TH79415A - The process for preparing the replaced pyrimidine - Google Patents
The process for preparing the replaced pyrimidineInfo
- Publication number
- TH79415A TH79415A TH301002160A TH0301002160A TH79415A TH 79415 A TH79415 A TH 79415A TH 301002160 A TH301002160 A TH 301002160A TH 0301002160 A TH0301002160 A TH 0301002160A TH 79415 A TH79415 A TH 79415A
- Authority
- TH
- Thailand
- Prior art keywords
- useful
- pyrimidine
- inhibitors
- preparing
- aurora
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract 4
- 229940079593 drug Drugs 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 102000003989 Aurora kinases Human genes 0.000 abstract 2
- 108090000433 Aurora kinases Proteins 0.000 abstract 2
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 abstract 2
- 239000005441 aurora Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 239000003909 protein kinase inhibitor Substances 0.000 abstract 2
- GDTSJMKGXGJFGQ-UHFFFAOYSA-N 3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound O1B([O-])OB2OB([O-])OB1O2 GDTSJMKGXGJFGQ-UHFFFAOYSA-N 0.000 abstract 1
Abstract
DC60 (14/03/48) การประดิษฐ์นี้ได้จัดเตรียมกระบวนการที่ง่ายสำหรับการเตรียมไตร- และ เตตราซับสติติวเต็ดไพริมิดีน กระบวนการมีประโยชน์สำหรับการเตรียมสารยับยั้งโปรตีน ไคเนส โดยเฉพาะออโรร่าไคเนส สารยับยั้งเหล่านี้มีประโยชน์สำหรับการบำบัด หรือการ ลดความรุนแรงของโรคหรือสภาวะที่มีออโรร่าเป็นสื่อ การประดิษฐ์นี้ได้จัดเตรียมกระบวนการที่ง่ายสำหรับการเตรียมไตร-และ เตตราขับสติติวเต็ดไพริมิดีน กระบวนการมีประโยชน์สำหรับการเตรียมสารยับยั้งโปรตีน ไคเนส โดยเฉพาะออโรร่าไคเนส สารยับยั้งเหล่านี้มีประโยชน์สำหรับการบำบัด หรือการ ลดความรุนแรงของโรคหรือสภาวะที่มีออโรร่าเป็นสื่อ สิทธิบัตรยา DC60 (14/03/48) This invention provides a simple process for the preparation of tri- and tetraborate, pyrimidine. The process is useful for the preparation of protein kinase inhibitors, especially aurora kinase. These inhibitors are useful for treating or reducing the severity of disease or aurora-mediated conditions. This invention provides an easy process for preparing tri- and Tetra, stealthy, pyrimidine The process is useful for the preparation of protein kinase inhibitors, especially aurora kinase. These inhibitors are useful for treating or reducing the severity of disease or conditions in which the aurora-mediated drug patent may be used.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH79415A true TH79415A (en) | 2006-08-24 |
Family
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