, C1-4 fluoroalkyl, F, mono- or di-substituted phenyl, mono- or di-substituted benzyl, mono- or di-substituted heteroaryl, mono- or di-substituted heteroarylmethyl where the substitute is chosen from groups consisting of (1) hydrogen, (2) halo, (3) C1-3 alkyl, (4) C1-3 alkoxy, (5) C1-3. Alkylthio (6)CN and (7)CF3R4 were selected from groups consisting of (a) hydrogen, (b)C1-3 alkyl, (c)C1-3 alkoxy, (d)C1-3 alkylthio, and (e)-OH. R9 and R10 are combined with the carbon they are bound to to form carbonyls. 23. The compounds according to claim 22, where X is O, Y is O, R1 is chosen from groups consisting of (a) SO2CH3 and (b) SO2NR16R17, R2 is chosen from propyl and butyl, R3 is chosen from hydrogen and C1-3 alkyl, R4 is chosen from hydrogen and C1-3 alkyl, and R9 and R10 combine with the carbon they are bound to to form carbonyls. 24. The compounds according to claim 23, where X is O, Y is O, R1 is chosen from the groups consisting of (a) SO2CH3 and (b) SO2NR16R17, R2 is chosen from propyl, R3 is chosen from methyl and ethyl, R4 is chosen from methyl and ethyl, and R9 and R10 are combined with the carbon they are attached to to form carbonyls. 25. The compound according to claim 24, where each R16 and R17 is hydrogen. 26. The compound according to claim 25 where R1 is SO2CH3. 27. The compounds under claim 25 in which (a) 5,5-dimethyl-4(4-methylsulfonylphenyl)-3(5-bromopyridin-2-yloxy)-5H-furan-2-one and (b) 5,5-dimethyl-4(4-methylsulfonylphenyl)-3(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salts. 28. The compound according to claim 1, which is 5,5-dimethyl-4(4-methylsulfonylphenyl)-3(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salt. 29. Pharmaceutical ingredients consisting of the compounds specified in claim 28 in combination with pharmaceutically acceptable carriers. 30. Use of the compounds under claim 28 in the preparation of pharmaceutical formulations for the treatment of inflammatory diseases in mammalian patients. 31. The compounds according to claim 1 are selected from the group consisting of (1) 2-(3,4-difluorophenoxy)-3(4-methylsulfonylphenyl)-cyclopent-2-enone (2) 3-(5-benzothiophenyloxy)-5-dimethyl-4(4-methylsulfonylphenyl)-5H-furan-2-one (3) 5,5-dimethyl-4(4-methylsulfonylphenyl)-3(pyridyl-4-oxy)-5H-furan-2-one (4) 5,5-dimethyl-4(4-methylsulfonylphenyl)-3(pyridyl-4-oxy)-5H-furan-2-one 3-(2-methyl-5-pyridyloxy)-5,5-dimethyl-4(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 6 ) 3-(2-fluoro-4-difluoromethyl)phenoxy-4-(4-(methylsulfonyl)phenyl)-5, 5-dimethyl-5H-furan-2-one ( 7 ) 3-(5-chloro-2-pyridylthio)-5,5-dimethyl-4(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 8 ) 2-(3,5-difluorophenoxy)-3(4-methylsulfonylphenyl ( 9 ) 3-(3-pyridylooxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl) -5H-furan-2-one ( 10 ) 3-(3-methyl-2-pyridylooxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl) -5H-furan-2-one ( 11 ) 3-(3-chloro-5-pyridylooxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl) -5H-furan-2-one ( 12 ) 3-(3-(1,2,5-thiadiazolyl)oxy)-4,(4-(methylsulfonyl)phenyl)-5,5-dimethyl -5H-furan-2-one ( 13 ) 3-(5-isoquinolinoxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl -5H-furan-2-one ( 14 ) 3-(6-amino-2-pyridyloxy) )-5,5-dimethyl -4,(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 15 ) 3-(3-chloro-4-fluoro)phenoxy)- 4 - (methylsulfonyl)phenyl) -5,5-dimethyl -5H-furan-2-one ( 16 ) 3-(6-quinolinoxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl -5H-furan-2-one ( 17 ) 