TR200000988T2 - Bakteri kolonizasyonunun kontrol edilmesi için bileşimler - Google Patents
Bakteri kolonizasyonunun kontrol edilmesi için bileşimlerInfo
- Publication number
- TR200000988T2 TR200000988T2 TR2000/00988T TR200000988T TR200000988T2 TR 200000988 T2 TR200000988 T2 TR 200000988T2 TR 2000/00988 T TR2000/00988 T TR 2000/00988T TR 200000988 T TR200000988 T TR 200000988T TR 200000988 T2 TR200000988 T2 TR 200000988T2
- Authority
- TR
- Turkey
- Prior art keywords
- enzyme
- anchor
- bacterial
- compositions
- complex
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 208000034309 Bacterial disease carrier Diseases 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 210000000214 mouth Anatomy 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Birds (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Bakteri büyümesi/kolonizasyonunun kontrol edilmesi için bir bilesim temin edilmistir. Bilesim, bir enzimi, bir enzim-ankor kompleksini olusturmak üzere enzime baglanmis bir ankor molekülünü içermektedir, ankor, bir bakteri kolonisine yakin bir alt-tabakaya baglanabilmektedir. Alt-tabakaya baglanma, bakteri kolonisinin kompleksin etkililigini arttirmak üzere mevcut oldugu kisimda, enzim-ankor kompleksinin tutulma süresini uzatmaktadir. Bulus, ayni zamanda, agiz boslugunda bakteri plakinin kolonizasyonunun kontrol edilmesi için bir yöntem olmanin yanisira, agiz boslugu içinde bakteri kolonilerinin çogalmasinin kontrol edilmesi için bir bilesimin olusturulmasi için bir yöntemdir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/951,393 US5871714A (en) | 1997-10-16 | 1997-10-16 | Compositions for controlling bacterial colonization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000988T2 true TR200000988T2 (tr) | 2000-08-21 |
Family
ID=25491643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00988T TR200000988T2 (tr) | 1997-10-16 | 1998-10-13 | Bakteri kolonizasyonunun kontrol edilmesi için bileşimler |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5871714A (tr) |
| EP (1) | EP1023084A1 (tr) |
| JP (1) | JP2001519404A (tr) |
| KR (1) | KR20010015757A (tr) |
| CN (1) | CN1276732A (tr) |
| AU (1) | AU742762B2 (tr) |
| BR (1) | BR9812923A (tr) |
| CA (1) | CA2306459A1 (tr) |
| CU (1) | CU22838A3 (tr) |
| CZ (1) | CZ20001237A3 (tr) |
| EA (1) | EA002244B1 (tr) |
| HU (1) | HUP0100016A2 (tr) |
| ID (1) | ID24368A (tr) |
| IL (1) | IL135628A0 (tr) |
| IN (1) | IN2002DE00891A (tr) |
| MX (1) | MXPA00003618A (tr) |
| NO (1) | NO20001885L (tr) |
| NZ (1) | NZ503974A (tr) |
| PL (1) | PL339900A1 (tr) |
| TR (1) | TR200000988T2 (tr) |
| WO (1) | WO1999018999A1 (tr) |
| ZA (1) | ZA989024B (tr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830745B1 (en) * | 1997-10-16 | 2004-12-14 | Pharmacal Biotechnologies, Llc | Compositions for treating biofilm |
| US6159447A (en) * | 1997-10-16 | 2000-12-12 | Pharmacal Biotechnologies, Llc | Compositions for controlling bacterial colonization |
| US20020022005A1 (en) * | 1997-10-16 | 2002-02-21 | Budny John A. | Compositions for treating cystic fibrosis |
| US5972311A (en) * | 1998-01-26 | 1999-10-26 | Duke University | Method of preventing dental caries and other oral lesions |
| DE19909770A1 (de) | 1999-03-05 | 2000-09-07 | Werner Lubitz | Bakterienghosts als Träger- und Targetingvehikel |
