TH98376A - Pyrolo [2,3-B] pyridine and pyrolo [2,3-B] pyridine [2,3-B] that have been replaced with heteroauryl as inhibitors. Janus Kines - Google Patents

Abstract

DC60 The present invention provides heteroaryl-replaced pyrrolo[2,3-b]pyrimidine and heteroaryl-replaced pyrrolo[2,3-d]pyrimidine which control the action of januskinase and are useful in the treatment of diseases associated with the action of januskinase, including, for example, autoimmune diseases, skin disorders, myeloid proliferation disorders, cancer and other diseases.

Claims (86)

OCR 11RK 1. Compounds of the formula (chemical formula) or gastically acceptable salts of this substance, where T, U, and V are independently chosen from O, S, N, CR5, and NR6, where the 5-membered ring formed by carbon atoms, nitrogen atoms, U, T, and V are aromatic, X is N or CR4, n is 0 or n is 1, and Y is C1-8 alkylene, C2-8 alkynelene, (CR11R12)pC(O)(CR11R12)q, (CR11R12)pC(O)NR0(CR11R12)q, (CR11R12)pC(O)O(CR11R12)q, or (CR11R12)pOC(O)(CR11R12q, where such C1-8 alkylene or C2-8 alkynelene may be selectively replaced by 1, 2, or 3 halo. OH,CN, amino, C1-4 alkylamino or C2-8 dialkylamino, Z is aryl, cycloalkyl, heteroaryl or heterocycloalkyl, each may be selectively substituted by 1, 2, 3, 4, 5 or 6 independently selected substituents from the halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C-4 haloalkyl, C1-4 hycroxyalkyl, C1-4 cyanoalkyl, Cy1,CN,NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd,NRcC(O)ORa,S(O)NRcRd,S(O)2Rb,NRcS(O)2Rb and S(O)2NRcRd Cy1 are independently selected from aryl, heteroaryl, cycloalkyl and heterocycloalkyl, each of which may be selected to be replaced by 1, 2, 3, 4 or 5 independently selected substituents from halo, C1-4 alkyl, C2-4 aldenyl, C2-4 alkynyl, C1-4 haloalkyl, CN,NO2,ORa",SRa",C(O)Rb". C(O)NRc"Rd",C(O)ORa",OC(O)Rb",OC(O)NRc"Rd",NRc"Rd",NRc"C(O)Rb",NRc"C(O)ORa",S(O)Rb", S(O)NRc"Rd",S(O)2Rb" and S(O)2NRc"Rd" R4 is H R5 is H, Halo, C1-4 alkyl, C2-4 alkynyl, C2-4 alkynyl, C1-4 haloalkyl, CN,NO2,OR7, SR7,C(O)R8,C(O)NR9R10,C(O)OR7,OC(O)R8,OC(O)NR9R10,NR9R10,NR9C(O)R8,NR9C(O)OR7, S(O)R8,S(O)NR9R10,S(O)2R8,NR9S(O)2R8,or S(O)2NR9R10 R6 is H, C2-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, OR7,C(O)R8, C(O)NR9R10,C(O)OR7,S(O)R8,S(O)NR9R10,S(O)2R8 or S(O)2NR9R10 R7 is H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 aldynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl Or, heterocycloalkyl alkyl R8 is H,C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 aldynyl, aryl, cycloyl, heteroaryl, heterocycloalkyl, arylkyl, heteroaryl aldyl, cycloalkyl, or heterocycloalkyl alkyl R9 and R10 are independently selected from H,C1-10 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkylcarbonyl, aryl carbonyl, C1-6 alkylsulfonyl, aryl sulfonyl, aryl, heteroaryl, cycloaldyl, heterocycloalkyl, aryl aldyl, Heteroaryl-alkyl, cycloaldyl-alkyl, and heterocycloalkyl-alkyl, or R9 and R10, together with the N atom to which they are attached, form heterocycloalkyl groups with 4-, 5-, 6-, or 7-members. R11 and R12 are independently selected from H, halo, OH, CN, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkynyl, C2-4 aldynyl, C1-4 hydroxyalkyl, C1-4 cyanoalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl. Ra and Ra" are independently selected from H, C1-6 alkyl, C1-6 haloaldyl, C2-6 alkynyl, C2-6 alkynyl. Eril, cycloalkyl, heteroeril, heterocycloalkyl, erilalil, heteroerilalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 aldinil, C2-6 aldynil, eril, cycloalkyl, heteroeril, heterocycloil, erilalalkyl The aforementioned pteroaryl alkyl, cycloalkyl alkyl, or heterocyclocycloalkyl alkyl are replaced by 1, 2, or 3 independently selected substituents from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalalkyl, aryl, aryl alkyl, heteroaryl, heterocycloalkyl, and heterocycloalkyl Rb and Rb" independently selected from H, C1-6 alkyl, C1-6 haloalalkyl, C2-6 alkynyl, C2-6 alkinyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, aryl alkyl, heryl alkyl, cycloalkyl alkyl, and Heterocycloalkyl alkyl, where C1-6 alkyl, C1-6 haloalkyl, C2-6 aldenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclohalkyl, aryl alkyl, heteroaryl aldil, cycloalkyl alkyl, or heterocycloidol alkyl such as may be selected. Substituted by 1, 2, or 3 independently selected substituents from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, and heterocycloalkyl. Rc and Rd are independently selected from H, C1-10 aldyl, C1-6 haloalkyl, C2-6 aldinyl, C2-6 aldinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where C1-10 alkyl, C1-6 haloalkyl, C2-6 aldinyl, C2-6 alkynil, aryl, heteroaryl, cycloalkil, heterocycloalkil, arylalkil, heteroarylalkil, cycloalkylalkil, or heterocyclocycloallylalkil may be selected. It can be replaced by 1, 2, or 3 independently selected substituents from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, or heterocycloalkyl, or Rc and Rd, together with the N atom to which it is attached, forming a 4-, 5-, 6-, or 7-membered heterocycloalyl group that may be selected to be replaced by 1, 2, or 3 independently selected substituents from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, and heterocycloalkyl, or Rc" and Rd". Independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 aldinyl, C2-6 aldinyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroeryrlalkyl, cycloalkylalkyl, and heterocycloalkylalkyl, where such C1-10 alkyl, C1-6 haloalkyl, C2-6 alkynyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heteroeryrlcycloalkyl, arylalkyl, heteroeryrlalkyl, cycloalkylalkyl, or heterocycloalkylaldyl may be selected. It is replaced by 1, 2, or 3 independently selected substituents from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, and heterocycloalkyl, or Rc" and Rd" together with the N atom to which it is attached, forming a heterocycloalkyl group with 4-, 5-, 6-, or 7-members that may be selected to be replaced by 1, 2, or 3 independently selected substituents from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalkyl, aryl, aryl alkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, and heterocycloalkyl. p is 0,1,2,3,4,5,4,5 or 6 and q is 0,1,2,3,4,5 or 6. 2. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where X is N. 3. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where X is CR. 4. Compounds of claim 1 or pharmaceutically acceptable salts of this substance in which the 5-membered heteroeryl ring formed by carbon, nitrogen, U, T and V atoms is pyrrolyl, pyrazoyl or imitazoyl. 5. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where n is 0. 6. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where n is 1. 7. The compounds of claim 1, or the pharmaceutically acceptable salts of this substance, are 1 and Y, i.e., C1-8 alkylene,(CR11R12)pC(O)(CR11R12)q,(CR11R12)pC(O)NRc(CR11R12)q or (CR11R12)pC(O)O(CR11R12)q, where such C1-8 alkylene may be selectively substituted with 1,2 or 3 halo, OH,CN, amino, C1-4 alkylamino or C2-8 dialkylamino. 8. Compounds of claim 1 or pharmaceutically acceptable salts of this substance, where n is 1 and Y is C1-8 alkylene selectively replaceable with 1, 2 or 3 halo, OH, CN, amino, C1-4 alkylamino or C2-8 alkylamino. 9. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where n is 1 and Y is (CR11R12)pC(O)(CR11R12)q,(CR11R12)pC(O)NRc(CR11R12)q or (CR11R12)pC(O)O(CR11R12)q. 10. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where p is 0. 11. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where p is 1. 12. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where p is 2. 13. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where q is 0. 14. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where q is 1. 15. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where q is 2. 16. A compound of claim 1 or a pharmaceutically acceptable salt of this substance, where one of the p and q is and the other of the p and q is 1, 2 or 3. 17. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where Z is a cycloalkyl, which may be selectively substituted by a 1, 2, 3, 4, 5 or 6 selective substituent. Independent of halo, C1-4 aldil, C2-4 aldinil, C3-4 alkynil, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 cyanol-alkyl, Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa,OC(O)Rb, OC(O)NRcRd,NRcRd, NRc(O)Rb, NRcC(O)NRcRd,NRcC(O)ORa,S(O)Rb,S(O)NRcRd,S(O)2Rb, NRcS(O)2Rb and S(O)2NRcRd 18. The compound of claim 17 or the pharmaceutically acceptable salt of this substance, where n is 1. 19. The compound of claim 17 or the pharmaceutically acceptable salt of this substance, where n is 0. 20. Compounds of claim 1 or pharmaceutically acceptable salts of this substance where Z is a heterocycloalkyl, selectively substituted by 1, 2, 3, 4, 5 or 6 independently selected substituents of halo, C1-4 aldyl, C2-4 aldenyl, C2-4 alkynyl, C1-4. Haloalkyls, C1-4 hydroxyalkyl, C1-4 cyanoalkyls, Cy1,CN,NO2,ORa,SRa,C(O)Rb,C(O)NRcRd,C(O)ORa,OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)NRcRd, NRcC(O)ORa, S(O)Rb, S(O)NRcRd, S(O)2Rb, NRcS(O)2Rb and S(O)2NRcRd (chemical formulas) 21. The compound of claim 20, or the pharmaceutically acceptable salt of this substance, where n is 1. 22. The compound of claim 20 or the pharmaceutically acceptable salt of this substance, where n is 0. 23. A compound of claim 1 or a pharmaceutically acceptable salt of this substance in which Z is tolerated by at least one substituent containing at least one CN group. 24. Compounds of claim 1 or pharmaceutically acceptable salts of this substance where R5 is H, halo, C1-4 alkyl, C1-4 haloalkyl, halosulfanyl, CN or NR9R10. 25. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where R5 is H. 26. Compounds of claim 1 or pharmaceutically acceptable salts of this substance where R6 is H or C1-4 alkyl. 27. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, where R6 is H. 28. The compound of claim 1 or the pharmaceutically acceptable salt of this substance, having the formula (chemical formula). 29. The compound of claim 1 or the pharmaceutically acceptable salt of this substance with formula IV (chemical formula). 