TJ272B - Quinazoline compounds or their pharmaceutical acceptable salts and pharmaceutical composition - Google Patents

Quinazoline compounds or their pharmaceutical acceptable salts and pharmaceutical composition

Info

Publication number: TJ272B
Authority: TJ; Tajikistan
Prior art keywords: compounds; quinazoline compounds; pharmaceutical; acceptable salts; pharmaceutical composition
Prior art date: 1992-03-31

Application number

TJ96000367A

Other languages

English (en)

Inventor

Stephen Webber

Ted M Bleckman

John Attard

Terence R Jones

Michael D Varney

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-31

Filing date

1993-03-26

Publication date

2000-10-05

1993-03-26 Application filed by Agouron Pharma filed Critical Agouron Pharma

2000-10-05 Publication of TJ272B publication Critical patent/TJ272B/xx

Links

125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
108010022394 Threonine synthase Proteins 0.000 abstract 2
102000005497 Thymidylate Synthase Human genes 0.000 abstract 2
241000894006 Bacteria Species 0.000 abstract 1
241000233866 Fungi Species 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TJ96000367A 1992-03-31 1993-03-26 Quinazoline compounds or their pharmaceutical acceptable salts and pharmaceutical composition TJ272B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/861,030 US5430148A (en)	1992-03-31	1992-03-31	Antiproliferative quinazolines
PCT/US1993/002636 WO1993020055A1 (en)	1992-03-31	1993-03-26	Antiproliferative quinazolines

Publications (1)

Publication Number	Publication Date
TJ272B true TJ272B (en)	2000-10-05

Family

ID=25334675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TJ96000367A TJ272B (en)	1992-03-31	1993-03-26	Quinazoline compounds or their pharmaceutical acceptable salts and pharmaceutical composition

Country Status (20)

Country	Link
US (3)	US5430148A (de)
EP (1)	EP0637300B1 (de)
JP (1)	JP3272357B2 (de)
KR (1)	KR100226114B1 (de)
AT (1)	ATE205197T1 (de)
AU (1)	AU681075B2 (de)
CA (2)	CA2474211C (de)
DE (1)	DE69330715T2 (de)
DK (1)	DK0637300T3 (de)
ES (1)	ES2162818T3 (de)
FI (1)	FI113765B (de)
HU (1)	HU222523B1 (de)
MD (1)	MD1638G2 (de)
NO (1)	NO307829B1 (de)
NZ (1)	NZ251804A (de)
PT (1)	PT637300E (de)
RU (1)	RU2135481C1 (de)
SG (2)	SG46672A1 (de)
TJ (1)	TJ272B (de)
WO (1)	WO1993020055A1 (de)