3-(5-nitro-2-pyridyloxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl -5H-furan-2-one ( 18 ) 3-(2-thiazolylthio)-4(4-methylsulfonyl)phenyl)-5,5-dimethyl -5H-furan-2-one ( 19 ) 3-(3-chloro-5-pyridylooxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl) -5H-furan-2-one ( 20 ) 5,5-dimethyl-4(4-methylsulfonyl)phenyl)-3-(2-propoxy) -5H-furan-2-one ( 21 ) 3-(3-trifluoromethyl)phenoxy-4(4-methylsulfonyl)phenyl-5,5-dimethyl -5H-furan-2-one ( 22 ) 5,5-dimethyl-4(4-methylsulfonyl)phenyl nil)-3-(xbgxvibfuo-1-carbonyl)-5H-furan-2-one ( 23 ) 5,5-dimethyl-3(2-butoxy)-4-(4-methylsulfonylphenyl)-5H-furan-2-one ( 24 ) 5,5-dimethyl-4(4-methylsulfonylphenyl)-3(3-penpoxy)-5H-furan-2-one ( 25 ) 2-(5-chloro-2-pyridyloxy)-3- ( 4-methylsulfonyl)phenylcyclopent-2-one ( 26 ) 3-(4-methyl-2-pyridyloxy (27) (5R)-3-(3,4-difluorophenox C)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl-5H-furan-2-one (28) (5R)-3-(4-chlorophenox C)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl-5H-furan-2-one (29) 3-(2-methyl-3-pyridyoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one (30) 3-(4-methyl-5-nitro-2-pyridyoxy) C)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 31 ) 3-(5-chloro-4-methyl-2-pyridyoxy C)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 32 ) 3 - ( 5-fluoro - 4 - methyl - 2 - pyridyoxy )-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 33 ) 3-( 3-chloro-2-pyridyoxy )-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 34 ) 3-(4-fluorophenoxy)-5-methyl-4(4-methylsulfonyl)phenyl)-5-propyl-5H-furan-2-one ( 35 ) 3-( N,N-diethylamino )-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5-propyl-5H-furan-2-one ( 36 ) 5,5-dimethyl-4(4-methylsulfonyl-phenyl)-3-(3,5-dichloro-2-pyridyloxy)-5H-furan-2-one ( 37 ) (5R)-3-(4-bromophenoxy C)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl-5H-furan-2-one ( 38 ) (SR)-3-(4-methylphenoxy C)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl-5H-furan-2-one ( 39 ) (5R)-3-(5-chloro-2-pyridyloxy C)-5-methyl-4(4-methylsulfonyl)phenyl-5-(2,2,2-difluoroethyl)-5H-furan-2-one ( 40 ) 3-( 5-chloro-2-pyridyloxy )-5-methyl-4(4-methylsulfonyl)phenyl-5-propyl-5H-furan-2-one ( 41 ) 5-methyl-4(4-methylsulfonyl-phenyl)-3-(2-(propoxy)-5-(2-trifluoroethyl) -5H-furan-2-one ( 42 ) S(R)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one ( 43 ) 5,5-dimethyl-3-(2,2-dimethylpropyloxy)-4-(4-(methylsulfonyl-phenyl)-5H-furan-2-one ( 44 ) S(R) 3-(1-cyclopropyl-ethox C)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 45 ) 5(S) S-ethyl-5-methyl-4(4-methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one ( 46 ) 3-(1-cyclopropyl-ethok C)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 47 ) 3-(1-cyclopropyl-ethok C)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 48 ) 5,5-dimethyl-3-(isobutoxy)-4-(4-(methylsulfonyl) 3-(4-bromophenoxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 49 ) 3-(4-bromophenoxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 50 ) 3-(2-quinolenoxoxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 51 ) 3-(2-chloro-5-pyridyloxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 52 ) 3-(6-benzothiazolyloxy C)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 53 ) 3-(6-chloro-2-pyridyloxi C)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 54 ) 3-(4-quinazolioxy)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 55 ) (5R)-3-(5-fluoro-2-pyridyloxi C)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 56 ) (5R)-3-(4-fluorophenoxy C)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 57 ) (5R)-3-(5-fluoro-2-pyridyloc C)-5-methyl-4(4-methylsulfonyl)phenyl)-5(2,2,2-trifluoroethyl)-5H-furan-2-one ( 58 ) 3-(1-isoquinolinillox C)-5,5-dimethyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 59 ) (5R)-3-(4-fluorophenoxy)-5-methyl-4(4-methylsulfonyl)phenyl)-5H-furan-2-one (5R)-3-(3,4-difluorophenoxy)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one ( 60 ) 3-(3-fluorophenoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 61 ) (5R)-3-(3,4-difluorophenoxy)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one ( 62 ) (5R)-3-(5-chloro-2-pyridyloxy C)-5-ethyl-5-methyl-4(4-methylsulfonyl)phenyl-5H-furan-2-one ( 63 ) 3-(3,4-difluorophenoxy)-5-methyl-5-trifluoromethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 64 ) 3-(3,4-difluorophenoxy)-5-methyl-4-(4-methylsulfonyl)phenyl)-5-propyl-5H-furan-2-one ( 65 ) 3-cyclobutyloxy-5,5-dimethyl-4-(4-methylsulfonyl)-5H-furan-2-one ( 66 ) 3-(1-indanyloxy-5,5-dimethyl-4-(4-(methylsulfonyl) ( 67 ) 3-(2-indanyloxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one ( 68 ) 3-cyclopentyoxy-5,5-dimethyl-4-(4-methylsulfonyl)-5H-furan-2-one ( 69 ) 3-(3,3-dimethylcyclopentyoxy)-5,5-dimethyl-4-(4-methylsulfonyl-phenyl)-5H-furan-2-one ( 70 ) 3-icypropoxy-5-methyl-4-(4-methylsulfonylphenyl)-5H-furan-2-one (3,4-difluorophenoxy)-5-propyl-5H-furan-2-one ( 71 ) 3-(2-methoxy-5-pyridylooxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 72 ) 3-(5-methyl-2-pyridylooxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H-furan-2-one ( 73 ) (5RS)-3-(3,4-difluorophenoxy)-5methyl-4-(4-methylsulfonyl)phenyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one ( 74 ) 3-(3-chloro-4-methoxyphenoxy (5R)-3-(3-chloro-4-methoxyphenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 75 ) (5R)-3-(3-chloro-4-methoxyphenoxy)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 76 ) (5R)-3-(4-chlorophenoxy)-5-trifluoroethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 77 ) (5R)-3-(4-bromophenoxy)-5-trifluoroethyl Ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 78 ) 5-cyclopropylmethyl-3-(3,4-difluorophenox C)-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 79 ) (5R)-3-(3-fluorophenox C)-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 80 ) (5R)-3-(4-chloro-3-fluorophenox (5R)-3-phenoxy-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 81 ) (5R)-3-phenoxy-5-ethyl-5-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 82 ) (5R)-3-(4-chloro-3-methylphenoxy)-5-ethyl-methyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 83 ) 3-(4-chloro-3-methylphenoxy)-5,5-drymethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 84 ) (5R)-3-(5-bromo-2-pyridylox C)-5-methyl-4-(4-methylsulfonylphenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-5H-furan-2-one ( 85 ) (5R)-3-(5-bromo-2-pyridyloxy)-4-(4-methylsulfonylphenyl)-5-ethyl-5-methyl-5H-furan-2-one ( 86 ) 3-(5-chloro-6-methyl-2-pyridyloxy C)-5,5-drymethyl-4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 87 ) 3-(5-cyclopropyl-2-pyridyloxy C)-5,5-drymethyl4-(4-methylsulfonyl)phenyl-5H-furan-2-one ( 88 ) 3-(1-cyclopropylethoxy)-4-(4-methylsulfonyl)phenyl-5H-furan-2-one and ( 89 ) 3-(cyclopropylethoxy)-4-(4-methylsulfonyl)phenyl-5H-furan-2-one 32. Compounds were selected from groups containing (5S)-5-ethyl-5-methyl-4(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one, (SR)-5-ethyl-5-methyl-4(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one, and (RS)-5-ethyl-5-methyl-4(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one, or their pharmaceutically acceptable salts or hydrates. 