TR200000578T2 - Heparanas aktiviteye sahip olan bir polipeptit deşifre eden polinükleotit ve çevrilmiş hücrelerde aynısını izahı. - Google Patents

Heparanas aktiviteye sahip olan bir polipeptit deşifre eden polinükleotit ve çevrilmiş hücrelerde aynısını izahı.

Info

Publication number
TR200000578T2
TR200000578T2 TR2000/00578T TR200000578T TR200000578T2 TR 200000578 T2 TR200000578 T2 TR 200000578T2 TR 2000/00578 T TR2000/00578 T TR 2000/00578T TR 200000578 T TR200000578 T TR 200000578T TR 200000578 T2 TR200000578 T2 TR 200000578T2
Authority
TR
Turkey
Prior art keywords
polypeptide
activity
heparanas
same
polynucleotide
Prior art date
Application number
TR2000/00578T
Other languages
English (en)
Inventor
Pecker Iris
Vlodavsky Israel
Feinstein Elena
Original Assignee
Insight Strategy And Marketing Ltd.
Hadasit Medical Research Services & Development Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25446621&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200000578(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Insight Strategy And Marketing Ltd., Hadasit Medical Research Services & Development Ltd. filed Critical Insight Strategy And Marketing Ltd.
Publication of TR200000578T2 publication Critical patent/TR200000578T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Biophysics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)

Abstract

Heparanez aktivitesine sahip olan bir polipeptiti desifre eden polinükleotit (hpa), heparanaz aktiviteye sahip olan rekombinant bir protein ve heparanaz ifade eden ayni dönüsük hücrelerle birlikte vektörlesir.
TR2000/00578T 1997-09-02 1998-08-31 Heparanas aktiviteye sahip olan bir polipeptit deşifre eden polinükleotit ve çevrilmiş hücrelerde aynısını izahı. TR200000578T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/922,170 US5968822A (en) 1997-09-02 1997-09-02 Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US10938698A 1998-07-02 1998-07-02

Publications (1)

Publication Number Publication Date
TR200000578T2 true TR200000578T2 (tr) 2000-07-21

Family

ID=25446621

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00578T TR200000578T2 (tr) 1997-09-02 1998-08-31 Heparanas aktiviteye sahip olan bir polipeptit deşifre eden polinükleotit ve çevrilmiş hücrelerde aynısını izahı.

Country Status (12)

Country Link
US (2) US5968822A (tr)
EP (5) EP1676912A3 (tr)
JP (1) JP4187408B2 (tr)
CN (1) CN1272886A (tr)
AT (1) ATE318912T1 (tr)
AU (1) AU735116B2 (tr)
CA (1) CA2296758A1 (tr)
DE (1) DE69833667T2 (tr)
ES (1) ES2259816T3 (tr)
PL (1) PL338949A1 (tr)
TR (1) TR200000578T2 (tr)
WO (1) WO1999011798A1 (tr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US20030161823A1 (en) * 1998-08-31 2003-08-28 Neta Ilan Therapeutic and cosmetic uses of heparanases
US5968822A (en) * 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US6699672B1 (en) * 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US6348344B1 (en) * 1997-09-02 2002-02-19 Insight Strategy & Marketing Ltd. Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same
JP2002510462A (ja) * 1997-10-28 2002-04-09 ジ・オーストラリアン・ナショナル・ユニバーシティー 哺乳類のエンドグルクロニダーゼをコードする単離された核酸分子およびその使用
GB9802725D0 (en) * 1998-02-09 1998-04-08 Ciba Geigy Ag Organic compounds
EP1060252A2 (en) * 1998-02-24 2000-12-20 PHARMACIA & UPJOHN COMPANY Human platelet heparanase polypeptides, polynucleotide molecules that encode them, and methods for the identification of compounds that alter heparanase activity
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
JP2003527822A (ja) * 1998-08-27 2003-09-24 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ
US20020068054A1 (en) * 2000-09-11 2002-06-06 Insight Strategy & Marketing Ltd. And Hadasit Medical Research Services And Development Ltd. Therapeutic and cosmetic uses of heparanases
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
WO2000052178A1 (en) * 1999-03-01 2000-09-08 Insight Strategy & Marketing Ltd. Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
CA2370539C (en) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
US20040224922A1 (en) * 1999-08-26 2004-11-11 Malcolm King Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
EP1214423A1 (en) * 1999-09-23 2002-06-19 MERCK PATENT GmbH Heparanase-2, a member of the heparanase protein family
IL149889A0 (en) * 1999-12-22 2002-11-10 Oxford Glycosciences Uk Ltd Heparanase-like proteins and nucleotides encoding them
CA2402160C (en) * 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
DE60138115D1 (de) * 2000-09-12 2009-05-07 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
CA2426517A1 (en) 2000-09-15 2002-03-21 Reddy Us Therapeutics, Inc. Methods and compositions for glycosidase assays
EP1333862A4 (en) * 2000-10-17 2004-08-18 Insight Strategy & Marketing METHOD AND PHARMACEUTICAL COMPOSITIONS FOR IMPROVING THE IMPLANTATION OF EMBRYOS
AU2002224408B2 (en) 2000-10-18 2007-08-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
AU2002241532A1 (en) * 2000-11-30 2002-06-11 Sangamo Biosciences, Inc. Human heparanase gene regulatory sequences
FR2818131B1 (fr) * 2000-12-14 2005-02-11 Oreal Composition cosmetique comprenant de l'heparanase
CA2432157A1 (en) * 2000-12-19 2002-06-27 Insight Strategy And Marketing Ltd. The use of ecm degrading enzymes for the improvement of cell transplantation
AU2002243630A1 (en) 2001-01-23 2002-08-06 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
CA2453566A1 (en) * 2001-07-13 2003-01-23 Imclone Systems Incorporated Method and composition for inhibiting heparanase activity
US6671189B2 (en) * 2001-11-09 2003-12-30 Minebea Co., Ltd. Power converter having primary and secondary side switches
CH696701A5 (de) 2001-12-18 2007-10-15 Hoffmann La Roche Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen.
DE60334220D1 (de) * 2002-06-03 2010-10-28 Massachusetts Inst Technology Rationell konstruierte, von chondroitinase b abgeleitete lyasen
EP1547979A1 (en) * 2002-06-21 2005-06-29 Sanden Corporation Mineral water making apparatus
WO2004043989A2 (en) * 2002-11-07 2004-05-27 Medarex, Inc. Human monoclonal antibodies to heparanase
WO2005014619A2 (en) 2003-03-28 2005-02-17 Thomas Jefferson University Heparin-binding peptides and uses thereof
WO2004108065A2 (en) * 2003-06-09 2004-12-16 Insight Biopharmaceuticals Ltd. Heparanase activity neutralizing anti- heparanase monoclonal antibody and other anti-heparanase antibodies
EP1670917A1 (en) * 2003-09-26 2006-06-21 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Synthetic heparanase molecules and uses thereof
WO2007034480A2 (en) * 2005-09-20 2007-03-29 Carmel-Haifa University Economic Corp. Ltd Heparanases and splice variants thereof, ponucleotides encoding them and uses thereof
WO2008057265A2 (en) * 2006-10-27 2008-05-15 University Of Maryland Single nucleotide polymorphisms and the identification of lactose intolerance
CN102711463B (zh) * 2009-12-03 2015-05-13 Opko健康公司 超硫酸化双糖制剂
EP2964253A1 (en) * 2013-03-05 2016-01-13 Baylor College Of Medicine Heparanase expression in human t lymphocytes

