TR200000500T2 - Sütlerinde oligosakaritler üreten transgenik memeliler. - Google Patents

Sütlerinde oligosakaritler üreten transgenik memeliler.

Info

Publication number
TR200000500T2
TR200000500T2 TR2000/00500T TR200000500T TR200000500T2 TR 200000500 T2 TR200000500 T2 TR 200000500T2 TR 2000/00500 T TR2000/00500 T TR 2000/00500T TR 200000500 T TR200000500 T TR 200000500T TR 200000500 T2 TR200000500 T2 TR 200000500T2
Authority
TR
Turkey
Prior art keywords
milk
transgenic mammals
produce oligosaccharides
oligosaccharides
produce
Prior art date
Application number
TR2000/00500T
Other languages
English (en)
Inventor
A. Prieto Pedro
J. Kopchick John
D. Cummings Richard
M. Pierce James
F. Smith David
W. Moremen Kelley
Original Assignee
Abbott Laboratories
Ohio University
University Of Georgia Research Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories, Ohio University, University Of Georgia Research Foundation, Inc. filed Critical Abbott Laboratories
Publication of TR200000500T2 publication Critical patent/TR200000500T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Saccharide Compounds (AREA)
  • Fodder In General (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Bu bulus sütlerinde çesitli oligosakaritleri ve glikokonjügeleri üreten insan olmayan transgenik memeliler üretmeye yönelik yöntemlere iliskindir. Ayrica bu bulus memelilerin kendilerine, ürettikleri süte, sütü içeren bilesimlere, sütün bölümlerine ve sütte bulunan saflastirilmis oligosakaritlere ve glikokonjügelere iliskindir.
TR2000/00500T 1997-09-05 1998-09-04 Sütlerinde oligosakaritler üreten transgenik memeliler. TR200000500T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/925,834 US6204431B1 (en) 1994-03-09 1997-09-05 Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk

Publications (1)

Publication Number Publication Date
TR200000500T2 true TR200000500T2 (tr) 2000-12-21

Family

ID=25452320

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00500T TR200000500T2 (tr) 1997-09-05 1998-09-04 Sütlerinde oligosakaritler üreten transgenik memeliler.

Country Status (20)

