TR200000764T2 - Fosfolamban inhibitörleri olarak, 1-okza, aza ve tiyanaftalin-2-on'ların biseterleri. - Google Patents

Fosfolamban inhibitörleri olarak, 1-okza, aza ve tiyanaftalin-2-on'ların biseterleri.

Info

Publication number
TR200000764T2
TR200000764T2 TR2000/00764T TR200000764T TR200000764T2 TR 200000764 T2 TR200000764 T2 TR 200000764T2 TR 2000/00764 T TR2000/00764 T TR 2000/00764T TR 200000764 T TR200000764 T TR 200000764T TR 200000764 T2 TR200000764 T2 TR 200000764T2
Authority
TR
Turkey
Prior art keywords
alkyl
arylalkyl
aryl
hydrogen
alkenyl
Prior art date
Application number
TR2000/00764T
Other languages
English (en)
Inventor
Pystynen Jarmo
Tiainen Eija
L�nnberg Kari
Nore Pennti
Parhi Seppo
Karjalainen Arto
Haikala Heimo
Levijoki Jouko
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of TR200000764T2 publication Critical patent/TR200000764T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Formül (I) veya (II)'ye sahip, terapötik olarak aktif bilesikler olup, söz konusu formüllerdeki R1; hidrojen, alkil, alkenil, aril, arilalkil, hidroksialkil, halojenalkil, alkoksi, COR10, CONR10R11, OR10, S(O)mR10, NR10COR11 veya NR10R11 olup, R10; hidrojen, alkil, alkenil, aril, arilalkil, hidroksialkil, halojenalkil, alkoksi veya hidroksi'dir ve R11 ise hidrojen, alkil, aril, arilalkil, alkoksi, ariloksi, hidroksi veya asil'dir veya X'in NR11 olmasi durumunda, R1; karboksialkil de olabilmektedir, R6; hidrojen, alkil, alkenil, aril, arilalkil' dir, R2 ve R7; hidrojen, alkil, alkenil, aril, arilalkil, COR10, CONR10R11, halojen, triflorometil, nitro veya siyano'dur, buradaki R10 ve R11 ise yukarida tanimlandigi gibidir, R3; hidrojen, alkil, aril veya arilalkil'dir, A; alkil veya substitüsyon islemine tabi tutulan alkil'dir, m; 0-2'dir ve n ise 1-3'tür, Y; O, NR11 veya S'tir, buradaki R11 ise yukarida tanimlananla aynidir, X; O, NR11 veya S'tir, buradaki R11 ise yukarida (DEVAMI VAR...)
TR2000/00764T 1997-09-24 1998-09-24 Fosfolamban inhibitörleri olarak, 1-okza, aza ve tiyanaftalin-2-on'ların biseterleri. TR200000764T2 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93711997A 1997-09-24 1997-09-24
US99015097A 1997-12-12 1997-12-12
US10411498A 1998-06-25 1998-06-25

Publications (1)

Publication Number Publication Date
TR200000764T2 true TR200000764T2 (tr) 2001-03-21

Family

ID=27379660

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00764T TR200000764T2 (tr) 1997-09-24 1998-09-24 Fosfolamban inhibitörleri olarak, 1-okza, aza ve tiyanaftalin-2-on'ların biseterleri.

Country Status (18)

Country Link
EP (1) EP1017691A1 (tr)
JP (1) JP2003525838A (tr)
KR (1) KR20010015607A (tr)
CN (1) CN1143857C (tr)
AU (1) AU735729B2 (tr)
BR (1) BR9813216A (tr)
CA (1) CA2304849A1 (tr)
EA (1) EA003084B1 (tr)
EE (1) EE04494B1 (tr)
HU (1) HUP0003647A3 (tr)
ID (1) ID24373A (tr)
IL (1) IL134662A0 (tr)
NO (1) NO20001569L (tr)
NZ (1) NZ503044A (tr)
PL (1) PL339493A1 (tr)
SK (1) SK3902000A3 (tr)
TR (1) TR200000764T2 (tr)
WO (1) WO1999015523A1 (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002008217A2 (en) * 2000-07-21 2002-01-31 Chugai Seiyaku Kabushiki Kaisha COUMARIN DERIVATIVES USEFUL AS TNFα INHIBITORS
ATE348100T1 (de) * 2001-03-30 2007-01-15 Pfizer Prod Inc Zwischenprodukten für die herstellung von pyridazinon aldose reductase inhibitoren.
US7572910B2 (en) 2003-02-20 2009-08-11 Pfizer, Inc. Pyridazinone aldose reductase inhibitors
FR2970964B1 (fr) * 2011-01-28 2013-12-13 Univ Claude Bernard Lyon Nouveaux derives d'azacoumarines presentant une activite inhibitrice des pompes mdr
UY40699A (es) 2023-04-05 2024-08-30 Ionis Pharmaceuticals Inc Compuestos y métodos para reducir la expresión de pln

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2543945A1 (de) * 1975-10-02 1977-04-21 Troponwerke Gmbh & Co Kg 2-benzopyranonderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
ES2070151T3 (es) * 1988-08-10 1995-06-01 Otsuka Pharma Co Ltd Agentes cardiotonicos.
CA2022236A1 (en) * 1989-07-31 1991-02-01 Hiroaki Yanagisawa Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders
DE4337906A1 (de) * 1993-11-08 1995-05-11 Cassella Ag Verwendung von Cumarinderivaten

Also Published As

Publication number Publication date
KR20010015607A (ko) 2001-02-26
HUP0003647A2 (hu) 2001-08-28
EE200000179A (et) 2001-04-16
SK3902000A3 (en) 2000-12-11
BR9813216A (pt) 2000-08-29
AU9350898A (en) 1999-04-12
NZ503044A (en) 2001-08-31
CA2304849A1 (en) 1999-04-01
NO20001569D0 (no) 2000-03-24
EP1017691A1 (en) 2000-07-12
EE04494B1 (et) 2005-06-15
HUP0003647A3 (en) 2002-12-28
CN1143857C (zh) 2004-03-31
EA003084B1 (ru) 2002-12-26
NO20001569L (no) 2000-03-24
AU735729B2 (en) 2001-07-12
PL339493A1 (en) 2000-12-18
JP2003525838A (ja) 2003-09-02
EA200000352A1 (ru) 2000-10-30
CN1271357A (zh) 2000-10-25
IL134662A0 (en) 2001-04-30
WO1999015523A1 (en) 1999-04-01
ID24373A (id) 2000-07-13

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