TR200000812T2 - 2-metil-tieno- benzodiazepin formülasyonu. - Google Patents

2-metil-tieno- benzodiazepin formülasyonu.

Info

Publication number
TR200000812T2
TR200000812T2 TR2000/00812T TR200000812T TR200000812T2 TR 200000812 T2 TR200000812 T2 TR 200000812T2 TR 2000/00812 T TR2000/00812 T TR 2000/00812T TR 200000812 T TR200000812 T TR 200000812T TR 200000812 T2 TR200000812 T2 TR 200000812T2
Authority
TR
Turkey
Prior art keywords
thieno
methyl
benzodiazepine formulation
formulation
olanzapine
Prior art date
Application number
TR2000/00812T
Other languages
English (en)
Inventor
James Allen Douglas
Douglas Dekemper Kurt
Harry Ferguson Thomas
James Garvin Stuart
Carmeron Murray Linda
Dale Brooks Norman
Arthur Bunnell Charles
Arnold Hendriksen Barry
Singh Mascarenhas Snethlata
Louise Shinkle Sharon
Vincente Sanchez-Felix Manuel
Edward Tupper David
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR200000812T2 publication Critical patent/TR200000812T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Biochemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Bulus, olanzapin veya bunun pamoat tuzu veya solvatinin farmasötik olarak kabul edilebilir oleajinöz veya kolesterol mikrosfer formülasyonunu saglamaktadir. Bulus, ayrica yeni olanzapin paomat tuzlari veya bunun solvatlarini saglamaktadir.
TR2000/00812T 1997-09-30 1998-09-30 2-metil-tieno- benzodiazepin formülasyonu. TR200000812T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6049397P 1997-09-30 1997-09-30

Publications (1)

Publication Number Publication Date
TR200000812T2 true TR200000812T2 (tr) 2001-07-23

Family

ID=22029843

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00812T TR200000812T2 (tr) 1997-09-30 1998-09-30 2-metil-tieno- benzodiazepin formülasyonu.

Country Status (20)