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AR012634A1 (es) *	1997-05-02	2000-11-08	Sugen Inc	Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
ATE413881T1 (de) *	1997-08-08	2008-11-15	Celmed Oncology Usa Inc	Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden
US7462605B2 (en) *	1998-01-23	2008-12-09	Celmed Oncology (Usa), Inc.	Phosphoramidate compounds and methods of use
ES2172303T3 (es)	1998-01-23	2002-09-16	Newbiotics Inc	Agentes terapeuticos obtenidos por catalisis enzimatica.
US6706721B1 (en) *	1998-04-29	2004-03-16	Osi Pharmaceuticals, Inc.	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
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US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
UA74803C2 (uk)	1999-11-11	2006-02-15	Осі Фармасьютікалз, Інк.	Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
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CZ20031262A3 (en) *	2000-10-16	2004-03-17	Neopharm, Inc.	Liposomal formulation of mitoxantrone
US6486199B1 (en)	2001-06-21	2002-11-26	Medicines For Malaria Venture Mmv International Centre Cointrin	Spiro and dispiro 1,2,4-trioxolane antimalarials
AU2002346471A1 (en) *	2001-11-20	2003-06-10	Cytokinetics, Inc.	Process for the racemization of chiral quinazolinones
US7009049B2 (en) *	2002-02-15	2006-03-07	Cytokinetics, Inc.	Syntheses of quinazolinones
TWI275390B (en) *	2002-04-30	2007-03-11	Wyeth Corp	Process for the preparation of 7-substituted-3- quinolinecarbonitriles
AU2003270015A1 (en)	2002-05-09	2003-12-02	Cytokinetics, Inc.	Compounds, compositions, and methods
US7166595B2 (en) *	2002-05-09	2007-01-23	Cytokinetics, Inc.	Compounds, methods and compositions
WO2003103575A2 (en) *	2002-05-23	2003-12-18	Cytokinetics, Inc.	Compounds, compositions, and methods
CA2489367A1 (en) *	2002-06-14	2003-12-24	Cytokinetics, Inc.	Compounds, compositions, and methods
US7371778B2 (en) *	2002-06-21	2008-05-13	Medicines For Malaria Venture Mmv	Spiro and dispiro 1,2,4-trioxolane antimalarials
US20080125441A1 (en) *	2002-06-21	2008-05-29	Medicines For Malaria Venture Mmv	Spiro and dispiro 1,2,4-trioxolane antimalarials
US6906205B2 (en) *	2002-06-21	2005-06-14	Medicines For Malaria Venture Mmv	Spiro and dispiro 1,2,4-trioxolane antimalarials
WO2004009036A2 (en) *	2002-07-23	2004-01-29	Cytokinetics, Inc.	Compounds compositions and methods
EP1539180A4 (de) *	2002-08-21	2006-08-30	Cytokinetics Inc	Verbindungen, zusammensetzungen und verfahren
WO2004034972A2 (en) *	2002-09-30	2004-04-29	Cytokinetics, Inc.	Compounds, compositions, and methods
US7232824B2 (en) *	2003-09-30	2007-06-19	Scios, Inc.	Quinazoline derivatives as medicaments
JP2007510652A (ja) *	2003-11-03	2007-04-26	サイトキネティクス・インコーポレーテッド	ピリミジン−４−オン化合物、組成物、および方法
WO2005046588A2 (en) *	2003-11-07	2005-05-26	Cytokinetics, Inc.	Compounds, compositions, and methods
EP1692112A4 (de) *	2003-12-08	2008-09-24	Cytokinetics Inc	Verbindungen, zusammensetzungen und verfahren
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CN1303080C (zh) *	2005-07-18	2007-03-07	康辰医药发展有限公司	盐酸洛拉曲克的合成工艺
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
CN101353343B (zh) *	2007-07-27	2012-07-04	上海医药工业研究院	高纯度盐酸诺拉曲塞二水合物的制备方法
US8426430B2 (en) *	2008-06-30	2013-04-23	Hutchison Medipharma Enterprises Limited	Quinazoline derivatives
EP2440533B1 (de)	2009-06-12	2015-09-23	Socpra-Sciences Et Génie S.E.C.	Guanin-riboswitch-bindende verbindungen und ihre verwendung als antibiotika
JP5697685B2 (ja)	2009-12-18	2015-04-08	バジリアファルマスーチカアーゲーＢａｓｉｌｅａＰｈａｒｍａｃｅｕｔｉｃａＡＧ	三環式抗生物質
CN103635474B (zh)	2011-06-17	2016-04-27	巴斯利尔药物股份公司	三环抗生素
RU2507198C1 (ru) *	2012-09-10	2014-02-20	Владимир Иванович Петров	Производные хиназолина, обладающие ноотропной и антигипоксической активностью
RU2507199C1 (ru) *	2012-09-10	2014-02-20	Владимир Иванович Петров	Производные хиназолина, обладающие антидепрессивной, анксиолитической и ноотропной активностью
RU2622638C1 (ru) *	2016-07-14	2017-06-19	Владимир Иванович Петров	Производные хиназолин-4(3н)-она, обладающие нейро- и кардиопротекторной активностью
CN113727733B (zh)	2019-02-14	2023-01-24	索姆创新生物技术公司	用于治疗苯丙酮尿症的氨苯蝶啶或诺拉曲塞
TW202517614A (zh)	2023-07-12	2025-05-01	瑞士商先正達農作物保護股份公司	２－（三氟甲基）吡啶－４－胺的合成

