TR199900157T2 - Hücre proliferasyon inhibisyonu için ikame edilmis bisindolilmaleimidleri. - Google Patents

Hücre proliferasyon inhibisyonu için ikame edilmis bisindolilmaleimidleri.

Info

Publication number
TR199900157T2
TR199900157T2 TR1999/00157T TR9900157T TR199900157T2 TR 199900157 T2 TR199900157 T2 TR 199900157T2 TR 1999/00157 T TR1999/00157 T TR 1999/00157T TR 9900157 T TR9900157 T TR 9900157T TR 199900157 T2 TR199900157 T2 TR 199900157T2
Authority
TR
Turkey
Prior art keywords
cell proliferation
proliferation inhibition
formula
bisindolylmaleimides
substituted
Prior art date
Application number
TR1999/00157T
Other languages
English (en)
Inventor
Mary Huryn Donna
Dalton Keith Denn�S
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR199900157T2 publication Critical patent/TR199900157T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Formül (I)'e göre bilesikler ve bu bilesiklerin farmakolojik kabul edilebilir ön ilaçlari veya formül (I)'e göre olan asidik bilesiklerin baza sahip tuzlari veya formül (I)'e göre olan aside sahip ana bilesikleri kanser tedavisinde kullanisli antiproliferatif maddelerdir. (Formül (I))
TR1999/00157T 1996-07-29 1997-07-19 Hücre proliferasyon inhibisyonu için ikame edilmis bisindolilmaleimidleri. TR199900157T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2207996P 1996-07-29 1996-07-29

Publications (1)

Publication Number Publication Date
TR199900157T2 true TR199900157T2 (tr) 1999-04-21

Family

ID=21807711

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00157T TR199900157T2 (tr) 1996-07-29 1997-07-19 Hücre proliferasyon inhibisyonu için ikame edilmis bisindolilmaleimidleri.

Country Status (23)

Country Link
US (2) US5856517A (tr)
EP (1) EP0915872B1 (tr)
JP (1) JP2000516589A (tr)
KR (1) KR20000029637A (tr)
CN (2) CN1495182A (tr)
AR (1) AR008267A1 (tr)
AT (1) ATE240318T1 (tr)
AU (1) AU739742B2 (tr)
BR (1) BR9711605A (tr)
CA (1) CA2262092A1 (tr)
CO (1) CO4900055A1 (tr)
CY (1) CY2483B1 (tr)
DE (1) DE69722003T2 (tr)
DK (1) DK0915872T3 (tr)
ES (1) ES2198001T3 (tr)
HR (1) HRP970414A2 (tr)
MA (1) MA24287A1 (tr)
PE (1) PE91698A1 (tr)
PT (1) PT915872E (tr)
SA (1) SA97180473A (tr)
TR (1) TR199900157T2 (tr)
WO (1) WO1998004552A1 (tr)
ZA (1) ZA976492B (tr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2203111T3 (es) * 1998-03-17 2004-04-01 F. Hoffmann-La Roche Ag Maleimidas bisindol sustituidas para la inhibicion de proloferacion celular.
ES2220585T3 (es) * 1999-12-16 2004-12-16 Eli Lilly And Company Agentes y procedimiento para el tratamiento de enfermedades proliferativas.
WO2001044247A2 (en) * 1999-12-16 2001-06-21 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6743785B2 (en) * 1999-12-16 2004-06-01 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6281356B1 (en) 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
TW201041580A (en) * 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
TWI280128B (en) * 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
ATE486872T1 (de) 2005-02-09 2010-11-15 Arqule Inc Maleimid-derivate, pharmazeutische zusammensetzungen und verfahren zur behandlung von krebs
ES2410955T3 (es) * 2006-12-19 2013-07-04 Novartis Ag Derivados de indolilmaleimida como inhibidores de la quinasa
WO2009002806A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
AU2008268613A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
EP2392574B1 (en) 2007-06-22 2013-12-18 ArQule, Inc. Indolyl pyrrolidines for the treatment of cancer
JP2009035537A (ja) * 2007-07-10 2009-02-19 Nippon Synthetic Chem Ind Co Ltd:The Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
EP3104706B1 (en) 2014-02-11 2022-03-23 Mitokinin, Inc. Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
EP3641545A4 (en) 2017-06-21 2021-02-24 Mitokinin, Inc. COMPOSITIONS AND METHODS USING THEM FOR THE TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
WO1993018765A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
AU3769097A (en) 1998-02-20
ATE240318T1 (de) 2003-05-15
PE91698A1 (es) 1998-12-24
US5856517A (en) 1999-01-05
HRP970414A2 (en) 1998-06-30
CN1151149C (zh) 2004-05-26
US6030994A (en) 2000-02-29
WO1998004552A1 (en) 1998-02-05
KR20000029637A (ko) 2000-05-25
CY2483B1 (en) 2005-06-03
JP2000516589A (ja) 2000-12-12
EP0915872A1 (en) 1999-05-19
MA24287A1 (fr) 1998-04-01
CN1226247A (zh) 1999-08-18
EP0915872B1 (en) 2003-05-14
DE69722003D1 (de) 2003-06-18
CN1495182A (zh) 2004-05-12
CA2262092A1 (en) 1998-02-05
CO4900055A1 (es) 2000-03-27
AU739742B2 (en) 2001-10-18
ZA976492B (en) 1998-01-29
AR008267A1 (es) 1999-12-29
SA97180473A (ar) 2005-12-03
DK0915872T3 (da) 2003-09-08
BR9711605A (pt) 1999-08-24
ES2198001T3 (es) 2004-01-16
DE69722003T2 (de) 2004-04-01
PT915872E (pt) 2003-09-30

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