TR200100027T2 - Poliketidler, bunların hazırlanmaları ve kullanılan maddeler - Google Patents

Poliketidler, bunların hazırlanmaları ve kullanılan maddeler

Info

Publication number
TR200100027T2
TR200100027T2 TR2001/00027T TR200100027T TR200100027T2 TR 200100027 T2 TR200100027 T2 TR 200100027T2 TR 2001/00027 T TR2001/00027 T TR 2001/00027T TR 200100027 T TR200100027 T TR 200100027T TR 200100027 T2 TR200100027 T2 TR 200100027T2
Authority
TR
Turkey
Prior art keywords
polylinker
nucleic acid
polycetides
preparation
decipher
Prior art date
Application number
TR2001/00027T
Other languages
English (en)
Inventor
Laurenz Kellenberger Johannes
Prancis Leadlay Peter
Staunton James
Jonelle Stutzman-Engwall Kim
ALASTA�R IRVINE McARTHUR HAMISH
Original Assignee
Biotica Technology Limited
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Technology Limited, Pfizer Inc. filed Critical Biotica Technology Limited
Publication of TR200100027T2 publication Critical patent/TR200100027T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Tip I poliketid sentazin en azindan bir kismini desifre eden ve indirgeme ile iliskili enzimleri desifre eden bir ya da daha fazla PKS geninin yerine çok sayida restriksiyon enzim bölgesi olan bir polilinkere sahip olan nükleik asit molekülleri, ayrica istege bagli olarak polilinker içine dahil edilen nükleik asidi içerir, ayrica nükleik asit bir ya da daha fazla redüktif enzimi desifre eder; bu tip nükleik asitleri içine alan plazmidler; bu tip plazmidler ile transfekte olan konak hücreler; bunlara iliskin yöntemleri kapsar.
TR2001/00027T 1998-07-06 1999-07-06 Poliketidler, bunların hazırlanmaları ve kullanılan maddeler TR200100027T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9814622.8A GB9814622D0 (en) 1998-07-06 1998-07-06 Polyketides,their preparation,and materials for use therein

Publications (1)

Publication Number Publication Date
TR200100027T2 true TR200100027T2 (tr) 2001-07-23

Family

ID=10835024

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00027T TR200100027T2 (tr) 1998-07-06 1999-07-06 Poliketidler, bunların hazırlanmaları ve kullanılan maddeler

Country Status (22)

Country Link
US (1) US7001747B1 (tr)
EP (1) EP1095147B1 (tr)
JP (1) JP2002519066A (tr)
KR (1) KR20010074652A (tr)
CN (1) CN1316002A (tr)
AT (1) ATE321138T1 (tr)
AU (1) AU762185B2 (tr)
BR (1) BR9911898B1 (tr)
CA (1) CA2332491A1 (tr)
CZ (1) CZ200123A3 (tr)
DE (1) DE69930515T2 (tr)
GB (1) GB9814622D0 (tr)
HU (1) HUP0105464A2 (tr)
ID (1) ID27760A (tr)
IL (1) IL140439A0 (tr)
MX (1) MXPA00012894A (tr)
NZ (1) NZ509602A (tr)
PL (1) PL345851A1 (tr)
TR (1) TR200100027T2 (tr)
WO (1) WO2000001827A2 (tr)
YU (1) YU1001A (tr)
ZA (1) ZA200100775B (tr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000245457A (ja) 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子
US20040101936A1 (en) * 2000-02-24 2004-05-27 Hirofumi Endo Process for producing avermectin derivative
KR20020012395A (ko) * 2000-08-07 2002-02-16 김종하 사이버 카드 매매제어방법
AT4929U1 (de) * 2001-03-29 2002-01-25 Plansee Tizit Ag Verfahren zur herstellung von hartmetallgranulat
MXPA04008071A (es) * 2002-02-19 2004-11-26 Dow Agrosciences Llc Nuevas sintasas de poliquetida que producen espinosina.
CA2492153C (en) 2002-07-16 2012-05-08 Biotica Technology Limited Production of polyketide fkbp-ligand analogues
US7407941B2 (en) 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
EP2342335B1 (en) 2008-09-24 2015-09-16 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Novel gene cluster
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
AU2011214135B2 (en) 2010-02-09 2014-07-31 Neurovive Pharmaceutical Ab Sanglifehrin based compounds
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
CN106916836B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN106619540A (zh) * 2016-10-10 2017-05-10 东莞市麦亘生物科技有限公司 一种抗肝癌纳米核酸类冻干粉及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
EP0391594B1 (en) * 1989-03-31 1995-10-18 Merck & Co. Inc. Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use
NZ240150A (en) * 1990-10-15 1993-07-27 Merck & Co Inc Fermentation medium and its use in the production of ivermectin derivatives
AP1029A (en) * 1996-07-05 2001-12-11 Biotica Tech Limited Erythromycins and process for their preparation.
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis

Also Published As

Publication number Publication date
IL140439A0 (en) 2002-02-10
DE69930515D1 (de) 2006-05-11
EP1095147B1 (en) 2006-03-22
CA2332491A1 (en) 2000-01-13
NZ509602A (en) 2003-12-19
WO2000001827A2 (en) 2000-01-13
CZ200123A3 (cs) 2001-12-12
PL345851A1 (en) 2002-01-14
GB9814622D0 (en) 1998-09-02
KR20010074652A (ko) 2001-08-04
ATE321138T1 (de) 2006-04-15
CN1316002A (zh) 2001-10-03
ID27760A (id) 2001-04-26
BR9911898A (pt) 2001-03-27
WO2000001827A3 (en) 2000-04-27
JP2002519066A (ja) 2002-07-02
AU762185B2 (en) 2003-06-19
AU4636599A (en) 2000-01-24
BR9911898B1 (pt) 2010-11-30
MXPA00012894A (es) 2002-07-02
HUP0105464A2 (hu) 2002-04-29
EP1095147A2 (en) 2001-05-02
US7001747B1 (en) 2006-02-21
DE69930515T2 (de) 2006-12-14
YU1001A (sh) 2003-04-30
ZA200100775B (en) 2001-11-05
HK1034535A1 (en) 2001-10-26

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