33. The compound according to claim 32 is named (5S)-5-ethyl-5-methyl-4(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one or its pharmacologically acceptable salt or hydrate (formula temi). 34. The compound according to claim 32 is named (5S)-5-ethyl-5-methyl-4(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salts or hydrates. 35. The compound according to claim 32 is named (RS)-5-ethyl-5-methyl-4(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one or its pharmaceutically acceptable salts or hydrates. 36. Pharmaceutical ingredients consisting of the compounds specified in Claim 32 in combination with pharmaceutically acceptable carriers. 37. The use of the compounds described in claim 32 in the preparation of pharmaceutical mixtures for the treatment of inflammatory diseases in mammalian patients requiring such treatment. 38. The use of the compounds described in claim 32 in the preparation of pharmaceutical mixtures for therapeutic use in cyclooxygenase-mediated diseases in mammalian patients requiring such treatment. 39. The use of the compounds described in claim 32 in the preparation of pharmaceutical formulations for the treatment of arthritis in mammals requiring such treatment. 40. Use of the compounds under claim 39 where arthritis is osteoarthritis. 41. Use of the compounds under claim 39 where the arthritis is rheumatoid arthritis. 42. Use of the compounds described in claim 32 in the preparation of pharmaceutical formulations for the treatment of pain in mammalian patients. 43. The compound with the name 3-(cyclopropylmethoxy)-5,5-dimethyl-4(4-(methylsulfonyl)phenyl)-5H-furan-2-one, or its salt or hydrate, that is pharmaceutically acceptable (chemical formula). 44. Pharmaceutical ingredients consisting of the compounds specified in Patent 43 in combination with pharmaceutically acceptable carriers. 45. Use of the compounds under claim 43 in the preparation of pharmaceutical formulations for the treatment of inflammatory diseases in mammalian patients requiring such treatment. 46. Use of the compounds under claim 43 in the preparation of pharmaceutical formulations for the treatment of cyclooxygenase-mediated diseases in mammalian patients requiring such treatment. 47. Use of the compounds under claim 46 where the disease mediated by cyclooxygenase is osteomyelitis or rheumatoid arthritis. 48. The use of the compounds under claim 43 in the preparation of pharmaceutical mixtures for the treatment of pain in mammalian patients requiring such treatment. 49. A pharmaceutically acceptable compound is 3-(1-cyclopropyl-ethox C)-5,5-dimethyl-4(4-(methylsulfonyl)phenyl)-5H-furan-2-one, or its salt or hydrate. 50. Pharmaceutical ingredients consisting of compounds as specified in Patent 49 in combination with pharmaceutically acceptable carriers. 51. Use of the compounds under claim 49 in the preparation of pharmaceutical formulations for the treatment of inflammatory diseases in mammalian patients requiring such treatment. 52. Use of the compounds under claim 49 in the preparation of pharmaceutical formulations for the treatment of cyclooxygenase-mediated diseases in mammalian patients. 53. Use of the compounds under claim 52 where the disease mediated by cyclooxygenase is osteomyelitis or rheumatoid arthritis. 54. The use of the compounds under claim 49 in the preparation of pharmaceutical formulations for the treatment of pain in mammalian patients requiring such treatment (Clause 54, 38 pages, 0 images).