Country Link
US (1) US6169084B1 (tr)
EP (1) EP1018880A4 (tr)
JP (2) JP4503826B2 (tr)
KR (1) KR100537713B1 (tr)
CN (1) CN1239158C (tr)
AU (1) AU752552C (tr)
BR (1) BR9813228A (tr)
CA (1) CA2304568C (tr)
CZ (1) CZ300725B6 (tr)
EA (1) EA002825B1 (tr)
HR (1) HRP20000181B1 (tr)
HU (1) HUP0004534A3 (tr)
ID (1) ID25533A (tr)
IL (2) IL135295A0 (tr)
NO (1) NO20001631L (tr)
NZ (1) NZ503641A (tr)
PL (1) PL339864A1 (tr)
TR (1) TR200000812T2 (tr)
UA (1) UA73715C2 (tr)
WO (1) WO1999016313A1 (tr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617321B2 (en) * 1997-09-30 2003-09-09 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
AU759751B2 (en) * 1998-09-30 2003-05-01 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
DE10041479A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
US20040067936A1 (en) * 2000-08-31 2004-04-08 Reguri Buchi Reddy Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine
US6988887B2 (en) * 2002-02-18 2006-01-24 3M Innovative Properties Company Orthodontic separators
US7323459B2 (en) * 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
ATE504588T1 (de) 2004-01-27 2011-04-15 Synthon Bv Stabile salze von olanzapin
US7728015B2 (en) * 2004-04-22 2010-06-01 Mor Research Applications Ltd. Compositions for weight management
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
EP2623095A1 (en) * 2004-11-16 2013-08-07 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
US20090155331A1 (en) * 2005-11-16 2009-06-18 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
WO2006071520A2 (en) * 2004-12-10 2006-07-06 University Of Connecticut Shape memory polymer orthodontic appliances, and methods of making and using the same
EP1838716B1 (en) * 2005-01-05 2011-06-01 Eli Lilly And Company Olanzapine pamoate dihydrate
CZ2006697A3 (cs) * 2006-11-07 2008-05-21 Zentiva, A. S. Kompozice depotních olanzapinových injekcních systému
US9161943B2 (en) 2007-12-31 2015-10-20 Industrial Technology Research Institute Sustained release composition and manufacturing method thereof
WO2010144325A1 (en) * 2009-06-08 2010-12-16 Boston Scientific Scimed, Inc. Crosslinked bioabsorbable medical devices
KR101435296B1 (ko) 2009-06-24 2014-08-27 머크 샤프 앤 도메 비.브이. 아세나핀을 함유하는 주사가능한 제제 및 그를 사용한 치료 방법
WO2011091142A2 (en) 2010-01-20 2011-07-28 Teva Pharmaceutical Industries Ltd. Crystalline and amorphous forms of olanzapine pamoate
JP5222917B2 (ja) * 2010-09-21 2013-06-26 財團法人工業技術研究院 徐放性組成物およびその製造方法
US9469630B2 (en) 2010-10-18 2016-10-18 Sumitomo Dainippon Pharma Co., Ltd. Sustained-release formulation for injection
ES2972387T3 (es) 2011-03-18 2024-06-12 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden ésteres de sorbitán
WO2013078608A1 (en) 2011-11-29 2013-06-06 Ziqiang Gu Donepezil pamoate and methods of making and using the same
WO2013088255A1 (en) * 2011-12-15 2013-06-20 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
WO2013142202A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
CA2867121C (en) 2012-03-19 2021-05-25 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
US9999670B2 (en) 2012-03-19 2018-06-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
JP6042153B2 (ja) * 2012-09-26 2016-12-14 株式会社トクヤマ オランザピンの製造方法
US20160175313A1 (en) 2013-08-06 2016-06-23 Dongkook Pharmaceutical Co., Ltd., Entecavir microspheres and pharmaceutical composition for parenteral administration containing same
US9883922B2 (en) 2013-11-29 2018-02-06 Dentsply Sirona Inc. Dental wedge
AU2015231278B2 (en) 2014-03-20 2020-01-23 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
ITUB20153652A1 (it) * 2015-09-16 2017-03-16 Fatro Spa Microsfere contenenti lattoni macrociclici antielminitici
US20170079985A1 (en) * 2015-09-21 2017-03-23 Teva Pharmaceuticals International Gmbh Sustained release olanzapine formulations
EP3600258A1 (en) 2017-03-20 2020-02-05 Teva Pharmaceuticals International GmbH Sustained release olanzapine formulaitons
EP3735223A4 (en) 2018-01-05 2021-10-13 Impel Neuropharma Inc. INTRANASAL ADMINISTRATION OF OLANZAPINE BY A PRECISION OLFACTORY DEVICE
AU2019230014B2 (en) 2018-03-05 2024-11-28 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
CN108969478A (zh) * 2018-08-29 2018-12-11 江南大学 一种美金刚难溶盐缓释注射剂及其制备方法
AU2021269223A1 (en) * 2020-05-05 2022-12-08 Syneurx International (Taiwan) Corp. Salts of neuroceuticals and uses thereof
CN112569191A (zh) * 2020-10-16 2021-03-30 长春斯菲尔生物科技有限公司 一种奥氮平双羟萘酸盐缓释微粒制剂喷雾制备方法
HUP2100259A1 (hu) 2021-07-07 2023-01-28 Richter Gedeon Nyrt Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények
KR20240130825A (ko) * 2022-01-20 2024-08-29 테바 파마슈티컬스 인터내셔널 게엠베하 올란자핀, 이의 조성물 및 이의 사용 방법
CN116675654B (zh) * 2022-02-22 2025-06-13 上海云晟研新生物科技有限公司 卡利拉嗪药用盐及其晶型、药物组合物、制备方法和用途
EP4618961A4 (en) * 2022-11-16 2026-05-27 Foresee Pharmaceuticals Co Ltd DEPOT COMPOSITIONS FOR VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) INHIBITORS

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324192A1 (de) * 1983-07-05 1985-01-17 Troponwerke Gmbh & Co Kg Depot-antiphlogistika
US4816247A (en) * 1985-09-11 1989-03-28 American Cyanamid Company Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs
US4784845A (en) * 1985-09-16 1988-11-15 American Cyanamid Company Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
JPH01284333A (ja) * 1988-05-11 1989-11-15 T Hasegawa Co Ltd 乳化液組成物
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5605897A (en) * 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
TW376319B (en) * 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
CA2178592C (en) 1993-12-09 2009-07-28 Zentaris Gmbh Long-acting injection suspensions and a process for their preparation
JP3701693B2 (ja) * 1993-12-28 2005-10-05 日本製薬株式会社 鎮痛薬含有注射用徐放性脂肪乳剤
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US5776928A (en) * 1995-04-21 1998-07-07 Eli Lilly And Company Method for treating dyskinesias with olanzapine
CA2222073A1 (en) * 1995-06-01 1996-12-05 Charles Merritt Beasley Jr. Method for treating anorexia
US5602897A (en) * 1995-06-29 1997-02-11 Picker International, Inc. High-voltage power supply for x-ray tubes
US5891461A (en) 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
JPH09157159A (ja) * 1995-12-11 1997-06-17 Lion Corp カロチノイド含有組成物