| US8522127B2 (en) | 2001-07-16 | 2013-08-27 | Robert G. Adamson, III | Allowing operating system access to non-standard fonts in a network document |
| US10810355B1 (en) | 2001-07-16 | 2020-10-20 | Clantech, Inc. | Allowing operating system access to non-standard fonts in a network document |
| US8394379B2 (en) * | 2003-05-15 | 2013-03-12 | Iogenetics, Llc | Targeted cryptosporidium biocides |
| US20050014932A1 (en) * | 2003-05-15 | 2005-01-20 | Iogenetics, Llc | Targeted biocides |
| US7566447B2 (en) * | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
| US8703134B2 (en) | 2003-05-15 | 2014-04-22 | Iogenetics, Llc | Targeted cryptosporidium biocides |
| US7220405B2 (en) * | 2003-09-08 | 2007-05-22 | E. I. Du Pont De Nemours And Company | Peptide-based conditioners and colorants for hair, skin, and nails |
| CA2585017A1 (en) * | 2004-10-20 | 2006-12-14 | Iogenetics, Llc | Biocides |
| EP2099466B1 (en) * | 2006-12-01 | 2015-06-03 | Laclede, Inc. | Use of hydrolytic and oxidative enzymes to dissolve biofilm in ears |
| JP5628031B2 (ja) | 2007-07-25 | 2014-11-19 | スリーエム イノベイティブ プロパティズ カンパニー | 治療用歯科用組成物及び関連する方法 |
| JP5453260B2 (ja) * | 2007-07-25 | 2014-03-26 | スリーエム イノベイティブ プロパティズ カンパニー | 被膜形成歯科用組成物及び関連する方法 |
| EP2092834A1 (en) * | 2008-02-19 | 2009-08-26 | Innopact B.V. | Methods and compositions of sphingolipid for preventing treating microbial infections |
| WO2012087966A2 (en) | 2010-12-20 | 2012-06-28 | E. I. Du Pont De Nemours And Company | Targeted perhydrolases |
| BR112013015459B8 (pt) | 2010-12-20 | 2018-06-12 | Du Pont | método, produto de cuidado oral e composição de geração de perácido |
| CN102219597B (zh) * | 2011-04-11 | 2013-09-11 | 北京中农瑞利源高科技发展有限公司 | 酶控剂和酶控系列肥料及其在农业中的应用 |
| US20120315260A1 (en) * | 2011-06-13 | 2012-12-13 | Svetlana A. Ivanova | Compositions and Methods to Prevent and Treat Biofilms |
| US10420822B2 (en) | 2011-06-13 | 2019-09-24 | Ziolase, Llc | Compositions and methods to prevent and treat biofilms |
| US9763881B2 (en) | 2012-06-11 | 2017-09-19 | Council Of Scientific And Industrial Research | Rice bran-lipids based formulation and process for preparation thereof for selective delivery of genes to cancer cells |
| KR102360720B1 (ko) * | 2015-06-30 | 2022-02-10 | (주)아모레퍼시픽 | 프라그 기질 용해제 |
| CN111551416B (zh) * | 2020-03-22 | 2021-08-06 | 华南理工大学 | 一种基于细胞膜磷脂酰丝氨酸荧光染色的细菌类凋亡评价方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1373487A (en) * | 1970-10-26 | 1974-11-13 | Guggenheim B | Enzymes their preparation and uses |
| US4335101A (en) * | 1971-08-10 | 1982-06-15 | Merck & Co., Inc. | Oral hygiene enzymes and method for preparation |
| JPS5536317B2 (tr) * | 1972-04-22 | 1980-09-19 | ||
| GB1433593A (en) * | 1972-06-09 | 1976-04-28 | Royal College Of Surgeons | Conjugates |
| US4138476A (en) * | 1977-08-03 | 1979-02-06 | The United States Of America As Represented By The Secretary Of The Navy | Plaque dispersing enzymes as oral therapeutic agents by molecular alteration |
| JPS57165312A (en) * | 1981-04-03 | 1982-10-12 | Handai Biseibutsubiyou Kenkyukai | Production of oral composition |
| JPH0641424B2 (ja) * | 1984-11-06 | 1994-06-01 | ライオン株式会社 | う蝕予防剤 |
