TH46010A - Sample detection to start timing the electrochemical analysis - Google Patents

Abstract

DC60 (05/10/15) Electrochemical Analysis consists of Methods for highly accurate timing Much of which examples have been In order to bridge the gap between the electrodes of the electrochemical cell, the method involves allowing a small amount of current to travel across the gap while the difference in The electric potential between the electrodes when the sample crosses the gap is made Marked as Rapid fall of electric potential Electric potential difference The constant will be provided after the sample is received. Determination has been made and the current and / or charge passed through the sample will be monitored over a period of time from the measured currents and charges, the concentration of the analyte of interest can be calculated. Electricity consists of Methods for highly accurate timing Much of which examples have been The feed is welded across the gap between the electrodes of the electrochemical cell.The method involves having a small amount of current across the gap while the difference potential between the electrodes is observed, the time at which the sample crosses the gap. Been done Marked as ok The constant potential is fed after the sample has been detected and the current and / or charge through the sample is monitored throughout. For a period of time from the measured currents and charges, the concentration of the analyte of interest can be calculated.

Claims (15)

1. A method for measuring the concentration of the analytical substance in biological fluid samples using an electrochemical strip analyzer consisting of a working electrode and a reference electrode placed side-by-side. The method consists of (a) applying a constant current source between the working electrode and the reference electrode (b) observing the potential difference across the electrodes (c) stripping the sample (d) determining the sample detection time by observing when the potential difference drops below a predetermined threshold potential difference (e) applying a predetermined constant potential difference to the sample (f) measuring the electrical response at a predetermined time after the application of the constant potential difference, and (g) calculating the analytical concentration using the measured electrical response. 2. A method of claim 1 in which the measured electrical response is a current flowing through the sample at a predetermined time. 3. The method of Claim 1 in which the measured electrical response is a charge passing through the sample from the time of sample detection to a predetermined time. 4. The method of claim 1 also involves applying a second predetermined electrical potential after a predetermined time and measuring the second electrical response after the application of the second predetermined potential. 5. The method of claim 4, where the second-order electrical response is the ratio of the decrease in current through the sample. 6. The method of claim 4 in which the second electrical response is a charge passing through the sample during a predetermined time interval after a second electrical potential has been applied. 7. A device for measuring the concentration of the analytical substance in a biological fluid sample supplied between the working electrode and the reference electrode of an electrically connected analytic strip shall consist of (a) a device for supplying a predetermined current between the working electrode and the reference electrode; (b) a device for monitoring the potential difference across the electrodes; (c) a device for determining when the potential difference falls below a predetermined threshold potential to indicate sample detection; (d) a device for responding to sample detection to supply a predetermined constant potential to the sample; (e) a device for measuring the resulting electrical response; and (f) a device for calculating the analytical concentration using the measured electrical response. 8. The measure of claim number 7, which is an ammeter, shall be the device for measuring the resultant electrical response. 9. The measure of claim number 7, for which the device to measure the resultant electrical response shall be a coulomb meter. 10. The measures of claim 7 also include a device for applying a second predetermined electrical potential to the sample and a device for measuring the resultant electrical response. 11. The measure of claim 10, which is the device for measuring the second-order resultant electrical response, shall be an ammeter. 12. The measure of claim 10, which is the device for measuring the second-order resultant electrical response, shall be a Coulomb meter. 13. A method for measuring the concentration of the analytical substance in a biological fluid sample using an electrochemical strip analyzer consisting of a working electrode and a reference electrode placed side-by-side. The method consists of (a) applying a constant current source between the working electrode and the reference electrode (b) observing the potential difference across the electrodes (c) applying the sample to the strip (d) determining the sample detection time by observing when the potential difference drops below a predetermined threshold potential difference (e) applying a fixed constant potential difference to the sample (f) applying a second predetermined potential to the sample after the first predetermined time (g) measuring the electrical response at a predetermined time after the first predetermined time, and (h) calculating the analytical concentration using the electrical response. 14. The method of claim 13 in which the measured electrical response is the rate of decrease of the current through the sample. 15. The method of claim 13 in which the measured electrical response is a charge passing through the sample during a predetermined time period after a second predetermined potential has been applied.