Also Published As

Publication number Publication date
HUP0004534A2 (hu) 2001-05-28
CA2304568A1 (en) 1999-04-08
PL339864A1 (en) 2001-01-15
NZ503641A (en) 2002-09-27
UA73715C2 (en) 2005-09-15
EP1018880A4 (en) 2006-06-14
AU9591498A (en) 1999-04-23
WO1999016313A1 (en) 1999-04-08
US6169084B1 (en) 2001-01-02
IL135295A0 (en) 2001-05-20
EP1018880A1 (en) 2000-07-19
JP2010138208A (ja) 2010-06-24
KR20010030774A (ko) 2001-04-16
JP4503826B2 (ja) 2010-07-14
CN1271251A (zh) 2000-10-25
ID25533A (id) 2000-10-12
HUP0004534A3 (en) 2002-10-28
CZ20001162A3 (cs) 2000-09-13
EA002825B1 (ru) 2002-10-31
JP2001517685A (ja) 2001-10-09
EA200000381A1 (ru) 2000-10-30
NO20001631L (no) 2000-05-30
HRP20000181A2 (en) 2000-12-31
CN1239158C (zh) 2006-02-01
AU752552C (en) 2003-09-11
IL135295A (en) 2006-10-31
AU752552B2 (en) 2002-09-19
NO20001631D0 (no) 2000-03-29
HRP20000181B1 (en) 2006-07-31
KR100537713B1 (ko) 2005-12-20
BR9813228A (pt) 2000-08-29
CA2304568C (en) 2008-08-12
CZ300725B6 (cs) 2009-07-29

Similar Documents

Publication Publication Date Title
BR9813228A (pt) Formulação de 2-metil-tieno-benzodiazepina
DK1468689T3 (da) 2-methyl-thieno-benzodiazepine formulation
NO20010556D0 (no) Fremgangsmåte for oftalmisk administrering
PT1000048E (pt) Derivados substituidos do 1,2,3,4-tetrahidronaftaleno
MX210114B (es) Formulacion de cemento.
IT1295645B1 (it) Apparecchio per l'elettroemanazione di principi attivi.
PT921125E (pt) Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
TR199800988A3 (tr) 5' Deoksi-Sitidin türevleri.
NO20001514L (no) Vitronectin-reseptor-antagonist
IT1302243B1 (it) Sintesi dell'1,1,1,3,3-pentafluoropropano.
NO974934L (no) 10,13,15-trioksatrisyklo£9.2.1.19.6|pentadekanonderivater, fremgangsmÕte for deres fremstilling og legemidler som inneholder disse forbindelsene
TR199800403A3 (tr) a-Bromo-laktam türevlerinin hazirlanmasi için yöntem.
DK1073447T3 (da) N1-modificerede glycopeptider
UY26574A1 (es) " procedimiento para la separación enzimática de racematos de derivados de aminometil-aril-ciclohexanol".
TR199800068A3 (tr) Benzofenon türevlerinin hazirlanmasina yönelik metodlar.
NO965165D0 (no) Anvendelse av 8,9-dehydroestron som en antioksydant
TR199900757A3 (tr) Fenoksifenilsülfonil halidlerin hazirlanmasi için islem.
ID16434A (id) Senyawa-senyawa 1,4-dihidropiridin
IT9022507A0 (it) Procedimento per la preparazione di n-(26ammino63,5-dibromo-benzil)-trans-4-amminocicloesanolo3.
ECSP972052A (es) Quinoxalinadionas
ITBO970720A0 (it) Procedimento per il trattamento di tessuti.
ITMI970682A0 (it) Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4- tetraidroisochinolin-3- carbossiammide
ITMI930340A0 (it) Procedimento per la preparazione di 5-oxo-2-pirroliconcarbossilato di piridossina
ITBZ930044A0 (it) Procedimento per la ricerca di anticorpi anti-endomisio umani.
ITRM940151A0 (it) Impiego di esteruretani per la riconcia.