30. The compound of claim 1 selected from 4-[1-(1-methyl-3-pyrazol-1-yl-propyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-6]pyridine (4-[1-(1-methyl-3-pyrazol-1-yl-propyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine 4-[1-(3-imidazol-1-yl-1-methyl-propyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-6]pyridine (4-[1-(3-imidazol-1-yl-1-methyl-propyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine) 4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile (4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile) 3-cyclopenty1-4-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-pyrazol-1-yl]-pyrinitrile (4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile) 3-cyclopenty1-4-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-pyrazol-1-yl]-pyrinitrile (4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile 3-cyclopenty-3-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-pyrazol-1-yl]-pyrinitrile (4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile 3-cyclopenty-3-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-pyrazol-1-yl]-pyrinitrile (4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile 3-cyclopenty1-4-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-pyrazol-1-yl]-pyroponitrile (4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile 4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile (4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile) 3-cyclopenty1-4-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-pyrazol-1-yl]-pyrazol-1-yl)-butyronitrile (4-cyclopenty1-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-butyronitrile) 1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclopropylacetonitrile(1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl]-1H-pyrazol-1-yl]cyclopropylacetonitrile) 4-1-[(pyrroldine-2-yl)methyl]-1H-pyrazol-4-yl-7H-pyrrolo[2,3-d]pyrimidine(4-1- [(pyrroldine-yl)methyl]-1H-pyrazol-4-yl-7H-pyrrolo[2,3-d]pyrimidine) 4-(1-[1-(methylsulfonyl)pyrolidin-2-yl]methyl-1H-pyrazol-4-yl)-7H-pyrolo[2,3-pyrimidine (4-(1-[1-(methylsulfonyl)pyrolidin-2-yl]methyl-1H-pyrazol-4-yl)-7H-pym pyrimidine) 3-cyclopentyl-3-[4-(7H-pyrolo[2,3-4pyrimidin-4-yl)-1H-pyrazol-1-yl]acrylonitile (3-cyclopentyl-3-[4-(7H-pymolol2,3-d]pyrimidin-4-yl)-1IH-pyrazol-1-lacrylonitile) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-cyclopentane-carbonitrile (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-cyclopentane-carbonitrile) 3-[3-(hydroxymethyl)cyclopentane]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propenitrile (3-[3-(hydroxymethy1)cyclopentyi]-3-[4-(7H-p d]pyrimidin-4-yl)-1H-pyrazol-1-yllpropanenitile) 1-benzyl-1H-pyrazol-4-yl)-1H-pyrolo[2,3-b)pyridine (4-(1-benzyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) 4-[1-(2-naphthyhmethyl)-1H-pyrazole-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-(2-naphthyhmethyl)-1H-pyrazol-4-yi)-1)-pyrcobolo[2,3]byridine) 4-(1-phenyl-1H-pyrazole-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-phenyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) [4-(111-pyrrolo[2,3-6pyridin-4-yl)-1H-pyrazole-1-yl]benzonitrile ( pytrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-y|benzonitrile) 4-methyl-3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]benzonitrile (4- methy1-3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-ylbenzonitrile) 4-[1-(3,5-dimethoxybenzyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1-(3,5-dimethoxybenzyl)-111-pyrazol-4-11-1H-pyrololol2-blpypyridine) 4-[1-(1-phenylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1-(1-phenylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine) [1-(cyclohexylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1- (cyclcherylmethyl)-1H-pyrazol-4-yl)-1H-pymolo[2-3-bjpyrine) 3-([4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]methyl)benzonitrile(3- ([4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yilmethyl)benzonitrile) [4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]methyl)benzonitrile (2- 2-([4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-IH-pyrazol-1-yl]methyl) benzo [4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-1H-pyrazol-1-yl]methyl)benzonitrile(4- 4-([4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-y1]methyl)benzonitrile) 1-phenyl-2-[4-(1H-pyrrolo[2,3-b]pyridin-yl)-1H-pyrazol-1-yl]ethanone (1- phenyl-2-14-1H-pyrololo(2,3-bjpvidin-4-yl)-pyrezol-yi]-yllethamone) 4-(1-[(5-methylisoxazol-3-yl)methyl]-1H-pyrazol-4-yl)-1H-pyrrololo[2,3,3-b] pyridine (4-(1-[(5-methylisoxazol-3-yl)methyl]-1H-pyrazol-4-yl)-1H-pyrrololo[2,3-b] 4-[1-(tetrahydro-2H-pyran-2-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrrololo[2,3,3-6 pyridine (4-[1-(tetrahydro-2H-pyran-2-yimethyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-b]pyridine) (1-cyclohex-2-en-1-yl-1H-pyrazol-4-yl)-1H-pymolo[2,3-b]pyridine cyclohex-2-en-1-yi-1H-pyrazol-4-yl)-1H-pymolo[2,3-bjpyridine) 4-(1-cyclohexyl-1H-pyrazol-4-yl)-1H-pymolo[2,3-b]pyridine (4-(1-cyclohexy]-1H-pyrazol-4-yi)-1H-pyrrolo[2,3-blpyridine) 4'-[[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-jH-pyrazole-1-yl]methyl)biphenyl-2-carbonitrile (4'-([4-(1H-pyrololo[2-b]pyridin-4-y1)-1H-pyrazol-1-yi)methyl) biphenyl-2-carbonitrile) 4-[1-(2-nitrobenzyl)-1H-pyrazole-4-yl]-1H-pyrolo[2,3-b]pyridine (4-[1-(2- nitrobenzyl)-1H-pyrazol-4-yi]-1H-pymolo[2,3-b]pyridine) '4-(1-[2,6-dichloro-4-(trifluoromethyi)phenyl]-1H-pyrazole-4-yl)-1H-pyrolo[2,3- b]pyridine (4-(1-[2,6-dichloro-4-(trifluoromethyi)phenyl]-1H-pyrazol-4-yl)-1H-pyrolo[2,3- b]pyridine) 4-[1-(3-nitrobenzyl)-1H-pyrazole-4-yl]-1H-pyrolo[2,3-b)pyridine (4-[1-(3- nitrobenzyl)-1H-pyrazol-4-yl]-1H-pymolo[2,3-bjpyridine) 1-(2-bromobenzyl)-1H-pyrazol-4-yl]-1H-pyrololo[2,3-b]pyridine (4-[1-(2-bromobenzyl)-IH-pyrazol-4-yl]-1H-pyrololo[2,3-b]pyridine) -phenyl-2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]propanamide(N-phenyl-2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-ylpropanamide) 4-(1-[3-(trifouromethoxy)benzyl]-1H-pyrazol-4-yl)-1H-pyrololo[2,3-b]pyridine (4-(1-[3-(rifluoromethoxy)benzyl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-bjpyridine) 4-(1-[2-fluoro-5-(trifluoromethyl)benzyl]-1H-pyrazole-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-[2-6moro-5-(trifluoromethy1)benzyl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-6] 1-[3-(trifluoromethyl)benzyl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]py 4-[1-(pyridin-3-ylmethyl)-1H-pyrazole-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1- pyridin-3-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyri 4-(1-[1-phenyibutyl]-1H-pyrazole-4-yl)-1H-pyrrolo[2,3-b]py : (4-(1-[1-phenyibutyl]-1H-pyrazol-4-yl)-1H-pyrridine) 1-phenyl-2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]propan-1-one (1-phenyl-2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-ylpropan-1-one) 4-[1-(2,6-dichlorobenzyl)-1H-pyrazole-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1-(2,6- dichlorobenzyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-bjpyridine) 4-[1-(2,6-dimethylphenyl)-1H-pyrazole-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1-(2,6- dimethyiphenyl)-1H-pyrazol-4-yi]-1H-pymololo(2,3-bjpyidine) 2-[4-(1H-pyrrolo[2,3-b]pyridine-4-yl)-1H-pyrazole-1-yl]-5-(trifluoromethyl)-benzonitrile (2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-y1]-5-(trifluoromethyl)- benzonitrile) 4-[1-(4-bromo-3,5,6-trifluoropyridin-2-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3- b]pyridine (4-[1-(4-bromo-3,5,6-tritiuoropzidin-2-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine) 4-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1- (cyclopropyimethyl)-1H-pyrazol-4-yil-pymololololo-pyridine) [1-(2,5-chymethylphenyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-b]pyridine (4-[1-(2,5- dimethylphenyl)-1H-pyrazol-4-yi]-1H-pymolololololgyridine) 4-[1-(2-methoxyphenyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-b]pyridine (4-[1-(2- methoxyphenyl)-1H-pyrazol-4-yi]-1H-pyroholo[2,3-b]pyidine) 4-[1-(2-methoxyphenyl)-1H-pyrazol-4-yl]-1H-pyroholo[2,3-b]pyidine (4-[1-(2-methoxyphenyl)-1H-pyrazol-4-yi]-1H-pyroholo[2,3-b]pyidine) 3-(1-[4-(1H-pyroholo[2,3-b]pyridine-4-yl)-1H-pyrazol-1-yl]ethyl)benzonitrile (3-(1-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]ethylybenzonitrile) 3-chloro-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitrile (3- chloro-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yijbenzonitrile) 4-[1-(1-cyclohexylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1-(1- cyclohexylethyl)-1H-pyrazol-4-yl]-1H-pyrololo[3-blpyridine) 4-fluoro-2-[4-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]benzonitrile (4-fluoro-2-[4-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitrile) 2-fluoro-4-[4-1H-pyrrolo[2,3-b]pyridin-4-yl)-111-pyrazole-1-yl)benzonitrile (2-fluoro-4-[4-1H-pyrololo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yllbenzonitrile) 3-fluoro-4-[4-1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitrile 3-fluoro-4-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yi]benz 4-(1-{1-[3-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-(1-[3-(trifluoromethyl!)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) 4-[1-(3,5-dimethylphenyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1-(3,5-dimethyipheny)-1H-pyrazol-4-yl)-11-py-pyrololo[2-byridine) 4-[4-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-yijbenzonitrile (4-[4-(1H- pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-yijbenzonitrile) (4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]phenyl)acetonitrile ({4- [4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]phenyl)acetonitrile) 4-(1-phenylpropyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b](4-[1-(1- phenyipropyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine) 4-(1-(1-[4-(methylphonyl)phenyl]ethyl)-1H-pyrazole-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-(1-[4-(methylsulfonyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) 4-(1-(1-[4-(methylphonyl)phenyl]ethyl)-1H-pyrazole-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-(1-[4-(methylsulfonyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) 4-(1-(1-[4-(methylsulfonyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-(1-[4-(methylsulfonyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) 4-(1-(1-[3,5-bis(trifluoromethyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-(1-[3,5-bis(tuoromethyl)phery1]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3- b]pyridine) 4-(1-[4-(1H-pyrrolo[2,3-b]pyridine-4-yl)-1H-pyrazole-1-yl]ethyl)benzonyl (4-(1-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]ethyl)benzonitile) 4-(1-(1-[4-(methylphonyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-(1-[4-(methylsulfonyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) 3-methyl-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitile (3- methyl-4-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yijbenzonitrile) 4-[1-(2-chlorophenyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-6]pyridine (4-[1-(2- chlorophenyl)-1H-pyrazol-4-yl)-1H-pyrolololo,3-bjpyridine) 3-bromo-4-[4-(1H-pyrolo[2,6]pyridin-4-yl)-1H-pyrazol-1-yl]benzoate(3- romo-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yi]benzo ethyl 4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzoate (ethyl 4- [4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yijbenz 4-(1-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl)-1H-pyrrolo- 2,3-b]pyridine (4-(1-[2-chloro-nitro-4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl)-[2,3-b]pyridine) 4-(1-{1-[4-(trifluoromethyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine(4-(1-{1-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) 4-[1-(2,3-dihydro-1H-inden-1-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine(4- (1-(2,3-dihydro-1H-inden-1-yl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-b]pyridine) 4-[1-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-6] pyridine (4-[1-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine) 4-(1-(1-[2-chloro-5-(trifluoromethyl)phenyl]ethyl)-1H-pyrazole-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-{1-[2-chloro-5-(tritluoromethyl)phenyl]ethyl)-1H-pyrazol-4-yl)-1H pyrrolo[2,3-b]pyridine) 4-(1-[1-(2,4-dichloro-5-fluorophenyl)ethyl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3- b]pyridine (4-(1-[1-(2,4-dichloro-5-fluorophenyl)ethyl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3- b]pyridine) 4-[1-(1-cyclopentylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine(4-[1-(1- cyclopentylethyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-b]pyridine) 4-[1-(1-methyl-3-phenylpropyl)-1H-pyrazole-4-yl]-1H-pyrrolo[2,3-b]pyridine(4-[1-(1-methyl1-3-phenylpropyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine) 4-[1-(1-cyclobutyletyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b)pyridine(4-[1-(1-cyclobutyletyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-blpyridine) [2-[4-(1H-pyrrolo[2,3-b]byridine-4-yl)-1H-pyrazol-1-yl]-5-(trifluoromethyl) phenyl]-acetonitrile ([2-[4-(1H-pyrrolo[2,3-b]byridine-4-y1)-1H-pyrazol-1-yl)-5-(trifluoromethyl) phenyl]-acetonitrile) [5-[4-(1H-pyrrolo[2,3-b]pyridine-4-yl)-1H-pyrazol-1-yl]-2-(trifluoromethyl) phenyl)-acetonitrile ([5-[4-(1H-pyrolo[2,3-b]pyridine-4-yl)-1H-pyrazol-yl]-2-(trifluoromethyl) phenyl]-acetonitrile) 4-(1-[4-phenylbut-3-en-1-yl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine (4-(1-[4- phenylbut-3-en-1-yl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) [3-chloro-2-[4-(1H-pyrrolo[2,3-b]pyridine-4-yl)-1H-pyrazol-1-yl]-5-(trifluoromethyl)phenyl]-acetonitrile ([3-chloro-2-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-pyrazol-1-yl]-5- (trifluoromethyl)phenyl)-acetonitrile) 5-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-2-(trifluoromethyl)- benzonitrile (5-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-2-(trifluoromethyl)- benzonitrile) 4-(1-[2-chloro-4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b) pyridine (4-(1-[2-chloro-4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl)-1H-pyrolo[2,3-b]pyridine) -[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]-2-(trifluoro) benzonitrile (4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-2-(trifluoromethyl)- benzonitrile) 2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]benzonitrile (2-[4-(1H- pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-yl)benzonitile) 3-chloro-2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitile (3- chloro-2-[4-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitile) 4-amino-5,6-difluoro-2-[4-(1H-pyrrolo[2,3-b)pyridin-4-yl)-1H-pyrazol-1-yl) isophthalotyl (4-amino-5,6-difluoro-2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]isophthalonitrile) 1-([4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]methyl)-cycloprodpon-carbonitrile (1-([4-(1H-pyzolo[2,3-byridin-4-yl)-1H-pyrazol-yl]methyl)-cyclopropane-carbonitrile) 5-bromo-2-[4-(1H-pyrolo(2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitrile(5-bromo-2-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitrile) 3-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-4-(trifluoromethyl)-benzonitrile (3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-4-(trifluoromethyl)- benzonitrile) 2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-3-(trifluoromethyl)- benzonitrile (2-[4-(1H-pymolo[2,3-b]pyridin-4-yi)-1H-pyrazol-1-yl]-3-(trifluoromethyl)- benzonitrile) 3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-4-(trifluoromethyl) benzonitrile (3-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-y1]-4-(trifluoromethyl)benzamide) 3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]cyclohexanone(3-[4-(1H- pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-yl]cyclohexanone) 2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]cyclohexanone(3-[4-(1H- pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-yl]cyclohexanone) 4-([1-(methylsulfonyl)piperidin-4-il]methyl)-1H-pyrazole-4-il)-1H-thi[2,3-b]pyridine (4-(1-([1-(methylsulfonyl)piperidin-4-yl]methyl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3- b]pyridine) 2-[4-(1H-pyrrolo[2,3-6]pyridin-4-yl)-1H-pyrazole-1-yl)cyclohexancarbonitrile (2-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]cyclohexancarbonitrile) 4-(1-[2-(trifluoromethyl)phenyl]-1H-pyrazole-4-yl)-1H-pyrrolo[2,3-6]pyridine (4- (1-[2-(trifluoromethyi)phenyl]-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine) 4-[1-(2,6-dichlorophenyl)-1H-pyrazole-4-yl]-1H-pyrolo[2,3-b]pyridine (4-[1-(2,6 dichloropheny:)-1H-pyrazol-4-yl)-1H-pyrololo[2,3-b]pyridine) 4-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]methyl) cyclohexyl((4-([4-(1H-pyzrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yilmethyl)cyclohexy 4-[1-(tetrahydrofuran-2-ilmethyl)-1H-pyrazole-4-il]-1H-pyrrolo[2,3-b]pyridine (4-[1-(tetrahydrofuran-2-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-b]pyridine) 4-[1-(1-cyclopentyprophyl)-1H-pyrazole-4-yl]-1H-pyrolo[2,3-b]pyridine [1-(1- cyolopentyipropyi)-18-pyrazol-4-yl]-1H-pymolo[2,3-bjpyridine) -[1-(tetrahydrofuran-3-ylmethyl)-1H-pyrazole-4-yl]-1H-pyrolo[2,3- (4-[1-(tetrahydrofuran-3-ylmethyl)-1H-pyrazol-4-yi]-1H-pyrolo[2,3-blpyridine) 2-chloro-3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitrile) 3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-3,3-thiazole-5-yl) propanenitrile (3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-3-(1,3-thiazol-5-yl) propanenitrile) 3-(1-methyl-1H-imidazol-5-yl)-3-(1H-pyrololo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-1-methyl-1H-imidazol-5-yl)-3-(4-(1H-pyrololo[2,3)pyridin-4-91)-1H-pyrazol-1-yl]propanenitrile) 3-[4-(IH-pyrro Lo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]-3-(3-thienyl)propanmai sa (3-[4-(1H-pymolol2,3-b]pyridin-4-yl)-1H-pyrazol-1-y1]-3-(3-thienyl)prop {1-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]cyclopentyl)acetonitrile ((1-[4-(1H-pyrrolo[2,3-blpyridin-4-yl)-1H-pyrazol-1-yl]cyclopentyl)acetonitrile) 4-chloro-3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzonitrile (4- chloro-3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yljbenzonitr 4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]phthalonitile (4-[4-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-yilphthalonitile) 3-methyl-4-[4-(1H-pyrrolo[2,3-b] 4-4-yl)-1H-pyrazol-1-yl)benzaldehyde (3- methyl-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]benzaldehyde) 4-[1-(2-methyl-4-nitropberyl)-1H-pyrazole-4-yl]-1H-pyrrolo[2,3-b]pyridine (4-[1-(2-methyl-4-nitropberyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine) 3-[4(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazole-1-yl]cyclopentanone (3-[4 (IH-pymolo[2,3-blpyridin-4-y1)-1H-pyrazol-1-yl]cyclopentanons) 4-[1-(3-furyimethyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-6]pyridine(4-[1-(3-furyimethyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-b]pyridine) 4-[1-(2-furyimethyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-6]pyridine(4-[1-(2-furyimethyl)-1H-pyrazol-4-yl]-1H-pyrolo[2,3-b]pyridine) 3-(2-cyano-1-[4-(1H-pyrolo[2,3-6]pyridine-4-yl)-1H-pyrazol-1-yl]ethyl} Benzonitrile (3-{2-cyano-1-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-l-yl]ethyl} benzonitrile) {3-methyl-4-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}methanol ({3-methyl-4-[4-1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]phenyl}methanol) 3-(1-benzofuran-2-yl)-3-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl] propanenitrile (3-(1-benzofuran-2-y1)-3-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-furyl)-3-[4-(1H-pyrolo[2,3-6]-4-yl)-11H-pyrazol-1-yl]propanenitrile (3-(3-furyl)-3-[4-(1H-pyrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]propanenitrile) {3-methyl-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]phenyl)acetonitrile ({3-methyl-4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]phenyl)acetonitrile) 4-methyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]benzotrile (4-methy1-3-[4-(7H-pyrololo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]benzonitile) 4-[1-(1-cyclopentylpropyl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine (4-[1- (1-cyclopentylpropyl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine) {1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclopentylpropyl)acetonite- (11-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yllcyclopentyl)ac 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) benzonitrile (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) benzonitrile) 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-3-thienyl)propanenitile (3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yi)-1H-pyrazol-1-yl]-3-(3-thienyl)propanenitile) 4-chloro-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]benzonitrile (4-chloro-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]benzonitrile) 3-(3-furyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanintrile (3-(3-furyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanintrile 3-(1-[4-(7H-pyrolo[2,3-]pyrimidin-4-il)-1H-pyrazole-1-il]cyclopentyl)-propanenityl (3-11-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclopentyl}-propanenitrile) {1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexyl)acetonitrile({1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexyl)acetonitrile) {3-methyl-4-[4(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]phenyl)methanol ({3-methyl-4-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yilphenyl)methanol) uas 3-pyridin-4-yl-3-[4-(7H-pyrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-pyridin-4-y1-3-[4-(7H-pyrolo[2,3-djpyrimidin-4-y1)-1H-pyrazol-yl]propanenitrile) or the pharmaceutically acceptable salts of this substance. 