Country Link
US (1) US6204431B1 (tr)
EP (1) EP1007651A1 (tr)
JP (1) JP2001520001A (tr)
KR (1) KR20010023645A (tr)
CN (1) CN1273602A (tr)
AR (1) AR017515A1 (tr)
AU (1) AU9220398A (tr)
BG (1) BG104236A (tr)
BR (1) BR9811733A (tr)
CA (1) CA2302777A1 (tr)
CO (1) CO4930313A1 (tr)
HU (1) HUP0004709A2 (tr)
IL (1) IL133992A0 (tr)
MX (1) MXPA00002266A (tr)
NO (1) NO20001105L (tr)
PL (1) PL339132A1 (tr)
SK (1) SK3042000A3 (tr)
TR (1) TR200000500T2 (tr)
WO (1) WO1999011773A1 (tr)
ZA (1) ZA987504B (tr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129745A1 (en) 1999-10-28 2003-07-10 Robl James M. Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
US7625756B2 (en) 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7863020B2 (en) * 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
ES2252261T3 (es) * 2000-06-28 2006-05-16 Glycofi, Inc. Metodos para producir glicoproteinas modificadas.
US6576464B2 (en) * 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US6921665B2 (en) * 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
US20060253913A1 (en) * 2001-12-21 2006-11-09 Yue-Jin Huang Production of hSA-linked butyrylcholinesterases in transgenic mammals
WO2003054182A2 (en) * 2001-12-21 2003-07-03 Nexia Biotechnologies, Inc. Production of butyrylcholinesterases in transgenic mammals
US7169548B2 (en) * 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7429690B2 (en) 2002-11-08 2008-09-30 Kirin Holdings Kabushiki Kaisha Transgenic bovines having reduced prion protein production
US20040231010A1 (en) * 2003-01-09 2004-11-18 Murray James D. Lysozyme transgenic ungulates
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
US7514593B2 (en) 2003-05-30 2009-04-07 The University Of North Carolina At Chapel Hill Animal model for chronic obstructive pulmonary disease and cystic fibrosis
US7771978B2 (en) * 2003-09-22 2010-08-10 Henrik Clausen β1,4mannosyltransferases
WO2005055944A2 (en) 2003-12-05 2005-06-23 Cincinnati Children's Hospital Medical Center Oligosaccharide compositions and use thereof in the treatment of infection
CN103627670B (zh) * 2004-02-13 2016-12-21 格莱克托普有限公司 高活性糖蛋白加工条件及其有效生产方法
AU2005237494B2 (en) * 2004-04-22 2010-06-10 Kyowa Hakko Kirin Co., Ltd Transgenic animals and uses thereof
WO2005117576A2 (en) * 2004-05-28 2005-12-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Modification of sugar metabolic process in transgenic cells, tissues and animals
CA2649134C (en) * 2006-02-09 2013-07-02 Thomas Paccalet Synthesis of sialic acid in plants
US7663019B2 (en) * 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
US8124831B2 (en) * 2006-07-06 2012-02-28 Duke University Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
US20090208480A1 (en) * 2006-08-04 2009-08-20 Yue Huang Long half-life recombinant butyrylcholinesterase
WO2009033011A1 (en) 2007-09-07 2009-03-12 Children's Hospital Medical Center Use of secretor, lewis and sialyl antigen levels as predictors for disease
MX2010005132A (es) * 2007-11-08 2010-06-02 Nestec Sa Uso de oligosacaridos conteniendo n-acetilactosamina para maduración de las respuestas inmunes en neonatos.
CA2757169A1 (en) 2009-04-13 2010-10-21 Children's Hospital Medical Center Milk oligosaccharide compositions and use thereof in treating infection in animals
DK2440661T3 (en) * 2009-06-08 2018-03-12 Jennewein Biotechnologie Gmbh HMO synthesis
ES2651067T3 (es) 2009-07-06 2018-01-24 Children's Hospital Medical Center Inhibición de la inflamación con oligosacáridos de la leche
CN102497868A (zh) 2009-07-15 2012-06-13 N.V.努特里奇亚 用于刺激免疫系统的不可消化低聚糖的混合物
PL2453901T3 (pl) 2009-07-15 2015-03-31 Nutricia Nv Fukozyloklaktoza jako identyczny z mlekiem kobiecym niestrawny oligosacharyd do leczenia i/lub zapobiegania infekcji wirusowych
CA2784861A1 (en) 2009-12-21 2011-07-14 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
US20130243744A1 (en) * 2011-01-06 2013-09-19 Michael J. Betenbaugh Method of production of recombinant glycoproteins with increased circulatory half-life in mammalian cells
DK2722394T3 (en) 2011-06-07 2018-06-18 Hero Ag OBJECTIVES OF OLIGOSACCHARIDES BY A BIOTECHNOLOGICAL PROCEDURE
NL2007268C2 (en) 2011-08-16 2013-02-19 Friesland Brands Bv Nutritional compositions comprising human milk oligosaccharides and uses thereof.
CN102839157A (zh) * 2012-07-12 2012-12-26 扬州大学 稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
US10034921B2 (en) * 2013-02-13 2018-07-31 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
EP3594230A1 (en) 2013-02-13 2020-01-15 Laboratoire Français du Fractionnement et des Biotechnologies Highly galactosylated anti-tnf-alpha antibodies and uses thereof
US10626460B2 (en) 2013-02-21 2020-04-21 Children's Hospital Medical Center Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease
CN103196725B (zh) * 2013-03-26 2015-07-08 上海交通大学 制备与富集单个微纳米珠携带单根多聚物分子的方法
EP3288389A4 (en) 2015-04-28 2018-10-10 Children's Hospital Medical Center Use of oligosaccharide compositions to enhance weight gain
FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
WO2019031961A1 (en) 2017-08-11 2019-02-14 N.V. Nutricia OLIGOSACCHARIDE OF HUMAN MILK TO IMPROVE PHYSICAL IMMUNE CONDITION
EP3820497A4 (en) 2018-07-11 2022-03-23 Ohio University Peptide-based inhibitors of growth hormone action and methods of use thereof
US11266129B2 (en) 2019-11-05 2022-03-08 Versiti Blood Research Institute Foundation, Inc. Murine model of fetal/neonatal alloimmune thrombocytopenia
CN120168665A (zh) 2019-11-05 2025-06-20 弗尔斯蒂血液研究所基金会股份有限公司 胎儿/新生儿同种免疫性血小板减少症的鼠模型
CN117480261A (zh) * 2020-12-11 2024-01-30 澳优有限公司 山羊的2'-fl增产
EP4259827B1 (en) * 2020-12-11 2025-01-01 Ausnutria B.V. Increased 2'-fl production by goats
EP4730993A1 (en) 2023-06-20 2026-04-29 Institut National de la Santé et de la Recherche Médicale A new relevant non-human animal model of progressive metabolic dysfunction-associated steatotic liver disease (masld) and atherosclerosis development

