TR200001892T2 - Monomer cinsi ensülin analogları ve bunların kullanımı. - Google Patents

Monomer cinsi ensülin analogları ve bunların kullanımı.

Info

Publication number
TR200001892T2
TR200001892T2 TR2000/01892T TR200001892T TR200001892T2 TR 200001892 T2 TR200001892 T2 TR 200001892T2 TR 2000/01892 T TR2000/01892 T TR 2000/01892T TR 200001892 T TR200001892 T TR 200001892T TR 200001892 T2 TR200001892 T2 TR 200001892T2
Authority
TR
Turkey
Prior art keywords
monomer
genus
insulin analogues
insulin analog
administration
Prior art date
Application number
TR2000/01892T
Other languages
English (en)
Inventor
Dennis Dimarchi Richard
Garrick Harrison Roger
Keith Wolff Ronald
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR200001892T2 publication Critical patent/TR200001892T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Mevcut bulus, diyabet tedavisi için, monomer cinsi bir ensülin analogunun solunum vasitasiyla verilmesini ve hiperglisemi için bir ensülin analogunun solunum vasitasiyla verilmesini içeren, bir ensülin analogunun solunumla kullanimi ile ilgilidir.
TR2000/01892T 1998-01-08 1999-01-07 Monomer cinsi ensülin analogları ve bunların kullanımı. TR200001892T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7075298P 1998-01-08 1998-01-08

Publications (1)

Publication Number Publication Date
TR200001892T2 true TR200001892T2 (tr) 2000-11-21

Family

ID=22097181

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/01891T TR200001891T2 (tr) 1998-01-08 1999-01-07 ASPB28- İnsan ensülini ve kullanımı.
TR2000/01892T TR200001892T2 (tr) 1998-01-08 1999-01-07 Monomer cinsi ensülin analogları ve bunların kullanımı.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TR2000/01891T TR200001891T2 (tr) 1998-01-08 1999-01-07 ASPB28- İnsan ensülini ve kullanımı.

Country Status (16)

Country Link
US (2) US20010007853A1 (tr)
EP (2) EP0951911A3 (tr)
JP (2) JP2002500192A (tr)
KR (2) KR20010033940A (tr)
CN (2) CN1287492A (tr)
AU (2) AU754707B2 (tr)
BR (2) BR9906813A (tr)
CA (2) CA2317733A1 (tr)
EA (2) EA200000748A1 (tr)
HU (2) HUP0101293A3 (tr)
IL (2) IL137150A0 (tr)
NO (2) NO20003050L (tr)
PL (2) PL342745A1 (tr)
TR (2) TR200001891T2 (tr)
WO (2) WO1999034815A1 (tr)
ZA (2) ZA99104B (tr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US20060171899A1 (en) * 1998-12-10 2006-08-03 Akwete Adjei Water-stabilized aerosol formulation system and method of making
US6858199B1 (en) * 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
AU5453300A (en) * 1999-06-29 2001-01-31 Eli Lilly And Company Insulin crystals for pulmonary administration
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
WO2002043580A2 (en) 2000-10-27 2002-06-06 Epic Therapeutics, Inc. Production of microspheres
EP1418890B1 (en) * 2001-08-16 2008-05-14 Baxter International Inc. Propellant-based microparticle formulations
EP1944016A1 (en) 2001-08-16 2008-07-16 Baxter International Inc. Propellant-based microparticle formulatons
JP2005514188A (ja) * 2001-12-07 2005-05-19 エイフェル テクノロジーズ リミテッド 小粒子の合成
US20050107441A1 (en) * 2001-12-21 2005-05-19 Kliewer Steven A. Compositions and methods for altering glucose production
US6985798B2 (en) * 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
US6889690B2 (en) 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US7118010B2 (en) 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
SI1535349T1 (sl) 2002-06-27 2014-10-30 Oriel Therapeutics, Inc. Naprave, sistemi in ustrezni postopki za predelavo, izdajo in/ali vrednotenje nefarmacevtskih suhih praškov
WO2005044173A1 (en) 2003-10-27 2005-05-19 Oriel Therapeutics, Inc. Blister packages and associated methods of fabricating dry powder drug containment systems
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
WO2005065756A2 (en) 2003-12-30 2005-07-21 Oriel Therapeutics, Inc. Dry powder nebulizers and associated methods of dispensing dry powders
US7624733B2 (en) 2004-02-09 2009-12-01 Oriel Therapeutics, Inc. Inhalers with extendable/retractable forward member and associated methods of dispensing inhalant substances
US8365725B2 (en) * 2004-09-13 2013-02-05 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
AU2006283113B2 (en) * 2005-08-25 2011-12-01 Oriel Therapeutics, Inc. Drug containment systems with sticks, related kits, dry powder inhalers and methods
AU2007210177C1 (en) 2006-01-31 2012-11-01 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
EP2060268A1 (en) * 2007-11-15 2009-05-20 Novo Nordisk A/S Pharmaceutical compositions for pulmonary or nasal delivery of peptides
CA2732842C (en) 2008-09-26 2018-01-09 Oriel Therapeutics, Inc. Inhalers with airway disks having discrete airway channels and related disks and methods
EP2346554B1 (en) 2008-09-26 2015-09-16 Oriel Therapeutics, Inc. Inhaler mechanisms with radially biased piercers and related methods
US8381721B2 (en) 2008-09-26 2013-02-26 Oriel Therapeutics, Inc. Dry powder inhalers with dual piercing members and related devices and methods
US9050427B2 (en) * 2008-09-30 2015-06-09 Oriel Therapeutics, Inc. Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods
WO2010039200A2 (en) * 2008-09-30 2010-04-08 Oriel Therapeutics, Inc. Dry powder inhalers with endless strips and cooperating piercers and related methods
WO2010039202A2 (en) * 2008-10-01 2010-04-08 Oriel Therapeutics, Inc. Dry powder inhalers with rotating piercing mechanisms and related devices and methods
JP5341532B2 (ja) * 2009-01-19 2013-11-13 第一電子工業株式会社 １対の誤嵌合防止キー及び該キーを用いた電気コネクタ
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法
CA2786996A1 (en) 2010-01-27 2011-07-07 Dan Adler Dry powder inhaler
USD635246S1 (en) 2010-03-26 2011-03-29 Oriel Therapeutics, Inc. Dose disk for dry powder inhalers
USD641076S1 (en) 2010-03-26 2011-07-05 Oriel Therapeutics, Inc. Dry powder inhaler
US10238820B2 (en) 2014-01-08 2019-03-26 Seroton, Inc. Dry-powder inhalation device
US11491288B2 (en) 2014-01-08 2022-11-08 Seroton, Inc. Dispenser for dry-powder inhalation devices
WO2024100652A1 (en) 2022-11-07 2024-05-16 Kritzman Kadron Amnon High performance dry powder inhaler