31. The compound of claim 1 selected from 3-pyridin-3-yl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propane-nitritel (3-pyridin-3-y1-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]prop 3-[4-(methylthio)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]-phennitrile (3-[4-(methylthio)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H yl]propanenitrile) 3-(3-methoxyphenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]phennitrile (3-(3-methoxyphenyl)-3-[4-(7H-pyrolo[2,3-dlpyrimidin-4-yl)-1 yl]propanenitrile) 3-(4-methoxyphenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(4-methoxyphenyl))-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1 yl]propanenitrile) (3-methyl-4-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]phenyl)ajito-trile ((3-methy1-4-[4-(7H-pyrrololo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yljphenyl)a 3-[4-(methylsulfonyl)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[4-(methyisulfinyl)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-4-1H-pyrazol-1-yl]propanenitrile) 3-[4-(methylsulfonyl)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[4-(methyisulfony)pheny1]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl]-1H-pyrazol-1-yl]propanenitrile) 3-[3-(cyanomethoxy)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-(cyanomethoxy)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl]-1H-pyrazol-1-yl]propanenitrile) 3-(6-chloropyridin-3-yl)-3-[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanenitrile (3-(6-chloropyridin-3-y)-3-[4-(TH-pymolo[2,3-d)pyrimidim-4-1H-pyrazol-1-yl]propanenitrile) 5-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) ridine-2-carbonitrile (5-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) pyridine-2-carbonitrile) 3-(3,5-dimethyl isoxazole-4-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3,5-dimethylisoxazol-4-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-[6-(trifuoromethyl)din-3-yl]propanenitrile (3-[4-(7H-pyrrololo[2,3-d]pyrimidin-4-ylH-pyrazol-1-yl)-3-[6- (trifluoromethyl)pyridin-3-yl]propanenitrile) 3-(6-methoxypyridin-3-yl)-3-(7H-pyrrololo[2,3-6]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(6-methoxypyridin-3-yl)-3-[4-(7H-pyrolo[3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-pyridin-2-yl-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-pyridin-2-y1-3-[4-(7H-pymolo,3-d]pyrimidin-4-y1)-1H-pyrazol-1-yl]propanenitrile) 3-(6-bromopyridin-2-yl)-3-[4-(7-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]- Propanenitrile (3-(6-bromopyridin-2-y1)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl]-1H-pyrazol-1-yl]propanenitrile) 6-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) pyridine-2-carbonitrile (6-(2-cyano-1-[4-(7H-pyrolo(2,3-dlpyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl}pyridine-2-carbonitrile) 3-(5-bromopyridin-3-yl)-3-[4-(7H-pyrlo[2,3-4]pyridin-4-yl)-1H-pyrazol-1-yl]-propanintrile (3-(5-bromopyridin-3-y1)-3-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 5-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)ethyl) nicotinonitrile (5-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) nicotinonitrile) 3-(2-methoxypyridin-3-yl)-3-[4-(7H-pyrolo[2,3-d]pyrimimikin-4-yl)-1H-pyrazol-1-yl]propanonitrile (3-(2-methoxypyridin-3-yl)-3-[4-(7H-pyrolo[2-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[4-(cychanomethoxy)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1--15azol-1-yl]propanenitrile (3-[4-(cyanomethoxy)phenyl]-3-[4-(7H-pyrolo[2,3-d)pyrimidin-4-4-1H-pyrazol-1-yl]propanenitrile) 3-[2-(cyanomethoxy)phenyl]-3-[4-(7H-pyrolo[2,3-4]pyrimidin-4-yl)-1-15-sol-1-yl]propanenitrile (3-[2-(cyanomethoxy)phenyl]-3-[4-(7H-pyrololo[2-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3,5-tribromophenyl)-3-[4-(7H-pyrololo[2,3-5]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3,5-dibromophenyl)-3-(7H-pymolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]propanenitrile) 3-(3.5-dibromophenyl)-3-[4-(7H-pymolo[2,3-5]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3,5dibromophenyl)-3-[4-(7H-pymolo[2,3-d]pyrimidin-4-4-1H-pyrazol-1-yl]propanenitrile) 5-(2-cychano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) isophthalotyl (5-(2-cyano-1-[4-(7H-pyzrolo(2,3-d|pyrimidin-4-yl)-1H-pyrazol-1-yl)ethyl) isophthalonitrile) 3-[6-(dimethylamino)pyridin-2-yl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanonitrile (3-[6-(dimethylamino)pyridin-2-yl]-3-[4-(7H-pymolo[2,3-d]pyrimidin-4-y1)-1H-pyrazoi-1-yilpropanenitrile) 3-(4-bromo-2-thienyl)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]propanenitrile (3-(4-bromo-2-thienyl)-3-[4-(7H-pyrolo[2,3-d)pyrimidin-4-y1H-pyrazol-1-yl)-propanenitrile) 5-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) thiofin-3-carbonitrile (5-(2-cyano-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethy1) thiophene-3-carbonitrile) 3-(5-bromo-2-fluorophenyl)-3-[4-(7H-pyrrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(5-bromo-2-fluorophenyl)-3-[4-(7H-pyrrolo[2-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-nitrophenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3-nitrophenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(5-bromo-2-methoxyphenyl)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(5-bromo-2-methoxyphenyl)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-12-cyano-1-[4-(7H-pyrolo[2,d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-4-methoxybenzonitrile (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-dlpyrimidin-4-1H-pyrazol-1-yl]ethyl)-4-methoxybenzonitrile) 3-(3-bromophenyl)-3-[4-(7H-pyrolo[2,3 d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propane-nitrol (3-(3-bromophenyl)-3-(7FI-pymolo[2,3-dlpyrimidin-4-yl)-1H-pyrazol-1-yl]propane-nitrol) 3-(2-cyano-1-[4-(7H-pyrolo[2,d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-4- Fluorobenzonitrile (3-(2-cyano-1-[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1~ yl]ethyl)-4-fluorobenzonitrile) 3-[5-bromo-2-(cyanomethoxy)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanonitrile (3-[5-bromo-2-(cyanomethoxy)phenyl]-3-(7H-pymolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(4-bromo-2-furyl)-3-[4-pyrolo[2[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]propanenitrile (3-(3-(4-bromo-furyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 4-(cyanomethoxy)-3-(2-cyano-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)ethyl)benzonitrile (4-(cyanomethoxy)-3-(2-cyano-1-[4-(7H-pyrolo[2,3-d) pyrimidin-4-yl)-1H-pyrazol-1-yllethyi)benzonitrile) 3-(4-bromopyridin-2-yl)-3-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-propanonitrile (3-(4-bromopyridin-2-yl)-3-[4-(TH-pyrolo[2,3-d]pyrimidin-4-1H-pyrazol-1-yl]propanenitrile) 2-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) isonicotinonitrile (2-(2-cyano-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-yi)-pyrazol-1-yl) ethyl) isonicotinonitrile) 5-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-3-furonitrile (5-(2-cyano-1-[4(7H-pyrolo[2,3-d]pyrimidin-4-y1)-1H-pyrazol-1-y1]ethyl)-3-3-furonitrile) 3-[2-bromo-5-(cyanomethoxy)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-111-pyrazol-1-yl]propanenitrile (3-[2-bromo-5-(cyanomethoxy)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-ylpropanenitrile) 4-(cyanomethoxy)-2-(2-cyano-1-(7EB-pyrolo[2,3-d]pyrimidin-4-yl)-111-pyrazol-1-yl]ethyl)benzonitrile (4-(cyanomethoxy)-2-(2-cyano-1-[4-(7H-pyrolo[2,3- d]pyrimidin-4-yi)-1H-pyrazol-1-yijethyl)benzonitrile) 3-pyrimidin-5-yl-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]propanenitrile (3-pyrimidin-5-y1-3-[4-(7H-pyrolol2,3-djpyrimidin-4-yl)-1H-pyrazol-1-yi]propanenitrile) 3-(2-bromopyridin-4-yl)-3-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-propanenitrile (3-(2-bromopyridin-4-yl)-3-[4-(TH-pymolo[2,3-d]pyrimidin-4-1H-pyrazol-1-yl]propanenitrile) 4-(2-cyano-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) pyridine-2-carbonitrile (4-(2-cyeno-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)pyridine-2-carbonitrile) 3-(5-methoxypyridin-3-yl)-3-(7H-pyrolo[2,3-5]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanin-dryl (3-(5-methoxypyridin-3-yi)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-chlorophenyl)-3-[4-(7H-pyrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazol-1-yl]propane-nitrile (3-(3-chlorophenyl)-3-(7H-pymolo[2-alpyrimidin-4-yI)-1H-pyrazol-1-yi]propane-nitrile) 3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1111-pyrazol-1-yl]-3-(trifluoromethyl) [Phenyl]-propane in the drive. (3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-(trifluoro- methyl)phenyl]-propanenitrile) 3-(3-phenoxyphenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl] propanenitrile . (3-(3-phenoxypheny)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-y) propanenitrile) 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-[3-(trifluoromethyl)phenyl]-propanenitrile [Thoxy]-phenyl-propane in trile (3-[4-(7H-prolo[2,3-d]pyrimidin-4-ylH-pyrazol-1-yl]-3-3-[3- (trifluoromethoxy)-phenyl]-propanenitrile) methyl 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl] ethyl) benzoate (methyl 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl1H-pyrazol-1-1-yl) ethyl benzoate) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-]pyrimidin-4-yl)-1H-pyrazole-1-yl]ethyl) Benzoic acid (3-(2-cyano-1-[4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yllethyl) benzoic acid) 3-[3-(1H-pyrazole-4-yl)phenyl]-3-[4-(7H-pyrrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanintrile (3-[3-(1H-pyrazol-4-y)phenyl]-3-[4-(7H-pyrolo[2,3-dlpyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-aminophenyl)-3-[4-(7H-rolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3-aminophenyl)-3-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-y1] propanenitrile) N-(3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)acetamide (N-(3-(2-cyano-1-(7H-pyrololo[2,3-d|pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)acetamide) N-(3-(2-cyano-1-[4-(7H-pyrololo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)-methenesulfonamide (N-(3-(2-cyano-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyi)-methanesulfonamide) 