TR200000231T2 - Indole and 2,3-dihydroindole derivatives, their preparation and use. - Google Patents
Indole and 2,3-dihydroindole derivatives, their preparation and use.Info
- Publication number
- TR200000231T2 TR200000231T2 TR2000/00231T TR200000231T TR200000231T2 TR 200000231 T2 TR200000231 T2 TR 200000231T2 TR 2000/00231 T TR2000/00231 T TR 2000/00231T TR 200000231 T TR200000231 T TR 200000231T TR 200000231 T2 TR200000231 T2 TR 200000231T2
- Authority
- TR
- Turkey
- Prior art keywords
- indole
- preparation
- dihydroindole derivatives
- formula
- dihydroindole
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical class C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 239000003727 serotonin 1A antagonist Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Mevcut bulus, enantiyomerlerinden herhangi biri veya bunlarin herhangi bir karisimindan olusan formül (I)' e veya A, R1, R2, R3, W, X, Y ve Z' nin tarifte belirtildigi gibi oldugu bunlarin asit ilaveli bir tuzuna sahip indol ve 2,3-dihidroindol türevleri ile ilgilidir. Bilesikler, potansiyel bir sekilde serotoninin yeniden alinmasini önlerler ve 5-HT1A alici antagonist aktivitesi gösterirler. Formül (I)The present invention consists of formula (I) consisting of any of its enantiomers or any combination thereof, or an acid addition salt of A, R1, R2, R3, W, X, Y and Z, as specified in the description, and 2, It relates to 3-dihydroindole derivatives. The compounds potentially prevent re-uptake of serotonin and show 5-HT1A receptor antagonist activity. Formula (I)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK89297 | 1997-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000231T2 true TR200000231T2 (en) | 2000-07-21 |
Family
ID=8098721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00231T TR200000231T2 (en) | 1997-07-25 | 1998-07-20 | Indole and 2,3-dihydroindole derivatives, their preparation and use. |
Country Status (12)
| Country | Link |
|---|---|
| CN (3) | CN1293075C (en) |
| AR (1) | AR013206A1 (en) |
| BR (1) | BR9810790A (en) |
| EA (1) | EA001890B1 (en) |
| IL (1) | IL133990A (en) |
| IS (1) | IS2024B (en) |
| NO (1) | NO318610B1 (en) |
| PL (1) | PL190924B1 (en) |
| SK (1) | SK284866B6 (en) |
| TR (1) | TR200000231T2 (en) |
| UA (1) | UA59408C2 (en) |
| ZA (1) | ZA986237B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103420989B (en) * | 2012-05-15 | 2016-03-23 | 华中科技大学 | Benzodioxane derivative and application thereof |
| CN120817935A (en) * | 2024-04-15 | 2025-10-21 | 复旦大学附属肿瘤医院 | A hetero(aromatic) ring substituted cyclic diamine compound and its use in preparing drugs for treating and/or preventing tumors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| DE4127849A1 (en) * | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | BENZODIOXAN DERIVATIVES |
| FR2692264B1 (en) * | 1992-06-12 | 1994-08-05 | Adir | NOVEL 1,4-DISUBSTITUTED PIPERAZINES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1998
- 1998-07-13 AR ARP980103400 patent/AR013206A1/en active IP Right Grant
- 1998-07-14 ZA ZA986237A patent/ZA986237B/en unknown
- 1998-07-20 CN CNB03106003XA patent/CN1293075C/en not_active Expired - Fee Related
- 1998-07-20 PL PL338194A patent/PL190924B1/en not_active IP Right Cessation
- 1998-07-20 UA UA2000020949A patent/UA59408C2/en unknown
- 1998-07-20 EA EA200000162A patent/EA001890B1/en not_active IP Right Cessation
- 1998-07-20 CN CN 03106002 patent/CN1286833C/en not_active Expired - Fee Related
- 1998-07-20 IL IL13399098A patent/IL133990A/en not_active IP Right Cessation
- 1998-07-20 TR TR2000/00231T patent/TR200000231T2/en unknown
- 1998-07-20 SK SK95-2000A patent/SK284866B6/en not_active IP Right Cessation
- 1998-07-20 BR BR9810790-9A patent/BR9810790A/en not_active Application Discontinuation
- 1998-07-20 CN CN 98807554 patent/CN1127501C/en not_active Expired - Fee Related
-
2000
- 2000-01-11 IS IS5334A patent/IS2024B/en unknown
- 2000-01-25 NO NO20000372A patent/NO318610B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1030220A1 (en) | 2001-04-27 |
| HK1066806A1 (en) | 2005-04-01 |
| EA001890B1 (en) | 2001-10-22 |
| CN1515568A (en) | 2004-07-28 |
| CN1265107A (en) | 2000-08-30 |
| NO318610B1 (en) | 2005-04-18 |
| IL133990A0 (en) | 2001-04-30 |
| UA59408C2 (en) | 2003-09-15 |
| NO20000372D0 (en) | 2000-01-25 |
| CN1515569A (en) | 2004-07-28 |
| HK1066807A1 (en) | 2005-04-01 |
| SK284866B6 (en) | 2006-01-05 |
| BR9810790A (en) | 2000-07-25 |
| IS2024B (en) | 2005-08-15 |
| CN1293075C (en) | 2007-01-03 |
| IL133990A (en) | 2003-09-17 |
| IS5334A (en) | 2000-01-11 |
| CN1286833C (en) | 2006-11-29 |
| PL338194A1 (en) | 2000-10-09 |
| EA200000162A1 (en) | 2000-10-30 |
| SK952000A3 (en) | 2001-03-12 |
| CN1127501C (en) | 2003-11-12 |
| NO20000372L (en) | 2000-03-21 |
| ZA986237B (en) | 1999-03-31 |
| AR013206A1 (en) | 2000-12-13 |
| PL190924B1 (en) | 2006-02-28 |
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