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1992
- 1992-03-31 US US07/861,030 patent/US5430148A/en not_active Expired - Lifetime
1993
- 1993-03-26 MD MD96-0277A patent/MD1638G2/ro not_active IP Right Cessation
- 1993-03-26 CA CA002474211A patent/CA2474211C/en not_active Expired - Fee Related
- 1993-03-26 HU HU9402799A patent/HU222523B1/hu not_active IP Right Cessation
- 1993-03-26 KR KR1019940703402A patent/KR100226114B1/ko not_active Expired - Fee Related
- 1993-03-26 JP JP51751493A patent/JP3272357B2/ja not_active Expired - Fee Related
- 1993-03-26 NZ NZ251804A patent/NZ251804A/en not_active IP Right Cessation
- 1993-03-26 EP EP93909143A patent/EP0637300B1/de not_active Expired - Lifetime
- 1993-03-26 DE DE69330715T patent/DE69330715T2/de not_active Expired - Fee Related
- 1993-03-26 ES ES93909143T patent/ES2162818T3/es not_active Expired - Lifetime
- 1993-03-26 WO PCT/US1993/002636 patent/WO1993020055A1/en not_active Ceased
- 1993-03-26 CA CA002132514A patent/CA2132514C/en not_active Expired - Fee Related
- 1993-03-26 AT AT93909143T patent/ATE205197T1/de not_active IP Right Cessation
- 1993-03-26 RU RU94045251A patent/RU2135481C1/ru not_active IP Right Cessation
- 1993-03-26 SG SG1996008023A patent/SG46672A1/en unknown
- 1993-03-26 AU AU39664/93A patent/AU681075B2/en not_active Ceased
- 1993-03-26 PT PT93909143T patent/PT637300E/pt unknown
- 1993-03-26 DK DK93909143T patent/DK0637300T3/da active
- 1993-03-26 TJ TJ96000367A patent/TJ272B/xx unknown
1994
- 1994-09-29 FI FI944525A patent/FI113765B/fi active
- 1994-09-29 NO NO943629A patent/NO307829B1/no unknown
1995
- 1995-04-07 US US08/418,415 patent/US5707992A/en not_active Expired - Fee Related
1996
- 1996-02-22 SG SG9800739A patent/SG93183A1/en unknown
1997
- 1997-09-04 US US08/923,117 patent/US5885996A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MD1638G2 (ro)	2001-09-30
DE69330715D1 (de)	2001-10-11
NO307829B1 (no)	2000-06-05
NO943629D0 (no)	1994-09-29
HUT68580A (en)	1995-06-28
HU222523B1 (hu)	2003-08-28
HU9402799D0 (en)	1994-12-28
FI113765B (fi)	2004-06-15
RU2135481C1 (ru)	1999-08-27
WO1993020055A1 (en)	1993-10-14
DE69330715T2 (de)	2002-02-14
JP3272357B2 (ja)	2002-04-08
FI944525L (fi)	1994-09-29
EP0637300A1 (de)	1995-02-08
US5707992A (en)	1998-01-13
CA2132514C (en)	2004-10-26
CA2474211C (en)	2006-10-03
US5885996A (en)	1999-03-23
RU94045251A (ru)	1996-07-20
JPH07505395A (ja)	1995-06-15
SG93183A1 (en)	2002-12-17
DK0637300T3 (da)	2001-12-10
ES2162818T3 (es)	2002-01-16
NO943629L (no)	1994-09-29
US5430148A (en)	1995-07-04
FI944525A0 (fi)	1994-09-29
CA2474211A1 (en)	1993-10-14
AU681075B2 (en)	1997-08-21
KR100226114B1 (ko)	1999-10-15
NZ251804A (en)	1997-06-24
MD1638F2 (en)	2001-03-31
CA2132514A1 (en)	1993-10-14
SG46672A1 (en)	1998-02-20
ATE205197T1 (de)	2001-09-15
EP0637300B1 (de)	2001-09-05
AU3966493A (en)	1993-11-08
PT637300E (pt)	2002-01-30

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