4-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) thiofin-2-carbolyte (4-(2-cyano-1-[4-(7H-pyrrolo(2,3-d]pyrimidin-4-ylH-pyrazol-1-yl]ethy1) thiophene-2-carbonitrile) 5-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) thiophene-2-carbonitrile (5-(2-cyano-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethy1) thiophene-2-carbonitrile) 3-[3-(morpholin-4-yl carbonyl)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1F-pyrazol-1-yl)propanenitrile (3-[3-(morpholin-4-ylcarbonyl)phenyl)-3-[4-(7H-pyrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yilpropanenitrile) N-(2-aminoethyl)-3-(2-no-1-[4-(7H-pyrolo[2,3-5]]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzamide (N-(2-aminoethyl)-3-(2-cyano-1-(7H-pyrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzamide) 3-(5-formyl-3-thienyl)-3-[4-(7H-pyrolo[2,3-dll (3-(5-formyl-3-thienyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H yl]propanenitrile) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]ethyl)-N-methylbenzamide (3-(2-cyano-1-[4-(TH-pywolo[2,3-d]pyrimidin-4-y1)-1H-pyrazol-1-yethyl)-N- methylbenzamide) 2-cyano-N-(3-(2-cyano-1-[4-(7H-pyrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazol-1- yl]ethyl)phenyl)acetamide (2-cyano-N-(3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)acetamide) N-(3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) nyl)nicotinamide (N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yi)-1H-pyrazol phenyl)nicotinamide) N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)-N'-isopropyuria (N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)phenyl)-N'-isopropylurea) isopropyl (3-(2-cyano-1-[4-(7F-pyrolo[2,3-s]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)phenyl)carbamate (isopropyl (3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)phenyl)carbamate) 3-(5-phenylpyridin-3-yl)-3-[4 7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]propanenitrile (3-(5-phenylpyridin-3-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H yl]propanenitrile) 3-(3,3'-bipyridin-5-yl)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]propanenitrile (3-(3,3'-bipyridin-5-yl)-3-(7H-pymolol2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-propanenitrile) 3-(5-pyrimidin-5-ylpyridin-3-yl)-3-(7H-pymolololo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(5-pyrimidin-5-ylpyridin-3-yl)-3-(7H-pymolololo[3-d) pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[5-(1<methyl-1H-pyrazol-4-yl)pyridin-3-yl]-3-[4-(7H-pymolololo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[5-(1-methy!-1H-pyrazol-4-yi)pyridin-3-y1]-3-(7H- pyrrolo[2,3-d]pyrimidin-4-yi)-1H-pyrazol-1-yl]propanenitrile) and 3-(5-ethynylpyridin-3-yl)-3-(7H-pyrrolo[2,3-s]pyrimidin-4-yl)-1H-pyrazole-1-yl]propanenitrile a (3-(5-ethynylpyridin-3-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H- pyrazol-1-yl]propanenitrile) or the pharmaceutically acceptable salts of this substance. 32. The compound of claim 1 selected from 3-[5-(phenyithio)pyridin-3-yl]-3-(7H-pyrrolo[2,3-4-]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[5-(phenyithio)pyridin-3-yl]-3-[4-(7H-pyrrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(2-bromo-1,3-thiazole-5-yl)-3-(7H-pyrrolo[2,3-d]midin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(2-bromo-1,3-thiazol-5-yl)-3-[4-(7H-pyrolo(2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(5-morpholin-4-ylpyridin-3-yl)-3-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(5-morpholin-4-ylpyridin-3-yl)-3-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(1-methyl-1H-pyrazole-4-yl)-3-(7H-pyrrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazole-1-yl]propanenitrile (3-1-methyl-1H-pyrazol-4-yl)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-pyridin-3-ylphenyl)-3-[4-(7E-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]propanenitrile (3-(3-pyridin-3-yiphen)-3-[4-(TH-pyrolo(2,3-djpyrimidin-4-yl)-pyrazol-1-yl]propanenitrile) 3-[5-(phenylsulfinyl)pyridin-3-yl]-4-(7H-pyrolo[2,3-]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[5-(phenylsulfinyl)pyridin-3-yl]-3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile) 3-[5-(phenylsulfinyl)pyridin-3-yl]-4-(7H-pyrrolo[2,3-]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[5-(phenylsulfinyl)pyridin-3-y1]-3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile) 3-[4-(7H-pyrrolo[2,3-4]pyrimidin-4-yl)-11H-pyrazol-1-yl]-3-(1,3-thiazole-2-ylthio)pyridin-3-yl]propanenitrile (3-[4-(TH-pyrololol2-d)pyrimidin-4-yl)-1H-pyrazol-1-3-[5-(1,3-thiazol-2-ylthio)pyridin-3-yl]propanenitrile) 3-[5-(ethylthio)pyridin-3-yl]-3-(7H-pyrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[5-(ethylthio)pyridin-3-yi]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 4-(1-[1-methyl-2-(1H-1,4-dryazole-1-yl)ethyl]-1H-pyrazol-4-yl)-7H-pyrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (4-(1-[1-methyl-2-11,2,4-tiazol-1-yl)ethyl)-1H-pyrazol-4-7H-pyrrololo[2,3-d]pyrimidine) 1-phenyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]propan-1-one (1-pheny1-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yilpropan-1-one) 3-[5-(ethylsulfonyl)pyridin-3-yl]-3-[4-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]propanintril (3-[5-(ethylsul)pyridin-3-y1)-3-(7H-py-pymol2,3-dlpyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[5-(ethylsulfonyl)pyridin-3-yl1-3-(7H-pyrolo[2.3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[5-(ethylsulfonyl)pyridin-3-y1]-3-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[5-(cyclohexylthio)pyridin-3-yl]-3-[4-(7H-pyrolo[2-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-[5-(cyclohexylthio)pyridin-3-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yilpropanenitrile) 1-phenyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propan-1-ol (1- phenyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propan-1-ol) 3-[3-(ethylthio)phenyl]-3-[4-(7H-pyrrolo[2,3,3-d]l (3-[3-(ethylthio)phenyl]-3-[4-(7H-pywolo[2,3-dlpyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[3-(ethylsulfinyl)phenyl]-3-[4-(7H-pyrlo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-(ethyisulfinyl)phenyi]-3-[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)-pyrazol-1-yl]propanenitrile) 3-[3-(ethyisulfinyl)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-(ethylsulfonyl)pheryl)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[5-(cyclohexylsulfonyl)pyridin-3-yl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl]propanenitrile (3-[5-(cyclohexyisulfonyl)pyridin-3-yl]-3-[4-(7H-pyrolo[2,3- d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[5-(cyclohexyisulfonyl)pyridin-3-yl]-3-[4-(7H-pyrolo[2,3-dpyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[5-(cyclobexylsulfinyl)pyridin-3-y1]-3-(7H-pyrololo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yllpropanenitrile) 4-[1-(1-methyl-2-phenylethyl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine (4-[1-(1-methyl-2-phenylethyl)-1H-pyrazol-4-y1]-7H-pyrrolo[2,3-d]pyrimidine) 4-(1-[1-methyl-2-(3-thienyl)ethyl]-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine (4-(1-[1-methyl-2-(3-thienyl)ethyi]-1H-pyrazol-4-yl)-7H-pyrololo[2,3-d]pyrimidine) 3-(1-[4-(7H-pyrololo[2,3-d]pyrimidine-4-yl)-1H-pyrazole-1-yl]ethyl)benzonitrile (3-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yi]ethyl)benzonitrile) 4-(1-[2-(1H-imidazol-1-yl)-1-methylethyl]-1H-pyrazol-4-yl)-7H-pyrrololol[2,3,3-d] pyrimidine(4-(1-[2-(1H-imidazol-1-yI)-1-methylethyl]-1H-pyrazol-4-yl)-7H-pyrrololol2,3-d] pyrimidine) 4-(1-[1-methyl-2-(3-methyl-1,2,4-oxadiazole-5-yl)ethyl]-1H-pyrazol-4-yl)- 7H-pyrrolo[2,3-4pyrimidine (4-(4-[1-methyi-1,2,4-oxadiazol-5-yl)ethyll-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine) 3-[3-(methylsulfonyl)phenyl]-3-[4-(7H-pyrrolo[2,3-[pyrimidine-4-4-yl)-1H-pyrazole-1-yl]propanintril (3-[3-(methylsulfonyl)phenyl]-3-[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) (3-pyridin-4-ylphenyl)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-propanenitrile (3-(3-pyridin-yipheny))-3-(7H-pymolo(2,3-d)pyrimidin-4-4-yl)-pyrazol-1-yl]propanenitrile) 3-[5-(isopropyltyl Pyridin-3-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[5-(isopropyithio)pyridin-3-y1]-3-[4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yilpropanenitrile) 3-[5-(isopropylsulpenyl)pyridin-3-yl]-3-[4-(7?-pyrrolo[2,3-d]pyrimidin-4-yl-1H-pyrazol-1-yl]propanenitrile (3-[5-(isopropylsulfinyl)pyridin-3-y1]-3-[4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yilpropanenitile) 3-[5-(isopropylsulfinyl)pyridin-3-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitile (3-[5-(isopropyisulfonyl)pyridin-3-y1]-3-[4-(7H-pyrrolo[2,3-d) pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-[5-(trifluoromethyl) pyridin-3-yl]propanenitrile (3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-(trifluoromethyl)pyridin-3-yl]propanenitrile) H-pyrrolo[2,3-a]pyrimidin-4-yl)-1H-pyrazol-1-yl]-N-[3-(trifluorophenyl]propanamide (2-[4-7H-pyrololo[2,3-d]pyrimidin-4-y1)-1H-pyrazol-1-y1]-N-[3-(trifluorophenyl)propanamide) N-2-napthyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanamide (N-2-naphthyl-2-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanamide) N-1-naphthyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanamide (N-1-naphthyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-ylpropanamide N-(3-cyanophenyl)-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-propanamide) N-benzyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-propanamide -benzyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yllpropanamide -phenyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide) N-(4-phenoxyphil)-2-[4-(7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide N-(4-phenoxypbenyl)-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1H-pyrazol-1-y1) butanamide) N-2-naptyl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1H-pyrazol-1-y1]butanamide (N-2-naphthyl-2-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide) N-(3-cyanophenyl)-2-[4-(-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide (N-(3-cyanophenyl)-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide) N-baipinyl-4-yl-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-111-pyrazol-1-yl]butanamide (N-biphenyl-4-yl-2-[4-(7H-pyrro[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide) N-(biphenyl-4-ylmethyl)-2-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide (N-(bipheny1-4-ylmethyl)-2-(7H-pymololo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-butanamide) N-(biphenyl-4-ylmethyl)-2-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-butanamide) N-(biphenyl-4-ylmethyl)-2-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-butanamide (N-(biphenyl-3-yimethyl)-2-[4-pyrrolol2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)-butanamide) N-(4-cyanophenyl)-2-[4-(7H-pyrolo[2,3-9]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide (N-(4-cyanophenyl)-2-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide) N-1-naptyl-2-[4-(7H-pyrolo[2,d]pyrimitinin-4-yl)-1H-pyrazol-1-yl]butanamide (N-1-naphthyl-2-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanamide) 5-(2-cyano-1-[4-(7H-pyrolo[2,3-d]rimidin-4-yl)-1H-pyrazol-1-yl)ethyl)-N- nicotinamide (5-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl}-N-phenylnicotinamide) N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-5]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)-3-(trifluoromethyl)benzamide (N-(3-(2-cyano-1-[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)- 1H-pyrazol-1-yi]ethyl) phenyl)-3-(trifluoromethyl)benzamide) N-(3-1[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl)phenyl)-3- (trifluoromethyl)benzamide (N-(3-([4-(7H-pymololo(2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl)phenyi)-3-(trifluoromethy)benzamide) 3-[3-(methylsulfonyl)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanintril (3-[3-(methylsulfonyl)pheny1]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) N-(3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl)phenyl)benzene-sulfonamide (N-(3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl benzenesulfonamide) 3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl)-N-[3-(trifluor- [3-([4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yi]methyl)-N- [3-(trifluoromethyl)phenyl]benzamide) 3-(2-cychano-1-[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl}-N,N- dimethylbenzene sulfonamide (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-yl]ethyl)-N,N-dimethylbenzenesulfonamide) N-benzyl-3-{2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzenesulfonamide (N-benzyl-3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzenesulfonamide) N-benzyl-3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzenesulfonamide) N-benzyl-3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzenesulfonamide Ethyl(on(samide)) (N-benzy1-3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1- y1]ethyl) benzamide) 3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)- benzamide (3-(2-cyano-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)- phenylbenzamide) 3-(2-cyano-1-[4-(7H-pyrolo[2,d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N- [3-<trifluoromethyl)phenyl]benzamide (3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-[3-(trifluoromethyl)phenyl]benzamide) N-(3-cyanophenyl)-3-([4-(7H-pyrolo[2,3-3-]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-[3-(trifluoromethyl)phenyl]benzamide (N-(3-cyanophenyl)-3-([4-(TH-pyrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl benzamide) N-benzyl-3-([4-(7H-pyrolo[2,3,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl) benzamide(N-benzyl-3-([4-(7H-pyrolo-[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl} benzamide) N-2-naptyl-3-([4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl}benzamide Benzamide (N-2-naphthyl-3-{[4-(7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl} benzamide) N-2-naphthyl-3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl}benzamide N-2-naphthyl-3-{[4-(7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl} benzamide) N-(3-{[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl}phenyl)-2- naphthamide) N-(3-{[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl}phenyl)-1- Naphthamide A (N-(3-([4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)methyl) phenyl)-1- naphthamide) 2-phenyl-N-(3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl)phenyl)- acetamide (2-phenyl-N-(3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl}phenyl) acetamide) 3-chloro-N-(3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]methyl) phenyl)benzamide (3-chloro-N-(3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yi)-1H-pyrazol-l-yl]methyl} phenyl)benzamide) N-(3-12-cychano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-11-pyrazol-1-yl]ethyl) phenyl)-2-naphthamide (N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-l-yl] ethyl)phenyl)-2-naphthamide) N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) nyl)-1-naphthamide (N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-l-yl] ethyl}phenyl)-1-naphthamide) N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazol-1-yl]-ethyl) phenyl)-2-phenylacetamide (N-(3-(2-cyano-1-[4-(711-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]- ethyl)phenyl)-2-phenylacetamide) 3-cyano-N-(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1- ethyl)phenyl)benzamide (3-cyano-N-(3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)benzamide) N-(3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenylbenzamide (N-(3-(2-cyano-1-(7H-pyololo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)benzamide) N-(3-(2-cyano-1-[4-(7H-pyrotho[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) phenyl)-4-(trifluoromethyl)benzamide (N-(3-(2-cyano-1-[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)- 1H-pyrazol-1-ydlethyl)phenyl)-4-(triquoromethy)benzamide) (3-12-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl phenyl)-N'-phenylurea (N-(3-(2-cyano-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yi)-pyrazol-1-yl]ethyl) pheny1)-N'-phenylurea) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N- [4-(trifluoromethyl)phenyl]benzamide (3-(2-cyano-1-[4-(7H-pyrolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-(4-(trifuoromethyl)phenyl]benzamide) 3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-(4-(trifuoromethyl)phenyl)benzamide (3-(2-cyano-1-[4-(7?-pymolo[2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-(4-methylphenyl)benzamide) N-(4-cyanophenyl)-3-(2-cyano-[4-(7H-pyrolo[2,3-]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzamide (N-(4-cyanophenyl)-3-(2-cyano-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) benzamide) 3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-2-naphthylbenzamide (3-(2-cyano-1-(7H-pyrrolololo[2,3-d]pyrimidin-4-yi)-1H-pyrazol-1-yi]ethyl)-N- 2-naphthylbenzamide) 3-(2-cyano-1-[4-(7H-pyrrolololo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-1- naphthylbenzamide (3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl}-N- 1-naphthylbenzamide) 3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl) -1H-pyrazol-1-yl]ethyl N,N-dimethinbenzamide (3-(2-cyano-1-[4-(7H-pymolo[2,3-djpyrimidin-4-yi)-pyrazol-1-yl] ethyl)-N,N-dimethylbenzamide) 3-(2-cyano-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N pyridin-3-ylbenzamide (3-(2-oyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl] ethyl)-N-pyridin-3-ylbenzamide) 3-[2-yano-1-[4-(7H-pyrrolo[2,3-]pyrimidin-4-yl)-1H-pyrazol-1-yl] ethyl-N-pyridin-3-ylbenzamide (3-(2-cyano-1-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl] ethyl)-N-methyl-N-phenylbenzamide) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-cyclohexylbenzamide (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl) ethyl)-N-cyclohexylbenzamide) N-(3-cyanophenyl)- ... N-(3-cyanophenyl)-3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yilethyl)benzamide) N-biphenyl-4-yl-3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzamide (N-bipheny1-4-y1-3-(2-cyano-1-[4-(7I-pyrolo[2,3-d]pyrimidin-4-yl)-1H- pyrazol-1-yl]ethyl benzamide) N-(4-chlorophenyl)-3-(2-cyano-1-(7H-pyrolo[2,3-d)pyrimidin-4-yl)-1H- pyrazol-1-yl)ethyl benzamide (N(4-chlorophenyl)-3-(2-cyano-1-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl}benzamide) 3-(2-cyano-1-[4-(7H-pyrrolo[2,d]pyrimidin-4-yl)-1F-pyrazol-1-yl]ethyl)-N- (3,4-dimethylphenyl)benzamide (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-(3,4-dimethylphenyl)benzamide) 3-{2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-isoxazole-3-ylbenzamide (3-(2-cyano-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-isoxazol-3-ylbenzamide) 3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-methyl-N-phenylbenzenesulfonamide (3-(2-cyano-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-y)-1H-pyrazol-1-yl)ethyl)-N-methyl-N-phenylbenzenesulfonamide) 3-(2-cyano-1-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-propylbenzenesulfonamide (3-(2-cyano-1-[4-(TH-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-propylbenzenesulfonamide) 3-{2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-propylbenzenesulfonamide (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl}-N-phenylbenzenesulfonamide) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-2-cyclopropylbenzenesulfonamide (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1H-pyrazol-1-yl]ethyl)-N-2-naphthylbenzenesulfonamide) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-cyclopropylbenzenesulfonamide (3-(2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H- pyrazol-1-yljethyl)-N-cyclopropylbenzenesulfonamide) 3-[3-(piperidin-1-ylsulfonyl)phenyl]-3-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H- sol-1-yl]propanintril (3-[3-(piperidin-1-ylsulfonyl)phenyl]-3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[3-(morpholin-4-ylsulfonyl)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-(morpholin-4-ylsulfonyl)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yilpropanenitrile) (2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl}-N-(4-methylphenyl)benzene sulfonamide (3-[2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-(4-methylphenyl)benzenesulfonamide) 3-{2-cyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-(3,4-dimethylphenyl)benzenesulfonamide (3-{2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-(3,4-dimethylphenyl)benzenesulfonamide) 3-[3-(benzylsulfonyl)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanintril (3-[3-(benzyisulfonyl)pheny1]-3-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[3-(benzyisulfonyl)phenyl]-3-[4-7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanenitrile (3-[3-(benzylthio)pheny1]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 4-{[(3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)phenyl)sulfonyl]methyl)benzonitrile (4-((3-(3-(2-cyano-1-[4-(7H-pyrolol2,3-dlpyrimidin-4-yl)- 1H-pyrazol-I-y1]ethyl/phenyl)sulfonyl]methyl benzonzonitile) 3-{2-cyano-1-[4-(7H-pyrolol[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N- methylbenzene sulfonamide (3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-methylbenzenesulfonamide) 3-{2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-naptylbenzenesulfonamide (3-(2-cyano-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-1-naphthylbenzenesulfonamide) N-biphenyl-4-yl-3-(2-cyano-1-[4-(7H-pyrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)benzenesulfonamide (N-bipheny1-4-yl-3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl]benzenesulfonamide) 3-[3-(benzyloxy)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-sol-1-yl]-ethyl}-N-propanenitryl (3-[3-(benzyloxy)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-cyclohexylbenzenesulfonamide (3-(2-eyano-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-cyclohexylbenzenesulfonamide) 3-[3-(3,4-dihydroizodvinol-2(1H)-ylsulfonite)phenyl]-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitryl (3-[3-(3,4-dihydroisoquinolin-2(1H)- ylsulfonyl)pheny1]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitile) 3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N,N- diethylbenzenesulfonamide (3-{2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-y)-1H-pyrazol-1-yl]ethyl)-N,N-diethyibenzenesulfonamide) 3-{3-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl)-3-[4-(7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitryl (3-{3-[(4-ethyipiperazin-1-yl)sulfonylpheny1}-3-[4-(7 pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) N-1,3-benzodioxol-5-yl-3-{2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl]ethyl)benzene sulfonamide (N-1,3-benzodioxol-5-yl-3-(2-cyano-1-[4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl}benzenesulfonamide) 3-(3-[(2,6-chymethylmorpholin-4-yl)sulfonyl]pyrol)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propaninyl (3-{3-[(2,6-dimethylmorpholin-4-yi)sulfony)pheryl)- 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-[(4-oxopiperidin-1-yl)sulfonyl]phenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3-[(4-oxopiperidin-1-yl)sulfonyl]phenyl)-3-[4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[3-(isopropylsulfonyl)phenyl]-3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-(isopropylsalfony)phenyl]-3-[4-(7H-pyrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-[(cyclohexylmethyl)sulfonyl]phenyl)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl]propanenitrile (3-[3-[(cyclohexylmethyl)sulfonyl)phenyl)-3-[4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[3-(octahydroisoquinol-2(1H)-ylsulfonyl)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-(octabydroisoquinolim-2(1H)- ylsulfonyl)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-yl]propanenitrile) 3-(3-(2-phenylethyl)-sulfonyl)phenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H- . proprazol-1-yl]propanenitrile (3-(3-[(2-phenylethyl)-sulfonyl]phenyl)-3-[4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) cis-4-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexylacedo-nitrile (cis-4-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexylacetonitrile) 3-cis-4-[4-(7H-pyrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexyl- Propanenitrile (3-cis-4-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexyl-propanenitrile) cis-4-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexanecarbonitrile (cis-4-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)cyclohexanecarbonitrile) 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexylacetonitrile (3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexanecarbonitrile) 5-({sis-4-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexyl) thio)-1H-1,2,4-triazole-3-amine (5-(cis-4-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclohexyl}thio)-1H-1,2,4-triazol-3-amine) and [cis-4-[4-(7H-pyrrolo[2-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-1-(1H-1,2,4-triazol-1-yl)cyclohexyl]acetonitrile ((cis-4-[4-(7H-Pymolo[2,3-dlpyrimidin-4-yl)-1H-pyrazol-1-yl]-I-(IH-1,2,4-triazol-1-yi)cyclohexyi]acetonitrile) or the pharmaceutically acceptable salts of this substance. 33. The compound of claim 1 selected from 3-[3-(piperazin-1-ylsulfonyl)phenyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-(piperazin-1-ylsulfonyl)phenyl]-3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-[3-(thiomorfolin-4-ylsulfonyl)phenyl]propanenitrile (3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-1H-pyrazol-1-yl]-3-[4- [3-(thiomorpholin-4-ylsulfonyl)phenyl]propanenitile) 3-(3-[(4-hytrocchipiperidin-1-yl)sulfonyl]phenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)-1H-pyrazol-1-yl]propanenitile (3-13-[(4-hydroxypiperidin-1-yl)sulfonyl]pheny1)-3-[4- (7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[3-(isobutylsulfonyl)phenyl]-3-[4-(7H-pyrrolo[2,3-4]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[3-(isobutyisulforyi)phenyl)-3-[4-(7H-pyrolo[2,3-djpyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-111-pyrazol-1-yl]-3-(3-[(tetrahydro-2H-pyran-4-ylmethyl)sulfonyl]phenyl) propanenitrile (3-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H- pyrazol-1-yl]-3-(3-(tetrahydro-2H-pyran-4-ylmethyl)sulfony1]phenyl}propanenitrile) 3-(3-(3-furylmethyl)sulfonyl]phenyl)-3-[4-(7H-pyrolo[23-d]pyrimidin-4-yl)-1H- pyrazol-1-yl]propanenitrile (3-(3-(3-fuylmethy1)sulfonyilphenyl)-3-[4-(7H-pyrrol[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-[(1,1-chioxydothiomorphol-4-yl)sulfonyl]phenyl)-3-[4-(7H-pyrrol[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-{3-[(1,1-dioxidothiomorpholin-4-yl) sulfonyl]phenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-{3-[pyridin-4-ylmethyl)sulfonyl]phenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimitinin-4-yl)- 1H-pyrazol-1-yl]propanenitrile (3-(3-[(pyridin-4-ylmethyl)sulfonyl]phenyl)-3-[4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrle) 3-{3-hydroxy-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl)- N,N-dimethylbenzene sulfonamide (3-(3-bydroxy-1-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-l-yl]propyl)-N,N-dimethylbenzenesulfonanamide) 3-(1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)but-3-en-1-yl) benzonitrile (3-(1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-ylbut-3-en-1-yl) benzonitrile) 4-(1-[1-(3-bromophenyl)but-3-en-1-yl]-1H-pyrazol-4-yl)-7H-pyrrololo[2,3-d]pyrimidine (4-(1-[1-(3-bromophenyl)but-3-en-1-yl]-1H-pyrazol-4-yl)-pyrrololo[2,3-d]pyrimidine) 3-(4,4-difluoro-1-[4-(7H-pyrrololo[2,3-4]pyrimidine-4-yl)-1H-pyrazol-1-yl]but-3-en-1-yl)benzonite (3-(4,4-difuoro-1-(7H-pymolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]but-3-en-1-yl)benzonitrile) 4-(1-(4,4-difluoro-1-[3-(morfolin-4-ylsulfonyl)phenyl]but-3-en-1-yl)-1H-pyrazol-4-id)-7H-pyrolo[2,3-d]pyrimidin (4-(4,4-diftuoro-1-[3-(morpholin-4-ylsulfony])phyl] but-3-en-1-yl)-1H-pyrazol-4-yl)-7H-pyrrolol2,3-djpyrimidine) 4-(1-(1-[3-(ethylsulfonyl)phenyl]-4-difluorobut-3-en-1-yl)-1H-pyrazole-4-yl)-7H-pyrrolol[2,3-d]pyrimidine (4-(1-(1-[3-(ethylsulfonyl)phenyl)-4,4-diffuorobut-3-en-1-yi)- 1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine) 4-(1-(1-[3-(benzyloxy)phenyl]-4,4-difluorobut-3-en-1-yl)-1H-pyrazol-4-yl)- TH-pyrrolo[2,3-4]pyrimidine (4-(1-(1-[3-(benzyloxy)phenyl]-4-difluorobut-3-en-1-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine) 4-(1-(4,4-difluoro-1-[3-(methsylphonyl)phenyl]but-3-en-1-yl)-1F-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine (4-(1-(4-ditiuoro-I-[3-(methylsulfony)phenyl]but-3-en-1-yl)- 1H-pyrazol-4-yl)-7H-pyrolo[2,3-d]pyrimidine) 3-([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]methyl)benzonitrile (3- ([4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-y1]methyl)benzonitrile) 3-(1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-yl]butyl)benzonitrile (3-(1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-butyl)benzonitrile) 4-(1-(1-[3-(ethsulfonyl)phenyl]-4,4-difluorobutyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin (4-(1-(1-[3-(ethylsulfonyl)phenyl1]-4,4-difluorobutyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine) 4-[1-1-cyclopentylbutyl-3-en-1-yl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d] (4-[1-(1-cyclopentylbutyl-3-en-1-yl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine) 4-[1-(1-cyclopentylbutyl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine (4-[1-(1- cyclopentylbutyl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine) 4-[1-(1-cyclopentyl-4-difluorobut-3-en-1-yl)-1H-pyrazole-yl]-7H-pyrrolo[2,3-d]pyrimidine (4[1-(1-cyclopentyl-4,4-dithuorobut-3-en-1-yl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine) 4-(1-[4,4-difluoro-1-(tetrahydrofuran-3-yl)but-3-en-1-yl]-1H-pyrazole-4-yl)-7H-pyrrolo[2,3-4]pyrimidine (4-(1-[4,4-difuoro-1-(tetrahydrofuran-3-yl)but-3-en-1-yl]-1H- pyrazol-4-yl)-7H-pyrolo[2,3-d]pyrimidine) 4-[1-(1-cycloprophyll-4-difluorobut-34on-1-yl)-1H-pyrazol-4-yl]-7H-pyrolo[2,3-d]pyrimidine (4-[1-(1-cyclopropyl-4,4-difluorobutyl)-1H-pyrazol-4yl]-7H-pyrrolo[2,3-d]pyrimidine) 4-[1-(1-cyclopentyl-4-difluorobutyl)-1H-pyrazole-4-yl]-7H-pyrolo[2,3-d]pyrimidine (4-[1-(1-cyclopentyl-4,4-difluorobutyl)-1H-pyrazol-4-yl]-7H-pyrolo(2,3-d]pyrimidine) 3-(1-methylcyclopentyl)-3-[4-(7H-pyrolo[2,3-d]pyrimidine-4-yl)-1H-pyrazole-1-yl] proponetrile (3-(1-methylcyclopentyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 1-(2-cyclano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl) cyclopropenedarbonitrile (1-(2-cyano-1-[4-(7H-pyrololo[2,3-d]pyridin-4-yl)-1H-pyrazol-1-yl]ethyI)cyclopropanecarbonitrile) 3-[1-(methylsulfonyl)pyrolidin-3-yl]-3-[4-(7H-pyrololo[2,d]pyridin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-[1-(methyisulfonyl)pyzrolidin-3-yl)-3-[4-(7H-pyrololo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yllpropanenitrile) 4-(1-[2,2,2-trifuguoro-1-1H-imidazole-2-ylmethyl)ethyl]-1H-pyrazole-4-yl)-7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl ... (4-(1-[2,2,2-tluoro-1-(1H-imidazol-2-ylmethyl)ethyl]-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine) 4-(1-(1R)-2,2,2-trifluoro-1-[(4-methyl-1,3-thiazole-2-yl)methyl]ethyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine (4-(1-(1R)-2,2-triluoro-1-[(4-methyi-1,3-thiazol- 2-yl)methyi]ethyt-1H-pyrazol-4-yl)-7H-pyrolo[2,3-d]pyrimidine) 4-(1-[1-(5-bromopyridin-3-yl)-4-difluorobut-3-en-1-yl]-1H-pyrazol-4-yl)- 7H-pyrolo[2,3-d]pyrimidine (4-(1-[1-(5-bromopyridin-3-yI)-4-difluorobut-3-en-l-yl]-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine) 5-(4,4-difluorobut-1-[4-(7H-pyrrolo[2,4]pyrimidine-4-yl)-1H-pyrazol-1-yl]but-3-en-1-yl)nicotinonitrile (5-(4,4-dinuoro-1-[4-(7H-pymolo[2,3-dlpyrimidin-4-yl)-1H-pyrazol- 