| US5306639A (en) * | 1985-03-20 | 1994-04-26 | Aizo Matsushiro | DNA encoding glucanase enzymes |
| US4737359A (en) * | 1985-04-18 | 1988-04-12 | Colgate-Palmolive Company | Control of dental plaque and caries using emulsan |
| GB8528761D0 (en) * | 1985-11-22 | 1985-12-24 | Axon Healthcare Ltd | Enzyme-coupled antibodies |
| WO1991000112A1 (en) * | 1989-06-30 | 1991-01-10 | Brunswick Corporation | Antibody-lactate oxidase conjugates |
| JPH0363215A (ja) * | 1989-07-29 | 1991-03-19 | Nakano Vinegar Co Ltd | 歯垢分解組成物 |
| AU642980B2 (en) * | 1990-03-21 | 1993-11-04 | Quest International B.V. | Ultilization of enzymes |
| AU642979B2 (en) * | 1990-03-21 | 1993-11-04 | Quest International B.V. | Utilization and delivery of enzymes |
| GB9021671D0 (en) * | 1990-10-05 | 1990-11-21 | Unilever Plc | Delivery of agents |
| US5202113A (en) * | 1990-04-30 | 1993-04-13 | The United States Of America As Represented By The Department Of Health And Human Services | Plaque-inhibiting protein from bacteroides loeschei and methods for using the same |
| US5362480A (en) * | 1991-12-31 | 1994-11-08 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions containing amino sugars as antiplaque agents |
| US5409902A (en) * | 1991-12-31 | 1995-04-25 | Lever Brothers Company | Oral hygiene compositions containing glyceroglycolipids as antiplaque compounds |
| US5320831A (en) * | 1992-12-30 | 1994-06-14 | The Procter & Gamble Company | Oral compositions |
| US5490978A (en) * | 1993-10-15 | 1996-02-13 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Block copolymers of polysaccharides and polyalkylene oxides |
| EP0824019B1 (en) * | 1996-08-13 | 2002-11-20 | Quest International B.V. | Inhibition or reduction of oral malodour |
-
1997
- 1997-10-16 US US08/951,393 patent/US5871714A/en not_active Expired - Lifetime
-
1998
- 1998-10-02 ZA ZA989024A patent/ZA989024B/xx unknown
- 1998-10-13 CZ CZ20001237A patent/CZ20001237A3/cs unknown
- 1998-10-13 NZ NZ503974A patent/NZ503974A/en unknown
- 1998-10-13 PL PL98339900A patent/PL339900A1/xx unknown
- 1998-10-13 BR BR9812923-6A patent/BR9812923A/pt not_active IP Right Cessation
- 1998-10-13 JP JP2000515630A patent/JP2001519404A/ja active Pending
- 1998-10-13 EP EP98952294A patent/EP1023084A1/en not_active Withdrawn
- 1998-10-13 HU HU0100016A patent/HUP0100016A2/hu unknown
- 1998-10-13 AU AU98028/98A patent/AU742762B2/en not_active Ceased
- 1998-10-13 IL IL13562898A patent/IL135628A0/xx unknown
- 1998-10-13 ID IDW20000675A patent/ID24368A/id unknown
- 1998-10-13 EA EA200000422A patent/EA002244B1/ru not_active IP Right Cessation
- 1998-10-13 WO PCT/US1998/021656 patent/WO1999018999A1/en not_active Ceased
- 1998-10-13 CA CA002306459A patent/CA2306459A1/en not_active Abandoned
- 1998-10-13 KR KR1020007003979A patent/KR20010015757A/ko not_active Withdrawn
- 1998-10-13 TR TR2000/00988T patent/TR200000988T2/tr unknown
- 1998-10-13 CN CN98810256A patent/CN1276732A/zh active Pending
-
2000
- 2000-04-12 CU CU20000079A patent/CU22838A3/es unknown
- 2000-04-12 NO NO20001885A patent/NO20001885L/no not_active Application Discontinuation
- 2000-04-13 MX MXPA00003618 patent/MXPA00003618A/es unknown
-
2002
- 2002-09-02 IN IN891DE2002 patent/IN2002DE00891A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ID24368A (id) | 2000-07-13 |