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK179286D0 (da) * 1986-04-18 1986-04-18 Nordisk Gentofte Insulinpraeparat
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
US5230884A (en) * 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
DE122006000015I1 (de) * 1993-06-21 2006-06-29 Novo Nordisk As Asp-B28-Insulinkristalle
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US5451569A (en) * 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
AR002976A1 (es) * 1995-03-31 1998-05-27 Lilly Co Eli Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
AU5724996A (en) * 1995-05-05 1996-11-21 Eli Lilly And Company Single chain insulin with high bioactivity

Also Published As

Publication number Publication date
ZA99104B (en) 2000-07-07
NO20003050D0 (no) 2000-06-14
EP0951910A2 (en) 1999-10-27
BR9906813A (pt) 2001-03-20
PL341592A1 (en) 2001-04-23
WO1999034816A1 (en) 1999-07-15
EP0951911A2 (en) 1999-10-27
WO1999034815A1 (en) 1999-07-15
US20010007853A1 (en) 2001-07-12
CN1287491A (zh) 2001-03-14
EP0951910A3 (en) 2002-06-19
AU754707B2 (en) 2002-11-21
IL137150A0 (en) 2001-07-24
HUP0101293A3 (en) 2001-12-28
AU747619B2 (en) 2002-05-16
JP2002500193A (ja) 2002-01-08
EP0951911A3 (en) 2002-06-19
ZA99105B (en) 2000-07-07
JP2002500192A (ja) 2002-01-08
BR9906796A (pt) 2000-11-14
NO20003050L (no) 2000-06-14
AU2107399A (en) 1999-07-26
CA2317733A1 (en) 1999-07-15
HUP0100391A2 (hu) 2001-08-28
IL137105A0 (en) 2001-06-14
NO20003051L (no) 2000-06-14
CA2317739A1 (en) 1999-07-15
US20010053761A1 (en) 2001-12-20
HUP0100391A3 (en) 2001-12-28
EA200000748A1 (ru) 2000-12-25
KR20010033941A (ko) 2001-04-25
CN1287492A (zh) 2001-03-14
EA200000747A1 (ru) 2000-12-25
NO20003051D0 (no) 2000-06-14
KR20010033940A (ko) 2001-04-25
AU2312299A (en) 1999-07-26
CN1195543C (zh) 2005-04-06
HUP0101293A2 (hu) 2001-08-28
TR200001891T2 (tr) 2000-11-21
PL342745A1 (en) 2001-07-02

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