TR200000649T2 - PTHrP analogları kullanılarak kırıkların iyileştirilmesi. - Google Patents

PTHrP analogları kullanılarak kırıkların iyileştirilmesi.

Info

Publication number
TR200000649T2
TR200000649T2 TR2000/00649T TR200000649T TR200000649T2 TR 200000649 T2 TR200000649 T2 TR 200000649T2 TR 2000/00649 T TR2000/00649 T TR 2000/00649T TR 200000649 T TR200000649 T TR 200000649T TR 200000649 T2 TR200000649 T2 TR 200000649T2
Authority
TR
Turkey
Prior art keywords
fractures
improvement
pthrp analogs
pthrp
polypeptide
Prior art date
Application number
TR2000/00649T
Other languages
English (en)
Inventor
Brian Vickery Henry
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200000649T2 publication Critical patent/TR200000649T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Mevcut bulus, paratiroid hormonu ile ilgili peptitin polipeptit bir analogunun (PTHrP) ve bunun tuzlarinin etkili bir miktarinin buna ihtiyaci olan bir hastaya verilmesini içeren kemik iyilestirme ve kirik onarimi tedavisi için bir ilacin hazirlanmasinda bu tip bir polipeptidin kullanimini sunmakta olup, burada amino asit kalintilari 22-31, amfipatik bir alfa-helis olusturur.
TR2000/00649T 1997-09-09 1998-09-02 PTHrP analogları kullanılarak kırıkların iyileştirilmesi. TR200000649T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5832497P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
TR200000649T2 true TR200000649T2 (tr) 2000-09-21

Family

ID=22016113

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00649T TR200000649T2 (tr) 1997-09-09 1998-09-02 PTHrP analogları kullanılarak kırıkların iyileştirilmesi.

Country Status (31)

Country Link
US (1) US6583114B2 (tr)
EP (1) EP1005359B1 (tr)
JP (1) JP2002509854A (tr)
KR (1) KR100679778B1 (tr)
CN (1) CN1210059C (tr)
AR (1) AR015435A1 (tr)
AT (1) ATE297754T1 (tr)
AU (1) AU752925B2 (tr)
BR (1) BR9812068A (tr)
CA (1) CA2302255C (tr)
CO (1) CO4890856A1 (tr)
CZ (1) CZ298701B6 (tr)
DE (1) DE69830591T2 (tr)
ES (1) ES2244090T3 (tr)
HR (1) HRP20000109A2 (tr)
HU (1) HU226866B1 (tr)
IL (2) IL134719A0 (tr)
MA (1) MA26545A1 (tr)
MY (1) MY121291A (tr)
NO (1) NO323740B1 (tr)
NZ (1) NZ502970A (tr)
PE (1) PE117399A1 (tr)
PL (1) PL195703B1 (tr)
RS (1) RS49707B (tr)
RU (1) RU2224539C2 (tr)
SA (1) SA98190565B1 (tr)
TR (1) TR200000649T2 (tr)
TW (1) TW552139B (tr)
UY (1) UY25172A1 (tr)
WO (1) WO1999012561A2 (tr)
ZA (1) ZA988030B (tr)