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US5061689A (en) * 1986-12-24 1991-10-29 Bioderm, Inc. Zinc bacitracin containing wound dressing
US5571506A (en) * 1989-08-14 1996-11-05 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aromatic oligomeric compounds useful as mimics of bioactive macromolecules
ATE167230T1 (de) * 1989-08-23 1998-06-15 Hadassah Med Org Wundheilmittel enthaltend heparanase
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CA2108143A1 (en) * 1992-03-23 1993-09-24 George Martyn Livingston Use of an antiviral coating for latex viral barrier items such as condoms
EP0708838A1 (en) * 1993-07-29 1996-05-01 PHARMACIA & UPJOHN COMPANY Use of heparanase to identify and isolate anti-heparanase compound
US5565193A (en) * 1993-08-05 1996-10-15 Procter & Gamble Hair styling compositions containing a silicone grafted polymer and low level of a volatile hydrocarbon solvent
HUP9900459A3 (en) * 1996-01-23 1999-11-29 Rapigene Inc Bothell Methods and compositions for detecting binding of ligand pair using non-fluorescent label
US5968822A (en) * 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US6348344B1 (en) 1997-09-02 2002-02-19 Insight Strategy & Marketing Ltd. Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
JP2002510462A (ja) * 1997-10-28 2002-04-09 ジ・オーストラリアン・ナショナル・ユニバーシティー 哺乳類のエンドグルクロニダーゼをコードする単離された核酸分子およびその使用
GB9802725D0 (en) 1998-02-09 1998-04-08 Ciba Geigy Ag Organic compounds

Also Published As

Publication number Publication date
EP0998569A4 (en) 2000-08-16
ES2259816T3 (es) 2006-10-16
DE69833667D1 (de) 2006-04-27
CA2296758A1 (en) 1999-03-11
EP0998569B1 (en) 2006-03-01
ATE318912T1 (de) 2006-03-15
EP1439226A2 (en) 2004-07-21
JP2001514855A (ja) 2001-09-18
PL338949A1 (en) 2000-12-04
US6664105B1 (en) 2003-12-16
EP1439193A2 (en) 2004-07-21
CN1272886A (zh) 2000-11-08
EP1489183A1 (en) 2004-12-22
WO1999011798A1 (en) 1999-03-11
AU735116B2 (en) 2001-06-28
DE69833667T2 (de) 2007-03-08
EP1439193B1 (en) 2013-08-28
EP1439193A3 (en) 2004-10-06
EP1676912A3 (en) 2008-12-31
EP1489183B1 (en) 2011-10-26
EP1676912A2 (en) 2006-07-05
JP4187408B2 (ja) 2008-11-26
AU9125898A (en) 1999-03-22
US5968822A (en) 1999-10-19
EP1439226A3 (en) 2004-10-06
EP0998569A1 (en) 2000-05-10

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