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435363A (en) 1981-07-02 1984-03-06 Exxon Nuclear Company, Inc. Continuous countercurrent liquid-solids contactor
DE3334167A1 (de) 1983-09-21 1985-04-04 Siemens AG, 1000 Berlin und 8000 München Halbleiterdiode
US5366894A (en) 1986-06-30 1994-11-22 Pharmaceutical Proteins Limited Peptide production
GB8615942D0 (en) 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
AU7879987A (en) 1986-08-28 1988-03-24 Immunex Corp. Expression of heterologous proteins by transgenic lactating mammals
EP0832981A1 (en) 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
GB8826446D0 (en) 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
US5032519A (en) 1989-10-24 1991-07-16 The Regents Of The Univ. Of California Method for producing secretable glycosyltransferases and other Golgi processing enzymes
CA2351200A1 (en) 1989-12-01 1991-06-13 Gene Pharming Europe Bv Production of recombinant polypeptides by bovine species and transgenic methods
WO1991016449A1 (en) 1990-04-16 1991-10-31 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
DE69133557D1 (de) 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US5198466A (en) 1990-11-09 1993-03-30 Warner-Lambert Company Oxysulfonyl urea acat inhibitors
US5362480A (en) 1991-12-31 1994-11-08 Lever Brothers Company, Division Of Conopco, Inc. Oral hygiene compositions containing amino sugars as antiplaque agents
DK8892D0 (da) 1992-01-23 1992-01-23 Symbicom Ab Humant proteingen
US5401723A (en) 1992-12-02 1995-03-28 Colgate-Palmolive Company Glycoconjugate inhibition of Streptococcus pyrogenes adhesion
WO1994018986A1 (en) 1993-02-26 1994-09-01 Jan Staffan Normark Use of oligosaccharide glycosides as inhibitors of bacterial adherence
DK76193D0 (da) 1993-06-25 1993-06-25 Astra Ab Kulhydratderivater
WO1995024494A1 (en) * 1994-03-09 1995-09-14 Abbott Laboratories Humanized milk
AU692841B2 (en) * 1994-03-09 1998-06-18 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
US5750176A (en) 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
US5625124A (en) 1994-07-11 1997-04-29 Washington University Animal model for helicobacter pylori infection
CZ89098A3 (cs) 1995-09-29 1998-09-16 Glycim Oy Syntetické polylaktosaminy obsahující až multivalentní sLEX a metody pro jejich použití
AU1122897A (en) 1995-11-13 1997-06-05 Glycomed Incorporated Novel oligosaccharide glycosides having mammalian immunosuppressive and tolerogenic properties
CA2238262A1 (en) 1995-11-22 1997-05-29 The Research And Development Institute, Inc. Therapeutic and diagnostic agents for the treatment of microbial infections

Also Published As

Publication number Publication date
MXPA00002266A (es) 2000-10-01
NO20001105D0 (no) 2000-03-03
US6204431B1 (en) 2001-03-20
NO20001105L (no) 2000-05-05
EP1007651A1 (en) 2000-06-14
CO4930313A1 (es) 2000-06-27
AR017515A1 (es) 2001-09-12
IL133992A0 (en) 2001-04-30
PL339132A1 (en) 2000-12-04
WO1999011773A1 (en) 1999-03-11
JP2001520001A (ja) 2001-10-30
CA2302777A1 (en) 1999-03-11
AU9220398A (en) 1999-03-22
BG104236A (en) 2000-12-29
BR9811733A (pt) 2000-09-05
HUP0004709A2 (hu) 2001-04-28
ZA987504B (en) 1999-03-15
SK3042000A3 (en) 2000-09-12
KR20010023645A (ko) 2001-03-26
CN1273602A (zh) 2000-11-15

Similar Documents

Publication Publication Date Title
TR200000500T2 (tr) Sütlerinde oligosakaritler üreten transgenik memeliler.
TR199501628A2 (tr) Yüksek safliktaki melamin imal edilmesine mahsus usul.
TR199700537A3 (tr) Diyete uygun dengelenmis süt ürünü.
DE59106117D1 (de) Fahrzeugsitz.
TR28460A (tr) Ozellikle otomobillerdeki alternatör tellerinin uclari icin baglanti elemani.
NO954573D0 (no) Melkeprodukt
DE69204617D1 (de) Armlehne für Fahrzeuge.
NO913776D0 (no) Helfarget, tredimensjonalt fremvisersystem.
IT1307618B1 (it) Sedile per autoveicolo.
NO904488L (no) Sadelhenger.
DE69108362D1 (de) Schienenfahrzeugrad.
DE59102629D1 (de) Sitzträger für einen Bürostuhl o.dgl.
IT220027Z2 (it) Cambio elettrico per automobili per bambini.
ITRM960108V0 (it) Pista per vetture elettriche.
DE69926019D1 (de) G.723.1 audiokodierer
FR2684947B1 (fr) Engin de traction ferroviaire.
ES1029431Y (es) Modulo multiple para la formacion de panteones.
FI982844A0 (fi) Reititys WDM-järjestelmässä
IT212872Z2 (it) Cravatta con svasatura laterale verso la mezzeria.
ES1027971Y (es) Modulo integrado audiovisual.
ITBO940296A0 (it) SEGNALATORE SONORO, OVVEROSSIA AVVISATORE SONORO, DI FRENATA PER VEI- COLI, PIù BANALMENTE DEFINIBILE COME STOP ACUSTICO.
ES1018239Y (es) Ensamblador para la fabricacion de marcos.
ITBO940007V0 (it) Veicolo ferroviario modulare.
IT1266725B1 (it) Sedile antivibrazione per veicoli.
DE69111495D1 (de) Transversalentzerrer.