1-y1]but-3-en-1-yl)nicotinonitrile) 3-[3-(pyrolidin-1-ylsulfonyl)phenyl]-3-[4-(7H-pyrolo-[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanonitrile (3-[3-(pyrolidin-1-ylsulfonyl)-phenyl]-3-[4-(7H-pyrrolo-[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanenitrile) N-benzyl-3-(2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl] ethyl)-N-methylbenzenesulfonyl (N-benzy1-3-(2-cyano-1-[4-(7H-pyrrolo[2-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-methylbenzenesulfonamide) 3-([(3-(2-cyano-1-[4-(7H-pyrrolo[2,3,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-phenyl)-sulfonyl]methyl)-benzomityl (3-([(3-(2-cyano-1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyi)-phenyl)sulfony1]methyl)-benzonitrile) 3-(3-[(24napthylmethyl)-sulfonyl]-phenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3-[(2-naphthylmethyi)-sulfonyi]-phenyi)-3-[4-(7H-py [2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-[(1-phenylethyl)sulfonyl]-phenyl)-3-[4-(7H-pyrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanenitrile (3-(3-[1-phcnylethy1)sulfonyl]-phenyl)-3-(7H-pyrrolo[2,3- dl-pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanenitrile) 3-(2-cyano-1-[4-(7H-pyrrolo-[2,3-d]midin-4-yl)-1H-pyrazol-1-yl]ethyl)-N- (2-morpholin-4-ylethyl)-benzenesulfonamide (3-(2-cyano-1-[4-(7H-pymolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yi]ethyl)-N-(2-morpholin-4-ylethyl)-benzenesulfonamide) 3-(2-cyano-1-[4-(7H-pyrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-[(1S)-1-phenylethyl]benzenesulfonamide (3-cyano-1-[4-(TH-pyrolo-[2,3-dlpyrimidin-4-yl)-1H- pyrazol-1-yl]ethyl)-N-[(1S)-1-phenylethy1]benzenesulfonamide) 3-(2-cyano-1-[4-(7H-pyrolo-[2,3-]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N- phenyl-benzamide (3-(2-cyano-1-(7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-phenyl-benzamide) 3-(2-cyano-1-[4-(7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]ethyl)-N-(tetrahydrofuran-2-yl-methyl)benzenesulfonamide (3-(2-cyano-[4-(7H-pyrrolo-[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1-yilethyl)-N-(tetrahydrofuran-2-yI-methyl)benzenesulfonamide) 3-(3-[(cyclopropylmethyl)sulfonyl]phenyl)-3-[4-(7H-pyrrolo(2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl]propanintril (3-(3-[(cyclopropyimethyl)sulfonyl)phenyl)-3-[4-3-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) 3-(3-(4-methylpiperazin-1-yl)-sulfonyl]phenyl)-3-[4-(7H-pyrrolo[2,3-dpyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3-[(4-methylpiperazin-1-yl)-sulfonyi]phenl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) and 3-(3-[(1-oxytothiomorfolin-4-yl)sulfonyl]phenyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (3-(3-[(1-oxidothiomorpholin-4-yi)sulfonyl) phenyi)-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yllpropanenitrile) or the pharmaceutically acceptable salts of this substance. 34. The compound of claim 1, where such compound is 3-cyclopenyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile (3-cyclopenyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile) or a pharmaceutically acceptable salt of this compound. 35. The compound of claim 1, where such compound is (R)-3-cyclopenty1-3-[4-(7H-pytrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrie ((R)-3-cyclopenty1-3-[4-(7H-pytrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrie) or the pharmacologically acceptable salt of this substance. 36. The compound of claim 1, where such compound is 3-cyclopropyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]-propionite or a pharmacologically acceptable salt of this compound. 37. A composition consisting of any compound of any of the claims 1 through 36, or a pharmaceutically acceptable salt of this substance, and at least one pharmaceutically acceptable carrier substance. 38. Elements of claim 37 which are suitable for exclusive granting. 39. The composition of claim 37 where such compound is 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile or a pharmaceutically acceptable salt of this compound. 40. The composition of claim 37 where such compound is (R)-3-cyclopentyl-3-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenittle ((R)-3-cyclopentyl-3-[4-(7H-pymolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-y:]propanenittle) or a pharmaceutically acceptable salt of this compound. 41. The composition of claim 37 where such compound is 3-cyclopropyl-3-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]-propionitile (3-cyclopropy1-3-3-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-pyrazol-l-yl]-propionitile) or a pharmaceutically acceptable salt of this compound. 42. The use of any of the compounds of claim 1 or 36, or the pharmaceutically acceptable salts of this substance, for the preparation of pharmaceuticals for use in modulating the activity of the janus dinase protein tyrosine kinase (JAK) family. 43. Use of claim 42 where such JAK is JAK1, JAK2, JAK3 or TYK2. 44. Application of claim 42 where the said JAK is JAK1 or JAK2. 45. Application of claim 42, in which the aforementioned JAK is JAK2. 46. The use of claim 42, where such adjustment is a veto. 47. Application of claim 42 where such compound is a selective inhibitor of JAK2 over JAK1, JAK3 or TYK2. 48. The use of any of the compounds of claim 1 or 36, or their salts, may be tolerated by patients whose disease is said to have been associated with the action of JAK. 49. Use of claim 48 where the disease is a rejection of the homologous transplant tissue or a disease between the transplanted tissue and the host. 50. Application of claim 48 where the disease is an autoimmune disease. 51. Use of claim 50 where such autoimmune disease is a skin disorder, multiple sclerosis, rheumatoid arthritis, childhood arthritis, type I diabetes mellitus, lupus, inflammatory bowel disease, Crohn's disease, muscular dystrophy, immunoglobulin nephropathy, myocarditis, or autoimmune thyroid disorder. 52. Use of claim 50 where the autoimmune disease is a blistering skin disorder. 53. Use of claim 52 where the blister-like skin abnormality is an enlarged purpura (PV) or an enlarged purpura (BP). 54. Use of claim 48 where langular disease is a skin disorder. 55. The use of claim 54 where such skin disorders are atopic dermatitis, psoriasis, hypersensitivity of the skin, skin irritation, skin rashes, skin reactions such as those caused by or due to an allergic reaction to a stimulus, or an allergic reaction to a substance. 56. Application of Claim 48 where the disease is a viral disease. 57. Use of claim 56 where the viral disease is Epstein-Barr virus (EBV), hepatitis B, hepatitis C, HIV, HTLV 1, varicella-schoster virus (VZV), or human papillomavirus (HPV). 58. Application of claim 48 where the disease is cancer. 59. Use of claim 58 where such cancer is prostate cancer, kidney cancer, liver cancer, breast cancer, lung cancer, thyroid cancer, posy eye cancer, Dastleman's disease, or pancreatic cancer. 60. Application of claim 58 where the cancer is prostate cancer. 61. Use of claim 58 where the cancer is lymphoma, leudemia, or multiple myeloma. 62. Application of claim 58 where the cancer is skin cancer. 63. The use of claim 62, namely skin cancer, is T-cell lymphoma of the skin or B-cell lymphoma of the skin. 64. Application of claim 58 where the cancer is multiple myeloma. 65. Application of Claim 48, in which the disease is characterized by a genetic predisposition to JAK2. 66. Application of claim 65 where at least one mutation of JAK2 resulting from such mutation resides in the pseudo-dines domain of JAK2. 67. The use of claim 48, in which the disease is a disorder that increases myelin sheath. 68. Use of claim 67 where the myeloproliferative disorder (MPD) is such as polysyzyme vera (PV), spontaneous thrombosyzyme (ET), myeloid metaplasm with myelofibrosis (MMM), chronic myeloma leukemia (CML), chronic myelomonacytig leukemia (CMML), leukocyte and eosinophilic syndrome (HES), or generalized mast cell disease (SMCD). 69. Use of claim 67 where the myelogenic abnormality (MPD) is polycythemia vera (PV). 70. Application of Claim 67 where the abnormality that increases myelosis (MPD) is spontaneously occurring thrombocytemia (ET). 71. Application of claim 67 where the abnormality that increases myelosis (MPD) is myeloid metaplasia with myelofibrosis (MMM). 72. Application of claim 48 where the disease is an inflammatory disease. 73. Application of claim 72 where the inflammatory disease is an inflammatory disease of the eye. 74. The use of claim 73, as stated by the previous commenter, is for uveitis, uveitis (inflammation of the middle layer of the eyeball), blepharitis, or conjunctivitis. 75. Application of claim 72 where the inflammatory disease is an inflammatory disease of the respiratory tract. 76. Application of claim 75 where the inflammatory disease of the respiratory tract involves the upper respiratory tract. 77. Application of claim 75 where the inflammatory disease of the respiratory tract involves the lower respiratory tract. 78. Application of claim 48 where the inflammatory disease is myositis. 79. Application of claim 72 where the inflammatory disease is myocarditis. 80. Use of Claim 48 where the condition is anorexia or emaciation resulting from or associated with cancer. 81. Use of Claim 48 where the disease is a result of or associated with cancer. 82. Application of claim 48 where the disease is psoriasis. 83. Use of any of the compounds of claims 34 through 36, the pharmaceutically acceptable salts of this substance, for the preparation of pharmaceuticals for use in the treatment of cancer, Kaposi's disease, Castleman's disease, scleroderma, hematological malignancies, localized thromboembolism or diseases associated with locally deficient events in the assistant. 84. Use of any of the claims 42 through 82 where such compound is 3-cyclopentyl-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenirile or its pharmaceutically acceptable salts. 85. Use of any one of the claims 42 through 82 where such compound is (R)-3-cyclopenty1-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrie ((R)-3-cyclopenty1-3-[4-(7H-pyrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrie) or a pharmacologically acceptable salt of this compound. 86. Use of any of the claims 42 through 82 where such compound is 3-cyclopropyl-3-[4(7H-pyrolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]-propionitrie (3-cyclopropy1-3-[4-(TH-pyrolo[2-d]pyrimidin-4-yl)-pyrazol-1-yl]-propionitrie) or its pharmaceutically acceptable salts.