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EP1295605A3 (en) * 1998-08-19 2003-10-29 Eli Lilly And Company Method of increasing bone toughness and stiffness and reducing fractures
CA2245903A1 (en) * 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
CA2364948C (en) 1999-03-05 2011-04-26 Duke University C16 unsaturated fp-selective prostaglandins analogs
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
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WO2003059291A2 (en) * 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
WO2005041998A1 (en) 2003-10-02 2005-05-12 Ali Sadat M Peptide for promoting healing of fractures
KR20070067136A (ko) * 2004-10-08 2007-06-27 포베스 메디-테크 (리서치) 인코포레이티드 혈관작용성 장내 폴리펩티드 제약
BRPI0618469A2 (pt) * 2005-11-10 2011-08-30 Univ Michigan Tech hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto
WO2007133580A2 (en) * 2006-05-09 2007-11-22 Zelos Therapeutics, Inc. Use of pth (1-31) and optionally g-csf for hematopoietic stimulation
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
CA2664734C (en) 2006-10-03 2023-08-01 Radius Health, Inc. Method of drug delivery for bone anabolic protein
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP5564167B2 (ja) * 2008-05-22 2014-07-30 日本たばこ産業株式会社 苦味マスキング剤及び苦味低減方法
US8870876B2 (en) 2009-02-13 2014-10-28 Tarsus Medical Inc. Methods and devices for treating hallux valgus
EP2411038B1 (en) 2009-03-27 2016-12-28 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8277459B2 (en) 2009-09-25 2012-10-02 Tarsus Medical Inc. Methods and devices for treating a structural bone and joint deformity
CA2782640A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8652141B2 (en) 2010-01-21 2014-02-18 Tarsus Medical Inc. Methods and devices for treating hallux valgus
US8696719B2 (en) 2010-06-03 2014-04-15 Tarsus Medical Inc. Methods and devices for treating hallux valgus
RS67458B1 (sr) 2014-03-28 2025-12-31 Univ Duke Lečenje kancera dojke pozitivnog na receptor estrogena upotrebom selektivnih modulatora receptora estrogena
CN104146961B (zh) * 2014-07-04 2018-02-27 深圳职业技术学院 一种薄膜蒸发法制备载细胞因子和骨蛋白微球的方法
KR102676629B1 (ko) 2015-04-29 2024-06-18 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
WO2017007777A2 (en) * 2015-07-06 2017-01-12 Zhengxin Dong NOVEL FORMULATIONS OF PTHrP ANALOGUE
CA3020333A1 (en) 2016-04-18 2017-10-26 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
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JOP20210218A1 (ar) 2019-02-12 2023-01-30 Radius Pharmaceuticals Inc عمليات ومركبات
EP4027899A4 (en) * 2019-09-12 2023-08-16 Radius Health, Inc. METHODS OF ENHANCING SPINE FUSION USING ABALOPARATIDE
CN112646042A (zh) * 2019-10-10 2021-04-13 陕西麦科奥特科技有限公司 活性多肽化合物
WO2022149066A1 (en) * 2021-01-05 2022-07-14 Radius Health, Inc. Treatment of long bone fractures with abaloparatide

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DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
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Also Published As

Publication number Publication date
CA2302255C (en) 2011-11-08
RS49707B (sr) 2007-12-31
EP1005359B1 (en) 2005-06-15
CN1210059C (zh) 2005-07-13
CO4890856A1 (es) 2000-02-28
ES2244090T3 (es) 2005-12-01
PE117399A1 (es) 1999-11-20
KR100679778B1 (ko) 2007-02-07
CZ298701B6 (cs) 2007-12-27
AU752925B2 (en) 2002-10-03
PL339449A1 (en) 2000-12-18
ATE297754T1 (de) 2005-07-15
WO1999012561A3 (en) 1999-05-14
DE69830591D1 (de) 2005-07-21
PL195703B1 (pl) 2007-10-31
HU226866B1 (en) 2009-12-28
CZ2000862A3 (cs) 2000-09-13
NO20001195D0 (no) 2000-03-08
HUP0004560A3 (en) 2005-11-28
SA98190565B1 (ar) 2006-07-30
CA2302255A1 (en) 1999-03-18
NO323740B1 (no) 2007-07-02
WO1999012561A9 (en) 2000-03-16
CN1269726A (zh) 2000-10-11
US20020077281A1 (en) 2002-06-20
RU2224539C2 (ru) 2004-02-27
YU12700A (sh) 2004-09-03
EP1005359A2 (en) 2000-06-07
HUP0004560A2 (hu) 2001-04-28
BR9812068A (pt) 2000-09-26
AR015435A1 (es) 2001-05-02
DE69830591T2 (de) 2006-05-04
US6583114B2 (en) 2003-06-24
TW552139B (en) 2003-09-11
MA26545A1 (fr) 2004-12-20
AU9740698A (en) 1999-03-29
MY121291A (en) 2006-01-28
KR20010023795A (ko) 2001-03-26
IL134719A0 (en) 2001-04-30
NO20001195L (no) 2000-03-08
NZ502970A (en) 2002-03-01
UY25172A1 (es) 2001-01-31
IL134719A (en) 2010-04-29
ZA988030B (en) 1999-03-09
JP2002509854A (ja) 2002-04-02
HK1030753A1 (zh) 2001-05-18
WO1999012561A2 (en) 1999-03-18
HRP20000109A2 (en) 2001-02-28

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