| BR9812923A (pt) | 2000-08-08 |
| IL135628A0 (en) | 2001-05-20 |
| US5871714A (en) | 1999-02-16 |
| NZ503974A (en) | 2002-05-31 |
| HUP0100016A2 (hu) | 2001-05-28 |
| PL339900A1 (en) | 2001-01-15 |
| ZA989024B (en) | 1999-04-07 |
| AU9802898A (en) | 1999-05-03 |
| EA002244B1 (ru) | 2002-02-28 |
| NO20001885L (no) | 2000-06-14 |
| AU742762B2 (en) | 2002-01-10 |
| CA2306459A1 (en) | 1999-04-22 |
| KR20010015757A (ko) | 2001-02-26 |
| CU22838A3 (es) | 2006-04-18 |
| NO20001885D0 (no) | 2000-04-12 |
| CZ20001237A3 (cs) | 2000-08-16 |
| IN2002DE00891A (tr) | 2005-01-21 |
| CN1276732A (zh) | 2000-12-13 |
| WO1999018999A1 (en) | 1999-04-22 |
| EP1023084A1 (en) | 2000-08-02 |
| JP2001519404A (ja) | 2001-10-23 |
| EA200000422A1 (ru) | 2000-10-30 |
| MXPA00003618A (es) | 2001-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200000422A1 (ru) | Композиция для управления образованием бактериальных колоний | |
| MXPA02012326A (es) | Peptidos quimicamente modificados, composiciones y metodos para su produccion y uso. | |
| ATE300272T1 (de) | Verwendung von zahnprothesenhaftmitteln zur zahnsteinbildungskontrolle | |
| IL121895A (en) | Slow release composition for oral consumption containing a zinc compound an amino acid and copper compound | |
| BG103977A (en) | Low molecular rotamase enzymic activity inhibitors | |
| GEP20022617B (en) | 3-Heterocyclic YL-Substituted Benzoyl Derivatives, Method for Their Production, Herbicidal Preparation and Method for Undesirable Plants Control | |
| UA41275C2 (uk) | Гербіцидна композиція та спосіб контролю росту небажаних рослин | |
| DE60332101D1 (de) | Antimikrobielle zusammensetzung | |
| ATE331496T1 (de) | Zahnprothesenhaftmittel mit zahnsteinbildungskontrolle | |
| EP0743311A4 (en) | FLAVANONOL DERIVATIVES AND COMPOSITION CONTAINING SUCH DERIVATIVES SUITABLE FOR FEEDING HAIR AND STIMULATING THEIR GROWTH | |
| BR0317520A (pt) | Composições de inibidores de proteìna de transferência de ésteres de colesterilo e inibidores de hmg-coa redutase | |
| PT999750E (pt) | Composicao antifungica | |
| DE60334846D1 (de) | VERWENDUNG von LIGNINPEROXIDASE ZUR HAUT- UND HAARAUFHELLUNG | |
| NZ502239A (en) | Synergistic antimicrobial compositions containing a dimethylamide of a carboxylic acid with a mixture of 2-(thiocyanomethylthio) benzothiazole and methylene-bis(thiocyanate) | |
| EP0469040A4 (en) | HYGIENIC TOOTH COMPOSITION TO REDUCE PERIODONTAL DISEASES. | |
| EP1503798B8 (en) | Stabilised solid compositions of modified factor vii | |
| MXPA04001248A (es) | Reduccion del crecimiento del vello. | |
| GR3032698T3 (en) | Organic compounds | |
| SI1525188T1 (sl) | Novi derivati 4,4-ditiobis-(3-aminobutan-1-sulfonatov) in sestavki, ki jih vsebujejo | |
| ATE185682T1 (de) | Für die vermeidung/begrenzung von mikrobiologisch beeinflusster korrosion und verfärbung verwendbare borate | |
| GR980100040A (el) | Ζιζανιοκτονος συνεργικη συνθεση και μεθοδος ελεγχου ζιζανιων | |
| EP1088896A3 (en) | Chromogenic media containing blood or hemin | |
| EP1133991A4 (en) | BACTERIOSTATIC COMPOSITIONS AGAINST SALMONELLA | |
| MX9605346A (es) | Compuesto antimicrobianos con velocidad rapida de eliminacion. | |
| FI940917L (fi) | Menetelmä ja koostumus mikro-organismien kasvun kontrolloimiseksi |